{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:19:15Z","timestamp":1784067555803,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.jaut.2012.10.002","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T05:46:19Z","timestamp":1352094379000},"page":"19-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Mouse liver-specific CD8+ T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes"],"prefix":"10.1016","volume":"42","author":[{"given":"Sylvie","family":"Chabot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Fakhfakh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathie","family":"B\u00e9land","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Lamarre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.A.","family":"Oldstone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idriss","family":"Djilali-Saiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2012.10.002_bib1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1146\/annurev.immunol.021908.132629","article-title":"The liver as a lymphoid organ","volume":"27","author":"Crispe","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaut.2012.10.002_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2009.08.008","article-title":"Immune tolerance: what is unique about the liver","volume":"34","author":"Tiegs","year":"2010","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2012.10.002_bib3","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/nri2858","article-title":"Antigen-presenting cell function in the tolerogenic liver environment","volume":"10","author":"Thomson","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaut.2012.10.002_bib4","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMra050408","article-title":"Autoimmune hepatitis","volume":"354","author":"Krawitt","year":"2006","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaut.2012.10.002_bib5","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1172\/JCI200421593","article-title":"The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity","volume":"114","author":"Bowen","year":"2004","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaut.2012.10.002_bib6","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.3748\/wjg.15.1035","article-title":"Update on autoimmune hepatitis","volume":"15","author":"Teufel","year":"2009","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jaut.2012.10.002_bib7","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.3748\/wjg.14.3306","article-title":"Aetiopathogenesis of autoimmune hepatitis","volume":"14","author":"Vergani","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.jaut.2012.10.002_bib8","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.coi.2005.09.014","article-title":"CD8+ T cells in autoimmunity","volume":"17","author":"Walter","year":"2005","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaut.2012.10.002_bib9","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1084\/jem.166.4.823","article-title":"Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells","volume":"166","author":"Bendelac","year":"1987","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaut.2012.10.002_bib10","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.0105-2896.2005.00244.x","article-title":"The good turned ugly: immunopathogenic basis for diabetogenic CD8+ T cells in NOD mice","volume":"204","author":"DiLorenzo","year":"2005","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaut.2012.10.002_bib11","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/hep.21658","article-title":"Cytochrome P450IID6-specific CD8 T cell immune responses mirror disease activity in autoimmune hepatitis type 2","volume":"46","author":"Longhi","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2012.10.002_bib12","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1084\/jem.188.6.1147","article-title":"Liver damage preferentially results from CD8(+) T cells triggered by high affinity peptide antigens","volume":"188","author":"Russell","year":"1998","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaut.2012.10.002_bib13","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/hep.510250504","article-title":"Clonotypic analysis of T cells in patients with autoimmune and viral hepatitis","volume":"25","author":"Tanaka","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2012.10.002_bib14","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S1074-7613(04)00050-0","article-title":"B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes","volume":"20","author":"Dong","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2012.10.002_bib15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.0105-2896.2006.00414.x","article-title":"Regulatory T cells in the periphery","volume":"212","author":"Lohr","year":"2006","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaut.2012.10.002_bib16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1159\/000282067","article-title":"Mouse models for experimental autoimmune hepatitis: limits and chances","volume":"28","author":"Hardtke-Wolenski","year":"2010","journal-title":"Dig Dis"},{"key":"10.1016\/j.jaut.2012.10.002_bib17","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1002\/hep.20885","article-title":"Early intrahepatic antigen-specific retention of naive CD8+ T cells is\u00a0predominantly ICAM-1\/LFA-1 dependent in mice","volume":"42","author":"Bertolino","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2012.10.002_bib18","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jaut.2008.04.015","article-title":"Hepatitis resulting from liver-specific expression and recognition of self-antigen","volume":"31","author":"Buxbaum","year":"2008","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2012.10.002_bib19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/(SICI)1521-4141(199801)28:01<221::AID-IMMU221>3.0.CO;2-F","article-title":"Hepatocytes induce functional activation of naive CD8+ T lymphocytes but fail to promote survival","volume":"28","author":"Bertolino","year":"1998","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaut.2012.10.002_bib20","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1084\/jem.20011063","article-title":"CD8(+) T cell tolerance to a tumor-associated antigen is maintained at the level of expansion rather than effector function","volume":"195","author":"Ohlen","year":"2002","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaut.2012.10.002_bib21","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.4049\/jimmunol.165.5.2415","article-title":"Break of T cell ignorance to a viral antigen in the liver induces hepatitis","volume":"165","author":"Voehringer","year":"2000","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2012.10.002_bib22","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1053\/j.gastro.2010.05.075","article-title":"Effects and regulation of autoreactive CD8+ T cells in a transgenic mouse model of autoimmune hepatitis","volume":"139","author":"Zierden","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2012.10.002_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/viro.1995.1314","article-title":"CTL escape viral variants. I. Generation and molecular characterization","volume":"210","author":"Lewicki","year":"1995","journal-title":"Virology"},{"key":"10.1016\/j.jaut.2012.10.002_bib24","doi-asserted-by":"crossref","first-page":"9374","DOI":"10.1073\/pnas.142284899","article-title":"Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice","volume":"99","author":"Baker","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaut.2012.10.002_bib25","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0022-1759(95)00002-R","article-title":"Cassette vectors directing expression of T cell receptor genes in transgenic mice","volume":"180","author":"Kouskoff","year":"1995","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.jaut.2012.10.002_bib26","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.4049\/jimmunol.169.9.4889","article-title":"DNA vaccination breaks tolerance for a neo-self antigen in liver: a transgenic murine model of autoimmune hepatitis","volume":"169","author":"Djilali-Saiah","year":"2002","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2012.10.002_bib27","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1128\/JVI.01811-07","article-title":"Novel plant virus-based vaccine induces protective cytotoxic T-lymphocyte-mediated antiviral immunity through dendritic cell maturation","volume":"82","author":"Lacasse","year":"2008","journal-title":"J\u00a0Virol"},{"key":"10.1016\/j.jaut.2012.10.002_bib28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jaut.2005.11.001","article-title":"Type 2 autoimmune hepatitis murine model: the influence of genetic background in disease development","volume":"26","author":"Lapierre","year":"2006","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2012.10.002_bib29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-1759(03)00265-5","article-title":"Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation","volume":"281","author":"Betts","year":"2003","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.jaut.2012.10.002_bib30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nri701","article-title":"The enemy within: keeping self-reactive T cells at bay in the periphery","volume":"2","author":"Walker","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaut.2012.10.002_bib31","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1172\/JCI24219","article-title":"Developmental control of CD8 T cell-avidity maturation in autoimmune diabetes","volume":"115","author":"Han","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaut.2012.10.002_bib32","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/ni1073","article-title":"CD8+ T cells maintain tolerance to myelin basic protein by \u2018epitope theft\u2019","volume":"5","author":"Perchellet","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1016\/j.jaut.2012.10.002_bib33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nri981","article-title":"Hepatic T cells and liver tolerance","volume":"3","author":"Crispe","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaut.2012.10.002_bib34","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jaut.2010.06.007","article-title":"The use of mouse models to better understand mechanisms of autoimmunity and tolerance","volume":"35","author":"Miyagawa","year":"2010","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2012.10.002_bib35","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.4049\/jimmunol.0901216","article-title":"Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver","volume":"184","author":"Oo","year":"2010","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2012.10.002_bib36","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1084\/jem.20081829","article-title":"The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion","volume":"206","author":"Haluszczak","year":"2009","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaut.2012.10.002_bib37","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1053\/j.gastro.2008.05.078","article-title":"Intrahepatic murine CD8 T-cell activation associates with a distinct phenotype leading to Bim-dependent death","volume":"135","author":"Holz","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2012.10.002_bib38","doi-asserted-by":"crossref","first-page":"16735","DOI":"10.1073\/pnas.1112251108","article-title":"Hepatocyte entry leads to degradation of autoreactive CD8 T cells","volume":"108","author":"Benseler","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaut.2012.10.002_bib39","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jhep.2004.08.002","article-title":"Liver autoimmune serology: a consensus statement from the committee for autoimmune serology of the International Autoimmune Hepatitis Group","volume":"41","author":"Vergani","year":"2004","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jaut.2012.10.002_bib40","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0022-1759(02)00016-9","article-title":"Autoantibody detection in type 2 autoimmune hepatitis using a chimera recombinant protein","volume":"262","author":"Vitozzi","year":"2002","journal-title":"J\u00a0Immunol Methods"},{"key":"10.1016\/j.jaut.2012.10.002_bib41","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1046\/j.0818-9641.2001.01048.x","article-title":"Role of primary intrahepatic T-cell activation in the \u2018liver tolerance effect\u2019","volume":"80","author":"Bertolino","year":"2002","journal-title":"Immunol Cell Biol"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841112001291?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841112001291?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:05:37Z","timestamp":1760256337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841112001291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":41,"alternative-id":["S0896841112001291"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2012.10.002","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mouse liver-specific CD8+ T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2012.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}