{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:20:42Z","timestamp":1784755242428,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1016\/j.jaut.2003.09.006","type":"journal-article","created":{"date-parts":[[2003,11,11]],"date-time":"2003-11-11T09:08:16Z","timestamp":1068541696000},"page":"21-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Apoptosis in feathers of Smyth line chickens with autoimmune vitiligo"],"prefix":"10.1016","volume":"22","author":[{"given":"X","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.F","family":"Erf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2003.09.006_BIB1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0002-9343(71)90232-4","article-title":"On the etiology of vitiligo and grey hair","volume":"51","author":"Lerner","year":"1971","journal-title":"Am J Med"},{"key":"10.1016\/j.jaut.2003.09.006_BIB2","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1001\/jama.1978.03280390079031","article-title":"Vitiligo. What is it? Is it important?","volume":"239","author":"Lerner","year":"1978","journal-title":"JAMA"},{"key":"10.1016\/j.jaut.2003.09.006_BIB3","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0738-081X(97)00126-0","article-title":"Immune mechanisms in vitiligo","volume":"15","author":"Bystryn","year":"1997","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1365-2133.1968.tb12282.x","article-title":"Vitiligo, Thyroid disease and autoimmunity","volume":"80","author":"Cunliffe","year":"1968","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB5","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1001\/jama.1972.03190320030010","article-title":"Vitiligo and multiple glandular insufficiencies","volume":"219","author":"McGregor","year":"1972","journal-title":"JAMA"},{"key":"10.1016\/j.jaut.2003.09.006_BIB6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0923-1811(93)90039-R","article-title":"The change of melanocyte cytotoxicity after systemic steroidtreatment in vitiligo patients","volume":"6","author":"Hann","year":"1993","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.jaut.2003.09.006_BIB7","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1159\/000251982","article-title":"Treatment of vitiligo by local application of betamethasone 17-valerate in a dimethyl sulfoxide cream base","volume":"146","author":"Koopmans-van Dorp","year":"1973","journal-title":"Dermatologica"},{"key":"10.1016\/j.jaut.2003.09.006_BIB8","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/1523-1747.ep12492607","article-title":"Relationship between the incidence and level of pigment cell antibodies and disease activity in vitiligo","volume":"97","author":"Harning","year":"1991","journal-title":"J Investig Dermatol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB9","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/1523-1747.ep12522891","article-title":"Detection of antibodies to melanocytes in vitiligo by immunoprecipitation","volume":"81","author":"Naughton","year":"1983","journal-title":"J Investig Dermatol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB10","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1365-4362.1983.tb02178.x","article-title":"Histopathology of vitiliginous skin","volume":"22","author":"Gokhale","year":"1983","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB11","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/labinvest.3780138","article-title":"Local immune response in skin of generalized vitiligo patients. Destruction of melanocytes is associated with the prominent presence of CLA+ T cells at the perilesional site","volume":"80","author":"Van den Wijngaard","year":"2000","journal-title":"Lab Invest"},{"key":"10.1016\/j.jaut.2003.09.006_BIB12","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.1073\/pnas.91.14.6458","article-title":"Identification of a human melanoma antigen recognized by tumor infiltrating lymphocytes associated with in vivo tumor rejection","volume":"91","author":"Kawakami","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jaut.2003.09.006_BIB13","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1073\/pnas.91.9.3515","article-title":"Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor","volume":"91","author":"Kawakami","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jaut.2003.09.006_BIB14","first-page":"3124","article-title":"Recognition of tyrosinase by tumor-infiltrating lymphocytes from a patient responding to immunotherapy","volume":"54","author":"Robbins","year":"1994","journal-title":"Cancer Res"},{"key":"10.1016\/j.jaut.2003.09.006_BIB15","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1084\/jem.181.2.799","article-title":"Identification of a gene encoding a melanoma tumor antigen recognized by HLA-A31-restricted tumor-infiltrating lymphocytes","volume":"181","author":"Wang","year":"1995","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaut.2003.09.006_BIB16","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1084\/jem.184.6.2207","article-title":"Identification of TRP-2 as a human tumor antigen recognized by cytotoxic T lymphocytes","volume":"184","author":"Wang","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaut.2003.09.006_BIB17","first-page":"5330","article-title":"Generation of antimelanoma cytotoxic T lymphocytes from healthy donors after presentation of melanoma-associated antigen-derived epitopes by dendritic cells in vitro","volume":"15","author":"Bakker","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/j.jaut.2003.09.006_BIB18","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1001\/archderm.1987.01660320095019","article-title":"Prognosticsignificance of hypopigmentation in malignant melanoma","volume":"123","author":"Bystryn","year":"1987","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB19","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0190-9622(83)70182-9","article-title":"Vitiligo in patients with metastatic melanoma: a good prognostic sign","volume":"9","author":"Nordlund","year":"1983","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB20","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1200\/JCO.1992.10.8.1338","article-title":"Sequential chemoimmunotherapy in the treatment of metastatic melanoma","volume":"10","author":"Richards","year":"1992","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/00002371-199601000-00009","article-title":"Vitiligo in patients with melanoma: normal tissue antigens can be targets for cancer immunotherapy","volume":"19","author":"Rosenberg","year":"1996","journal-title":"J Immunother Emphasis Tumor Immunol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB22","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1084\/jem.188.6.1203","article-title":"High frequency of skin-homing melanocyte-specific cytotoxic Tlymphocytes in autoimmune vitiligo","volume":"188","author":"Ogg","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaut.2003.09.006_BIB23","first-page":"1","article-title":"The Smyth chicken: a model for autoimmune amelanosis","volume":"2","author":"Smyth","year":"1989","journal-title":"Poultry Biol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB24","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/oxfordjournals.jhered.a109462","article-title":"The DAM chicken: a model for spontaneous postnatal cutaneous and ocular amelanosis","volume":"72","author":"Smyth","year":"1981","journal-title":"J Hered"},{"key":"10.1016\/j.jaut.2003.09.006_BIB25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3109\/08916939708994728","article-title":"Profiles of pulp infiltrating lymphocytes at various times throughout feather regeneration in Smyth line chickens with vitiligo","volume":"25","author":"Shresta","year":"1997","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jaut.2003.09.006_BIB26","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1006\/clin.1995.1105","article-title":"T cells in regenerating feathers of Smyth line chickens with vitiligo","volume":"76","author":"Erf","year":"1995","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0896-8411(03)00087-8","article-title":"Melanocyte-specific cell mediated immune response in vitiliginous Smyth line chickens","volume":"21","author":"Wang","year":"2003","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jaut.2003.09.006_BIB28","first-page":"133","article-title":"Apoptosis: The biochemistry and molecular biology of programmed cell death","volume":"14","author":"Schwartzman","year":"1993","journal-title":"Endocr"},{"key":"10.1016\/j.jaut.2003.09.006_BIB29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0065-2423(08)60336-4","article-title":"Apoptosis and programmed cell death in health and disease","volume":"31","author":"Vermes","year":"1994","journal-title":"Adv Clin Chem"},{"key":"10.1016\/j.jaut.2003.09.006_BIB30","doi-asserted-by":"crossref","first-page":"3509","DOI":"10.4049\/jimmunol.156.9.3509","article-title":"Programmed cell death in peripheral lymphocytes from HIV-infected persons increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression","volume":"156","author":"Gougeon","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB31","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1126\/science.274.5291.1363","article-title":"Melanoma cell expression of Fas (Apo-1\/CD95) ligand: implications for tumor immune escape","volume":"274","author":"Hahne","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.jaut.2003.09.006_BIB32","first-page":"3","article-title":"Clinical significance of serum soluble Fas ligand in patients with acute self-limited and fulminant hepatitis","volume":"101","author":"Shiota","year":"1998","journal-title":"Res Commun Mol Pathol Pharmacol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB33","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.4049\/jimmunol.158.8.3902","article-title":"Direct demonstration of delayed eosinophil apoptosis as a mechanism causing tissue eosinophilia","volume":"158","author":"Simon","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB34","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1084\/jem.184.6.2361","article-title":"Multiple sclerosis: Fas signaling in oligodendrocyte cell death","volume":"184","author":"D'Souza","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaut.2003.09.006_BIB35","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1126\/science.275.5302.960","article-title":"Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis","volume":"275","author":"Giordano","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.jaut.2003.09.006_BIB36","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s11626-999-0094-5","article-title":"Effects of commonly used mitogens of the cytotoxicity of 4-tertiary butylphenol to human melanocytes","volume":"35","author":"Yang","year":"1999","journal-title":"In Vitro Cell Dev Biol Animal"},{"key":"10.1016\/j.jaut.2003.09.006_BIB37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/00125480-199901000-00002","article-title":"Melan-A, a new melanocytic differentiation marker","volume":"6","author":"Busam","year":"1999","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB38","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0167-5699(97)01003-7","article-title":"Cellular environments and apoptosis: tissue microenvironments control activated T-cell death","volume":"18","author":"Amber","year":"1997","journal-title":"Immunol Today"},{"key":"10.1016\/j.jaut.2003.09.006_BIB39","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.iy.10.040192.001411","article-title":"Apoptosis and programmed cell death in immunity","volume":"10","author":"Cohen","year":"1992","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB40","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0190-9622(86)70085-6","article-title":"Aberrations in T lymphocytes and natural killer cells in vitiligo: a flow cytometric study","volume":"14","author":"Halder","year":"1986","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB41","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0190-9622(89)70069-4","article-title":"Circadian rhythm of natural killer cell activity in vitiligo","volume":"20","author":"Mozzanica","year":"1989","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0749.1994.tb00013.x","article-title":"Further evidence for involvement of both cell mediated and humoral immunity in generalized vitiligo","volume":"7","author":"Abdel-Naser","year":"1994","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jaut.2003.09.006_BIB43","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1046\/j.1523-1747.2001.01363.x","article-title":"HLA-A2 restricted, melanocyte-specific CD8+ T lymphocytes detected in vitiligo patients are related to disease activity and are predominantly directed against melanA\/MART1","volume":"116","author":"Lang","year":"2001","journal-title":"JInvestig Dermatol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB44","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(00)80178-6","article-title":"The role of Fas in autoimmune diabetes","volume":"89","author":"Chervonsky","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2003.09.006_BIB45","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1365-2133.2000.03712.x","article-title":"Expression and modulation of apoptosis regulatory molecules in human melanocytes: significance in vitiligo","volume":"143","author":"Van den Wijngaard","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.jaut.2003.09.006_BIB46","first-page":"3546","article-title":"Accelerated disappearance of melanocytes in bcl-2-deficient mice","volume":"56","author":"Yamamura","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.jaut.2003.09.006_BIB47","first-page":"731","article-title":"Melanogenesisand autophagocytosis of melanin within feather melanocytes of delayed amelanotic (DAM) chickens","volume":"1","author":"Boissy","year":"1985","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jaut.2003.09.006_BIB48","first-page":"49","article-title":"The melanocyte of the chicken: A review","volume":"256","author":"Bowers","year":"1988","journal-title":"Prog Clin Biol Res"},{"key":"10.1016\/j.jaut.2003.09.006_BIB49","first-page":"224","article-title":"Detection of interferon gamma mRNA in feathers of vitiliginous Smyth line chickens by Northern blotting","volume":"14","author":"Wang","year":"2001","journal-title":"Pigment Cell Res"},{"key":"10.1016\/j.jaut.2003.09.006_BIB50","doi-asserted-by":"crossref","first-page":"7284","DOI":"10.4049\/jimmunol.151.12.7284","article-title":"A novel, antigen-presenting function of melanocytes and its possible relation to hypopigmentary disorders","volume":"151","author":"Le Poole","year":"1993","journal-title":"J Immunol"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841103001501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841103001501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:53:55Z","timestamp":1760255635000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841103001501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["S0896841103001501"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2003.09.006","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2004,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apoptosis in feathers of Smyth line chickens with autoimmune vitiligo","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2003.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}