{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:40:59Z","timestamp":1792726859189,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Advanced Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.jare.2026.10.027","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:19:07Z","timestamp":1791991147000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between dental pulp necroptosis-related signaling and elodont incisor growth retardation in hyperglycemic rats"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1611-290X","authenticated-orcid":false,"given":"Min Guk","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7927-9838","authenticated-orcid":false,"given":"Heithem","family":"Ben Amara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Asa\u2019ad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1503-3476","authenticated-orcid":false,"given":"Chan Ho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jare.2026.10.027_b0005","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41684-024-01458-4","article-title":"The continued importance of animals in biomedical research","volume":"53","author":"Chang","year":"2024","journal-title":"Lab Anim"},{"issue":"9","key":"10.1016\/j.jare.2026.10.027_b0010","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/ncb437","article-title":"The mouse ascending: perspectives for human-disease models","volume":"9","author":"Rosenthal","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.jare.2026.10.027_b0015","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/s44222-023-00067-z","article-title":"Biomolecular sensors for advanced physiological monitoring","author":"Flynn","year":"2023","journal-title":"Nat Rev Bioeng"},{"issue":"1","key":"10.1016\/j.jare.2026.10.027_b0020","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/prd.12052","article-title":"Animal models for periodontal regeneration and peri-implant responses","volume":"68","author":"Kantarci","year":"2015","journal-title":"Periodontol 2000"},{"issue":"12","key":"10.1016\/j.jare.2026.10.027_b0025","doi-asserted-by":"crossref","first-page":"10309","DOI":"10.3390\/ijms241210309","article-title":"Experimental models to study diabetes mellitus and its complications: limitations and new opportunities","volume":"24","author":"Martin-Carro","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"10","key":"10.1016\/j.jare.2026.10.027_b0030","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1038\/nprot.2012.113","article-title":"Evaluation of bone regeneration using the rat critical size calvarial defect","volume":"7","author":"Spicer","year":"2012","journal-title":"Nat Protoc"},{"issue":"5","key":"10.1016\/j.jare.2026.10.027_b0035","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrd2476","article-title":"Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials","volume":"8","author":"Calcutt","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.jare.2026.10.027_b0040","first-page":"274","article-title":"Streptozotocin as a tool for induction of rat models of diabetes: a practical guide","volume":"22","author":"Ghasemi","year":"2023","journal-title":"EXCLI J"},{"issue":"1","key":"10.1016\/j.jare.2026.10.027_b0045","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s42826-021-00101-4","article-title":"Experimental animal models for diabetes and its related complications-a review","volume":"37","author":"Kottaisamy","year":"2021","journal-title":"Lab Anim Res"},{"key":"10.1016\/j.jare.2026.10.027_b0050","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1359685","article-title":"Animal models for type 1 and type 2 diabetes: advantages and limitations","volume":"15","author":"Singh","year":"2024","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.jare.2026.10.027_b0055","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.freeradbiomed.2022.03.019","article-title":"Oxidative stress in the pathophysiology of type 2 diabetes and related complications: current therapeutics strategies and future perspectives","volume":"184","author":"Bhatti","year":"2022","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"10.1016\/j.jare.2026.10.027_b0060","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/s41574-020-00443-4","article-title":"Type 1 diabetes mellitus as a disease of the beta-cell (do not blame the immune system?)","volume":"17","author":"Roep","year":"2021","journal-title":"Nat Rev Endocrinol"},{"issue":"9","key":"10.1016\/j.jare.2026.10.027_b0065","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1111\/jdi.14034","article-title":"Contribution of animal models to diabetes research: its history, significance, and translation to humans","volume":"14","author":"Yagihashi","year":"2023","journal-title":"J Diabetes Investig"},{"issue":"2","key":"10.1016\/j.jare.2026.10.027_b0070","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70600","article-title":"Oxidative stress: molecular mechanisms, diseases, and therapeutic targets","volume":"7","author":"Qin","year":"2020","journal-title":"MedComm"},{"issue":"3","key":"10.1016\/j.jare.2026.10.027_b0075","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1056\/NEJM199801153380307","article-title":"Protective and damaging effects of stress mediators","volume":"338","author":"McEwen","year":"1998","journal-title":"N Engl J Med"},{"issue":"15","key":"10.1016\/j.jare.2026.10.027_b0080","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.128834","article-title":"Necroptosis: a crucial pathogenic mediator of human disease","volume":"4","author":"Choi","year":"2019","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.jare.2026.10.027_b0085","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/s41420-023-01581-0","article-title":"Different types of cell death and their shift in shaping disease","volume":"9","author":"Shen","year":"2023","journal-title":"Cell Death Discov"},{"issue":"5","key":"10.1016\/j.jare.2026.10.027_b0090","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","article-title":"The molecular machinery of regulated cell death","volume":"29","author":"Tang","year":"2019","journal-title":"Cell Res"},{"key":"10.1016\/j.jare.2026.10.027_b0095","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-pathol-052016-100247","article-title":"Necroptosis: mechanisms and relevance to disease","volume":"12","author":"Galluzzi","year":"2017","journal-title":"Annu Rev Pathol"},{"issue":"5","key":"10.1016\/j.jare.2026.10.027_b0100","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMra1310050","article-title":"Necroptosis","volume":"370","author":"Linkermann","year":"2014","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.jare.2026.10.027_b0105","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/s12276-021-00634-7","article-title":"Necroptosis molecular mechanisms: recent findings regarding novel necroptosis regulators","volume":"53","author":"Seo","year":"2021","journal-title":"Exp Mol Med"},{"issue":"5","key":"10.1016\/j.jare.2026.10.027_b0110","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1038\/s41423-020-00630-3","article-title":"Necroptosis, pyroptosis and apoptosis: an intricate game of cell death","volume":"18","author":"Bertheloot","year":"2021","journal-title":"Cell Mol Immunol"},{"issue":"1","key":"10.1016\/j.jare.2026.10.027_b0115","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41420-020-00370-3","article-title":"Mitochondrial ROS prime the hyperglycemic shift from apoptosis to necroptosis","volume":"6","author":"Deragon","year":"2020","journal-title":"Cell Death Discov"},{"issue":"26","key":"10.1016\/j.jare.2026.10.027_b0120","doi-asserted-by":"crossref","first-page":"13753","DOI":"10.1074\/jbc.M116.716027","article-title":"Hyperglycemic conditions prime cells for RIP1-dependent necroptosis","volume":"291","author":"LaRocca","year":"2016","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.jare.2026.10.027_b0125","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1038\/s41418-024-01357-8","article-title":"The PRMT6\/STAT1\/ACSL1 axis promotes ferroptosis in diabetic nephropathy","volume":"31","author":"Hong","year":"2024","journal-title":"Cell Death Differ"},{"issue":"5","key":"10.1016\/j.jare.2026.10.027_b0130","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/s41418-025-01612-6","article-title":"USP13 ameliorates diabetic cardiomyopathy via deubiquitinating NLRP3 and inhibiting pyroptosis in cardiomyocytes","volume":"33","author":"Xu","year":"2026","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jare.2026.10.027_b0135","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41420-018-0058-1","article-title":"Hyperglycemia potentiates a shift from apoptosis to RIP1-dependent necroptosis","volume":"4","author":"McCaig","year":"2018","journal-title":"Cell Death Discov"},{"issue":"1","key":"10.1016\/j.jare.2026.10.027_b0140","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.1038\/s41467-021-27032-x","article-title":"Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis","volume":"12","author":"Meng","year":"2021","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jare.2026.10.027_b0145","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1038\/s41467-020-16887-1","article-title":"MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis","volume":"11","author":"Samson","year":"2020","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.jare.2026.10.027_b0150","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/s41418-019-0396-4","article-title":"Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate","volume":"27","author":"Ma","year":"2020","journal-title":"Cell Death Differ"},{"issue":"1\u20132","key":"10.1016\/j.jare.2026.10.027_b0155","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cell.2011.11.030","article-title":"The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways","volume":"148","author":"Wang","year":"2012","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.jare.2026.10.027_b0160","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1038\/s41467-020-16312-7","article-title":"Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics","volume":"11","author":"Yu","year":"2020","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jare.2026.10.027_b0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0147792","article-title":"Mitochondrial protein PGAM5 regulates mitophagic protection against cell necroptosis","volume":"11","author":"Lu","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.jare.2026.10.027_b0170","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4049\/jimmunol.1501662","article-title":"The mitochondrial phosphatase PGAM5 is dispensable for necroptosis but promotes inflammasome activation in macrophages","volume":"196","author":"Moriwaki","year":"2016","journal-title":"J Immunol"},{"issue":"4","key":"10.1016\/j.jare.2026.10.027_b0175","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1002\/cpz1.78","article-title":"Streptozotocin-induced diabetic models in mice and rats","volume":"1","author":"Furman","year":"2021","journal-title":"Curr Protoc"},{"key":"10.1016\/j.jare.2026.10.027_b0180","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.17913","article-title":"Long-term passage impacts human dental pulp stem cell activities and cell response to drug addition in vitro","volume":"12","author":"Patntirapong","year":"2024","journal-title":"PeerJ"},{"key":"10.1016\/j.jare.2026.10.027_b0185","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.archoralbio.2017.12.012","article-title":"Three-dimensional growth pattern of the rat mandible revealed by periodic live micro-computed tomography","volume":"87","author":"Kim","year":"2018","journal-title":"Arch Oral Biol"},{"issue":"1","key":"10.1016\/j.jare.2026.10.027_b0190","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41467-017-02785-6","article-title":"A quiescent cell population replenishes mesenchymal stem cells to drive accelerated growth in mouse incisors","volume":"9","author":"An","year":"2018","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.jare.2026.10.027_b0195","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.1038\/s41467-020-18512-7","article-title":"Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth","volume":"11","author":"Krivanek","year":"2020","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.jare.2026.10.027_b0200","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1210\/endrev\/bnae032","article-title":"Insulin resistance in type 1 diabetes: pathophysiological, clinical, and therapeutic relevance","volume":"46","author":"Apostolopoulou","year":"2025","journal-title":"Endocr Rev"},{"issue":"6","key":"10.1016\/j.jare.2026.10.027_b0205","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cmet.2024.02.014","article-title":"Impaired skeletal muscle regeneration in diabetes: from cellular and molecular mechanisms to novel treatments","volume":"36","author":"Espino-Gonzalez","year":"2024","journal-title":"Cell Metab"},{"issue":"3","key":"10.1016\/j.jare.2026.10.027_b0210","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1476-5381.2012.01911.x","article-title":"The use of animal models in diabetes research","volume":"166","author":"King","year":"2012","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jare.2026.10.027_b0215","doi-asserted-by":"crossref","unstructured":"Metwaly A, Kriaa A, Hassani Z, Carraturo F, Druart C, Consortium I, et al. A consensus statement on establishing causality, therapeutic applications and the use of preclinical models in microbiome research. Nat Rev Gastroenterol Hepatol. 2025;22(5):343-56. doi: 10.1038\/s41575-025-01041-3.","DOI":"10.1038\/s41575-025-01041-3"},{"issue":"4","key":"10.1016\/j.jare.2026.10.027_b0220","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1464-5491.2005.01499.x","article-title":"Animal models of diabetes mellitus","volume":"22","author":"Rees","year":"2005","journal-title":"Diabet Med"},{"key":"10.1016\/j.jare.2026.10.027_b0225","article-title":"Recent progress in bone-repair strategies in diabetic conditions","volume":"23","author":"Sheng","year":"2023","journal-title":"Mater Today Bio"},{"issue":"1","key":"10.1016\/j.jare.2026.10.027_b0230","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.jds.2023.03.021","article-title":"Impaired pulp healing associated with underlying disorders in the dental pulp of rats with type 2 diabetes","volume":"19","author":"Tao","year":"2024","journal-title":"J Dent Sci"},{"issue":"8","key":"10.1016\/j.jare.2026.10.027_b0235","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/S0099-2399(96)80243-3","article-title":"Periapical lesions in rats with streptozotocin-induced diabetes","volume":"22","author":"Kohsaka","year":"1996","journal-title":"J Endod"},{"issue":"8","key":"10.1016\/j.jare.2026.10.027_b0240","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1111\/iej.12072","article-title":"Diabetes mellitus and inflammatory pulpal and periapical disease: a review","volume":"46","author":"Lima","year":"2013","journal-title":"Int Endod J"},{"issue":"5","key":"10.1016\/j.jare.2026.10.027_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e15533","article-title":"Self-recovery in diabetic Sprague Dawley rats induced by intraperitoneal alloxan and streptozotocin","volume":"9","author":"Fajarwati","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.jare.2026.10.027_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.123161","article-title":"A reliable strategy for establishment of an animal model of diabetic cardiomyopathy: Induction by a high-fat diet combined with single or multiple injections of low-dose streptozotocin","volume":"358","author":"Wen","year":"2024","journal-title":"Life Sci"},{"issue":"10","key":"10.1016\/j.jare.2026.10.027_b0255","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1038\/s12276-022-00868-z","article-title":"Roles of RIPK3 in necroptosis, cell signaling, and disease","volume":"54","author":"Morgan","year":"2022","journal-title":"Exp Mol Med"},{"issue":"1","key":"10.1016\/j.jare.2026.10.027_b0260","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41420-024-01957-w","article-title":"RIPK3 signaling and its role in regulated cell death and diseases","volume":"10","author":"Zhou","year":"2024","journal-title":"Cell Death Discov"}],"container-title":["Journal of Advanced Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226007885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2090123226007885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T03:30:38Z","timestamp":1792726238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2090123226007885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":52,"alternative-id":["S2090123226007885"],"URL":"https:\/\/doi.org\/10.1016\/j.jare.2026.10.027","relation":{},"ISSN":["2090-1232"],"issn-type":[{"value":"2090-1232","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between dental pulp necroptosis-related signaling and elodont incisor growth retardation in hyperglycemic rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Advanced Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jare.2026.10.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V. on behalf of Cairo University.","name":"copyright","label":"Copyright"}]}}