{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:30:01Z","timestamp":1791286201888,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["ashjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Hypertension"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.jash.2014.11.008","type":"journal-article","created":{"date-parts":[[2014,12,3]],"date-time":"2014-12-03T09:34:21Z","timestamp":1417599261000},"page":"86-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Diagnosis of preeclampsia with soluble Fms\u2013like tyrosine kinase 1\/placental growth factor ratio: an inter\u2013assay comparison"],"prefix":"10.1016","volume":"9","author":[{"given":"Louise Bj\u00f8rkholt","family":"Andersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Britta","family":"Frederiksen-M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrine","family":"Work Havelund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Dechend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Stener","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boye L.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3018-937X","authenticated-orcid":false,"given":"Sine","family":"Lykkedegn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torben","family":"Barington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Thybo","family":"Christesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jash.2014.11.008_bib1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)71003-5","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.jash.2014.11.008_bib2","first-page":"67","article-title":"Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002. American College of Obstetricians and Gynecologists","volume":"77","year":"2002","journal-title":"Obstet Gynecol"},{"key":"10.1016\/j.jash.2014.11.008_bib3","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","article-title":"Pre-eclampsia","volume":"376","author":"Steegers","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.jash.2014.11.008_bib4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1081\/PRG-120016792","article-title":"Summary of the NHLBI Working Group on Research on Hypertension During Pregnancy","volume":"22","author":"Roberts","year":"2003","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.jash.2014.11.008_bib5","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1161\/HYPERTENSIONAHA.111.00250","article-title":"Redefining preeclampsia using placenta-derived biomarkers","volume":"61","author":"Staff","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.jash.2014.11.008_bib6","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1056\/NEJMoa031884","article-title":"Circulating angiogenic factors and the risk of preeclampsia","volume":"350","author":"Levine","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jash.2014.11.008_bib7","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1161\/CIRCULATIONAHA.109.853127","article-title":"Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease","volume":"123","author":"Powe","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.jash.2014.11.008_bib8","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jash.2014.11.008_bib9","doi-asserted-by":"crossref","first-page":"25646","DOI":"10.1016\/S0021-9258(18)47298-5","article-title":"Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in\u00a0vitro and in\u00a0vivo, and high affinity binding to Flt-1 but not to Flk-1\/KDR","volume":"269","author":"Park","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jash.2014.11.008_bib10","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/87904","article-title":"Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions","volume":"7","author":"Carmeliet","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.jash.2014.11.008_bib11","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1210\/jc.2003-031244","article-title":"First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia","volume":"89","author":"Thadhani","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jash.2014.11.008_bib12","doi-asserted-by":"crossref","first-page":"161.e1","DOI":"10.1016\/j.ajog.2009.09.016","article-title":"An automated method for the determination of the sFlt-1\/PIGF ratio in the assessment of preeclampsia","volume":"202","author":"Verlohren","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jash.2014.11.008_bib13","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1161\/HYPERTENSIONAHA.111.00754","article-title":"Circulating angiogenic factors and urinary prolactin as predictors of adverse outcomes in women with preeclampsia","volume":"61","author":"Leanos-Miranda","year":"2013","journal-title":"Hypertension"},{"key":"10.1016\/j.jash.2014.11.008_bib14","doi-asserted-by":"crossref","first-page":"469.e1","DOI":"10.1016\/j.ajog.2011.06.058","article-title":"Angiogenic factors as diagnostic tests for preeclampsia: a performance comparison between two commercial immunoassays","volume":"205","author":"Benton","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jash.2014.11.008_bib15","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/HYPERTENSIONAHA.113.01787","article-title":"New gestational phase-specific cutoff values for the use of the soluble fms-like tyrosine kinase-1\/placental growth factor ratio as a diagnostic test for preeclampsia","volume":"63","author":"Verlohren","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.jash.2014.11.008_bib16","doi-asserted-by":"crossref","first-page":"407.e1","DOI":"10.1016\/j.ajog.2012.08.010","article-title":"Longitudinal evaluation of predictive value for preeclampsia of circulating angiogenic factors through pregnancy","volume":"207","author":"McElrath","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jash.2014.11.008_bib17","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1161\/HYPERTENSIONAHA.113.02293","article-title":"Angiogenic factors in diagnosis, management, and research in preeclampsia","volume":"63","author":"Rana","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.jash.2014.11.008_bib18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ajog.2005.03.016","article-title":"Circulating levels of the antiangiogenic marker sFLT-1 are increased in first versus second pregnancies","volume":"193","author":"Wolf","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jash.2014.11.008_bib19","doi-asserted-by":"crossref","first-page":"247.e1","DOI":"10.1016\/j.ajog.2014.03.020","article-title":"The association of body mass index with serum angiogenic markers in normal and abnormal pregnancies","volume":"211","author":"Zera","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"10.1016\/j.jash.2014.11.008_bib20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3109\/10641955.2013.784788","article-title":"Clinical characterization and outcomes of preeclampsia with normal angiogenic profile","volume":"32","author":"Rana","year":"2013","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.jash.2014.11.008_bib21","doi-asserted-by":"crossref","first-page":"A8","DOI":"10.1055\/s-0029-1216308","article-title":"Technical performance of the first fully automated assays for human soluble fms-like tyrosine kinase 1 and human placental growth factor","volume":"213","author":"Schneider","year":"2009","journal-title":"Z Geburtshilfe Neonatol"},{"key":"10.1016\/j.jash.2014.11.008_bib22","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/cen.12147","article-title":"Parity and tanned white skin as novel predictors of vitamin D status in early pregnancy: a population-based cohort study","volume":"79","author":"Andersen","year":"2013","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jash.2014.11.008_bib23","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/clinchem\/39.9.1953","article-title":"Rare earth cryptates and homogeneous fluoroimmunoassays with human sera","volume":"39","author":"Mathis","year":"1993","journal-title":"Clin Chem"},{"key":"10.1016\/j.jash.2014.11.008_bib24","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1651-2227.1996.tb14164.x","article-title":"Intrauterine growth curves based on ultrasonically estimated foetal weights","volume":"85","author":"Marsal","year":"1996","journal-title":"Acta Paediatr"},{"key":"10.1016\/j.jash.2014.11.008_bib25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"Bland","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.jash.2014.11.008_bib26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2307\/2532051","article-title":"A concordance correlation coefficient to evaluate reproducibility","volume":"45","author":"Lin","year":"1989","journal-title":"Biometrics"},{"key":"10.1016\/j.jash.2014.11.008_bib27","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/CIRCULATIONAHA.111.054361","article-title":"Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia","volume":"125","author":"Rana","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.jash.2014.11.008_bib28","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1161\/HYPERTENSIONAHA.112.195065","article-title":"Circulating angiogenic factors and risk of adverse maternal and perinatal outcomes in twin pregnancies with suspected preeclampsia","volume":"60","author":"Rana","year":"2012","journal-title":"Hypertension"},{"key":"10.1016\/j.jash.2014.11.008_bib29","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1055\/s-0032-1328601","article-title":"Prenatal Clinical Assessment of sFlt-1 (Soluble fms-like Tyrosine Kinase-1)\/PlGF (Placental Growth Factor) Ratio as a Diagnostic Tool for Preeclampsia, Pregnancy-induced Hypertension, and Proteinuria","volume":"73","author":"Lehnen","year":"2013","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"10.1016\/j.jash.2014.11.008_bib30","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3109\/10641955.2014.940236","article-title":"Response to Carbillon L et\u00a0al.\u00a0letter titled, \u201cThe imbalance of circulating angiogenic\/anti-angiogenic factors is mild or absent in obese women destined to develop preeclampsia.\u201d","volume":"33","author":"Rana","year":"2014","journal-title":"Hypertens Pregnancy"},{"key":"10.1016\/j.jash.2014.11.008_bib31","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1093\/cvr\/cvr133","article-title":"Preventing progression of cardiac hypertrophy and development of heart failure by paricalcitol therapy in rats","volume":"91","author":"Bae","year":"2011","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.jash.2014.11.008_bib32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000358595","article-title":"Maternal serum placental growth factor isoforms 1 and 2 at 11-13, 20-24 and 30-34 weeks' gestation in late-onset pre-eclampsia and small for gestational age neonates","volume":"35","author":"Nucci","year":"2014","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.jash.2014.11.008_bib33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1159\/000357842","article-title":"Maternal Serum Placental Growth Factor (PlGF) Isoforms 1 and 2 at 11-13 Weeks' Gestation in Normal and Pathological Pregnancies","volume":"36","author":"Nucci","year":"2014","journal-title":"Fetal Diagn Ther"},{"key":"10.1016\/j.jash.2014.11.008_bib34","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1161\/HYPERTENSIONAHA.113.02664","article-title":"Strategy for standardization of preeclampsia research study design","volume":"63","author":"Myatt","year":"2014","journal-title":"Hypertension"}],"container-title":["Journal of the American Society of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933171114008869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933171114008869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T20:02:14Z","timestamp":1650744134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933171114008869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["S1933171114008869"],"URL":"https:\/\/doi.org\/10.1016\/j.jash.2014.11.008","relation":{},"ISSN":["1933-1711"],"issn-type":[{"value":"1933-1711","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnosis of preeclampsia with soluble Fms\u2013like tyrosine kinase 1\/placental growth factor ratio: an inter\u2013assay comparison","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jash.2014.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 American Society of Hypertension. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}