{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:06:20Z","timestamp":1791173180653,"version":"4.1.0"},"reference-count":79,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,9,1]],"date-time":"2011-09-01T00:00:00Z","timestamp":1314835200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2011,9]]},"DOI":"10.1016\/j.jaut.2011.05.007","type":"journal-article","created":{"date-parts":[[2011,6,18]],"date-time":"2011-06-18T12:15:31Z","timestamp":1308399331000},"page":"144-150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Autoantibodies with enzymatic properties in human autoimmune diseases"],"prefix":"10.1016","volume":"37","author":[{"given":"Bharath","family":"Wootla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Lacroix-Desmazes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur E.","family":"Warrington","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan J.","family":"Bieber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srini V.","family":"Kaveri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2011.05.007_bib1","first-page":"51","article-title":"Chemical achievement and hope for the future","volume":"36","author":"Pauling","year":"1948","journal-title":"Am Scientist"},{"key":"10.1016\/j.jaut.2011.05.007_bib2","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1126\/science.3787262","article-title":"Selective chemical catalysis by an antibody","volume":"234","author":"Pollack","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.jaut.2011.05.007_bib3","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1126\/science.3787261","article-title":"Catalytic antibodies","volume":"234","author":"Tramontano","year":"1986","journal-title":"Science"},{"key":"10.1016\/j.jaut.2011.05.007_bib4","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.4049\/jimmunol.155.5.2695","article-title":"Unexpected presence of polyreactive catalytic antibodies in IgG from unimmunized donors and decreased levels in rheumatoid arthritis","volume":"155","author":"Kalaga","year":"1995","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2011.05.007_bib5","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.4049\/jimmunol.159.3.1530","article-title":"Characterization of thyroglobulin-directed and polyreactive catalytic antibodies in autoimmune disease","volume":"159","author":"Paul","year":"1997","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2011.05.007_bib6","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M312152200","article-title":"Ontogeny of proteolytic immunity: IgM serine proteases","author":"Planque","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jaut.2011.05.007_bib7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-5793(97)01163-0","article-title":"DNA-hydrolyzing activity of the light chain of IgG antibodies from milk of healthy human mothers","volume":"416","author":"Kanyshkova","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.jaut.2011.05.007_bib8","first-page":"521","article-title":"Phosphorylation of different human milk proteins by human catalytic secretory immunoglobulin A","volume":"39","author":"Kit","year":"1996","journal-title":"Biochem Molec Biol Intl"},{"key":"10.1016\/j.jaut.2011.05.007_bib9","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1126\/science.1077642","article-title":"Evidence of antibody-catalyzed ozone formation in bacterial killing and inflammation","volume":"298","author":"Wentworth","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.jaut.2011.05.007_bib10","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S0167-5699(99)01528-5","article-title":"A\u00a0possible role of catalytic antibodies in metabolism","volume":"20","author":"Friboulet","year":"1999","journal-title":"Immunol Today"},{"key":"10.1016\/j.jaut.2011.05.007_bib11","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1126\/science.2727702","article-title":"Catalytic hydrolysis of vasoactive intestinal peptide by human autoantibody","volume":"244","author":"Paul","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.jaut.2011.05.007_bib12","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1126\/science.1585181","article-title":"DNA hydrolyzing autoantibodies","volume":"256","author":"Shuster","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.jaut.2011.05.007_bib13","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.1093\/nar\/26.23.5243","article-title":"Characterization and selectivity of catalytic antibodies from human serum with RNase activity","volume":"26","author":"Vlassov","year":"1998","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.jaut.2011.05.007_bib14","first-page":"1239","article-title":"Polyclonal antibodies from blood and cerebrospinal fluid of patients with multiple sclerosis effectively hydrolyze DNA and RNA","volume":"63","author":"Baranovskii","year":"1998","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.jaut.2011.05.007_bib15","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.4049\/jimmunol.154.7.3328","article-title":"Catalytic activity of anti-thyroglobulin antibodies","volume":"154","author":"Li","year":"1995","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2011.05.007_bib16","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1074\/jbc.M707983200","article-title":"Autoantibody-catalyzed hydrolysis of amyloid beta peptide","volume":"283","author":"Taguchi","year":"2008","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jaut.2011.05.007_bib17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0022-1759(02)00324-1","article-title":"Catalytic antibodies in clinical and experimental pathology: human and mouse models","volume":"269","author":"Ponomarenko","year":"2002","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.jaut.2011.05.007_bib18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1073\/pnas.0509849103","article-title":"Autoantibodies to myelin basic protein catalyze site-specific degradation of their antigen","volume":"103","author":"Ponomarenko","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaut.2011.05.007_bib19","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.imlet.2005.10.006","article-title":"Catalytic activity of autoantibodies toward myelin basic protein correlates with the scores on the multiple sclerosis expanded disability status scale","volume":"103","author":"Ponomarenko","year":"2006","journal-title":"Immunol Lett"},{"key":"10.1016\/j.jaut.2011.05.007_bib20","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1073\/pnas.0500586102","article-title":"High levels of catalytic antibodies correlate with favorable outcome in sepsis","volume":"102","author":"Lacroix-Desmazes","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaut.2011.05.007_bib21","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1056\/NEJMoa011979","article-title":"The prevalence of proteolytic antibodies against factor VIII in hemophilia A","volume":"346","author":"Lacroix-Desmazes","year":"2002","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaut.2011.05.007_bib22","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1038\/12483","article-title":"Catalytic activity of antibodies against factor VIII in patients with hemophilia A","volume":"5","author":"Lacroix-Desmazes","year":"1999","journal-title":"Nat Med"},{"key":"10.1016\/j.jaut.2011.05.007_bib23","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.4049\/jimmunol.177.2.1355","article-title":"Catalytic IgG from patients with hemophilia A inactivate therapeutic factor VIII","volume":"177","author":"Lacroix-Desmazes","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2011.05.007_bib24","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.4049\/jimmunol.180.12.8455","article-title":"Hydrolysis of coagulation factors by circulating IgG is associated with a reduced risk for chronic allograft nephropathy in renal transplanted patients","volume":"180","author":"Wootla","year":"2008","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2011.05.007_bib25","doi-asserted-by":"crossref","first-page":"7714","DOI":"10.4049\/jimmunol.180.11.7714","article-title":"Factor VIII hydrolysis mediated by anti-factor VIII autoantibodies in acquired hemophilia","volume":"180","author":"Wootla","year":"2008","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2011.05.007_bib26","article-title":"Proteolytic antibodies activate factor IX in patients with acquired hemophilia","author":"Wootla","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2011.05.007_bib27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF02787941","article-title":"DNA-hydrolyzing autoantibodies","volume":"47","author":"Gabibov","year":"1994","journal-title":"Appl Biochem Biotechnol"},{"key":"10.1016\/j.jaut.2011.05.007_bib28","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF02787708","article-title":"Novel functional activities of anti-DNA autoantibodies from sera of patients with lymphoproliferative and autoimmune diseases","volume":"75","author":"Kozyr","year":"1998","journal-title":"Appl Biochem Biotechnol"},{"key":"10.1016\/j.jaut.2011.05.007_bib29","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1073\/pnas.92.1.254","article-title":"Cleavage of supercoiled plasmid DNA by autoantibody Fab fragment: application of the flow linear dichroism technique","volume":"92","author":"Gololobov","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jaut.2011.05.007_bib30","first-page":"313","article-title":"Isolation and characteristics of catalytic antibodies to DNA in systemic lupus erythematosis","volume":"58","author":"Gololobov","year":"1993","journal-title":"Biokhimiia"},{"key":"10.1016\/j.jaut.2011.05.007_bib31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1385\/ABAB:83:1-3:255","article-title":"Autoantibodies to nuclear antigens: correlation between cytotoxicity and DNA-hydrolyzing activity","volume":"83","author":"Kozyr","year":"2000","journal-title":"Appl Biochem Biotechnol"},{"key":"10.1016\/j.jaut.2011.05.007_bib32","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.bmc.2006.12.037","article-title":"Cell-penetrating autoantibody induces caspase-mediated apoptosis through catalytic hydrolysis of DNA","volume":"15","author":"Lee","year":"2007","journal-title":"Bioorg Med Chem"},{"key":"10.1016\/j.jaut.2011.05.007_bib33","first-page":"140539","article-title":"Alzheimer\u2019s disease: a pathogenetic autoimmune disorder caused by herpes simplex in a gene-dependent manner","volume":"2010","author":"Carter","year":"2010","journal-title":"Int J Alzheimers Dis"},{"key":"10.1016\/j.jaut.2011.05.007_bib34","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/WAD.0b013e3181c53b00","article-title":"A\u00a0single ascending dose study of bapineuzumab in patients with Alzheimer disease","volume":"24","author":"Black","year":"2010","journal-title":"Alzheimer Dis Assoc Disord"},{"key":"10.1016\/j.jaut.2011.05.007_bib35","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.nbd.2006.06.012","article-title":"Activated microglia stimulate transcriptional changes in primary oligodendrocytes via IL-1beta","volume":"23","author":"Howe","year":"2006","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.jaut.2011.05.007_bib36","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1159\/000090366","article-title":"Mechanisms of A beta plaque clearance following passive A beta immunization","volume":"2","author":"Morgan","year":"2005","journal-title":"Neurodegener Dis"},{"key":"10.1016\/j.jaut.2011.05.007_bib37","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/labinvest.3780235","article-title":"Multiple sclerosis: current pathophysiological concepts","volume":"81","author":"Wingerchuk","year":"2001","journal-title":"Lab Invest"},{"key":"10.1016\/j.jaut.2011.05.007_bib38","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1172\/JCI21357","article-title":"Multiple sclerosis","volume":"113","author":"Hafler","year":"2004","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaut.2011.05.007_bib39","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.bbadis.2010.06.009","article-title":"The role of antibodies in multiple sclerosis","volume":"1812","author":"Weber","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.jaut.2011.05.007_bib40","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1582-4934.2004.tb00325.x","article-title":"Hydrolysis of myelin basic protein by polyclonal catalytic IgGs from the sera of patients with multiple sclerosis","volume":"8","author":"Polosukhina","year":"2004","journal-title":"J\u00a0Cell Mol Med"},{"key":"10.1016\/j.jaut.2011.05.007_bib41","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1134\/S1607672907020068","article-title":"Substrate specificity of catalytic autoantibodies in neurodegenerative processes","volume":"413","author":"Belogurov","year":"2007","journal-title":"Dokl Biochem Biophys"},{"key":"10.1016\/j.jaut.2011.05.007_bib42","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.4049\/jimmunol.180.2.1258","article-title":"Recognition and degradation of myelin basic protein peptides by serum autoantibodies: novel biomarker for multiple sclerosis","volume":"180","author":"Belogurov","year":"2008","journal-title":"J\u00a0Immunol"},{"issue":"3","key":"10.1016\/j.jaut.2011.05.007_bib43","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1055\/s-0038-1650169","article-title":"A\u00a0survey of 215 non-hemophilic patients with inhibitors to factor VIII","volume":"45","author":"Green","year":"1981","journal-title":"Thromb Haemastos"},{"key":"10.1016\/j.jaut.2011.05.007_bib44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1365-2141.2003.04162.x","article-title":"Acquired haemophilia: review and meta-analysis focused on therapy and prognostic factors","volume":"121","author":"Delgado","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaut.2011.05.007_bib45","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1182\/blood-2006-06-029850","article-title":"Acquired hemophilia A in the United Kingdom: a 2-year national surveillance study by the United Kingdom Haemophilia Centre Doctors\u2019 Organisation","volume":"109","author":"Collins","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2011.05.007_bib46","doi-asserted-by":"crossref","first-page":"543","DOI":"10.7326\/0003-4819-77-4-543","article-title":"Circulating anticoagulants against factors IX and XI in systemic lupus erythematosus","volume":"77","author":"Castro","year":"1972","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaut.2011.05.007_bib47","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1097\/00042737-200212000-00016","article-title":"Acquired inhibitors to coagulation factors in patients with gastrointestinal diseases","volume":"14","author":"Kyriakou","year":"2002","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1016\/j.jaut.2011.05.007_bib48","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1365-2141.1974.tb00456.x","article-title":"Acquired factor-IX inhibitor in a nonhaemophilic patient with autoimmune disease","volume":"26","author":"Largo","year":"1974","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaut.2011.05.007_bib49","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000208364","article-title":"Acquired factor IX deficiency. A report of two cases","volume":"50","author":"Ozsoylu","year":"1973","journal-title":"Acta Haematol"},{"key":"10.1016\/j.jaut.2011.05.007_bib50","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1056\/NEJM197009032831020","article-title":"Acquired inhibitors to factor IX","volume":"283","author":"Roberts","year":"1970","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaut.2011.05.007_bib51","first-page":"376","article-title":"Inhibitors of factors VIII and IX in a child with Henoch-Schonlein syndrome","volume":"7","author":"Gouyon","year":"1985","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"10.1016\/j.jaut.2011.05.007_bib52","first-page":"549","article-title":"Combined factor VIII and IX inhibitors in a girl","volume":"16","author":"Reussi","year":"1966","journal-title":"Thromb Diath Haemorrh"},{"key":"10.1016\/j.jaut.2011.05.007_bib53","doi-asserted-by":"crossref","first-page":"15257","DOI":"10.1074\/jbc.270.25.15257","article-title":"Natural catalytic antibodies: peptide-hydrolyzing activities of Bence Jones proteins and VL fragments","volume":"270","author":"Paul","year":"1995","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jaut.2011.05.007_bib54","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0165-2478(01)00185-7","article-title":"Catalytic heterogeneity of polyclonal DNA-hydrolyzing antibodies from the sera of patients with multiple sclerosis","volume":"76","author":"Baranovskii","year":"2001","journal-title":"Immunol Lett"},{"key":"10.1016\/j.jaut.2011.05.007_bib55","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0165-2478(03)00042-7","article-title":"Amylolytic activity of IgM and IgG antibodies from patients with multiple sclerosis","volume":"86","author":"Saveliev","year":"2003","journal-title":"Immunol Lett"},{"key":"10.1016\/j.jaut.2011.05.007_bib56","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0092-8674(01)00477-9","article-title":"Complement-independent, peroxide-induced antibody lysis of platelets in HIV-1-related immune thrombocytopenia","volume":"106","author":"Nardi","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2011.05.007_bib57","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1073\/pnas.92.6.2145","article-title":"Unexpectedly high occurence of catalytic antibodies in MLR\/lpr and SLJ mice immunized with a transition-state analog: is there a linkage to autoimmunity","volume":"92","author":"Tawfik","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jaut.2011.05.007_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.autrev.2010.09.006","article-title":"Systemic lupus erythematosus and the SLE galaxy","volume":"10","author":"Meroni","year":"2010","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaut.2011.05.007_bib59","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.autrev.2010.07.004","article-title":"A\u00a0novel tolerogenic peptide, hCDR1, for the specific treatment of systemic lupus erythematosus","volume":"10","author":"Mozes","year":"2010","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaut.2011.05.007_bib60","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.autrev.2010.08.014","article-title":"SLE diagnosis and treatment: when early is early","volume":"10","author":"Doria","year":"2010","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaut.2011.05.007_bib61","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.autrev.2010.05.004","article-title":"Immunological profile in primary Sjogren syndrome: clinical significance, prognosis and long-term evolution to other auto-immune disease","volume":"9","author":"Fauchais","year":"2010","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaut.2011.05.007_bib62","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.autrev.2010.05.009","article-title":"MicroRNAs in Sjogren\u2019s syndrome as a prototypic autoimmune disease","volume":"9","author":"Alevizos","year":"2010","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaut.2011.05.007_bib63","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.autrev.2010.05.011","article-title":"Epigenetics in autoimmune disorders: highlights of the 10th Sjogren\u2019s syndrome symposium","volume":"9","author":"Lu","year":"2010","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaut.2011.05.007_bib64","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jaut.2010.06.003","article-title":"Moutsopoulos: a lifetime in autoimmunity","volume":"35","author":"Youinou","year":"2010","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2011.05.007_bib65","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.jaut.2010.06.008","article-title":"The odd couple: a fresh look at autoimmunity and immunodeficiency","volume":"35","author":"Mackay","year":"2010","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2011.05.007_bib66","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jaut.2010.06.009","article-title":"Innate immunity in systemic lupus erythematosus: sensing endogenous nucleic acids","volume":"35","author":"Kontaki","year":"2010","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2011.05.007_bib67","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jaut.2010.06.019","article-title":"Antinuclear antibodies: a contemporary nomenclature using HEp-2 cells","volume":"35","author":"Wiik","year":"2010","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2011.05.007_bib68","doi-asserted-by":"crossref","first-page":"J163","DOI":"10.1016\/j.jaut.2009.12.005","article-title":"Geo-epidemiology and autoimmunity","volume":"34","author":"Youinou","year":"2010","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2011.05.007_bib69","doi-asserted-by":"crossref","first-page":"J168","DOI":"10.1016\/j.jaut.2009.11.018","article-title":"Defining and analyzing geoepidemiology and human autoimmunity","volume":"34","author":"Shapira","year":"2010","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2011.05.007_bib70","doi-asserted-by":"crossref","first-page":"J207","DOI":"10.1016\/j.jaut.2009.12.006","article-title":"Epigenetics and autoimmunity","volume":"34","author":"Brooks","year":"2010","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2011.05.007_bib71","doi-asserted-by":"crossref","first-page":"J234","DOI":"10.1016\/j.jaut.2009.11.009","article-title":"The immune effects of naturally occurring and synthetic nanoparticles","volume":"34","author":"Chang","year":"2010","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2011.05.007_bib72","doi-asserted-by":"crossref","first-page":"J266","DOI":"10.1016\/j.jaut.2009.11.012","article-title":"Drugs and autoimmunity - a contemporary review and mechanistic approach","volume":"34","author":"Chang","year":"2010","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2011.05.007_bib73","doi-asserted-by":"crossref","first-page":"J276","DOI":"10.1016\/j.jaut.2009.11.014","article-title":"The complement system in systemic autoimmune disease","volume":"34","author":"Chen","year":"2010","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2011.05.007_bib74","doi-asserted-by":"crossref","first-page":"J314","DOI":"10.1016\/j.jaut.2009.12.001","article-title":"Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis","volume":"34","author":"Chandran","year":"2010","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2011.05.007_bib75","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.autrev.2010.02.006","article-title":"Wegener\u2019s granulomatosis vasculitis and granuloma","volume":"9","author":"Schilder","year":"2010","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaut.2011.05.007_bib76","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.autrev.2010.02.008","article-title":"Genetic and hormonal factors in female-biased autoimmunity","volume":"9","author":"Rubtsov","year":"2010","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaut.2011.05.007_bib77","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jaut.2009.07.007","article-title":"Navigating the passage between Charybdis and Scylla: recognizing the achievements of Noel Rose","volume":"33","author":"Ansari","year":"2009","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2011.05.007_bib78","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jaut.2009.09.006","article-title":"Clustering and commonalities among autoimmune diseases","volume":"33","author":"Mackay","year":"2009","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2011.05.007_bib79","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.jaut.2009.09.002","article-title":"Considering of strategies for hematopoietic cell transplantation","volume":"33","author":"Yaniv","year":"2009","journal-title":"J\u00a0Autoimmun"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841111000497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841111000497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:04:00Z","timestamp":1760256240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841111000497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":79,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0896841111000497"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2011.05.007","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2011,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autoantibodies with enzymatic properties in human autoimmune diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2011.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}