{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:53:55Z","timestamp":1790870035113,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.jaut.2011.07.003","type":"journal-article","created":{"date-parts":[[2011,8,29]],"date-time":"2011-08-29T19:59:40Z","timestamp":1314647980000},"page":"263-272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["The antigen specificity of the rheumatoid arthritis-associated ACPA directed to citrullinated fibrin is very closely restricted"],"prefix":"10.1016","volume":"37","author":[{"given":"Cristina","family":"Iobagiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Magyar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Cornillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Sebbag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Arnaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferenc","family":"Hudecz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Serre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2011.07.003_bib1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1146\/annurev.immunol.26.021607.090244","article-title":"Immunity to citrullinated proteins in rheumatoid arthritis","volume":"26","author":"Klareskog","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaut.2011.07.003_bib2","series-title":"The epigenetics of autoimmune diseases","first-page":"279","article-title":"Autoimmune response to posttranslationally modified (citrullinated) proteins: prime suspect in the pathophysiology of rheumatoid arthritis","author":"Sebbag","year":"2009"},{"issue":"Suppl. 4","key":"10.1016\/j.jaut.2011.07.003_bib3","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/ar537","article-title":"Autoantibodies to deiminated fibrinogen are the most efficient serological criterion for the diagnosis of rheumatoid arthritis","volume":"4","author":"Nogueira","year":"2002","journal-title":"Arthritis Res"},{"key":"10.1016\/j.jaut.2011.07.003_bib4","doi-asserted-by":"crossref","first-page":"R122","DOI":"10.1186\/ar2011","article-title":"Diagnostic value of anti-human citrullinated fibrinogen ELISA and comparison with four other anti-citrullinated protein assays","volume":"8","author":"Vander Cruyssen","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jaut.2011.07.003_bib5","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1002\/art.20018","article-title":"Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors","volume":"50","author":"Nielen","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2011.07.003_bib6","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1136\/ard.2003.014233","article-title":"Prediction of radiological outcome in early rheumatoid arthritis in clinical practice: role of antibodies to citrullinated peptides (anti-CCP)","volume":"63","author":"Forslind","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaut.2011.07.003_bib7","doi-asserted-by":"crossref","first-page":"585","DOI":"10.4049\/jimmunol.162.1.585","article-title":"The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues","volume":"162","author":"Girbal-Neuhauser","year":"1999","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2011.07.003_bib8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1172\/JCI1316","article-title":"Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies","volume":"101","author":"Schellekens","year":"1998","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaut.2011.07.003_bib9","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.4049\/jimmunol.166.6.4177","article-title":"The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin","volume":"166","author":"Masson-Bessi\u00e8re","year":"2001","journal-title":"J\u00a0Immunol"},{"issue":"Suppl. 1","key":"10.1016\/j.jaut.2011.07.003_bib10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/ar648","article-title":"Autoantibodies to deiminated fibrinogen are the most efficient serological criterion for early rheumatoid arthritis diagnosis","volume":"5","author":"Nogueira","year":"2003","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jaut.2011.07.003_bib11","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1046\/j.1365-2249.2000.01171.x","article-title":"In the rheumatoid pannus, anti-filaggrin autoantibodies are produced by local plasma cells and constitute a higher proportion of IgG than in synovial fluid and serum","volume":"119","author":"Masson-Bessi\u00e8re","year":"2000","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaut.2011.07.003_bib12","doi-asserted-by":"crossref","first-page":"5057","DOI":"10.4049\/jimmunol.174.8.5057","article-title":"Fibrin deimination in synovial tissue is not specific for rheumatoid arthritis but commonly occurs during synovitides","volume":"174","author":"Chapuy-Regaud","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2011.07.003_bib13","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/art.23284","article-title":"Induction of macrophage secretion of tumor necrosis factor alpha through Fcgamma receptor IIa engagement by rheumatoid arthritis-specific autoantibodies to citrullinated proteins complexed with fibrinogen","volume":"58","author":"Clavel","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2011.07.003_bib14","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1002\/art.22983","article-title":"Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation","volume":"56","author":"Foulquier","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2011.07.003_bib15","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/art.21269","article-title":"Antigen microarray profiling of autoantibodies in rheumatoid arthritis","volume":"52","author":"Hueber","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2011.07.003_bib16","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1002\/eji.200535790","article-title":"Epitopes of human fibrin recognized by the rheumatoid arthritis-specific autoantibodies to citrullinated proteins","volume":"36","author":"Sebbag","year":"2006","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaut.2011.07.003_bib17","first-page":"838","article-title":"Immunoblotting detection of autoantibodies to human epidermis filaggrin: a new diagnostic test for rheumatoid arthritis","volume":"25","author":"Vincent","year":"1998","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.jaut.2011.07.003_bib18","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0022-1759(87)90085-8","article-title":"Strategies for epitope analysis using peptide synthesis","volume":"102","author":"Geysen","year":"1987","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.jaut.2011.07.003_bib19","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1039\/c39900000536","article-title":"A\u00a0sensitive, general method for quantitative monitoring of continuous flow solid phase peptide synthesis","author":"Flegel","year":"1990","journal-title":"J\u00a0Chem Soc Chem Commun"},{"key":"10.1016\/j.jaut.2011.07.003_bib20","series-title":"Peptides 2004, Proceedings of 3rd international and 28th European peptide symposium","first-page":"900","article-title":"Enzymatic degradation of carbamoyl-nociceptin analogues","author":"Bosze","year":"2005"},{"key":"10.1016\/j.jaut.2011.07.003_bib21","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1093\/bioinformatics\/17.8.752","article-title":"Easier threading through web-based comparisons and cross-validations","volume":"17","author":"Douguet","year":"2001","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaut.2011.07.003_bib22","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1002\/elps.1150181505","article-title":"SWISS-MODEL and the Swiss-PdbViewer: an environment for comparative protein modeling","volume":"18","author":"Guex","year":"1997","journal-title":"Electrophoresis"},{"key":"10.1016\/j.jaut.2011.07.003_bib23","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1021\/bi0525369","article-title":"Structural basis for sequential cleavage of fibrinopeptides upon fibrin assembly","volume":"45","author":"Pechik","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.jaut.2011.07.003_bib24","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1747-0285.2006.00438.x","article-title":"Synthesis of overlapping fibrin citrullinated peptides and their use for diagnosing rheumatoid arthritis","volume":"68","author":"Perez","year":"2006","journal-title":"Chem Biol Drug Des"},{"key":"10.1016\/j.jaut.2011.07.003_bib25","doi-asserted-by":"crossref","first-page":"R135","DOI":"10.1186\/ar2802","article-title":"Diagnostic and prognostic value of antibodies against chimeric fibrin\/filaggrin citrullinated synthetic peptides in rheumatoid arthritis","volume":"11","author":"Sanmarti","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jaut.2011.07.003_bib26","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1021\/jm0701932","article-title":"Antibodies to citrullinated human fibrinogen synthetic peptides in diagnosing rheumatoid arthritis","volume":"50","author":"Perez","year":"2007","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.jaut.2011.07.003_bib27","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s001090000128","article-title":"Fine-specificity of the anti-CENP-A B-cell autoimmune response","volume":"78","author":"Mahler","year":"2000","journal-title":"J\u00a0Mol Med"},{"key":"10.1016\/j.jaut.2011.07.003_bib28","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1002\/art.10436","article-title":"Detection of antibodies to deiminated recombinant rat filaggrin by enzyme-linked immunosorbent assay: a highly effective test for the diagnosis of rheumatoid arthritis","volume":"46","author":"Vincent","year":"2002","journal-title":"Arthritis Rheum"},{"issue":"Pt 1","key":"10.1016\/j.jaut.2011.07.003_bib29","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1099\/0022-1317-71-1-85","article-title":"B\u00a0cell epitope mapping of human immunodeficiency virus envelope glycoproteins with long (19- to 36-residue) synthetic peptides","volume":"71","author":"Neurath","year":"1990","journal-title":"J\u00a0Gen Virol"},{"key":"10.1016\/j.jaut.2011.07.003_bib30","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1073\/pnas.84.8.2479","article-title":"A\u00a0conserved region at the COOH terminus of human immunodeficiency virus gp120 envelope protein contains an immunodominant epitope","volume":"84","author":"Palker","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jaut.2011.07.003_bib31","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1128\/jvi.61.8.2639-2641.1987","article-title":"Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human immunodeficiency virus","volume":"61","author":"Gnann","year":"1987","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jaut.2011.07.003_bib32","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0264-410X(00)00258-9","article-title":"Mapping of B-cell epitopes on human parvovirus B19 non-structural and structural proteins","volume":"19","author":"Tolfvenstam","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.jaut.2011.07.003_bib33","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1128\/JCM.36.6.1574-1577.1998","article-title":"Mapping and serodiagnostic application of a dominant epitope within the human\u00a0herpesvirus 8 ORF 65-encoded protein","volume":"36","author":"Pau","year":"1998","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.jaut.2011.07.003_bib34","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/1471-2180-7-113","article-title":"Identification of a human immunodominant B-cell epitope within the immunoglobulin A1 protease of Streptococcus pneumoniae","volume":"7","author":"De Paolis","year":"2007","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.jaut.2011.07.003_bib35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S1521-6616(03)00037-8","article-title":"Advances in B-cell epitope analysis of autoantigens in connective tissue diseases","volume":"107","author":"Mahler","year":"2003","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaut.2011.07.003_bib36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nm1167","article-title":"Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry","volume":"11","author":"McClain","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.jaut.2011.07.003_bib37","first-page":"729","article-title":"B-cell epitopes of the heterogeneous nuclear ribonucleoprotein A2: identification of a new specific antibody marker for active lupus disease","author":"Schett","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaut.2011.07.003_bib38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/312127a0","article-title":"The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein","volume":"312","author":"Tainer","year":"1984","journal-title":"Nature"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841111000746?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841111000746?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:04:22Z","timestamp":1760256262000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841111000746"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0896841111000746"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2011.07.003","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The antigen specificity of the rheumatoid arthritis-associated ACPA directed to citrullinated fibrin is very closely restricted","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2011.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}