{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:37:25Z","timestamp":1790422645014,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.jaut.2010.02.001","type":"journal-article","created":{"date-parts":[[2010,3,12]],"date-time":"2010-03-12T08:03:06Z","timestamp":1268380986000},"page":"52-57","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"title":["Autoimmune diseases and autoantibodies in the first degree relatives of patients with systemic sclerosis"],"prefix":"10.1016","volume":"35","author":[{"given":"Rajpreet K.","family":"Arora-Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shervin","family":"Assassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah J.","family":"del Junco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank C.","family":"Arnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Perry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzma","family":"Irfan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roozbeh","family":"Sharif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Mattar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen D.","family":"Mayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2010.02.001_bib1","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1002\/1529-0131(200106)44:6<1359::AID-ART228>3.0.CO;2-S","article-title":"Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three United States cohorts","volume":"44","author":"Arnett","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2010.02.001_bib2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1136\/ard.45.10.793","article-title":"Antinuclear antibodies in the relatives and spouses of patients with systemic sclerosis","volume":"45","author":"Maddison","year":"1986","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaut.2010.02.001_bib3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1136\/ard.52.5.365","article-title":"Antinuclear antibodies in patients with scleroderma (systemic sclerosis) and in their blood relatives and spouses","volume":"52","author":"Barnett","year":"1993","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaut.2010.02.001_bib4","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jaut.2008.05.002","article-title":"Polyautoimmunity and familial autoimmunity in systemic sclerosis","volume":"31","author":"Hudson","year":"2008","journal-title":"J Autoimmun"},{"key":"10.1016\/j.jaut.2010.02.001_bib5","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1086\/422827","article-title":"A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis","volume":"75","author":"Begovich","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaut.2010.02.001_bib6","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1086\/423790","article-title":"Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE","volume":"75","author":"Kyogoku","year":"2004","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaut.2010.02.001_bib7","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1002\/art.22196","article-title":"Association of the PTPN22 R620W polymorphism with anti-topoisomerase I- and anticentromere antibody-positive systemic sclerosis","volume":"54","author":"Gourh","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2010.02.001_bib8","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/sj.gene.6364138","article-title":"A functional polymorphism (1858C\/T) in the PTPN22 gene is linked and associated with type I diabetes in multiplex families","volume":"5","author":"Onengut-Gumuscu","year":"2004","journal-title":"Genes Immun"},{"key":"10.1016\/j.jaut.2010.02.001_bib9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/art.20771","article-title":"Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus","volume":"52","author":"Orozco","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2010.02.001_bib10","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1086\/429096","article-title":"Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes","volume":"76","author":"Criswell","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaut.2010.02.001_bib11","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1056\/NEJMoa0810440","article-title":"Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants","volume":"360","author":"Hirschfield","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaut.2010.02.001_bib12","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1056\/NEJMoa073003","article-title":"STAT4 and the risk of rheumatoid arthritis and systemic lupus erythematosus","volume":"357","author":"Remmers","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jaut.2010.02.001_bib13","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1093\/hmg\/ddp119","article-title":"The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype","volume":"18","author":"Rueda","year":"2009","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.jaut.2010.02.001_bib14","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/art.1780230510","article-title":"Preliminary criteria for the classification of systemic sclerosis (scleroderma)","volume":"23","author":"Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee","year":"1980","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2010.02.001_bib15","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"Leroy","year":"1988","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jaut.2010.02.001_bib16","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1002\/art.22647","article-title":"Clinical, immunologic, and genetic features of familial systemic sclerosis","volume":"56","author":"Assassi","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"Pt 6","key":"10.1016\/j.jaut.2010.02.001_bib17","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1093\/brain\/123.6.1102","article-title":"Autoimmune disease in first-degree relatives of patients with multiple sclerosis. A UK survey","volume":"123","author":"Broadley","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.jaut.2010.02.001_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.semarthrit.2005.03.005","article-title":"Autoantibodies in systemic sclerosis","volume":"35","author":"Steen","year":"2005","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.jaut.2010.02.001_bib19","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3109\/08830189509056707","article-title":"HLA and autoimmunity in scleroderma (systemic sclerosis)","volume":"12","author":"Arnett","year":"1995","journal-title":"Int Rev Immunol"},{"key":"10.1016\/j.jaut.2010.02.001_bib20","doi-asserted-by":"crossref","unstructured":"Arnett FC, Gourh P, Shete S, Ahn CW, Honey R, Agarwal SK, et\u00a0al. Major histocompatibility complex (MHC) class II alleles, haplotypes, and epitopes which confer susceptibility or protection in the fibrosing autoimmune disease systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls. Ann Rheum Dis doi:10.1136\/ard.2009.111906.","DOI":"10.1136\/ard.2009.111906"},{"key":"10.1016\/j.jaut.2010.02.001_bib21","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.3899\/jrheum.090340","article-title":"Primary biliary cirrhosis (PBC), PBC autoantibodies, and hepatic parameter abnormalities in a large population of systemic sclerosis patients","volume":"36","author":"Assassi","year":"2009","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jaut.2010.02.001_bib22","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.semarthrit.2005.12.004","article-title":"Atypical autoantibodies in patients with primary Sj\u00f6gren syndrome: clinical characteristics and follow-up of 82 cases","volume":"35","author":"Ramos-Casals","year":"2006","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.jaut.2010.02.001_bib23","series-title":"Measuring disease occurrence. Epidemiology beyond the basics","author":"Szklo","year":"2007"},{"key":"10.1016\/j.jaut.2010.02.001_bib24","first-page":"321","article-title":"Familial occurrence of progressive systemic sclerosis and systemic lupus erythematosus","volume":"11","author":"Flores","year":"1984","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jaut.2010.02.001_bib25","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1073\/pnas.0337679100","article-title":"Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus","volume":"100","author":"Baechler","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaut.2010.02.001_bib26","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/rheumatology\/kei244","article-title":"Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients","volume":"45","author":"Tan","year":"2006","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jaut.2010.02.001_bib27","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/art.24183","article-title":"Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: A new perspective for pulmonary fibrosis","volume":"60","author":"Dieude","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2010.02.001_bib28","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1086\/428480","article-title":"Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus","volume":"76","author":"Sigurdsson","year":"2005","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.jaut.2010.02.001_bib29","article-title":"Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations","author":"Gourh","year":"2009","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2010.02.001_bib30","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/ng.81","article-title":"Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci","volume":"40","author":"Harley","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaut.2010.02.001_bib31","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1056\/NEJMoa0707865","article-title":"Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX","volume":"358","author":"Hom","year":"2008","journal-title":"N Engl J Med"},{"issue":"107 Suppl","key":"10.1016\/j.jaut.2010.02.001_bib32","first-page":"743","article-title":"Epidemiologic studies of environmental agents and systemic autoimmune diseases","volume":"5","author":"Mayes","year":"1999","journal-title":"Environ Health Perspect"},{"key":"10.1016\/j.jaut.2010.02.001_bib33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1177\/096120339600500112","article-title":"Systemic lupus erythematosus after heavy exposure to quartz dust in uranium mines: clinical and serological characteristics","volume":"5","author":"Conrad","year":"1996","journal-title":"Lupus"},{"key":"10.1016\/j.jaut.2010.02.001_bib34","first-page":"1917","article-title":"Silica induced scleroderma\u2013clinical and experimental aspects","volume":"25","author":"Haustein","year":"1998","journal-title":"J Rheumatol"},{"key":"10.1016\/j.jaut.2010.02.001_bib35","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/art.1780400421","article-title":"Racial differences in scleroderma among women in Michigan","volume":"40","author":"Laing","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2010.02.001_bib36","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1136\/ard.51.12.1322","article-title":"What is the contribution of occupational environmental factors to the occurrence of scleroderma in men?","volume":"51","author":"Silman","year":"1992","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaut.2010.02.001_bib37","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1089\/105072502761016458","article-title":"Epidemiology and prevention of clinical and subclinical hypothyroidism","volume":"12","author":"Vanderpump","year":"2002","journal-title":"Thyroid"},{"key":"10.1016\/j.jaut.2010.02.001_bib38","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/S0140-6736(04)15696-1","volume":"363","author":"Roberts","year":"2004","journal-title":"Hypothyroidism. Lancet"},{"key":"10.1016\/j.jaut.2010.02.001_bib39","first-page":"2001","article-title":"The prevalence and accuracy of self-reported history of 11 autoimmune diseases","volume":"35","author":"Cooper","year":"2008","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.jaut.2010.02.001_bib40","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jaut.2006.09.001","article-title":"Autoantibody profiling to identify individuals at risk for systemic lupus erythematosus","volume":"27","author":"Wandstrat","year":"2006","journal-title":"J Autoimmun"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841110000247?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841110000247?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:01:52Z","timestamp":1760256112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841110000247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0896841110000247"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2010.02.001","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autoimmune diseases and autoantibodies in the first degree relatives of patients with systemic sclerosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2010.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}