{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:37:12Z","timestamp":1773275832610,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.jaut.2013.02.004","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T20:00:34Z","timestamp":1364328034000},"page":"18-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Immunization of mice with a newly identified thyroid-stimulating hormone receptor splice variant induces Graves'-like disease"],"prefix":"10.1016","volume":"43","author":[{"given":"Toyoshi","family":"Endo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teturo","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2013.02.004_bib1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/08916930310001604199","article-title":"Thyrotropin receptor autoantibodies (TSHRAbs): epitopes, origins and clinical significance","volume":"36","author":"Kohn","year":"2003","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jaut.2013.02.004_bib2","doi-asserted-by":"crossref","first-page":"10833","DOI":"10.1074\/jbc.270.18.10833","article-title":"Cloning and functional expression of a thyrotropin receptor cDNA from rat fat cells","volume":"270","author":"Endo","year":"1995","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jaut.2013.02.004_bib3","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1089\/thy.1998.8.1059","article-title":"Expression of thyrotropin receptor on clonal osteoblast-like rat osteosarcoma cell","volume":"8","author":"Inoue","year":"1998","journal-title":"Thyroid"},{"key":"10.1016\/j.jaut.2013.02.004_bib4","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0092-8674(03)00771-2","article-title":"TSH is a negative regulator of skeletal remodeling","volume":"115","author":"Abe","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2013.02.004_bib5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1172\/JCI0216234","article-title":"The TSH receptor reveals itself","volume":"110","author":"Davies","year":"2002","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaut.2013.02.004_bib6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1385\/ENDO:26:3:189","article-title":"Models of glycoprotein hormone receptor interaction","volume":"26","author":"Moyle","year":"2005","journal-title":"Endocrine"},{"key":"10.1016\/j.jaut.2013.02.004_bib7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1089\/thy.2007.0034","article-title":"Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody","volume":"17","author":"Sanders","year":"2007","journal-title":"Thyroid"},{"key":"10.1016\/j.jaut.2013.02.004_bib8","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/0006-291X(92)91315-H","article-title":"Cloning and sequencing of a 1.3\u00a0KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain","volume":"18","author":"Graves","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaut.2013.02.004_bib9","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/0006-291X(92)91360-3","article-title":"Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript","volume":"188","author":"Takeshita","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaut.2013.02.004_bib10","doi-asserted-by":"crossref","first-page":"E514","DOI":"10.1152\/ajpendo.90433.2008","article-title":"Thyroid-stimulating hormone receptor in brown adipose tissue is involved in the regulation of thermogenesis","volume":"295","author":"Endo","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.jaut.2013.02.004_bib11","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1210\/me.2007-0407","article-title":"The thyrotropin receptor hinge region is not simply a scaffold for the leucine-rich domain but contributes to ligand binding and signal transduction","volume":"22","author":"Mizutori","year":"2008","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.jaut.2013.02.004_bib12","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/0006-291X(91)91749-3","article-title":"Rabbit antibodies against two different extracellular domains of human thyrotropin receptor possess thyroid stimulating activities","volume":"179","author":"Endo","year":"1991","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.jaut.2013.02.004_bib13","first-page":"2147","article-title":"Isolation of purified plasma membranes from cultured cells and hepatomas by two-phase partition and preparative free-flow electrophoresis","volume":"49","author":"Navas","year":"1989","journal-title":"Cancer Res"},{"key":"10.1016\/j.jaut.2013.02.004_bib14","doi-asserted-by":"crossref","first-page":"4577","DOI":"10.1016\/S0021-9258(17)30050-9","article-title":"Inhibition by bilirubin of (Na+\u00a0+\u00a0K+)-activated adenosine triphosphatase and K+-activated p-nitrophenylphosphatase activities of NaI-treated microsomes from young rat cerebrum","volume":"254","author":"Kashiwamata","year":"1979","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jaut.2013.02.004_bib15","doi-asserted-by":"crossref","first-page":"45217","DOI":"10.1074\/jbc.M103727200","article-title":"Oligomerization of the human thyrotropin receptor: fluorescent protein-tagged hTSHR reveals post-translational complexes","volume":"276","author":"Latif","year":"2001","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jaut.2013.02.004_bib16","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1210\/en.2006-1077","article-title":"An improved Graves' disease model established by using in\u00a0vivo electroporation exhibited long-term immunity to hyperthyroidism in BALB\/c mice","volume":"148","author":"Kaneda","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.jaut.2013.02.004_bib17","doi-asserted-by":"crossref","first-page":"5157","DOI":"10.4049\/jimmunol.163.9.5157","article-title":"Induction of experimental autoimmune Graves' disease in BALB\/c mice","volume":"163","author":"Kaithamana","year":"1999","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2013.02.004_bib18","doi-asserted-by":"crossref","first-page":"11074","DOI":"10.1073\/pnas.93.20.11074","article-title":"Induction of Graves-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule","volume":"93","author":"Shimojo","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaut.2013.02.004_bib19","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1172\/JCI7665","article-title":"Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease","volume":"105","author":"Costagliola","year":"2000","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaut.2013.02.004_bib20","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.4049\/jimmunol.168.6.2789","article-title":"A\u00a0novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor","volume":"168","author":"Nagayama","year":"2002","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2013.02.004_bib21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0303-7207(94)90235-6","article-title":"Follicle-stimulating hormone receptor mRNA in the mouse ovary during post-natal development in the normal mouse and in the adult hypogonadal (hpg) mouse: structure of alternate transcripts","volume":"101","author":"O'Shaughnessy","year":"1994","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jaut.2013.02.004_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0303-7207(96)03816-6","article-title":"Expression of follicle-stimulating hormone-receptor mRNA alternate transcripts in bovine granulosa cells during luteinization in\u00a0vivo and in\u00a0vitro","volume":"120","author":"Rajapaksha","year":"1996","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.jaut.2013.02.004_bib23","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0015-0282(01)03221-6","article-title":"Alternatively spliced variants of the follicle-stimulating hormone receptor gene in the testis of infertile men","volume":"77","author":"Song","year":"2002","journal-title":"Fertil Steril"},{"key":"10.1016\/j.jaut.2013.02.004_bib24","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1091\/mbc.e05-09-0875","article-title":"Luteinizing hormone receptor ectodomain splice variant misroutes the full-length receptor into a subcompartment of the endoplasmic reticulum","volume":"17","author":"Apaja","year":"2006","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.jaut.2013.02.004_bib25","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1210\/en.2009-1430","article-title":"Thyrotropin (TSH) receptor residue E251 in the extracellular leucine-rich repeat domain is critical for linking TSH binding to receptor activation","volume":"15","author":"Chen","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.jaut.2013.02.004_bib26","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1210\/edrv-9-1-106","article-title":"Autoantibodies to the thyrotropin receptor","volume":"9","author":"Rees Smith","year":"1988","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jaut.2013.02.004_bib27","first-page":"673","article-title":"The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies","volume":"19","author":"Rapoport","year":"1998","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jaut.2013.02.004_bib28","doi-asserted-by":"crossref","first-page":"51590","DOI":"10.1074\/jbc.M404748200","article-title":"Identification of a novel epitope in the thyroid-stimulating hormone receptor ectodomain acting as intramolecular signaling interface","volume":"279","author":"Kleinau","year":"2004","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jaut.2013.02.004_bib29","doi-asserted-by":"crossref","first-page":"18048","DOI":"10.1074\/jbc.M800449200","article-title":"Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation","volume":"283","author":"Mueller","year":"2008","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jaut.2013.02.004_bib30","first-page":"81","article-title":"Crystal structure of the TSH receptor (TSHR) bound to a blocking-type TSHR autoantibody","volume":"46","author":"Sanders","year":"2011","journal-title":"J\u00a0Mol Endocrinol"},{"key":"10.1016\/j.jaut.2013.02.004_bib31","doi-asserted-by":"crossref","first-page":"e44669","DOI":"10.1371\/journal.pone.0044669","article-title":"Antibody protection reveals extended epitopes on the human TSH receptor","volume":"7","author":"Latif","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2013.02.004_bib32","first-page":"256","article-title":"Abstract P-YIA-3","volume":"89","author":"Nakahara","year":"2010","journal-title":"Folia Endocrinologica Japonica"},{"key":"10.1016\/j.jaut.2013.02.004_bib33","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.clim.2006.06.007","article-title":"Model of stimulation-responsive splicing and strategies in identification of immunogenic isoforms of tumor antigens and autoantigens","volume":"121","author":"Yang","year":"2006","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaut.2013.02.004_bib34","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.jaci.2004.09.006","article-title":"Increased noncanonical splicing of autoantigen transcripts provides the structural basis for expression of untolerized epitopes","volume":"114","author":"Ng","year":"2004","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089684111300036X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089684111300036X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:07:14Z","timestamp":1760256434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089684111300036X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":34,"alternative-id":["S089684111300036X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2013.02.004","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunization of mice with a newly identified thyroid-stimulating hormone receptor splice variant induces Graves'-like disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2013.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}