{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:44:16Z","timestamp":1791081856020,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.jaut.2006.08.002","type":"journal-article","created":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T07:38:46Z","timestamp":1160552326000},"page":"166-173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes"],"prefix":"10.1016","volume":"27","author":[{"given":"Ana Maria","family":"Barral","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen E.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor M.","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rima","family":"Darwiche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Rodrigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Christen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Ejrnaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas W.","family":"Kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias G.","family":"von Herrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2006.08.002_bib1","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1136\/bmj.318.7185.698","article-title":"Genetic determination of islet cell autoimmunity in monozygotic twin, dizygotic twin, and non-twin siblings of patients with type 1 diabetes: prospective twin study","volume":"318","author":"Redondo","year":"1999","journal-title":"BMJ"},{"key":"10.1016\/j.jaut.2006.08.002_bib2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF03401920","article-title":"T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agents","volume":"4","author":"Honeyman","year":"1998","journal-title":"Mol Med"},{"key":"10.1016\/j.jaut.2006.08.002_bib3","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.coi.2004.07.014","article-title":"The genetics of HLA-associated disease","volume":"16","author":"Larsen","year":"2004","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaut.2006.08.002_bib4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/jaut.1997.0131","article-title":"Pathological changes in the islet milieu precede infiltration of islets and destruction of beta-cells by autoreactive lymphocytes in a transgenic model of virus-induced IDDM","volume":"10","author":"von Herrath","year":"1997","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jaut.2006.08.002_bib5","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.2337\/diabetes.49.11.1801","article-title":"Virus-induced autoimmune diabetes: most beta-cells die through inflammatory cytokines and not perforin from autoreactive (anti-viral) cytotoxic T-lymphocytes","volume":"49","author":"Seewaldt","year":"2000","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2006.08.002_bib6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1038\/nm1176","article-title":"Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease","volume":"11","author":"Lang","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.jaut.2006.08.002_bib7","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1007\/s001250100021","article-title":"A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis","volume":"44","author":"Eizirik","year":"2001","journal-title":"Diabetologia"},{"key":"10.1016\/j.jaut.2006.08.002_bib8","doi-asserted-by":"crossref","first-page":"4481","DOI":"10.4049\/jimmunol.166.7.4481","article-title":"IFN-\u03b3\/TNF-\u03b1 synergism as the final effector in autoimmune diabetes: a key role for STAT1\/IFN regulatory factor-1 pathway in pancreatic beta cell death","volume":"166","author":"Suk","year":"2001","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2006.08.002_bib9","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2337\/diabetes.51.2.311","article-title":"Interleukin-1 plus gamma-interferon-induced pancreatic beta-cell dysfunction is mediated by beta-cell nitric oxide production","volume":"51","author":"Thomas","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2006.08.002_bib10","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.2337\/diabetes.54.8.2396","article-title":"Disruption of the {gamma}-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of {beta}-cells","volume":"54","author":"Gysemans","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2006.08.002_bib11","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev.immunol.22.091003.090312","article-title":"The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immune response","volume":"22","author":"Alexander","year":"2004","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaut.2006.08.002_bib12","doi-asserted-by":"crossref","first-page":"27945","DOI":"10.1074\/jbc.M110214200","article-title":"Suppressor of cytokine signaling-1 regulates the sensitivity of pancreatic beta cells to tumor necrosis factor","volume":"277","author":"Chong","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jaut.2006.08.002_bib13","doi-asserted-by":"crossref","first-page":"8384","DOI":"10.1073\/pnas.0932778100","article-title":"Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes","volume":"100","author":"Lieberman","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jaut.2006.08.002_bib14","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.4049\/jimmunol.172.9.5714","article-title":"Suppressor of cytokine signaling-1 overexpression protects pancreatic beta cells from CD8+ T cell-mediated autoimmune destruction","volume":"172","author":"Chong","year":"2004","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2006.08.002_bib15","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0092-8674(91)90164-T","article-title":"Ablation of \u201ctolerance\u201d and induction of diabetes by virus infection in viral antigen transgenic mice","volume":"65","author":"Ohashi","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2006.08.002_bib16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0092-8674(91)90165-U","article-title":"Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response","volume":"65","author":"Oldstone","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2006.08.002_bib17","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/j.1464-5491.2004.01182.x","article-title":"Coxsackie B virus serology and Type 1 diabetes mellitus: a systematic review of published case-control studies","volume":"21","author":"Green","year":"2004","journal-title":"Diabet Med"},{"key":"10.1016\/j.jaut.2006.08.002_bib18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/1074-7613(94)90101-5","article-title":"How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model","volume":"1","author":"von Herrath","year":"1994","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2006.08.002_bib19","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1172\/JCI2899","article-title":"IFN-\u03b3 action on pancreatic beta cells causes class I MHC up regulation but not diabetes","volume":"102","author":"Thomas","year":"1998","journal-title":"J Clin Invest"},{"issue":"Pt 8","key":"10.1016\/j.jaut.2006.08.002_bib20","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1099\/0022-1317-64-8-1689","article-title":"Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains","volume":"64","author":"Dutko","year":"1983","journal-title":"J Gen Virol"},{"key":"10.1016\/j.jaut.2006.08.002_bib21","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/1074-7613(95)90062-4","article-title":"Coexpression of B7-1 and viral (\u201cself\u201d) transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes","volume":"3","author":"von Herrath","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2006.08.002_bib22","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1084\/jem.180.5.1901","article-title":"Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus","volume":"180","author":"von Herrath","year":"1994","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaut.2006.08.002_bib23","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1128\/jvi.69.4.2297-2305.1995","article-title":"Optimal lymphocytic choriomeningitis virus sequences restricted by H-2Db major histocompatibility complex class I molecules and presented to cytotoxic T lymphocytes","volume":"69","author":"Gairin","year":"1995","journal-title":"J Virol"},{"key":"10.1016\/j.jaut.2006.08.002_bib24","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1002\/eji.1830251230","article-title":"Presentation of endogenous viral proteins in association with major histocompatibility complex class II: on the role of intracellular compartmentalization, invariant chain and the TAP transporter system","volume":"25","author":"Oxenius","year":"1995","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaut.2006.08.002_bib25","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.4049\/jimmunol.170.12.6292","article-title":"Fas is detectable on beta cells in accelerated, but not spontaneous, diabetes in non-obese diabetic mice","volume":"170","author":"Darwiche","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.jaut.2006.08.002_bib26","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1172\/JCI8185","article-title":"IL-1alpha, IL-1beta, and IFN-\u03b3 mark beta cells for Fas-dependent destruction by diabetogenic CD4(+) T lymphocytes","volume":"105","author":"Amrani","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jaut.2006.08.002_bib27","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/nri1502","article-title":"Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes","volume":"4","author":"Roep","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaut.2006.08.002_bib28","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1084\/jem.20050003","article-title":"SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CDS T cells, limiting their autoimmune potential","volume":"202","author":"Davey","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.jaut.2006.08.002_bib29","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.2337\/diabetes.50.12.2744","article-title":"gamma-lnterferon signaling in pancreatic beta-cells is persistent but can be terminated by overexpression of suppressor of cytokine signaling-1","volume":"50","author":"Chong","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2006.08.002_bib30","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/08916930410001713124","article-title":"IP-10 and type 1 diabetes: a question of time and location","volume":"37","author":"Christen","year":"2004","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jaut.2006.08.002_bib31","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.2337\/diabetes.52.8.2025","article-title":"Diabetogenic potential of human pathogens uncovered in experimentally permissive beta-cells","volume":"52","author":"Flodstrom","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2006.08.002_bib32","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1530\/eje.1.01856","article-title":"Suppressor of cytokine signaling gene expression in human pancreatic islets: modulation by cytokines","volume":"152","author":"Santangelo","year":"2005","journal-title":"Eur J Endocrinol"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841106000734?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841106000734?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T07:57:08Z","timestamp":1760255828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841106000734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S0896841106000734"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2006.08.002","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SOCS-1 protects from virally-induced CD8 T cell mediated type 1 diabetes","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2006.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}