{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:49:27Z","timestamp":1791582567854,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.jaut.2012.01.010","type":"journal-article","created":{"date-parts":[[2012,1,31]],"date-time":"2012-01-31T17:33:09Z","timestamp":1328031189000},"page":"43-48","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":76,"title":["Monoclonal gammopathy related to Sj\u00f6gren syndrome: A key marker of disease prognosis and outcomes"],"prefix":"10.1016","volume":"39","author":[{"given":"Pilar","family":"Brito-Zer\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Retamozo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myriam","family":"Gand\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Akasbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"P\u00e9rez-De-Lis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candido","family":"Diaz-Lagares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Bov\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"P\u00e9rez-Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Jos\u00e9","family":"Soto-C\u00e1rdenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Sis\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Ramos-Casals","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2012.01.010_bib1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/clin.1994.1123","article-title":"Sj\u00f6gren\u2019s syndrome: autoimmune epithelitis","volume":"72","author":"Moutsopoulos","year":"1994","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.jaut.2012.01.010_bib2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/ard.2004.025676","article-title":"Primary Sj\u00f6gren\u2019s syndrome: new clinical and therapeutic concepts","volume":"64","author":"Ramos-Casals","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaut.2012.01.010_bib3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1157\/13115353","article-title":"Prognosis of patients with primary Sj\u00f6gren\u2019s syndrome","volume":"130","author":"Brito-Zer\u00f3n","year":"2008","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.jaut.2012.01.010_bib4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.blre.2009.07.004","article-title":"The incidental monoclonal protein: current approach to management of monoclonal gammopathy of undetermined significance (MGUS)","volume":"23","author":"Madan","year":"2009","journal-title":"Blood Rev"},{"key":"10.1016\/j.jaut.2012.01.010_bib5","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1056\/NEJMoa01133202","article-title":"A\u00a0long-term study of prognosis in monoclonal gammopathy of undetermined significance","volume":"346","author":"Kyle","year":"2002","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaut.2012.01.010_bib6","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1182\/blood-2003-03-0801","article-title":"Long-term follow-up of IgM monoclonal gammopathy of undetermined significance","volume":"102","author":"Kyle","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2012.01.010_bib7","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1056\/NEJMoa054494","article-title":"Prevalence of monoclonal gammopathy of undetermined significance","volume":"354","author":"Kyle","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaut.2012.01.010_bib8","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/S0025-6196(11)61090-2","article-title":"Prevalence of monoclonal gammopathy of undetermined significance. Study of 52,802 persons in Nagasaki City, Japan","volume":"82","author":"Iwanaga","year":"2007","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jaut.2012.01.010_bib9","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1182\/blood.V40.5.719.719","article-title":"Incidence of monoclonal proteins in a Minnesota community with a cluster of multiple myeloma","volume":"40","author":"Kyle","year":"1972","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2012.01.010_bib10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/jcp.35.1.63","article-title":"Monoclonal gammopathies in the adult population of Finistere, France","volume":"35","author":"Saleun","year":"1982","journal-title":"J\u00a0Clin Pathol"},{"key":"10.1016\/j.jaut.2012.01.010_bib11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.0954-6820.1966.tb05453.x","article-title":"Frequency of pathological proteins (M-components) om 6,995 sera from an adult population","volume":"179","author":"Axelsson","year":"1966","journal-title":"Acta Med Scand"},{"key":"10.1016\/j.jaut.2012.01.010_bib12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1365-2141.2010.08207.x","article-title":"Monoclonal gammopathy of undetermined significance: a consensus statement","volume":"150","author":"Berenson","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaut.2012.01.010_bib13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1182\/asheducation-2010.1.295","article-title":"Monoclonal gammopathy of undetermined significance and smoldering myeloma: new insights into pathophysiology and epidemiology","volume":"2010","author":"Landgren","year":"2010","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"10.1016\/j.jaut.2012.01.010_bib14","unstructured":"Ramos-Casals M, Stone JH, Cid MC, Bosch X. The cryoglobulinaemias. Lancet 2011 Aug 23. [Epub ahead of print]."},{"key":"10.1016\/j.jaut.2012.01.010_bib15","series-title":"Current diagnosis & treatment in rheumatology","first-page":"237","article-title":"Primary Sj\u00f6gren syndrome","author":"Ramos-Casals","year":"2007"},{"key":"10.1016\/j.jaut.2012.01.010_bib16","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.4049\/jimmunol.130.6.2663","article-title":"High incidence of free monoclonal lambda light chains in the sera of patients with Sjogren\u2019s syndrome","volume":"130","author":"Moutsopoulos","year":"1983","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2012.01.010_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1136\/ard.44.2.109","article-title":"Demonstration and identification of monoclonal proteins in the urine of patients with Sj\u00f6gren\u2019s syndrome","volume":"44","author":"Moutsopoulos","year":"1985","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaut.2012.01.010_bib18","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/15027732.1986.12461391","article-title":"Cryoglobulinemia in primary Sj\u00f6gren\u2019s syndrome: a monoclonal process","volume":"61","author":"Tzioufas","year":"1986","journal-title":"Scand J Rheumatol Suppl"},{"key":"10.1016\/j.jaut.2012.01.010_bib19","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1002\/art.1780290907","article-title":"Cryoglobulinemia in autoimmune rheumatic diseases. Evidence of circulating monoclonal cryoglobulins in patients with primary Sj\u00f6gren\u2019s syndrome","volume":"29","author":"Tzioufas","year":"1986","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2012.01.010_bib20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/01.md.0000157398.37679.47","article-title":"Circulating monoclonal immunoglobulins in Sj\u00f6gren syndrome: prevalence and clinical significance in 237 patients","volume":"84","author":"Brito-Zer\u00f3n","year":"2005","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jaut.2012.01.010_bib21","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/acr.20173","article-title":"European league against rheumatism Sj\u00f6gren\u2019s task force. Accurate detection of changes in disease activity in primary Sj\u00f6gren\u2019s syndrome by the european league against rheumatism Sj\u00f6gren\u2019s syndrome disease activity index","volume":"62","author":"Seror","year":"2010","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.jaut.2012.01.010_bib22","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"European study group on classification criteria for Sj\u00f6gren\u2019s syndrome. Classification criteria for Sj\u00f6gren\u2019s syndrome: a revised version of the European criteria proposed by the American-European consensus group","volume":"61","author":"Vitali","year":"2002","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaut.2012.01.010_bib23","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/art.1780360309","article-title":"Preliminary criteria for the classification of Sjogren\u2019s syndrome. Results of a prospective concerted action supported by the European community","volume":"36","author":"Vitali","year":"1993","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2012.01.010_bib24","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.autrev.2004.04.004","article-title":"Hepatitis C virus, Sj\u00f6gren\u2019s syndrome and B-cell lymphoma: linking infection, autoimmunity and cancer","volume":"4","author":"Ramos-Casals","year":"2005","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaut.2012.01.010_bib25","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/MD.0b013e318181e6af","article-title":"GEMESS study group. Primary Sj\u00f6gren syndrome in Spain: clinical and immunologic expression in 1010 patients","volume":"87","author":"Ramos-Casals","year":"2008","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jaut.2012.01.010_bib26","series-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow","year":"2008"},{"key":"10.1016\/j.jaut.2012.01.010_bib27","first-page":"211","article-title":"Studies on conditions associated with disturbed gamma globulin formation (gammopathies)","volume":"56","author":"Waldenstrom","year":"1960","journal-title":"Harvey Lect"},{"key":"10.1016\/j.jaut.2012.01.010_bib28","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/0002-9343(78)90522-3","article-title":"Monoclonal gammopathy of undetermined significance. Natural history in 241 cases","volume":"64","author":"Kyle","year":"1978","journal-title":"Am J Med"},{"key":"10.1016\/j.jaut.2012.01.010_bib29","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/leu.2010.60","article-title":"Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management","volume":"24","author":"Kyle","year":"2010","journal-title":"Leukemia"},{"key":"10.1016\/j.jaut.2012.01.010_bib30","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1056\/NEJM197811302992204","article-title":"Evidence that the malignant lymphoma of Sj\u00f6gren\u2019s syndrome is a monoclonal B-cell neoplasm","volume":"299","author":"Zulman","year":"1978","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaut.2012.01.010_bib31","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2249.1990.tb05481.x","article-title":"Monoclonal process in primary Sj\u00f6gren\u2019s syndrome and cross-reactive idiotype associated with rheumatoid factor","volume":"82","author":"Katsikis","year":"1990","journal-title":"Clin Exp Immunol"},{"issue":"Suppl 5","key":"10.1016\/j.jaut.2012.01.010_bib32","first-page":"17","article-title":"Sj\u00f6gren\u2019s syndrome: an oligo-monoclonal B cell process","volume":"8","author":"Tzioufas","year":"1990","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jaut.2012.01.010_bib33","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1080\/15027732.1986.12461393","article-title":"Lymphoproliferative disorders in Japanese patients with Sjogren\u2019s syndrome","volume":"61","author":"Sugai","year":"1986","journal-title":"Scand J Rheumatol Suppl"},{"key":"10.1016\/j.jaut.2012.01.010_bib34","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1080\/15027732.1986.12461392","article-title":"Lymphoma in Sjogren\u2019s syndrome: urinary monoclonal free light chains as a diagnostic aid and a means of tumour monitoring","volume":"61","author":"Walters","year":"1986","journal-title":"Scand J Rheumatol Suppl"},{"key":"10.1016\/j.jaut.2012.01.010_bib35","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/MD.0b013e3181e763be","article-title":"Changing pattern of presentation in monoclonal gammopathy of undetermined significance: a single-center experience with 1400 patients","volume":"89","author":"Varettoni","year":"2010","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.jaut.2012.01.010_bib36","first-page":"247","article-title":"Monoclonal immunoglobulins in the serum of patients with primary Sjogren\u2019s syndrome","volume":"6","author":"Youinou","year":"1988","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jaut.2012.01.010_bib37","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1136\/ard.49.11.929","article-title":"Association of serum IgM kappa monoclonicity in patients with Sj\u00f6gren\u2019s syndrome with an increased proportion of kappa positive plasma cells infiltrating the labial minor salivary glands","volume":"49","author":"Moutsopoulos","year":"1990","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 9","key":"10.1016\/j.jaut.2012.01.010_bib38","first-page":"S140","article-title":"Prevalence of monoclonal gammopathy and myeloma in a cohort of primary Sj\u00f6gren\u2019syndrome","volume":"42","author":"Sibilia","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2012.01.010_bib39","doi-asserted-by":"crossref","first-page":"294","DOI":"10.7326\/0003-4819-129-4-199808150-00005","article-title":"Prevalence of monoclonal gammopathies in patients with hepatitis C virus infection","volume":"129","author":"Andreone","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.jaut.2012.01.010_bib40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0140-6736(90)91585-X","article-title":"False positive hepatitis C virus antibody tests in paraproteinaemia","volume":"336","author":"Boudart","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2012.01.010_bib41","first-page":"188","article-title":"Anti hepatitis C virus antibodies in monoclonal gammopathy: an appraisal using the second generation tests","volume":"77","author":"Marson","year":"1992","journal-title":"Haematologica"},{"key":"10.1016\/j.jaut.2012.01.010_bib42","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1182\/blood.V88.3.1125b.1125b","article-title":"Risk of hepatitis C virus infection, Waldenstrom\u2019s macroglobulinemia, and monoclonal gammopathies","volume":"88","author":"Silvestri","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2012.01.010_bib43","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/1521-4141(200203)32:3<903::AID-IMMU903>3.0.CO;2-D","article-title":"Salivary gland B cell lymphoproliferative disorders in Sjogren\u2019s syndrome present a restricted use of antigen receptor gene segments similar to those used by hepatitis C virus-associated non Hodgkin\u2019s lymphomas","volume":"32","author":"De Re","year":"2002","journal-title":"Eur J Immunol"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089684111200011X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089684111200011X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:04:20Z","timestamp":1760256260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089684111200011X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":43,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S089684111200011X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2012.01.010","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Monoclonal gammopathy related to Sj\u00f6gren syndrome: A key marker of disease prognosis and outcomes","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2012.01.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}