{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T07:51:16Z","timestamp":1789977076237,"version":"4.0.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.jaut.2005.01.006","type":"journal-article","created":{"date-parts":[[2005,2,26]],"date-time":"2005-02-26T19:44:48Z","timestamp":1109447088000},"page":"111-117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"title":["T-cell molecular mimicry in Chagas disease: identification and partial structural analysis of multiple cross-reactive epitopes between Trypanosoma cruzi B13 and cardiac myosin heavy chain"],"prefix":"10.1016","volume":"24","author":[{"given":"Leo Kei","family":"Iwai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Juliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz","family":"Juliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Kalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edecio","family":"Cunha-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jaut.2005.01.006_bib1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/clc.4960101113","article-title":"The role of active myocarditis in the development of heart failure in chronic Chagas' disease: a study based on endomyocardial biopsies","volume":"10","author":"Higuchi","year":"1987","journal-title":"Clin Cardiol"},{"issue":"2","key":"10.1016\/j.jaut.2005.01.006_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/clin.1997.4335","article-title":"An in situ quantitative immunohistochemical study of cytokines and IL-2R+ in chronic human chagasic myocarditis: correlation with the presence of myocardial Trypanosoma cruzi antigens","volume":"83","author":"Reis","year":"1997","journal-title":"Clin Immunol Immunopathol"},{"issue":"2","key":"10.1016\/j.jaut.2005.01.006_bib3","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4269\/ajtmh.1993.49.192","article-title":"Expression of major histocompatibility complex antigens and adhesion molecules in hearts of patients with chronic Chagas' disease","volume":"49","author":"Reis","year":"1993","journal-title":"Am J Trop Med Hyg"},{"issue":"6","key":"10.1016\/j.jaut.2005.01.006_bib4","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S1471-4922(02)02283-3","article-title":"Chemokines, inflammation and Trypanosoma cruzi infection","volume":"18","author":"Teixeira","year":"2002","journal-title":"Trends Parasitol"},{"issue":"2","key":"10.1016\/j.jaut.2005.01.006_bib5","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0002-9440(10)61741-5","article-title":"Modulation of chagasic cardiomyopathy by interleukin-4: dissociation between inflammation and tissue parasitism","volume":"159","author":"Soares","year":"2001","journal-title":"Am J Pathol"},{"issue":"10","key":"10.1016\/j.jaut.2005.01.006_bib6","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0169-4758(96)10058-2","article-title":"Autoimmunity in chagas disease cardiomyopathy: fulfilling the criteria at last?","volume":"12","author":"Kalil","year":"1996","journal-title":"Parasitol Today"},{"key":"10.1016\/j.jaut.2005.01.006_bib7","series-title":"Infection and autoimmunity","first-page":"451","article-title":"Autoimmunity in Chagas disease","author":"Cunha-Neto","year":"2004"},{"issue":"9","key":"10.1016\/j.jaut.2005.01.006_bib8","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1128\/iai.57.9.2640-2644.1989","article-title":"Autoimmunity in Chagas' disease: specific inhibition of reactivity of CD4+ T cells against myosin in mice chronically infected with Trypanosoma cruzi","volume":"57","author":"Rizzo","year":"1989","journal-title":"Infect Immun"},{"issue":"9","key":"10.1016\/j.jaut.2005.01.006_bib9","doi-asserted-by":"crossref","first-page":"5643","DOI":"10.1128\/IAI.69.9.5643-5649.2001","article-title":"Cardiac myosin autoimmunity in acute Chagas' heart disease","volume":"69","author":"Leon","year":"2001","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.jaut.2005.01.006_bib10","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1128\/IAI.72.6.3410-3417.2004","article-title":"A cardiac myosin-specific autoimmune response is induced by immunization with Trypanosoma cruzi proteins","volume":"72","author":"Leon","year":"2004","journal-title":"Infect Immun"},{"issue":"2","key":"10.1016\/j.jaut.2005.01.006_bib11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1006\/jaut.2001.0574","article-title":"Experimental chronic Chagas' disease myocarditis is an autoimmune disease preventable by induction of immunological tolerance to myocardial antigens","volume":"18","author":"Pontes-de-Carvalho","year":"2002","journal-title":"J Autoimmun"},{"issue":"8","key":"10.1016\/j.jaut.2005.01.006_bib12","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1073\/pnas.92.8.3541","article-title":"Autoimmunity in Chagas disease cardiopathy: biological relevance of a cardiac myosin-specific epitope crossreactive to an immunodominant Trypanosoma cruzi antigen","volume":"92","author":"Cunha-Neto","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"10.1016\/j.jaut.2005.01.006_bib13","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1172\/JCI118969","article-title":"Autoimmunity in Chagas' disease. Identification of cardiac myosin-B13 Trypanosoma cruzi protein crossreactive T-cell clones in heart lesions of a chronic Chagas' cardiomyopathy patient","volume":"98","author":"Cunha-Neto","year":"1996","journal-title":"J Clin Invest"},{"issue":"11","key":"10.1016\/j.jaut.2005.01.006_bib14","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1590\/S0100-879X1997001100007","article-title":"Molecular mimicry between cardiac myosin and Trypanosoma cruzi antigen B13: identification of a B13-driven human T cell clone that recognizes cardiac myosin","volume":"30","author":"Abel","year":"1997","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.jaut.2005.01.006_bib15","first-page":"40","article-title":"Autoimmunity in human Chagas' disease cardiomyopathy. Cytokine production and antigen recognition by T cells","volume":"31","author":"Cunha-Neto","year":"1997","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.jaut.2005.01.006_bib16","unstructured":"Abel LC. Peripheral cellular immune response to the recombinant B13 protein from T. cruzi in humans: antigenic recognition and cytokine profile [in Portuguese]. PhD Thesis. Sao Paulo, Brazil: Sao Paulo University; 1999."},{"issue":"2","key":"10.1016\/j.jaut.2005.01.006_bib17","doi-asserted-by":"crossref","first-page":"703","DOI":"10.4049\/jimmunol.159.2.703","article-title":"Different modes of peptide interaction enable HLA-DQ and HLA-DR molecules to bind diverse peptide repertoires","volume":"159","author":"Raddrizzani","year":"1997","journal-title":"J Immunol"},{"issue":"1","key":"10.1016\/j.jaut.2005.01.006_bib18","first-page":"31","article-title":"Presence of 2 different epitopes on the human beta 2-microglobulin defined by monoclonal antibodies [in French]","volume":"134C","author":"Crevat","year":"1983","journal-title":"Ann Immunol (Paris)"},{"issue":"3","key":"10.1016\/j.jaut.2005.01.006_bib19","first-page":"319","article-title":"Production of monoclonal antibodies against HBs [author's transl.]","volume":"132C","author":"Kalil","year":"1981","journal-title":"Ann Immunol (Paris)"},{"issue":"1","key":"10.1016\/j.jaut.2005.01.006_bib20","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1084\/jem.179.1.279","article-title":"Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones","volume":"179","author":"Wucherpfennig","year":"1994","journal-title":"J Exp Med"},{"issue":"3","key":"10.1016\/j.jaut.2005.01.006_bib21","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1074-7613(00)80360-X","article-title":"T cell receptor recognition of MHC class II-bound peptide flanking residues enhances immunogenicity and results in altered TCR V region usage","volume":"7","author":"Carson","year":"1997","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.jaut.2005.01.006_bib22","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/0092-8674(95)90348-8","article-title":"Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein","volume":"80","author":"Wucherpfennig","year":"1995","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.jaut.2005.01.006_bib23","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1084\/jem.184.2.647","article-title":"Identification of epitope mimics recognized by CTL reactive to the melanoma\/melanocyte-derived peptide MART-1(27\u201335)","volume":"184","author":"Loftus","year":"1996","journal-title":"J Exp Med"},{"issue":"8","key":"10.1016\/j.jaut.2005.01.006_bib24","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.4049\/jimmunol.160.8.3631","article-title":"Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology","volume":"160","author":"Hemmer","year":"1998","journal-title":"J Immunol"},{"issue":"2","key":"10.1016\/j.jaut.2005.01.006_bib25","doi-asserted-by":"crossref","first-page":"947","DOI":"10.4049\/jimmunol.170.2.947","article-title":"Systematic analysis of the combinatorial nature of epitopes recognized by TCR leads to identification of mimicry epitopes for glutamic acid decarboxylase 65-specific TCRs","volume":"170","author":"Uemura","year":"2003","journal-title":"J Immunol"},{"issue":"3","key":"10.1016\/j.jaut.2005.01.006_bib26","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ni891","article-title":"CDR3 loop flexibility contributes to the degeneracy of TCR recognition","volume":"4","author":"Reiser","year":"2003","journal-title":"Nat Immunol"},{"issue":"14-15","key":"10.1016\/j.jaut.2005.01.006_bib27","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.molimm.2003.11.007","article-title":"Heart infiltrating T cell clones from a rheumatic heart disease patient display a common TCR usage and a degenerate antigen recognition pattern","volume":"40","author":"Fae","year":"2004","journal-title":"Mol Immunol"},{"issue":"4","key":"10.1016\/j.jaut.2005.01.006_bib28","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/0022-2836(83)90053-0","article-title":"Periodic features in the amino acid sequence of nematode myosin rod","volume":"164","author":"McLachlan","year":"1983","journal-title":"J Mol Biol"},{"issue":"9","key":"10.1016\/j.jaut.2005.01.006_bib29","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0167-5699(98)01299-7","article-title":"A very high level of crossreactivity is an essential feature of the T-cell receptor","volume":"19","author":"Mason","year":"1998","journal-title":"Immunol Today"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841105000077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841105000077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:55:10Z","timestamp":1760255710000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841105000077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0896841105000077"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2005.01.006","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"T-cell molecular mimicry in Chagas disease: identification and partial structural analysis of multiple cross-reactive epitopes between Trypanosoma cruzi B13 and cardiac myosin heavy chain","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2005.01.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}