{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:01:30Z","timestamp":1761894090153,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.jaut.2005.01.002","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T12:53:21Z","timestamp":1109336001000},"page":"135-143","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Monoclonal ribosomal P autoantibody inhibits the expression and release of IL-12, TNF-\u03b1 and iNOS in activated RAW macrophage cell line"],"prefix":"10.1016","volume":"24","author":[{"given":"Kuang-Hui","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shye-Jye","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chau-Yaun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai-Ping","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi-Kuang","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Li","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang-Huan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2005.01.002_bib1","first-page":"103","article-title":"Comparative biochemistry and biophysics of ribosomal proteins","volume":"12","author":"Liljas","year":"1991","journal-title":"Int Rev Cytosol"},{"key":"10.1016\/j.jaut.2005.01.002_bib2","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1172\/JCI115707","article-title":"Autoantibodies to the ribosomal P proteins react with a plasma membrane-related target on human cells","volume":"89","author":"Koren","year":"1992","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaut.2005.01.002_bib3","first-page":"1123","article-title":"Presence of ribosomal P protein on the surface of human umbilical vein endothelial cells","volume":"23","author":"Reichlin","year":"1996","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jaut.2005.01.002_bib4","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1006\/jaut.1998.0219","article-title":"Cellular dysfunction induced by penetration of autoantibodies into living cells: cellular damage and dysfunction mediated by antibodies to dsDNA and ribosomal P proteins","volume":"11","author":"Reichlin","year":"1998","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jaut.2005.01.002_bib5","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1002\/art.1780391109","article-title":"Ribosomal P autoantibodies in systemic lupus erythematosus","volume":"39","author":"Arnett","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2005.01.002_bib6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1056\/NEJM198707303170503","article-title":"Association between lupus psychosis and anti-ribosomal P protein antibodies","volume":"317","author":"Bonfa","year":"1987","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaut.2005.01.002_bib7","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/art.1780390907","article-title":"Association of anti-ribosomal P protein antibodies with neuropsychiatric systemic lupus erythematosus","volume":"39","author":"Isshi","year":"1996","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2005.01.002_bib8","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/096120339600500106","article-title":"Fluctuations of antibody to ribosomal P proteins correlate with appearance and remission of nephritis in SLE","volume":"5","author":"Martin","year":"1996","journal-title":"Lupus"},{"key":"10.1016\/j.jaut.2005.01.002_bib9","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1002\/1529-0131(199912)42:12<2728::AID-ANR34>3.0.CO;2-M","article-title":"Evidence for the participation of anti-ribosomal P antibodies in lupus nephritis","volume":"42","author":"Reichlin","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2005.01.002_bib10","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1002\/art.1780360917","article-title":"Concomitant development of chronic active hepatitis and antibodies to ribosomal P proteins in a patient with systemic lupus erythematosus","volume":"36","author":"Koren","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2005.01.002_bib11","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1006\/clin.1995.1037","article-title":"Anti-ribosomal P antibodies in systemic lupus erythematosus: a case-control study correlating hepatic and renal disease","volume":"74","author":"Hulsey","year":"1995","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.jaut.2005.01.002_bib12","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/rheumatology\/41.12.1357","article-title":"Clinical and serological association of ribosomal P autoantibodies in systemic lupus erythematosus: prospective evaluation in a large cohort of Italian patients","volume":"41","author":"Gerli","year":"2002","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2005.01.002_bib13","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1046\/j.1365-2249.1997.3691261.x","article-title":"Anti-ribosomal and \u2018P-peptide\u2019-specific autoantibodies bind to T lymphocytes","volume":"109","author":"Stafford","year":"1997","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaut.2005.01.002_bib14","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.4049\/jimmunol.159.4.2033","article-title":"Autoantibodies to ribosomal P proteins penetrate into live hepatocytes and cause cellular dysfunction in culture","volume":"159","author":"Koscec","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jaut.2005.01.002_bib15","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1093\/rheumatology\/40.7.750","article-title":"Monoclonal antibodies against human ribosomal P proteins penetrate into living cells and cause apoptosis of Jurkat T cells in culture","volume":"40","author":"Sun","year":"2001","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2005.01.002_bib16","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1046\/j.1365-2567.2000.00970.x","article-title":"Monoclonal anti-double-stranded DNA autoantibody stimulates the expression and release of IL-1\u03b2, IL-6, IL-8, IL-10 and TNF-\u03b1 from normal human mononuclear cells involving in the lupus pathogenesis","volume":"99","author":"Sun","year":"2000","journal-title":"Immunology"},{"key":"10.1016\/j.jaut.2005.01.002_bib17","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/ar767","article-title":"Cytokines in systemic lupus erythematosus","volume":"5","author":"Rahman","year":"2003","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jaut.2005.01.002_bib18","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/S0952-7915(96)80018-5","article-title":"Cytokines in autoimmunity","volume":"8","author":"Brennan","year":"1996","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaut.2005.01.002_bib19","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0952-7915(96)80013-6","article-title":"Manipulation of the Th1\/Th2 balance in autoimmune disease","volume":"8","author":"Nicholson","year":"1996","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaut.2005.01.002_bib20","first-page":"262","article-title":"Anti-dsDNA antibodies cross-react with ribosomal P proteins expressed on the surface of glomerular mesangial cells to exert a cytostatic effect","volume":"85","author":"Sun","year":"1995","journal-title":"Immunology"},{"key":"10.1016\/j.jaut.2005.01.002_bib21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/256495a0","article-title":"Continuous cultures of fused cells secreting antibody of predefined specificity","volume":"256","author":"Kohler","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2005.01.002_bib22","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/1529-0131(199805)41:5<838::AID-ART10>3.0.CO;2-S","article-title":"Decreased production of interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus","volume":"41","author":"Horwitz","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2005.01.002_bib23","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/cyto.1999.0512","article-title":"Impaired production of IL-12 in systemic lupus erythematosus. III: deficient IL-12 p40 gene expression and cross-regulation of IL-12, IL-10 and IFN-gamma gene expression","volume":"11","author":"Liu","year":"1999","journal-title":"Cytokine"},{"key":"10.1016\/j.jaut.2005.01.002_bib24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1006\/cyto.1997.0268","article-title":"Impaired production of IL-12 in systemic lupus erythematosus. I. Excessive production of IL-10 suppresses production of IL-12 by monocytes","volume":"10","author":"Liu","year":"1998","journal-title":"Cytokine"},{"key":"10.1016\/j.jaut.2005.01.002_bib25","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1046\/j.1365-2249.2001.01466.x","article-title":"The effect of interleukin-10 and interleukin-12 on the in-vitro production of anti-double-stranded DNA antibodies from patients with systemic lupus erythematosus","volume":"124","author":"Tyrrell Price","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaut.2005.01.002_bib26","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1002\/1529-0131(200008)43:8<1790::AID-ANR15>3.0.CO;2-2","article-title":"Clinical and biological effects of anti-interleukin-10 monoclonal antibody administration in systemic lupus erythematosus","volume":"43","author":"Llorente","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2005.01.002_bib27","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.4049\/jimmunol.158.6.3009","article-title":"Kinetics of cytokine production in experimental systemic lupus erythematosus: involvement of T helper cell 1\/T helper cell 2-type cytokines in disease","volume":"158","author":"Segal","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.jaut.2005.01.002_bib28","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/rheumatology\/35.11.1067","article-title":"Tumor necrosis factor alpha and its soluble receptors parallel clinical disease and autoimmune activity in systemic lupus erythematosus","volume":"35","author":"Studnicka-Benke","year":"1996","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.jaut.2005.01.002_bib29","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/rheumatology\/keg045","article-title":"Elevated plasma concentrations of nitric oxide, soluble thrombomodulin and soluble vascular cell adhesion molecule-1 in patients with systemic lupus erythematosus","volume":"42","author":"Ho","year":"2003","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2005.01.002_bib30","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1084\/jem.188.9.1603","article-title":"Immune suppression by recombinant interleukin (rIL)-12 involves interferon \u03b3 induction of nitric oxide synthase 2 (iNOS) activity: inhibitors of NO generation reveal the extent of rIL-12 vaccine adjuvant effect","volume":"188","author":"Koblish","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaut.2005.01.002_bib31","doi-asserted-by":"crossref","first-page":"4062","DOI":"10.1002\/(SICI)1521-4141(199812)28:12<4062::AID-IMMU4062>3.0.CO;2-K","article-title":"Nitric oxide regulates Th1 cell development through the inhibition of IL-12 synthesis by macrophages","volume":"28","author":"Huang","year":"1998","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaut.2005.01.002_bib32","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/nri856","article-title":"Role of Fc receptors in autoimmunity","volume":"2","author":"Takai","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaut.2005.01.002_bib33","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/S0952-7915(02)00409-0","article-title":"Fc receptors are major mediators of antibody based inflammation in autoimmunity","volume":"14","author":"Hogarth","year":"2002","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaut.2005.01.002_bib34","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1084\/jem.170.6.2081","article-title":"Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones","volume":"170","author":"Fiorentino","year":"1989","journal-title":"J Exp Med"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089684110500003X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089684110500003X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:55:26Z","timestamp":1760255726000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089684110500003X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S089684110500003X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2005.01.002","relation":{},"ISSN":["0896-8411"],"issn-type":[{"type":"print","value":"0896-8411"}],"subject":[],"published":{"date-parts":[[2005,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Monoclonal ribosomal P autoantibody inhibits the expression and release of IL-12, TNF-\u03b1 and iNOS in activated RAW macrophage cell line","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2005.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}