{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T18:18:34Z","timestamp":1790965114217,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.jaut.2012.07.008","type":"journal-article","created":{"date-parts":[[2012,8,18]],"date-time":"2012-08-18T02:15:15Z","timestamp":1345256115000},"page":"21-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":75,"special_numbering":"C","title":["Astrocytic autoantibody of neuromyelitis optica (NMO-IgG) binds to aquaporin-4 extracellular loops, monomers, tetramers and high order arrays"],"prefix":"10.1016","volume":"40","author":[{"given":"Raffaele","family":"Iorio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P.","family":"Fryer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon R.","family":"Hinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Fallier-Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartwig","family":"Wolburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean J.","family":"Pittock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda A.","family":"Lennon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2012.07.008_bib1","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1084\/jem.20050304","article-title":"IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel","volume":"202","author":"Lennon","year":"2005","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaut.2012.07.008_bib2","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/S0140-6736(04)17551-X","article-title":"A\u00a0serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis","volume":"364","author":"Lennon","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2012.07.008_bib3","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1016\/S0021-9258(17)37486-0","article-title":"Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues","volume":"269","author":"Hasegawa","year":"1994","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jaut.2012.07.008_bib4","doi-asserted-by":"crossref","first-page":"13052","DOI":"10.1073\/pnas.91.26.13052","article-title":"Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance","volume":"91","author":"Jung","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaut.2012.07.008_bib5","doi-asserted-by":"crossref","first-page":"13609","DOI":"10.1073\/pnas.2235843100","article-title":"Aquaporin-4 square array assembly: opposing actions of M1 and M23 isoforms","volume":"100","author":"Furman","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaut.2012.07.008_bib6","doi-asserted-by":"crossref","first-page":"35850","DOI":"10.1074\/jbc.M109.071670","article-title":"Live cell analysis of aquaporin-4 m1\/m23 interactions and regulated orthogonal array assembly in glial cells","volume":"284","author":"Crane","year":"2009","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jaut.2012.07.008_bib7","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1001\/archneurol.2009.178","article-title":"Diagnosis of neuromyelitis spectrum disorders: comparative sensitivities and specificities of immunohistochemical and immunoprecipitation assays","volume":"66","author":"McKeon","year":"2009","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jaut.2012.07.008_bib8","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1212\/01.wnl.0000216139.44259.74","article-title":"Revised diagnostic criteria for neuromyelitis optica","volume":"66","author":"Wingerchuk","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.jaut.2012.07.008_bib9","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria","volume":"69","author":"Polman","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jaut.2012.07.008_bib10","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1073\/pnas.1109980108","article-title":"Molecular outcomes of neuromyelitis optica (NMO)-IgG binding to aquaporin-4 in astrocytes","volume":"109","author":"Hinson","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jaut.2012.07.008_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-386043-9.00001-3","article-title":"Structure and functions of aquaporin-4-based orthogonal arrays of particles","volume":"287","author":"Wolburg","year":"2011","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1016\/j.jaut.2012.07.008_bib12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jneuroim.2009.10.002","article-title":"Western blot analysis for the detection of serum antibodies recognizing linear aquaporin-4 epitopes in patients with neuromyelitis optica","volume":"217","author":"Marnetto","year":"2009","journal-title":"J\u00a0Neuroimmunol"},{"key":"10.1016\/j.jaut.2012.07.008_bib13","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1002\/glia.20855","article-title":"Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies","volume":"57","author":"Nicchia","year":"2009","journal-title":"Glia"},{"key":"10.1016\/j.jaut.2012.07.008_bib14","doi-asserted-by":"crossref","first-page":"16516","DOI":"10.1074\/jbc.M111.227298","article-title":"Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1\/M23 isoforms and orthogonal arrays","volume":"286","author":"Crane","year":"2011","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jaut.2012.07.008_bib15","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1021\/bi702146k","article-title":"The molecular composition of square arrays","volume":"47","author":"Sorbo","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.jaut.2012.07.008_bib16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jaut.2011.01.004","article-title":"Fine specificity of antibodies against AQP4: epitope mapping reveals intracellular epitopes","volume":"36","author":"Kampylafka","year":"2011","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2012.07.008_bib17","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1212\/01.WNL.0000289761.64862.ce","article-title":"Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica","volume":"69","author":"Hinson","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.jaut.2012.07.008_bib18","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1084\/jem.20081241","article-title":"Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2","volume":"205","author":"Hinson","year":"2008","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaut.2012.07.008_bib19","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1212\/WNL.0b013e318248dec1","article-title":"Serologic diagnosis of NMO: a multicenter comparison of aquaporin-4-IgG assays","volume":"78","author":"Waters","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.jaut.2012.07.008_bib20","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/ana.21802","article-title":"Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica","volume":"66","author":"Bennett","year":"2009","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jaut.2012.07.008_bib21","doi-asserted-by":"crossref","first-page":"e10455","DOI":"10.1371\/journal.pone.0010455","article-title":"Patterns of antibody binding to aquaporin-4 isoforms in neuromyelitis optica","volume":"5","author":"Mader","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2012.07.008_bib22","doi-asserted-by":"crossref","first-page":"4562","DOI":"10.1074\/jbc.M109.069245","article-title":"Evidences for a leaky scanning mechanism for the synthesis of the shorter M23 protein isoform of aquaporin-4: implication in orthogonal array formation and neuromyelitis optica antibody interaction","volume":"285","author":"Rossi","year":"2010","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jaut.2012.07.008_bib23","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jneuroim.2009.04.001","article-title":"Identification of binding sites for anti-aquaporin 4 antibodies in patients with neuromyelitis optica","volume":"211","author":"Tani","year":"2009","journal-title":"J\u00a0Neuroimmunol"},{"key":"10.1016\/j.jaut.2012.07.008_bib24","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.jmb.2005.10.081","article-title":"Implications of the aquaporin-4 structure on array formation and cell adhesion","volume":"355","author":"Hiroaki","year":"2006","journal-title":"J\u00a0Mol Biol"},{"key":"10.1016\/j.jaut.2012.07.008_bib25","doi-asserted-by":"crossref","first-page":"7437","DOI":"10.1073\/pnas.0902725106","article-title":"Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance","volume":"106","author":"Ho","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaut.2012.07.008_bib26","doi-asserted-by":"crossref","first-page":"9216","DOI":"10.1074\/jbc.M110.123000","article-title":"Identification of two major conformational aquaporin-4 epitopes for neuromyelitis optica autoantibody binding","volume":"286","author":"Pisani","year":"2011","journal-title":"J\u00a0Biol Chem"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841112001047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841112001047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:04:57Z","timestamp":1760256297000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841112001047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":26,"alternative-id":["S0896841112001047"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2012.07.008","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Astrocytic autoantibody of neuromyelitis optica (NMO-IgG) binds to aquaporin-4 extracellular loops, monomers, tetramers and high order arrays","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2012.07.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}