{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:34:21Z","timestamp":1793468061588,"version":"4.5.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Society of Hypertension"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.jash.2011.10.003","type":"journal-article","created":{"date-parts":[[2012,1,12]],"date-time":"2012-01-12T20:40:49Z","timestamp":1326400849000},"page":"40-47","source":"Crossref","is-referenced-by-count":47,"title":["Autoantibody activation of beta-adrenergic and muscarinic receptors contributes to an \u201cautoimmune\u201d orthostatic hypotension"],"prefix":"10.1016","volume":"6","author":[{"given":"Xichun","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavros","family":"Stavrakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Reim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneer","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Hamlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine W.","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Kem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 1","key":"10.1016\/j.jash.2011.10.003_bib1","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s10286-007-1001-3","article-title":"Prevalence of orthostatic hypotension","volume":"18","author":"Low","year":"2008","journal-title":"Clin Auton Res"},{"issue":"Suppl 1","key":"10.1016\/j.jash.2011.10.003_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s10286-007-1004-0","article-title":"The pathophysiology and diagnosis of orthostatic hypotension","volume":"18","author":"Robertson","year":"2008","journal-title":"Clin Auton Res"},{"key":"10.1016\/j.jash.2011.10.003_bib3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/CRD.0b013e31815c8032","article-title":"Pathophysiology, diagnosis, and treatment of orthostatic hypotension and vasovagal syncope","volume":"16","author":"Medow","year":"2008","journal-title":"Cardiol Rev"},{"key":"10.1016\/j.jash.2011.10.003_bib4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/CIRCULATIONAHA.108.805887","article-title":"Neurogenic orthostatic hypotension: a pathophysiological approach","volume":"119","author":"Goldstein","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jash.2011.10.003_bib5","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1056\/NEJM200009213431204","article-title":"Autoantibodies to ganglionic acetylcholine receptors in autoimmune autonomic neuropathies","volume":"343","author":"Vernino","year":"2000","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jash.2011.10.003_bib6","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.autneu.2008.09.005","article-title":"Autonomic ganglia, acetylcholine receptor antibodies, and autoimmune ganglionopathy","volume":"146","author":"Vernino","year":"2009","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.jash.2011.10.003_bib7","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1161\/HYPERTENSIONAHA.107.096750","article-title":"Autoimmune hypertensive syndrome","volume":"50","author":"Kem","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.jash.2011.10.003_bib8","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.jacc.2009.07.015","article-title":"Activating autoantibodies to the beta-1 adrenergic and m2 muscarinic receptors facilitate atrial fibrillation in patients with Graves\u2019 hyperthyroidism","volume":"54","author":"Stavrakis","year":"2009","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jash.2011.10.003_bib9","first-page":"H950","article-title":"Calcium measurement in isolated arterioles during myogenic and agonist stimulation","volume":"261","author":"Meininger","year":"1991","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jash.2011.10.003_bib10","doi-asserted-by":"crossref","first-page":"H345","DOI":"10.1152\/ajpheart.2000.278.2.H345","article-title":"Transient increases in diameter and [Ca(2+)](i) are not obligatory for myogenic constriction","volume":"278","author":"Hill","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jash.2011.10.003_bib11","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1540-8167.2008.01407.x","article-title":"Postural tachycardia syndrome (POTS)","volume":"20","author":"Low","year":"2009","journal-title":"J Cardiovasc Electrophysiol"},{"key":"10.1016\/j.jash.2011.10.003_bib12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/FJC.0b013e31819fd501","article-title":"An in-depth analysis of vasodilation in the management of hypertension: focus on adrenergic blockade","volume":"53","author":"Bakris","year":"2009","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.jash.2011.10.003_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0163-7258(90)90060-F","article-title":"Cyclic AMP and mechanisms of vasodilation","volume":"47","author":"Murray","year":"1990","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.jash.2011.10.003_bib14","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1007\/s00018-005-5451-2","article-title":"Beta-adrenergic receptors and nitric oxide generation in the cardiovascular system","volume":"63","author":"Queen","year":"2006","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.jash.2011.10.003_bib15","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0031-6997(25)06957-1","article-title":"Muscarinic receptor subtypes and smooth muscle function","volume":"48","author":"Eglen","year":"1996","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jash.2011.10.003_bib16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ejphar.2004.04.012","article-title":"Vasodilatory effects of cholinergic agonists are greatly diminished in aorta from M3R-\/- mice","volume":"493","author":"Khurana","year":"2004","journal-title":"Eur J Pharmacol"}],"container-title":["Journal of the American Society of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933171111002452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933171111002452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T19:19:07Z","timestamp":1742325547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933171111002452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S1933171111002452"],"URL":"https:\/\/doi.org\/10.1016\/j.jash.2011.10.003","relation":{},"ISSN":["1933-1711"],"issn-type":[{"value":"1933-1711","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}