{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:15:50Z","timestamp":1762175750566,"version":"build-2065373602"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1016\/j.jaut.2004.05.004","type":"journal-article","created":{"date-parts":[[2004,8,27]],"date-time":"2004-08-27T16:59:33Z","timestamp":1093625973000},"page":"183-190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["The interferon gamma gene in celiac disease: augmented expression correlates with tissue damage but no evidence for genetic susceptibility"],"prefix":"10.1016","volume":"23","author":[{"given":"Martin C.","family":"Wapenaar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine J.","family":"van Belzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin H.","family":"Fransen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aranzazu","family":"Fari\u00f1a Sarasqueta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roderick H.J.","family":"Houwen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos W.R.","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris J.J.","family":"Mulder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cisca","family":"Wijmenga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2004.05.004_BIB1","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1053\/gast.2000.8521","article-title":"Current concepts of celiac disease pathogenesis","volume":"119","author":"Schuppan","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2004.05.004_BIB2","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0016-5085(92)91819-P","article-title":"Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (\u2018celiac sprue\u2019)","volume":"102","author":"Marsh","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2004.05.004_BIB3","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1053\/gast.2001.22123","article-title":"Current approaches to diagnosis and treatment of celiac disease: an evolving spectrum","volume":"120","author":"Fasano","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2004.05.004_BIB4","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0140-6736(03)14027-5","article-title":"Coeliac disease","volume":"362","author":"Green","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2004.05.004_BIB5","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nri885","article-title":"Coeliac disease: dissecting a complex inflammatory disorder","volume":"2","author":"Sollid","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaut.2004.05.004_BIB6","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.4049\/jimmunol.161.4.1585","article-title":"Selective deamidation by tissue transglutaminase strongly enhances gliadin-specific T cell reactivity","volume":"161","author":"van de Wal","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.jaut.2004.05.004_BIB7","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1038\/nm0698-713","article-title":"Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease","volume":"4","author":"Molberg","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.jaut.2004.05.004_BIB8","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1136\/gut.35.8.1037","article-title":"Detection of interferon gamma mRNA in the mucosa of patients with coeliac disease by in situ hybridisation","volume":"35","author":"Kontakou","year":"1994","journal-title":"Gut"},{"key":"10.1016\/j.jaut.2004.05.004_BIB9","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0016-5085(98)70134-9","article-title":"Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease","volume":"115","author":"Nilsen","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2004.05.004_BIB10","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.1365-3083.1999.00523.x","article-title":"Cytokine profile in coeliac disease","volume":"49","author":"Lahat","year":"1999","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jaut.2004.05.004_BIB11","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1053\/gast.2002.35355","article-title":"Paradoxical coexpression of proinflammatory and down-regulatory cytokines in intestinal T cells in childhood celiac disease","volume":"123","author":"Forsberg","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2004.05.004_BIB12","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1046\/j.1365-2249.1999.00882.x","article-title":"Cytokine-producing cells in peripheral blood of children with coeliac disease secrete cytokines with a type 1 profile","volume":"116","author":"Hansson","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaut.2004.05.004_BIB13","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/gut.36.6.874","article-title":"Histological changes in small bowel mucosa induced by gliadin sensitive T lymphocytes can be blocked by anti-interferon gamma antibody","volume":"36","author":"Przemioslo","year":"1995","journal-title":"Gut"},{"key":"10.1016\/j.jaut.2004.05.004_BIB14","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1046\/j.1365-3083.2002.01195.x","article-title":"Interferon-gamma-secreting T cells localize to the epithelium in coeliac disease","volume":"56","author":"Olaussen","year":"2002","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.jaut.2004.05.004_BIB15","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/(SICI)1521-4141(199802)28:02<730::AID-IMMU730>3.0.CO;2-U","article-title":"Small bowel enteropathy: role of intraepithelial lymphocytes and of cytokines (IL-12, IFN-gamma, TNF) in the induction of epithelial cell death and renewal","volume":"28","author":"Guy-Grand","year":"1998","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaut.2004.05.004_BIB16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2370.1999.00122.x","article-title":"In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene","volume":"26","author":"Pravica","year":"1999","journal-title":"Eur J Immunogenet"},{"key":"10.1016\/j.jaut.2004.05.004_BIB17","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1007\/s11882-001-0061-z","article-title":"Genetic factors underlying gluten-sensitive enteropathy","volume":"1","author":"Pena","year":"2001","journal-title":"Curr Allergy Asthma Rep"},{"key":"10.1016\/j.jaut.2004.05.004_BIB18","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/S0016-5085(03)01205-8","article-title":"A major non-HLA locus in celiac disease maps to chromosome 19","volume":"125","author":"Van Belzen","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2004.05.004_BIB19","first-page":"1123","article-title":"Report of a working group of the United European Gastroenterology Week in Amsterdam. When is a coeliac a coeliac?","volume":"13","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.jaut.2004.05.004_BIB20","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1046\/j.1365-2036.2003.01687.x","article-title":"Azathioprine and prednisone combination therapy in refractory coeliac disease","volume":"18","author":"Goerres","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.jaut.2004.05.004_BIB21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.jaut.2004.05.004_BIB22","first-page":"439","article-title":"Complete multipoint sib-pair analysis of qualitative and quantitative traits","volume":"57","author":"Kruglyak","year":"1995","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaut.2004.05.004_BIB23","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/BF00418381","article-title":"Association of polymorphism in the interferon gamma gene with IDDM","volume":"37","author":"Awata","year":"1994","journal-title":"Diabetologia"},{"key":"10.1016\/j.jaut.2004.05.004_BIB24","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/107999000312595","article-title":"A CA repeat polymorphism of the IFN-gamma gene is associated with susceptibility to type 1 diabetes","volume":"20","author":"Jahromi","year":"2000","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.jaut.2004.05.004_BIB25","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/S0140-6736(00)02657-X","article-title":"Association between dinucleotide repeat in non-coding region of interferon-gamma gene and susceptibility to, and severity of rheumatoid arthritis","volume":"356","author":"Khani-Hanjani","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2004.05.004_BIB26","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/ana.410440525","article-title":"Interferon-gamma gene polymorphism-associated risk for multiple sclerosis in Sardinia","volume":"44","author":"Vandenbroeck","year":"1998","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jaut.2004.05.004_BIB27","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1089\/107999099313262","article-title":"Analysis of an IFN-gamma gene (IFNG) polymorphism in multiple sclerosis in Europe: effect of population structure on association with disease","volume":"19","author":"Goris","year":"1999","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.jaut.2004.05.004_BIB28","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1365-2370.2003.00428.x","article-title":"IL12B and IRF1 gene polymorphisms and susceptibility to celiac disease","volume":"30","author":"Seegers","year":"2003","journal-title":"Eur J Immunogenet"},{"key":"10.1016\/j.jaut.2004.05.004_BIB29","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1053\/gast.2000.8530","article-title":"Refractory celiac disease","volume":"119","author":"Ryan","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2004.05.004_BIB30","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1136\/gut.2003.018374","article-title":"A microarray screen for novel candidate genes in coeliac disease pathogenesis","volume":"53","author":"Diosdado","year":"2004","journal-title":"Gut"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841104000551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841104000551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:54:53Z","timestamp":1760255693000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841104000551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0896841104000551"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2004.05.004","relation":{},"ISSN":["0896-8411"],"issn-type":[{"type":"print","value":"0896-8411"}],"subject":[],"published":{"date-parts":[[2004,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The interferon gamma gene in celiac disease: augmented expression correlates with tissue damage but no evidence for genetic susceptibility","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2004.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}