{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:18:18Z","timestamp":1784621898698,"version":"3.55.0"},"reference-count":90,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","ashjournal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of the American Society of Hypertension"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.jash.2016.05.009","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T22:50:27Z","timestamp":1464907827000},"page":"656-670","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Renal denervation in the era of HTN-3. Comprehensive review and glimpse into the future"],"prefix":"10.1016","volume":"10","author":[{"given":"Joana Delgado","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard J.","family":"Gersh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lino","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.jash.2016.05.009_bib1","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1161\/HYPERTENSIONAHA.114.03194","article-title":"Eligibility for Renal Denervation Experience at 11 European Expert Centers","volume":"63","author":"Persu","year":"2014","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.jash.2016.05.009_bib2","doi-asserted-by":"crossref","first-page":"e000092","DOI":"10.1136\/openhrt-2014-000092","article-title":"Renal denervation and blood pressure reduction in resistant hypertension: a systematic review and meta-analysis","volume":"1","author":"Kwok","year":"2014","journal-title":"Open Heart"},{"issue":"10","key":"10.1016\/j.jash.2016.05.009_bib3","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1097\/HJH.0b013e328364ca4c","article-title":"2013 Practice guidelines for the management of arterial hypertension of the European Society of Hypertension (ESH) and the European Society of Cardiology (ESC): ESH\/ESC Task Force for the Management of Arterial Hypertension","volume":"31","year":"2013","journal-title":"J Hypertens"},{"key":"10.1016\/j.jash.2016.05.009_bib4","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","article-title":"Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies","volume":"360","author":"Lewington","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.jash.2016.05.009_bib5","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/ki.2009.439","article-title":"Prehypertension: is it relevant for nephrologists?","volume":"77","author":"Kalaitzidis","year":"2010","journal-title":"Kidney Int"},{"issue":"16","key":"10.1016\/j.jash.2016.05.009_bib6","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","volume":"120","author":"Alberti","year":"2009","journal-title":"Circulation"},{"issue":"18","key":"10.1016\/j.jash.2016.05.009_bib7","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1001\/jama.289.18.2420","article-title":"Hypertension prevalence and stroke mortality across populations","volume":"289","author":"Staessen","year":"2003","journal-title":"JAMA"},{"issue":"11","key":"10.1016\/j.jash.2016.05.009_bib8","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1136\/heartjnl-2013-305063","article-title":"High rates of non-adherence to antihypertensive treatment revealed by high-performance liquid chromatography-tandem mass spectrometry (HP LC-MS\/MS) urine analysis","volume":"100","author":"Tomaszewski","year":"2014","journal-title":"Heart"},{"issue":"13","key":"10.1016\/j.jash.2016.05.009_bib9","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1161\/CIRCULATIONAHA.111.068064","article-title":"Incidence and prognosis of resistant hypertension in hypertensive patients","volume":"125","author":"Daugherty","year":"2012","journal-title":"Circulation"},{"issue":"13","key":"10.1016\/j.jash.2016.05.009_bib10","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1161\/CIRCULATIONAHA.112.097345","article-title":"Resistant hypertension: incidence, prevalence, and prognosis","volume":"125","author":"Pimenta","year":"2012","journal-title":"Circulation"},{"issue":"15","key":"10.1016\/j.jash.2016.05.009_bib11","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1056\/NEJMoa1402670","article-title":"A Controlled Trial of Renal Denervation for Resistant Hypertension","volume":"370","author":"Bhatt","year":"2014","journal-title":"N Engl J Med"},{"issue":"9671","key":"10.1016\/j.jash.2016.05.009_bib12","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/S0140-6736(09)60566-3","article-title":"Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study","volume":"373","author":"Krum","year":"2009","journal-title":"Lancet"},{"issue":"9917","key":"10.1016\/j.jash.2016.05.009_bib13","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0140-6736(13)62192-3","article-title":"Percutaneous renal denervation in patients with treatment-resistant hypertension: final 3-year report of the Symplicity HTN-1 study","volume":"383","author":"Krum","year":"2014","journal-title":"Lancet"},{"issue":"9756","key":"10.1016\/j.jash.2016.05.009_bib14","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(10)62039-9","article-title":"Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): a randomised controlled trial","volume":"376","author":"Esler","year":"2010","journal-title":"Lancet"},{"issue":"25","key":"10.1016\/j.jash.2016.05.009_bib15","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1161\/CIRCULATIONAHA.112.130880","article-title":"Renal sympathetic denervation for treatment of drug-resistant hypertension: one-year results from the Symplicity HTN-2 randomized, controlled trial","volume":"126","author":"Esler","year":"2012","journal-title":"Circulation"},{"issue":"26","key":"10.1016\/j.jash.2016.05.009_bib16","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1093\/eurheartj\/ehu209","article-title":"Catheter-based renal denervation for treatment of patients with treatment-resistant hypertension: 36 month results from the SYMPLICITY HTN-2 randomized clinical trial","volume":"35","author":"Esler","year":"2014","journal-title":"Eur Heart J"},{"issue":"7","key":"10.1016\/j.jash.2016.05.009_bib17","first-page":"611","article-title":"The sympathetic nervous system through the ages: from Thomas Willis to resistant hypertension","volume":"96","author":"Esler","year":"2011","journal-title":"Exp Physiol"},{"issue":"16","key":"10.1016\/j.jash.2016.05.009_bib18","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1001\/jama.1953.03690160001001","article-title":"Splanchnicectomy for essential hypertension; results in 1,266 cases","volume":"152","author":"Smithwick","year":"1953","journal-title":"JAMA"},{"key":"10.1016\/j.jash.2016.05.009_bib19","first-page":"1","article-title":"A technique for splanchnic resection for hypertension","volume":"7","author":"Smithwick","year":"1940","journal-title":"Surgery"},{"issue":"3","key":"10.1016\/j.jash.2016.05.009_bib20","first-page":"97","article-title":"Surgical measures in hypertensive patients","volume":"18","author":"Smithwick","year":"1948","journal-title":"Univ West Ont Med J"},{"issue":"4","key":"10.1016\/j.jash.2016.05.009_bib21","first-page":"282","article-title":"End Results of thoracolumbar sympathectomy for advanced essential hypertension","volume":"70","author":"Hinton","year":"1949","journal-title":"Calif Med"},{"key":"10.1016\/j.jash.2016.05.009_bib22","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1056\/NEJM194702202360802","article-title":"Results of bilateral supra diaphragmatic splanchnicectomy for arterial hypertension","volume":"236","author":"Peet","year":"1947","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jash.2016.05.009_bib23","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0140-6736(53)91589-X","article-title":"Sympathectomy in the treatment of hypertension; review of 122 cases","volume":"1","author":"Morrissey","year":"1953","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jash.2016.05.009_bib24","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jcin.2011.12.011","article-title":"Renal Denervation for Hypertension","volume":"5","author":"Bertog","year":"2012","journal-title":"JACC Cardiovasc Interv"},{"key":"10.1016\/j.jash.2016.05.009_bib25","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fphys.2015.00075","article-title":"A clinician\u2019s perspective of the role of renal sympathetic nerves in hypertension","volume":"6","author":"Briasoulis","year":"2015","journal-title":"Front Physiol"},{"issue":"4","key":"10.1016\/j.jash.2016.05.009_bib26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/ar.10174","article-title":"Qualitative and quantitative morphology of renal nerves in C57BL\/6J mice","volume":"268","author":"Fazan","year":"2002","journal-title":"Anat Rec"},{"issue":"5","key":"10.1016\/j.jash.2016.05.009_bib27","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1161\/CIRCRESAHA.107.148338","article-title":"Angiotensin-converting enzyme and vascular remodeling","volume":"101","author":"Heeneman","year":"2007","journal-title":"Circ Res"},{"key":"10.1016\/j.jash.2016.05.009_bib28","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/CIRCRESAHA.116.303587","article-title":"Renin\u2013Angiotensin\u2013Aldosterone System Alterations","volume":"116","author":"TeRiet","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.jash.2016.05.009_bib29","doi-asserted-by":"crossref","first-page":"64241","DOI":"10.4061\/2011\/642416","article-title":"Pathophysiology of resistant hypertension: the role of sympathetic nervous system","volume":"2011","author":"Tsioufis","year":"2011","journal-title":"Int J Hypertens"},{"issue":"5","key":"10.1016\/j.jash.2016.05.009_bib30","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/ca.21280","article-title":"Micro-anatomy of the renal sympathetic nervous system: a human postmortem histologic study","volume":"25","author":"Atherton","year":"2012","journal-title":"Clin Anat"},{"key":"10.1016\/j.jash.2016.05.009_bib31","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1097\/HJH.0b013e32835821e5","article-title":"Morphological assessment of renal arteries after radiofrequency catheter-based sympathetic denervation in a porcine model","volume":"30","author":"Steigerwald","year":"2012","journal-title":"J Hypertens"},{"key":"10.1016\/j.jash.2016.05.009_bib32","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.trsl.2013.07.002","article-title":"Renal artery nerve distribution and densityin the porcine model: biologic implications for the development of radiofrequency ablation therapies","volume":"162","author":"Tellez","year":"2013","journal-title":"Transl Res"},{"issue":"7","key":"10.1016\/j.jash.2016.05.009_bib33","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.jacc.2014.03.059","article-title":"Anatomic assessment of sympathetic peri-arterial renal nerves in man","volume":"64","author":"Sakakura","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"7","key":"10.1016\/j.jash.2016.05.009_bib34","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1093\/ajh\/hpu258","article-title":"Catheter-Based Radiofrequency Renal Denervation: Location Effects on Renal Norepinephrine","volume":"28","author":"Henegar","year":"2015","journal-title":"Am J Hypertens"},{"issue":"16","key":"10.1016\/j.jash.2016.05.009_bib35","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1016\/j.jacc.2015.08.018","article-title":"Impact of Lesion Placement on Efficacy and Safety of Catheter-Based Radiofrequency Renal Denervation","volume":"66","author":"Mahfoud","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"285","key":"10.1016\/j.jash.2016.05.009_bib36","doi-asserted-by":"crossref","first-page":"285ra65","DOI":"10.1126\/scitranslmed.aaa3236","article-title":"Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension","volume":"7","author":"Tzafriri","year":"2015","journal-title":"Sci Transl Med"},{"issue":"9","key":"10.1016\/j.jash.2016.05.009_bib37","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.4244\/EIJV9I9A175","article-title":"What the interventionalist should know about renal denervation in hypertensive patients: a position paper by the ESH WG on the interventional treatment of hypertension","volume":"9","author":"Tsioufis","year":"2014","journal-title":"EuroIntervention"},{"issue":"28","key":"10.1016\/j.jash.2016.05.009_bib38","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1093\/eurheartj\/eht197","article-title":"Safety and efficacy of a multi-electrode renal sympathetic denervation system in resistant hypertension: the EnligHTN I trial","volume":"34","author":"Worthley","year":"2013","journal-title":"Eur Heart J"},{"issue":"13","key":"10.1016\/j.jash.2016.05.009_bib39","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.jacc.2015.01.037","article-title":"12-Month Blood Pressure Results of Catheter-Based Renal Artery Denervation for Resistant Hypertension The SYMPLICITY HTN-3 Trial","volume":"65","author":"Bakris","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"9981","key":"10.1016\/j.jash.2016.05.009_bib40","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/S0140-6736(14)61942-5","article-title":"Renal Denervation for Hypertension (DENERHTN) investigators. Optimum and stepped care standardised antihypertensive treatment with or without renal denervation for resistant hypertension (DENERHTN): a multicentre, open-label,randomised controlled trial","volume":"385","author":"Azizi","year":"2015","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.jash.2016.05.009_bib41","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1161\/HYPERTENSIONAHA.114.05010","article-title":"First report of the Global SYMPLICITY Registry on the effect of renal artery denervation in patients with uncontrolled hypertension","volume":"65","author":"B\u00f6hm","year":"2015","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.jash.2016.05.009_bib42","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1161\/HYPERTENSIONAHA.114.04019","article-title":"Randomized comparison of renal denervation versus intensified pharmacotherapy including spironolactone in true-resistant hypertension: six-month results from the Prague-15 study","volume":"65","author":"Rosa","year":"2015","journal-title":"Hypertension"},{"issue":"2","key":"10.1016\/j.jash.2016.05.009_bib43","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1161\/HYPERTENSIONAHA.115.06526","article-title":"Role of Adding Spironolactone and Renal Denervation in True Resistant Hypertension: One-Year Outcomes of Randomized PRAGUE-15 Study","volume":"67","author":"Rosa","year":"2016","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.jash.2016.05.009_bib44","doi-asserted-by":"crossref","first-page":"e002293","DOI":"10.1161\/CIRCINTERVENTIONS.114.002293","article-title":"Neuromatous regeneration as a nerve response after catheter-based renal denervation therapy in a large animal model: immunohistochemical study","volume":"8","author":"Rousselle","year":"2015","journal-title":"Circ Cardiovasc Interv"},{"key":"10.1016\/j.jash.2016.05.009_bib45","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1161\/CIRCRESAHA.113.302549","article-title":"Role of the autonomic nervous system in modulating cardiac arrhythmias","volume":"114","author":"Shen","year":"2014","journal-title":"Circ Res"},{"key":"10.1016\/j.jash.2016.05.009_bib46","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1161\/01.CIR.73.5.913","article-title":"Direct evidence from intraneural recordings for increased central sympathetic outflow in patients with heart failure","volume":"73","author":"Leimbach","year":"1986","journal-title":"Circulation"},{"key":"10.1016\/j.jash.2016.05.009_bib47","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1161\/01.HYP.25.4.560","article-title":"Sympathetic activation in obese normotensive subjects","volume":"25","author":"Grassi","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.jash.2016.05.009_bib48","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1172\/JCI118235","article-title":"Sympathetic neural mechanisms in obstructive sleep apnea","volume":"96","author":"Somers","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jash.2016.05.009_bib49","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1161\/CIRCRESAHA.116.303604","article-title":"The Sympathetic Nervous System Alterations in Human Hypertension","volume":"116","author":"Grassi","year":"2015","journal-title":"Circ Res"},{"key":"10.1016\/j.jash.2016.05.009_bib50","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1161\/CIRCULATIONAHA.113.005405","article-title":"Renal Nerve ablation for resistant hypertension, how did we get here, present status and future directions","volume":"129","author":"Papademetriou","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.jash.2016.05.009_bib51","unstructured":"Available at: http:\/\/www.medtronicrdn.com\/index.htm.\u00a02015."},{"key":"10.1016\/j.jash.2016.05.009_bib52","unstructured":"Available at: https:\/\/professional-intl.sjm.com.\u00a02015."},{"issue":"4","key":"10.1016\/j.jash.2016.05.009_bib53","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nrcardio.2016.1","article-title":"The rise, fall, and possible resurrection of renal denervation","volume":"13","author":"Gulati","year":"2016","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jash.2016.05.009_bib54","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jclinepi.2013.08.015","article-title":"Systematic review of the Hawthorne effect: new concepts are needed to study research participation effects","volume":"67","author":"McCambridge","year":"2014","journal-title":"J Clin Epidemiol"},{"issue":"15","key":"10.1016\/j.jash.2016.05.009_bib55","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.jacc.2014.08.008","article-title":"Do current clinical trials meet society's needs?: a critical review of recent evidence","volume":"64","author":"Pocock","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"10.1016\/j.jash.2016.05.009_bib56","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/eurheartj\/ehu441","article-title":"Predictors of blood pressure response in the SYMPLICITY HTN-3 trial","volume":"36","author":"Kandzari","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jash.2016.05.009_bib57","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.4244\/EIJV10I10A187","article-title":"Renal denervation reloaded: where to go from here?","volume":"10","author":"Mahfoud","year":"2015","journal-title":"EuroIntervention"},{"issue":"3","key":"10.1016\/j.jash.2016.05.009_bib58","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11906-014-0526-9","article-title":"Understanding the Importance of Race\/Ethnicity in the Care of the Hypertensive Patient","volume":"17","author":"Ferdinand","year":"2015","journal-title":"Curr Hypertens Rep"},{"issue":"1","key":"10.1016\/j.jash.2016.05.009_bib59","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/ije\/dyh299","article-title":"Regression to the mean: what it is and how to deal with it","volume":"34","author":"Barnett","year":"2005","journal-title":"Int J Epidemiol"},{"issue":"1","key":"10.1016\/j.jash.2016.05.009_bib60","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ahj.2015.08.021","article-title":"The SPYRAL HTN Global Clinical Trial Program: Rationale and design for studies of renal denervation in the absence (SPYRAL HTN OFF-MED) and presence (SPYRAL HTN ON-MED) of antihypertensive medications","volume":"171","author":"Kandzari","year":"2016","journal-title":"Am Heart J"},{"issue":"1","key":"10.1016\/j.jash.2016.05.009_bib61","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1161\/HYPERTENSIONAHA.114.04336","article-title":"Reduced effect of percutaneous renal denervation on blood pressure in patients with isolated systolic hypertension","volume":"65","author":"Ewen","year":"2015","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.jash.2016.05.009_bib62","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1161\/01.HYP.0000153793.84859.b8","article-title":"Aortic diameter, aortic stiffness, and wave reflection increase with age and isolated systolic hypertension","volume":"45","author":"O'Rourke","year":"2005","journal-title":"Hypertension"},{"issue":"12","key":"10.1016\/j.jash.2016.05.009_bib63","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1097\/HJH.0000000000000752","article-title":"Blood pressure changes after catheter-based renal denervation are related to reductions in total peripheral resistance","volume":"33","author":"Ewen","year":"2015","journal-title":"J Hypertens"},{"issue":"1","key":"10.1016\/j.jash.2016.05.009_bib64","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4244\/EIJV11I1A19","article-title":"Central pulse pressure predicts BP reduction after renal denervation in patients with treatment-resistant hypertension","volume":"11","author":"Ott","year":"2015","journal-title":"EuroIntervention"},{"issue":"5","key":"10.1016\/j.jash.2016.05.009_bib65","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3109\/08037051.2015.1058595","article-title":"Meta-analysis of randomized controlled trials of renal denervation in treatment-resistant hypertension","volume":"24","author":"Fadl Elmula","year":"2015","journal-title":"Blood Press"},{"issue":"6","key":"10.1016\/j.jash.2016.05.009_bib66","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1161\/HYPERTENSIONAHA.115.05283","article-title":"Randomized sham-controlled trial of renal sympathetic denervation in mild resistant hypertension","volume":"65","author":"Desch","year":"2015","journal-title":"Hypertension"},{"issue":"5","key":"10.1016\/j.jash.2016.05.009_bib67","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1161\/HYPERTENSIONAHA.113.02266","article-title":"Soluble fms-like tyrosine kinase-1 and endothelial adhesion molecules (intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1) as predictive markers for blood pressure reduction after renal sympathetic denervation","volume":"63","author":"D\u00f6rr","year":"2014","journal-title":"Hypertension"},{"issue":"11","key":"10.1016\/j.jash.2016.05.009_bib68","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.jacc.2014.11.071","article-title":"Brain-derived neurotrophic factor as a marker for immediate assessment of the success of renal sympathetic denervation","volume":"65","author":"D\u00f6rr","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.jash.2016.05.009_bib69","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/jhh.2014.91","article-title":"Blood pressure response to renal nerve stimulation in patients undergoing renal denervation: a feasibility study","volume":"29","author":"Gal","year":"2015","journal-title":"J Hum Hypertens"},{"issue":"12","key":"10.1016\/j.jash.2016.05.009_bib70","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1007\/s00392-015-0905-5","article-title":"Blood pressure reductions following catheter-based renal denervation are not related to improvements in adherence to antihypertensive drugs measured by urine\/plasma toxicological analysis","volume":"104","author":"Ewen","year":"2015","journal-title":"Clin Res Cardiol"},{"key":"10.1016\/j.jash.2016.05.009_bib71","unstructured":"Available at: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02392351.\u00a02015."},{"issue":"6","key":"10.1016\/j.jash.2016.05.009_bib72","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1161\/HYPERTENSIONAHA.111.169961","article-title":"Addition of spironolactone in patients with resistant arterial hypertension (ASPIRANT): a randomized, double-blind, placebo-controlled trial","volume":"57","author":"V\u00e1clav\u00edk","year":"2011","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.jash.2016.05.009_bib73","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1253\/circj.CJ-13-0997","article-title":"Progression of renal artery stenosis after renal denervation. Impact on 24-hour blood pressure","volume":"78","author":"Pucci","year":"2014","journal-title":"Circ J"},{"issue":"33","key":"10.1016\/j.jash.2016.05.009_bib74","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1093\/eurheartj\/ehv192","article-title":"Proceedings from the European clinical consensus conference for renal denervation: considerations on future clinical trial design","volume":"36","author":"Mahfoud","year":"2015","journal-title":"Eur Heart J"},{"issue":"5","key":"10.1016\/j.jash.2016.05.009_bib75","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jash.2015.02.012","article-title":"Renal denervation therapy for hypertension: pathways for moving development forward","volume":"9","author":"White","year":"2015","journal-title":"J Am Soc Hypertens"},{"issue":"2","key":"10.1016\/j.jash.2016.05.009_bib76","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.ijcard.2012.09.224","article-title":"Cryoenergy is effective in the treatment of resistant hypertension in non-responders to radiofrequency renal denervation","volume":"167","author":"Prochnau","year":"2013","journal-title":"Int J Cardiol"},{"issue":"5","key":"10.1016\/j.jash.2016.05.009_bib77","doi-asserted-by":"crossref","first-page":"640","DOI":"10.4244\/EIJV10I5A110","article-title":"Renal denervation with cryoenergy as second-line option is effective in the treatment of resistant hypertension in non-responders to radiofrequency ablation","volume":"10","author":"Prochnau","year":"2014","journal-title":"EuroIntervention"},{"issue":"1","key":"10.1016\/j.jash.2016.05.009_bib78","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4244\/EIJV8I1A10","article-title":"First experience with endovascular ultrasound renal denervation for the treatment of resistant hypertension","volume":"8","author":"Mabin","year":"2012","journal-title":"EuroIntervention"},{"issue":"4","key":"10.1016\/j.jash.2016.05.009_bib79","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4244\/EIJV11I4A96","article-title":"Renal sympathetic nerve denervation using intraluminal ultrasound within a cooling balloon preserves the arterial wall and reduces sympathetic nerve activity","volume":"11","author":"Pathak","year":"2015","journal-title":"EuroIntervention"},{"issue":"1","key":"10.1016\/j.jash.2016.05.009_bib80","doi-asserted-by":"crossref","first-page":"140","DOI":"10.4244\/EIJV9I1A20","article-title":"Ethanol-mediated perivascular renal sympathetic denervation: preclinical validation of safety and efficacy in a porcine model","volume":"9","author":"Fischell","year":"2013","journal-title":"EuroIntervention"},{"issue":"6","key":"10.1016\/j.jash.2016.05.009_bib81","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jcin.2015.11.041","article-title":"Transcatheter Alcohol-Mediated Perivascular Renal Denervation With the Peregrine System: First-in-Human Experience","volume":"9","author":"Fischell","year":"2016","journal-title":"JACC Cardiovasc Interv"},{"issue":"4","key":"10.1016\/j.jash.2016.05.009_bib82","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/jhh.2013.77","article-title":"Resistant hypertension: patient characteristics, risk factors, co-morbidities and outcomes","volume":"28","author":"Oliveras","year":"2014","journal-title":"J Hum Hypertens"},{"issue":"9","key":"10.1016\/j.jash.2016.05.009_bib83","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1097\/HJH.0b013e3283622e58","article-title":"Renal nerve ablation reduces augmentation index in patients with resistant hypertension","volume":"31","author":"Hering","year":"2013","journal-title":"J Hypertens"},{"key":"10.1016\/j.jash.2016.05.009_bib84","doi-asserted-by":"crossref","first-page":"R105","DOI":"10.4244\/EIJV9SRA18","article-title":"Obstructive sleep apnoea, resistant hypertension and renal denervation","volume":"9 Suppl R","author":"Witkowski","year":"2013","journal-title":"EuroIntervention"},{"issue":"6","key":"10.1016\/j.jash.2016.05.009_bib85","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/ejhf.83","article-title":"Renal denervation and heart failure","volume":"16","author":"B\u00f6hm","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jash.2016.05.009_bib86","doi-asserted-by":"crossref","first-page":"R110","DOI":"10.4244\/EIJV9SRA19","article-title":"Potential role of renal sympathetic denervation for the treatment of cardiac arrhythmias","volume":"9 Suppl R","author":"Ukena","year":"2013","journal-title":"EuroIntervention"},{"issue":"4","key":"10.1016\/j.jash.2016.05.009_bib87","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1161\/HYPERTENSIONAHA.114.04798","article-title":"Denervation of the renal arteries in metabolic syndrome: the DREAMS-study","volume":"65","author":"Verloop","year":"2015","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.jash.2016.05.009_bib88","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1097\/HJH.0000000000000556","article-title":"Renal denervation preserves renal function in patients with chronic kidney disease and resistant hypertension","volume":"33","author":"Ott","year":"2015","journal-title":"J Hypertens"},{"issue":"6","key":"10.1016\/j.jash.2016.05.009_bib89","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/cen.12003","article-title":"The sympathetic nervous system in polycystic ovary syndrome: a novel therapeutic target?","volume":"77","author":"Lansdown","year":"2012","journal-title":"Clin Endocrinol (Oxf)"},{"key":"10.1016\/j.jash.2016.05.009_bib90","unstructured":"Available at: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02064764?term=symplicity+af&rank=1.\u00a02015."}],"container-title":["Journal of the American Society of Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933171116303230?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933171116303230?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T06:00:52Z","timestamp":1568008852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933171116303230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":90,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["S1933171116303230"],"URL":"https:\/\/doi.org\/10.1016\/j.jash.2016.05.009","relation":{},"ISSN":["1933-1711"],"issn-type":[{"value":"1933-1711","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Renal denervation in the era of HTN-3. Comprehensive review and glimpse into the future","name":"articletitle","label":"Article Title"},{"value":"Journal of the American Society of Hypertension","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jash.2016.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 American Society of Hypertension. All rights reserved.","name":"copyright","label":"Copyright"}]}}