{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:35:32Z","timestamp":1772804132074,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","ashjournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Hypertension"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1016\/j.jash.2014.05.002","type":"journal-article","created":{"date-parts":[[2014,5,10]],"date-time":"2014-05-10T01:32:45Z","timestamp":1399685565000},"page":"503-513","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Lowering blood pressure to prevent stroke recurrence: a systematic review of long-term randomized trials"],"prefix":"10.1016","volume":"8","author":[{"given":"Carlos A.","family":"Feldstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jash.2014.05.002_bib1","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1161\/CIR.0b013e31828124ad","article-title":"Heart disease and stroke statistics\u20142013 update: a report from the American Heart Association","volume":"127","author":"Go","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.jash.2014.05.002_bib2","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/0140-6736(90)90878-9","article-title":"Blood pressure, stroke and coronary heart disease, part I: effects of prolonged differences in blood pressure: evidence from nine prospective observational studies corrected for the regression dilution bias","volume":"335","author":"MacMahon","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.jash.2014.05.002_bib3","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0140-6736(90)90944-Z","article-title":"Blood pressure, stroke and coronary heart disease, part 2: short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context","volume":"335","author":"Collins","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.jash.2014.05.002_bib4","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1161\/01.STR.22.3.312","article-title":"Probability of stroke: a risk profile from the Framingham study","volume":"22","author":"Wolf","year":"1991","journal-title":"Stroke"},{"key":"10.1016\/j.jash.2014.05.002_bib5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/bmj.313.7050.147","article-title":"Blood pressure and risk of stroke in patients with cerebrovascular disease: the United Kingdom Transient Ischaemic Attack Collaborative Group","volume":"313","author":"Rodgers","year":"1996","journal-title":"BMJ"},{"key":"10.1016\/j.jash.2014.05.002_bib6","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1161\/STROKEAHA.110.602615","article-title":"Risk and cumulative risk of stroke recurrence: a systematic review and meta-analysis","volume":"42","author":"Mohan","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.jash.2014.05.002_bib7","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1161\/01.STR.29.12.2491","article-title":"Long-term risk of first recurrent stroke in the Perth Community Stroke Study","volume":"29","author":"Hankey","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.jash.2014.05.002_bib8","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1001\/jama.284.22.2901","article-title":"Short-term prognosis after emergency department diagnosis of TIA","volume":"284","author":"Johnston","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.jash.2014.05.002_bib9","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1212\/01.WNL.0000152985.32732.EE","article-title":"Timing of TIAs preceding stroke: time window for prevention is very short","volume":"64","author":"Rothwell","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.jash.2014.05.002_bib10","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0140-6736(70)91577-1","article-title":"Hypotensive therapy in stroke survivors","volume":"1","author":"Carter","year":"1970","journal-title":"Lancet"},{"issue":"7817","key":"10.1016\/j.jash.2014.05.002_bib11","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/S0140-6736(73)91737-6","article-title":"Antihypertensive treatment and the course of established cerebral vascular disease","volume":"1","author":"Beevers","year":"1973","journal-title":"Lancet"},{"key":"10.1016\/j.jash.2014.05.002_bib12","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1001\/jama.1974.03230420021019","article-title":"Effect of antihypertensive treatment on stroke recurrence. Hypertension-Stroke Cooperative Study Group","volume":"229","year":"1974","journal-title":"JAMA"},{"key":"10.1016\/j.jash.2014.05.002_bib13","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1161\/01.STR.0000092488.40085.15","article-title":"Blood pressure reduction and secondary prevention of stroke and other vascular events: a systematic review","volume":"34","author":"Rashid","year":"2003","journal-title":"Stroke"},{"key":"10.1016\/j.jash.2014.05.002_bib14","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1161\/STR.0b013e3181f7d043","article-title":"Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"42","author":"Furie","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.jash.2014.05.002_bib15","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1161\/01.STR.24.4.543","article-title":"Trial of secondary prevention with atenolol after transient ischemic attack or nondisabling ischemic stroke. The Dutch TIA Trial Study Group","volume":"24","year":"1993","journal-title":"Stroke"},{"key":"10.1016\/j.jash.2014.05.002_bib16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1159\/000107813","article-title":"Atenolol in secondary prevention after stroke","volume":"5","author":"Eriksson","year":"1995","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.jash.2014.05.002_bib17","first-page":"CD007890","article-title":"Beta-blockers for preventing stroke recurrence","volume":"5","author":"De Lima","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jash.2014.05.002_bib18","first-page":"710","article-title":"The post-stroke antihypertensive treatment study. A preliminary result","volume":"108","year":"1995","journal-title":"Chinese Medical Journal"},{"key":"10.1016\/j.jash.2014.05.002_bib19","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/hr.2009.139","article-title":"Blood pressure reduction for the secondary prevention of stroke: a Chinese trial and a systematic review of the literature","volume":"32","author":"Liu","year":"2009","journal-title":"Hypertens Res"},{"key":"10.1016\/j.jash.2014.05.002_bib20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1056\/NEJM200001203420301","article-title":"Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators","volume":"342","author":"Yusuf","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jash.2014.05.002_bib21","first-page":"1647","article-title":"PROGRESS Perindopril Protection Against Recurrent Stroke Study: characteristics of the study population at baseline. PROGRESS Management Committee","volume":"17","year":"1999","journal-title":"J Hypertens"},{"key":"10.1016\/j.jash.2014.05.002_bib22","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(01)06178-5","article-title":"Randomised trial of a perindopril-based blood-pressure-lowering regimen among 6105 individuals with previous stroke or transient ischaemic attack","volume":"358","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jash.2014.05.002_bib23","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1097\/00004872-200306005-00003","article-title":"Perindopril pROtection aGainst REcurrent Stroke Study (PROGRESS): interpretation and implementation","volume":"21","author":"Chalmers","year":"2003","journal-title":"J Hypertens Suppl"},{"key":"10.1016\/j.jash.2014.05.002_bib24","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1097\/01.hjh.0000226212.34055.86","article-title":"Lower target blood pressures are safe and effective for the prevention of recurrent stroke: the PROGRESS trial","volume":"24","author":"Arima","year":"2006","journal-title":"J Hypertens"},{"key":"10.1016\/j.jash.2014.05.002_bib25","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1001\/jama.289.19.2560","article-title":"The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report","volume":"289","author":"Chobanian","year":"2003","journal-title":"JAMA"},{"key":"10.1016\/j.jash.2014.05.002_bib26","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1097\/01.hjh.0000431740.32696.cc","article-title":"2013 ESH\/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)","volume":"31","author":"Mancia","year":"2013","journal-title":"J Hypertens"},{"key":"10.1016\/j.jash.2014.05.002_bib27","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1161\/STROKEAHA.110.606764","article-title":"Effects of blood pressure lowering on major vascular events among patients with isolated diastolic hypertension: the perindopril protection against recurrent stroke study (PROGRESS) trial","volume":"42","author":"Arima","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.jash.2014.05.002_bib28","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1159\/000100105","volume":"23","author":"Diener","year":"2007","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.jash.2014.05.002_bib29","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1056\/NEJMoa0804593","article-title":"Telmisartan to prevent recurrent stroke and cardiovascular events","volume":"359","author":"Yusuf","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jash.2014.05.002_bib30","first-page":"3541","article-title":"Effect of telmisartan on functional outcome, recurrence, and blood pressure in patients with acute mild ischemic stroke","volume":"40","author":"Bath","year":"2009","journal-title":"A PRoFESS Subgroup Analysis Stroke"},{"key":"10.1016\/j.jash.2014.05.002_bib31","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1001\/jama.2011.1650","article-title":"Level of systolic blood pressure within the normal range and risk of recurrent stroke","volume":"306","author":"Ovbiagele","year":"2011","journal-title":"JAMA"},{"key":"10.1016\/j.jash.2014.05.002_bib32","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ahj.2004.03.020","volume":"148","author":"Teo","year":"2004","journal-title":"Am Heart J"},{"issue":"9644","key":"10.1016\/j.jash.2014.05.002_bib33","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/S0140-6736(08)61242-8","volume":"372","author":"Yusuf","year":"2008","journal-title":"Lancet"},{"key":"10.1016\/j.jash.2014.05.002_bib34","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1097\/01.hjh.0000357906.60778.7f","article-title":"Preventing stroke: the PRoFESS, ONTARGET, and TRANSCEND trial programs","volume":"27","author":"Diener","year":"2009","journal-title":"J Hypertens Suppl"},{"key":"10.1016\/j.jash.2014.05.002_bib35","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1161\/01.STR.0000166048.35740.a9","article-title":"Morbidity and mortality after stroke, eprosartan compared with nitrendipine for secondary prevention: principal results of a prospective randomized controlled study (MOSES)","volume":"36","author":"Schrader","year":"2005","journal-title":"Stroke"},{"key":"10.1016\/j.jash.2014.05.002_bib36","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1056\/NEJMoa0801317","article-title":"ONTARGET investigators, telmisartan, ramipril, or both in patients at high risk for vascular events","volume":"358","author":"Yusuf","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jash.2014.05.002_bib37","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(13)60852-1","article-title":"Blood-pressure targets in patients with recent lacunar stroke: the SPS3 randomised trial","volume":"382","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jash.2014.05.002_bib38","series-title":"Stroke Pathophysiology, Diagnosis and Management","article-title":"Pathology, in Barnett","author":"Garcia","year":"1998"},{"key":"10.1016\/j.jash.2014.05.002_bib39","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1212\/WNL.46.2.341","article-title":"Hemorrhagic transformation of brain infarct: predictability in the first five hours from stroke onset and influence on clinical outcome","volume":"46","author":"Toni","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.jash.2014.05.002_bib40","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1161\/STROKEAHA.111.648576","article-title":"Telmisartan on top of antihypertensive treatment does not prevent progression of cerebral white matter lesions in the prevention regimen for effectively avoiding second strokes (PRoFESS) MRI substudy","volume":"43","author":"Weber","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.jash.2014.05.002_bib41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.15420\/ecr.2010.6.1.37","article-title":"Blood pressure lowering for the prevention of stroke recurrence","volume":"6","author":"Wang","year":"2010","journal-title":"European Cardiology"},{"key":"10.1016\/j.jash.2014.05.002_bib42","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/jama.2013.284427","article-title":"Evidence-based guideline for the management of high blood pressure in adults report from the panel members appointed the eighth Joint National Committee (JNC 8)","volume":"311","author":"James","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.jash.2014.05.002_bib43","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/jch.12237","article-title":"Clinical practice guidelines for the management of hypertension in the community. A statement by the American Society of Hypertension and the International Society of Hypertension","volume":"16","author":"Weber","year":"2014","journal-title":"J Clin Hypertens (Greenwich)"}],"container-title":["Journal of the American Society of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193317111400552X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193317111400552X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,4]],"date-time":"2018-10-04T03:25:37Z","timestamp":1538623537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S193317111400552X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":43,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S193317111400552X"],"URL":"https:\/\/doi.org\/10.1016\/j.jash.2014.05.002","relation":{},"ISSN":["1933-1711"],"issn-type":[{"value":"1933-1711","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lowering blood pressure to prevent stroke recurrence: a systematic review of long-term randomized trials","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jash.2014.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}