{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T12:11:31Z","timestamp":1793621491258,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["DK61659"],"award-info":[{"award-number":["DK61659"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"crossref","award":["DK073681"],"award-info":[{"award-number":["DK073681"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.jaut.2013.04.002","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T16:51:57Z","timestamp":1368636717000},"page":"61-70","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Genetic analysis of interferon induced thyroiditis (IIT): Evidence for a key role for MHC and apoptosis related genes and pathways"],"prefix":"10.1016","volume":"44","author":[{"given":"Alia","family":"Hasham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaneet","family":"Lotay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Haggerty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Stefan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlinda","family":"Concepcion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas T.","family":"Dieterich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaron","family":"Tomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2013.04.002_bib1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/nrrheum.2009.237","article-title":"Type 1 interferons: crucial participants in disease amplification in autoimmunity","volume":"6","author":"Hall","year":"2010","journal-title":"Nat Rev Rheumatol"},{"issue":"4","key":"10.1016\/j.jaut.2013.04.002_bib2","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.ecl.2007.07.001","article-title":"Interferon alpha treatment and thyroid dysfunction","volume":"36","author":"Tomer","year":"2007","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"4","key":"10.1016\/j.jaut.2013.04.002_bib3","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/hep.21146","article-title":"The clinical and physiological spectrum of interferon-alpha induced thyroiditis: toward a new classification","volume":"43","author":"Mandac","year":"2006","journal-title":"Hepatology"},{"issue":"9","key":"10.1016\/j.jaut.2013.04.002_bib4","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1210\/jc.2012-1026","article-title":"Phenotypes of interferon-a-induced thyroid dysfunction among patients treated for hepatitis C are associated with pretreatment serum TSH and female sex","volume":"97","author":"Mammen","year":"2012","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.jaut.2013.04.002_bib5","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0016-5085(03)00394-9","article-title":"Side effects of therapy for chronic hepatitis C","volume":"124","author":"Russo","year":"2003","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.jaut.2013.04.002_bib6","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.4049\/jimmunol.1002631","article-title":"IFN-a mediates the development of autoimmunity both by direct tissue toxicity and through immune cell recruitment mechanisms","volume":"186","author":"Akeno","year":"2011","journal-title":"J\u00a0Immunol"},{"issue":"5","key":"10.1016\/j.jaut.2013.04.002_bib7","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0002-9343(96)00259-8","article-title":"Multiple changes in thyroid function in patients with chronic active HCV hepatitis treated with recombinant interferon-alpha","volume":"101","author":"Roti","year":"1996","journal-title":"Am J Med"},{"issue":"1","key":"10.1016\/j.jaut.2013.04.002_bib8","doi-asserted-by":"crossref","first-page":"E144","DOI":"10.1210\/jc.2012-2408","article-title":"Fine mapping of loci linked to autoimmune thyroid disease identifies novel susceptibility genes","volume":"98","author":"Tomer","year":"2013","journal-title":"J\u00a0Clin Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.jaut.2013.04.002_bib9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/ar3204","article-title":"Promise and pitfalls of the immunochip","volume":"13","author":"Cortes","year":"2011","journal-title":"Arth Res Ther"},{"issue":"3","key":"10.1016\/j.jaut.2013.04.002_bib10","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a toolset for whole-genome association and population-based linkage analysis","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"12","key":"10.1016\/j.jaut.2013.04.002_bib11","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1371\/journal.pgen.0020190","article-title":"Population structure and eigenanalysis","volume":"2","author":"Patterson","year":"2006","journal-title":"PLoS Genet"},{"issue":"8","key":"10.1016\/j.jaut.2013.04.002_bib12","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"Price","year":"2006","journal-title":"Nat Genet"},{"issue":"24","key":"10.1016\/j.jaut.2013.04.002_bib13","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1093\/hmg\/ddg357","article-title":"Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease","volume":"12","author":"Li","year":"2003","journal-title":"Hum Mol Genet"},{"issue":"6","key":"10.1016\/j.jaut.2013.04.002_bib14","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/jcbfm.2012.24","article-title":"TTC7B emerges as a novel risk factor for ischemic stroke through the convergence of several genome-wide approaches","volume":"32","author":"Krug","year":"2012","journal-title":"J\u00a0Cereb Blood Flow Metab"},{"issue":"2","key":"10.1016\/j.jaut.2013.04.002_bib15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1517\/phgs.4.2.171.22636","article-title":"Haplotype analysis in population genetics and association studies","volume":"4","author":"Zhao","year":"2003","journal-title":"Pharmacogenomics"},{"issue":"1","key":"10.1016\/j.jaut.2013.04.002_bib16","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1073\/pnas.77.1.572","article-title":"Insulin is ubiquitous in extrapancreatic tissues of rats and humans","volume":"77","author":"Rosenzweig","year":"1980","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.jaut.2013.04.002_bib17","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1073\/pnas.0308690100","article-title":"Extrapancreatic insulin-producing cells in multiple organs in diabetes","volume":"101","author":"Kojima","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.jaut.2013.04.002_bib18","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1517\/14740330903066726","article-title":"Type 1 IFNs and their role in the development of autoimmune diseases","volume":"8","author":"Burdick","year":"2009","journal-title":"Expert Opin Drug Saf"},{"issue":"5","key":"10.1016\/j.jaut.2013.04.002_bib19","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.autrev.2004.03.003","article-title":"Interferon induced autoimmune thyroid disease (AITD): a model for human autoimmunity","volume":"3","author":"Oppenheim","year":"2004","journal-title":"Autoimmun Rev"},{"issue":"17","key":"10.1016\/j.jaut.2013.04.002_bib20","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1056\/NEJMra1100030","article-title":"Genomics and the multifactorial nature of human autoimmune disease","volume":"365","author":"Cho","year":"2011","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.jaut.2013.04.002_bib21","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jaut.2008.08.001","article-title":"HCV E2 protein binds directly to thyroid cells and induces IL-8 production: a new mechanism for HCV induced thyroid autoimmunity","volume":"31","author":"Akeno","year":"2008","journal-title":"J\u00a0Autoimmun"},{"issue":"3\u20134","key":"10.1016\/j.jaut.2013.04.002_bib22","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jaut.2009.07.008","article-title":"The genetics of human autoimmune disease","volume":"33","author":"Invernizzi","year":"2009","journal-title":"J\u00a0Autoimmun"},{"issue":"1","key":"10.1016\/j.jaut.2013.04.002_bib23","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/ajg.2009.596","article-title":"PML nuclear body component Sp140 is a novel autoantigen in primary biliary cirrhosis","volume":"105","author":"Granito","year":"2010","journal-title":"Am J Gastrotenterol"},{"issue":"49","key":"10.1016\/j.jaut.2013.04.002_bib24","doi-asserted-by":"crossref","first-page":"7274","DOI":"10.1038\/sj.onc.1204854","article-title":"Role and fate of PML nuclear bodies in response to interferon and viral infections","volume":"20","author":"Regad","year":"2001","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.jaut.2013.04.002_bib25","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1432-1033.1996.0554z.x","article-title":"Interferon-modulated expression of genes encoding the nuclear-dot-associated proteins SP100 and promyelocytic leukemia protein (PML)","volume":"238","author":"Grotzinger","year":"1996","journal-title":"Eur J Biochem"},{"issue":"5","key":"10.1016\/j.jaut.2013.04.002_bib26","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/S0168-8278(99)80131-7","article-title":"HLA antigens in patients with interferon-\u03b1-induced autoimmune thyroid disorders in chronic hepatitis C","volume":"30","author":"Kakizaki","year":"1999","journal-title":"J\u00a0Hepatol"},{"issue":"2","key":"10.1016\/j.jaut.2013.04.002_bib27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1385\/ENDO:25:2:137","article-title":"Association between the TAP1 gene codon 637 polymorphism and Graves\u2019 disease","volume":"25","author":"Chen","year":"2004","journal-title":"Endocrine"},{"issue":"6","key":"10.1016\/j.jaut.2013.04.002_bib28","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.4049\/jimmunol.159.6.3068","article-title":"Reduced expression of Tap1 and Lmp2 antigen-processing genes in the nonobese diabetic (NOD) mouse due to a mutation in their shared bidirectional promoter","volume":"159","author":"Yan","year":"1997","journal-title":"J\u00a0Immunol"},{"issue":"1","key":"10.1016\/j.jaut.2013.04.002_bib29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0198-8859(96)00156-5","article-title":"TAP-polymorphisms in juvenile onset psoriasis and psoriatic arthritis","volume":"51","author":"Hohler","year":"1996","journal-title":"Hum Immunol"},{"issue":"3","key":"10.1016\/j.jaut.2013.04.002_bib30","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1365-2370.2002.00307.x","article-title":"TAP1 and TAP2 gene polymorphism in rheumatoid arthritis in a population in eastern France","volume":"29","author":"Zhang","year":"2002","journal-title":"Eur J Immunogenet"},{"issue":"1","key":"10.1016\/j.jaut.2013.04.002_bib31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1399-0039.1997.tb02704.x","article-title":"Polymorphisms of TAP1 and TAP2 genes in Graves' disease","volume":"49","author":"Rau","year":"1997","journal-title":"Tissue Antigens"},{"issue":"6380","key":"10.1016\/j.jaut.2013.04.002_bib32","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1038\/357702a0","article-title":"Processing pathways for presentation of cytosolic antigen to MHC Class II-restricted T cells","volume":"357","author":"Malnati","year":"1992","journal-title":"Nature"},{"issue":"1\u20132","key":"10.1016\/j.jaut.2013.04.002_bib33","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jaut.2007.11.010","article-title":"The HLA gene complex in thyroid autoimmunity: from epidemiology to etiology","volume":"30","author":"Jacobson","year":"2008","journal-title":"J\u00a0Autoimmun"},{"issue":"3\u20134","key":"10.1016\/j.jaut.2013.04.002_bib34","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jaut.2009.02.007","article-title":"The etiology of autoimmune thyroid disease: a story of genes and environment","volume":"32","author":"Tomer","year":"2009","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2013.04.002_bib35","article-title":"Hepatitis C virus infection of a thyroid cell line: implications for pathogenesis of HCV and thyroiditis","author":"Blackard","year":"2012","journal-title":"Thyroid"},{"issue":"10","key":"10.1016\/j.jaut.2013.04.002_bib36","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1089\/thy.2007.0208","article-title":"The role of apoptosis in thyroid autoimmunity","volume":"17","author":"Wang","year":"2007","journal-title":"Thyroid"},{"issue":"3","key":"10.1016\/j.jaut.2013.04.002_bib37","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.jaut.2008.04.009","article-title":"The consequences of apoptosis in autoimmunity","volume":"31","author":"Lleo","year":"2008","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2013.04.002_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2013.01.010","article-title":"The critical importance of epigenetics in autoimmunity","volume":"41","author":"Lu","year":"2013","journal-title":"J\u00a0Autoimmun"},{"issue":"36","key":"10.1016\/j.jaut.2013.04.002_bib39","doi-asserted-by":"crossref","first-page":"31168","DOI":"10.1074\/jbc.M111.247510","article-title":"Novel variant of thyroglobulin promoter triggers thyroid autoimmunity through an epigenetic interferon alpha-modulated mechanism","volume":"286","author":"Stefan","year":"2011","journal-title":"J\u00a0Biol Chem"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841113000498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841113000498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:06:44Z","timestamp":1760256404000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841113000498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":39,"alternative-id":["S0896841113000498"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2013.04.002","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic analysis of interferon induced thyroiditis (IIT): Evidence for a key role for MHC and apoptosis related genes and pathways","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2013.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}