{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:01:19Z","timestamp":1760295679507},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of the American Society of Hypertension"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.jash.2013.01.002","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T03:04:04Z","timestamp":1360724644000},"page":"118-127","source":"Crossref","is-referenced-by-count":13,"title":["Role of angiotensin II type 2 receptor during regression of cardiac hypertrophy in spontaneously hypertensive rats"],"prefix":"10.1016","volume":"7","author":[{"given":"Shant","family":"Der Sarkissian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bun-Seng","family":"Tea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhian M.","family":"Touyz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"deBlois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taben M.","family":"Hale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jash.2013.01.002_bib1","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1056\/NEJM199005313222203","article-title":"Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study","volume":"322","author":"Levy","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jash.2013.01.002_bib2","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0008-6363(02)00789-7","article-title":"Reversal of interstitial fibroblast hyperplasia via apoptosis in hypertensive rat heart with valsartan or enalapril","volume":"57","author":"Der Sarkissian","year":"2003","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jash.2013.01.002_bib3","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1161\/01.HYP.35.5.1069","article-title":"Proapoptotic and growth-inhibitory role of angiotensin II type 2 receptor in vascular smooth muscle cells of spontaneously hypertensive rats in\u00a0vivo","volume":"35","author":"Tea","year":"2000","journal-title":"Hypertension"},{"key":"10.1016\/j.jash.2013.01.002_bib4","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jjcc.2008.07.018","article-title":"Valsartan improves L-NAME-exacerbated cardiac fibrosis with TGF-beta inhibition and apoptosis induction in spontaneously hypertensive rats","volume":"52","author":"Akashiba","year":"2008","journal-title":"J Cardiol"},{"key":"10.1016\/j.jash.2013.01.002_bib5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1161\/01.HYP.34.2.229","article-title":"Apoptosis during regression of cardiac hypertrophy in spontaneously hypertensive rats. Temporal regulation and spatial heterogeneity","volume":"34","author":"Tea","year":"1999","journal-title":"Hypertension"},{"key":"10.1016\/j.jash.2013.01.002_bib6","first-page":"381","article-title":"Counterpoint: molecular analysis of the angiotensin II receptor","volume":"13","author":"Bernstein","year":"1992","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jash.2013.01.002_bib7","doi-asserted-by":"crossref","first-page":"243S","DOI":"10.1093\/ajh\/5.12.243S","article-title":"Clinical experience with angiotensin II receptor antagonists","volume":"5","author":"Brunner","year":"1992","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jash.2013.01.002_bib8","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1161\/CIRCULATIONAHA.108.784868","article-title":"Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction?","volume":"118","author":"Kaschina","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.jash.2013.01.002_bib9","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1161\/HYPERTENSIONAHA.111.180158","article-title":"Angiotensin type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke-prone spontaneously hypertensive rats","volume":"59","author":"Rehman","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.jash.2013.01.002_bib10","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1038\/sj.bjp.0705448","article-title":"Angiotensin AT2 receptors: cardiovascular hope or hype?","volume":"140","author":"Widdop","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.jash.2013.01.002_bib11","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1161\/01.HYP.0000193498.07087.83","article-title":"The continuing saga of the AT2 receptor: a case of the good, the bad, and the innocuous","volume":"46","author":"Reudelhuber","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.jash.2013.01.002_bib12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.coph.2010.11.002","article-title":"Non-peptide AT2-receptor agonists","volume":"11","author":"Steckelings","year":"2011","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.jash.2013.01.002_bib13","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1073\/pnas.93.1.156","article-title":"Angiotensin II type 2 receptor mediates programmed cell death","volume":"93","author":"Yamada","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jash.2013.01.002_bib14","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1161\/01.HYP.29.1.340","article-title":"Smooth muscle apoptosis during vascular regression in spontaneously hypertensive rats","volume":"29","author":"deBlois","year":"1997","journal-title":"Hypertension"},{"key":"10.1016\/j.jash.2013.01.002_bib15","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1172\/JCI115628","article-title":"Chronic coronary artery constriction leads to moderate myocyte loss and left ventricular dysfunction and failure in rats","volume":"89","author":"Anversa","year":"1992","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jash.2013.01.002_bib16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1161\/01.HYP.0000050101.90932.14","article-title":"Cardiac angiotensin II type 2 receptor activates the kinin\/NO system and inhibits fibrosis","volume":"41","author":"Kurisu","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.jash.2013.01.002_bib17","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1146\/annurev.pharmtox.45.120403.095802","article-title":"The cardiac fibroblast: therapeutic target in myocardial remodeling and failure","volume":"45","author":"Brown","year":"2005","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.jash.2013.01.002_bib18","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2143\/AC.62.5.2023404","article-title":"The signalling of AT2 and the influence on the collagen metabolism of AT2 receptor in adult rat cardiac fibroblasts","volume":"62","author":"Jiang","year":"2007","journal-title":"Acta Cardiol"},{"key":"10.1016\/j.jash.2013.01.002_bib19","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1161\/01.CIR.96.11.3954","article-title":"Angiotensin type 2 receptors are reexpressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism","volume":"96","author":"Ohkubo","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.jash.2013.01.002_bib20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1177\/0267659106074793","article-title":"Effect of angiotensin II on primary cardiac fibroblast matrix metalloproteinase activities","volume":"22","author":"Stacy","year":"2007","journal-title":"Perfusion"},{"key":"10.1016\/j.jash.2013.01.002_bib21","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1161\/01.HYP.0000048340.53100.43","article-title":"Cardioprotective role of AT2 receptor in postinfarction left ventricular remodeling","volume":"41","author":"Oishi","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.jash.2013.01.002_bib22","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1161\/01.CIR.0000072763.98069.B4","article-title":"Angiotensin II type 2 receptor deficiency exacerbates heart failure and reduces survival after acute myocardial infarction in mice","volume":"107","author":"Adachi","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.jash.2013.01.002_bib23","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1023\/B:MCBI.0000026062.29029.d4","article-title":"AT1 receptor blockade limits myocardial injury and upregulates AT2 receptors during reperfused myocardial infarction","volume":"260","author":"Jugdutt","year":"2004","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.jash.2013.01.002_bib24","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1172\/JCI45529","article-title":"Adult mouse epicardium modulates myocardial injury by secreting paracrine factors","volume":"121","author":"Zhou","year":"2011","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jash.2013.01.002_bib25","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1161\/CIRCRESAHA.110.233262","article-title":"A dynamic notch injury response activates epicardium and contributes to fibrosis repair","volume":"108","author":"Russell","year":"2011","journal-title":"Circ Res"},{"key":"10.1016\/j.jash.2013.01.002_bib26","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0014-2999(98)00110-1","article-title":"Pericardial mesothelial cells produce endothelin-1 and possess functional endothelin ETB receptors","volume":"347","author":"Kuwahara","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jash.2013.01.002_bib27","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1006\/jmcc.1996.0122","article-title":"In situ production of angiotensin II by fibrosed rat pericardium","volume":"28","author":"Ou","year":"1996","journal-title":"J\u00a0Mol Cell Cardiol"},{"key":"10.1016\/j.jash.2013.01.002_bib28","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.RES.82.10.1043","article-title":"Epicardium-derived cells contribute a novel population to the myocardial wall and the atrioventricular cushions","volume":"82","author":"Gittenberger-de Groot","year":"1998","journal-title":"Circ Res"},{"key":"10.1016\/j.jash.2013.01.002_bib29","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1006\/dbio.1996.0068","article-title":"Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ","volume":"174","author":"Mikawa","year":"1996","journal-title":"Dev Biol"},{"key":"10.1016\/j.jash.2013.01.002_bib30","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s004290050235","article-title":"Smooth muscle cells and fibroblasts of the coronary arteries derive from epithelial-mesenchymal transformation of the epicardium","volume":"199","author":"Vrancken Peeters","year":"1999","journal-title":"Anat Embryol (Berl)"},{"key":"10.1016\/j.jash.2013.01.002_bib31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/jsre.1999.5732","article-title":"Effects of angiotensin type-I receptor blockade on pericardial fibrosis","volume":"87","author":"Loging","year":"1999","journal-title":"J Surg Res"},{"key":"10.1016\/j.jash.2013.01.002_bib32","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/01.CIR.104.3.346","article-title":"Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension","volume":"104","author":"Ichihara","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.jash.2013.01.002_bib33","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1172\/JCI10037","article-title":"Evidence for angiotensin II type 2 receptor-mediated cardiac myocyte enlargement during in\u00a0vivo pressure overload","volume":"106","author":"Senbonmatsu","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jash.2013.01.002_bib34","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1161\/01.CIR.102.14.1684","article-title":"Inhibitory effect of angiotensin II type 2 receptor on coronary arterial remodeling after aortic banding in mice","volume":"102","author":"Akishita","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.jash.2013.01.002_bib35","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1161\/01.HYP.0000127563.14064.fd","article-title":"Prevention of cardiac hypertrophy by angiotensin II type-2 receptor gene transfer","volume":"43","author":"Metcalfe","year":"2004","journal-title":"Hypertension"},{"key":"10.1016\/j.jash.2013.01.002_bib36","doi-asserted-by":"crossref","first-page":"H1274","DOI":"10.1152\/ajpheart.00174.2006","article-title":"Pressure overload-induced hypertrophy in transgenic mice selectively overexpressing AT2 receptors in ventricular myocytes","volume":"294","author":"Yan","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"Suppl 1","key":"10.1016\/j.jash.2013.01.002_bib37","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1097\/01.hjh.0000388495.66330.63","article-title":"The angiotensin AT2 receptor in left ventricular hypertrophy","volume":"28","author":"Steckelings","year":"2010","journal-title":"J Hypertens"},{"key":"10.1016\/j.jash.2013.01.002_bib38","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.intimp.2007.06.012","article-title":"Angiotensin II-induced vasodilation via type 2 receptor: role of bradykinin and nitric oxide","volume":"8","author":"Yayama","year":"2008","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jash.2013.01.002_bib39","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1097\/00029330-200807010-00014","article-title":"Compensatory function of bradykinin B1 receptor in the inhibitory effect of captopril on cardiomyocyte hypertrophy and cardiac fibroblast proliferation in neonatal rats","volume":"121","author":"Zou","year":"2008","journal-title":"Chin Med J (Engl)"},{"issue":"Suppl 1","key":"10.1016\/j.jash.2013.01.002_bib40","doi-asserted-by":"crossref","first-page":"S346","DOI":"10.1097\/01.fjc.0000166265.09550.7c","article-title":"Endogenous bradykinin suppresses myocardial fibrosis through the cardiac-generated endothelin system under chronic angiotensin-converting enzyme inhibition in heart failure","volume":"44","author":"Fujii","year":"2004","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1016\/j.jash.2013.01.002_bib41","doi-asserted-by":"crossref","first-page":"110A","DOI":"10.1016\/S0002-9149(97)00465-7","article-title":"Effects of angiotensin-converting enzyme inhibition and angiotensin II AT1 receptor antagonism on cardiac parameters in left ventricular hypertrophy","volume":"80","author":"Zhu","year":"1997","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.jash.2013.01.002_bib42","first-page":"1","article-title":"Vascular and cardiac protection by ramipril in spontaneously hypertensive rats: prevention versus regression study","volume":"84","author":"Gohlke","year":"1996","journal-title":"Br J Clin Pract Suppl"},{"key":"10.1016\/j.jash.2013.01.002_bib43","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.RES.0000121103.03275.EC","article-title":"Phosphatidylinositol 3-kinase\/Akt regulates angiotensin II-induced inhibition of apoptosis in microvascular endothelial cells by governing survivin expression and suppression of caspase-3 activity","volume":"94","author":"Ohashi","year":"2004","journal-title":"Circ Res"},{"key":"10.1016\/j.jash.2013.01.002_bib44","doi-asserted-by":"crossref","first-page":"H1105","DOI":"10.1152\/ajpheart.01139.2002","article-title":"Angiotensin II modulates nitric oxide-induced cardiac fibroblast apoptosis by activation of AKT\/PKB","volume":"285","author":"Tian","year":"2003","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jash.2013.01.002_bib45","doi-asserted-by":"crossref","first-page":"H1958","DOI":"10.1152\/ajpheart.01070.2001","article-title":"Mechanisms of cytokine induced NO-mediated cardiac fibroblast apoptosis","volume":"283","author":"Tian","year":"2002","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.jash.2013.01.002_bib46","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1161\/01.RES.0000065619.36118.20","article-title":"Caspase-dependent cell death mediates the early phase of aortic hypertrophy regression in losartan-treated spontaneously hypertensive rats","volume":"92","author":"Marchand","year":"2003","journal-title":"Circ Res"},{"key":"10.1016\/j.jash.2013.01.002_bib47","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1242\/jcs.063545","article-title":"Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cells","volume":"123","author":"Lee","year":"2010","journal-title":"J Cell Sci"},{"key":"10.1016\/j.jash.2013.01.002_bib48","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bbrc.2012.07.003","article-title":"Angiotensin II induces apoptosis in intestinal epithelial cells through the AT2 receptor, GATA-6 and the Bax pathway","volume":"424","author":"Sun","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jash.2013.01.002_bib49","first-page":"H844","article-title":"Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts","volume":"267","author":"Lopez","year":"1994","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jash.2013.01.002_bib50","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1161\/01.HYP.28.4.635","article-title":"Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophy","volume":"28","author":"Booz","year":"1996","journal-title":"Hypertension"}],"container-title":["Journal of the American Society of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193317111300003X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193317111300003X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T17:23:48Z","timestamp":1562693028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S193317111300003X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,3]]}},"alternative-id":["S193317111300003X"],"URL":"https:\/\/doi.org\/10.1016\/j.jash.2013.01.002","relation":{},"ISSN":["1933-1711"],"issn-type":[{"value":"1933-1711","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}