{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T01:49:49Z","timestamp":1782438589010,"version":"3.54.5"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,8,1]],"date-time":"2014-08-01T00:00:00Z","timestamp":1406851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Gliknik Inc."}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1016\/j.jaut.2013.12.014","type":"journal-article","created":{"date-parts":[[2014,1,2]],"date-time":"2014-01-02T18:16:17Z","timestamp":1388686577000},"page":"64-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Recombinant IgG2a Fc (M045) multimers effectively suppress experimental autoimmune myasthenia gravis"],"prefix":"10.1016","volume":"52","author":[{"given":"Muthusamy","family":"Thiruppathi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Rong","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangcheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bellur S.","family":"Prabhakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7268-768X","authenticated-orcid":false,"given":"Matthew N.","family":"Meriggioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2013.12.014_bib1","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1172\/JCI29894","article-title":"Myasthenia gravis: past, present, and future","volume":"116","author":"Conti-Fine","year":"2006","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaut.2013.12.014_bib2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S1474-4422(09)70063-8","article-title":"Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity","volume":"8","author":"Meriggioli","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jaut.2013.12.014_bib3","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1212\/01.wnl.0000256698.69121.45","article-title":"IV immunoglobulin in patients with myasthenia gravis: a randomized controlled trial","volume":"68","author":"Zinman","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.jaut.2013.12.014_bib4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/(SICI)1097-4598(199603)19:3<388::AID-MUS20>3.0.CO;2-N","article-title":"Complications of intravenous gamma globulin in neuromuscular and other diseases","volume":"19","author":"Bertorini","year":"1996","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.jaut.2013.12.014_bib5","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1126\/science.291.5503.484","article-title":"Anti-inflammatory activity of IVIG mediated through inhibition of Fc receptor","volume":"291","author":"Samuelsson","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.jaut.2013.12.014_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1084\/jem.20061788","article-title":"The antiinflammatory activity of IgG: the intravenous IgG paradox","volume":"204","author":"Nimmerjahn","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaut.2013.12.014_bib7","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev.immunol.26.021607.090232","article-title":"Anti-inflammatory actions of intravenous immunoglobulin","volume":"26","author":"Nimmerjahn","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib8","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.4049\/jimmunol.120.5.1669","article-title":"The requirement for the Fc portion of antibody in antigen-antibody complex-mediated suppression","volume":"120","author":"Morgan","year":"1978","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1172\/JCI200522753","article-title":"Can antibodies with specificity for soluble antigens mimic the therapeutic effects of intravenous IgG in the treatment of autoimmune disease?","volume":"115","author":"Siragam","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaut.2013.12.014_bib10","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1365-2141.2004.05105.x","article-title":"Tetramolecular immune complexes are more efficient than IVIg to prevent antibody-dependent in\u00a0vitro and in\u00a0vivo phagocytosis of blood cells","volume":"127","author":"Bazin","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jaut.2013.12.014_bib11","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1182\/blood.V98.4.1095","article-title":"Therapeutic efficacy of intravenous immunoglobulin preparations depends on the immunoglobulin G dimers: studies in experimental immune thrombocytopenia","volume":"98","author":"Teeling","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2013.12.014_bib12","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.copbio.2009.10.012","article-title":"Discovery and development of biopharmaceuticals: current issues","volume":"20","author":"Strohl","year":"2009","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.jaut.2013.12.014_bib13","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.copbio.2009.10.010","article-title":"Receptor-Fc fusion therapeutics, traps, and MIMETIBODYTM technology","volume":"20","author":"Huang","year":"2009","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.jaut.2013.12.014_bib14","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/nri2155","article-title":"FcRn: the neonatal Fc receptor comes of age","volume":"7","author":"Roopenian","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib15","doi-asserted-by":"crossref","first-page":"18709","DOI":"10.1073\/pnas.0606304103","article-title":"Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodies","volume":"103","author":"Vaccaro","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaut.2013.12.014_bib16","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri2206","article-title":"Fc-receptors as regulators of immune responses","volume":"8","author":"Nimmerjahn","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib17","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1002\/emmm.201201379","article-title":"Fc-fusion proteins: new developments and future perspectives","volume":"4","author":"Czajkowsky","year":"2012","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.jaut.2013.12.014_bib18","first-page":"88","article-title":"IgG effector mechanisms","volume":"65","author":"Clark","year":"1997","journal-title":"Chem Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib19","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1189\/jlb.72.3.522","article-title":"In\u00a0vitro and in\u00a0vivo activities of OX40 (CD134)-IgG fusion protein isoforms with different levels of immune-effector functions","volume":"72","author":"Taylor","year":"2002","journal-title":"J\u00a0Leukoc Biol"},{"key":"10.1016\/j.jaut.2013.12.014_bib20","series-title":"The human IgG subclasses: molecular analysis of structure and function","first-page":"161","article-title":"Selective IgG subclass expression: biologic, clinical and functional aspects","author":"Scott","year":"1990"},{"key":"10.1016\/j.jaut.2013.12.014_bib21","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1128\/cdli.2.6.726-732.1995","article-title":"Selective increases in antibody isotypes and immunoglobulin G subclass responses to secreted antigens in tuberculosis patients and healthy household contacts of the patients","volume":"2","author":"Hussain","year":"1995","journal-title":"Clin Diagn Lab Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s10875-007-9088-9","article-title":"Intravenous immunoglobulin: an update on the clinical use and mechanisms of action","volume":"27","author":"Negi","year":"2007","journal-title":"J\u00a0Clin Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib23","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.it.2008.08.004","article-title":"Modulation of the cellular immune system by intravenous immunoglobulin","volume":"29","author":"Tha-","year":"2008","journal-title":"Trends Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib24","series-title":"Pediatric critical care study guide text and review","first-page":"427","article-title":"Use of blood products","author":"Cholette","year":"2012"},{"key":"10.1016\/j.jaut.2013.12.014_bib25","doi-asserted-by":"crossref","first-page":"R192","DOI":"10.1186\/ar4024","article-title":"Fully recombinant IgG2a Fc multimers (stradomers) effectively treat collagen-induced arthritis and prevent idiopathic thrombocytopenic purpura in mice","volume":"14","author":"Jain","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.jaut.2013.12.014_bib26","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1002\/eji.1830211003","article-title":"Experimental myasthenia gravis in congenic mice: sequence mapping and H-2 restriction of T helper epitopes on the \u03b1 subunits of Torpedo californica and murine acetylcholine receptors","volume":"21","author":"Bellone","year":"1991","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib27","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.4049\/jimmunol.177.8.5296","article-title":"Suppression of experimental autoimmune myasthenia gravis by granulocyte-macrophage colony-stimulating factor is associated with an expansion of FoxP3+ regulatory T cells","volume":"177","author":"Sheng","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib28","article-title":"Experimental autoimmune myasthenia gravis in the mouse","author":"Wu","year":"2001","journal-title":"Curr Protoc Immunol"},{"issue":"Pt C","key":"10.1016\/j.jaut.2013.12.014_bib29","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/0076-6879(81)74031-X","article-title":"Production and assay of antibodies to acetylcholine receptors","volume":"74","author":"Lindstrom","year":"1981","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.jaut.2013.12.014_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2005.02834.x","article-title":"Clinical uses of intravenous immunoglobulin","volume":"142","author":"Jolles","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib31","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1154315","article-title":"Recapitulation of IVIg anti-inflammatory activity with recombinant IgG Fc","volume":"320","author":"Anthony","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.jaut.2013.12.014_bib32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF00320302","article-title":"Are aggregates of IgG the effective part of high-dose immunoglobulin therapy in adult idiopathic thrombocytopenic purpura (ITP)?","volume":"50","author":"Augener","year":"1985","journal-title":"Blut"},{"key":"10.1016\/j.jaut.2013.12.014_bib33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jneuroim.2006.04.011","article-title":"Intravenous immunoglobulin suppresses experimental myasthenia gravis: immunological mechanisms","volume":"176","author":"Zhu","year":"2006","journal-title":"J\u00a0Neuroimmunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/jns5.12022","article-title":"Beneficial effect of a multimerized immunoglobulin Fc in an animal model of inflammatory neuropathy (experimental autoimmune neuritis)","volume":"18","author":"Niknami","year":"2013","journal-title":"J\u00a0Peripher Nerv Syst"},{"key":"10.1016\/j.jaut.2013.12.014_bib35","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1182\/blood.V77.2.376.376","article-title":"High doses of intravenous Ig inhibit in\u00a0vitro uptake of C4 fragments onto sensitized erythrocytes","volume":"77","author":"Basta","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2013.12.014_bib36","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1182\/blood.V88.1.184.184","article-title":"High doses of immunoglobulin G attenuate immune aggregate-mediated complement activation by enhancing physiologic cleavage of C3b in C3bn-IgG complexes","volume":"88","author":"Lutz","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2013.12.014_bib37","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1002\/lt.20594","article-title":"High dose intravenous immunoglobulin treatment: mechanisms of action","volume":"11","author":"Boros","year":"2005","journal-title":"Liver Transpl"},{"key":"10.1016\/j.jaut.2013.12.014_bib38","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.autrev.2013.03.011","article-title":"Ectopic germinal centers, BAFF, and anti-B-cell therapy in myasthenia gravis","volume":"12","author":"Berrih-Aknin","year":"2013","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaut.2013.12.014_bib39","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.4049\/jimmunol.171.11.5707","article-title":"CD40, but not CD154, expression on B cells is necessary for optimal primary B cell responses","volume":"171","author":"Lee","year":"2003","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib40","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/eji.200636623","article-title":"TACI attenuates antibody production costimulated by BAFF-R and CD40","volume":"37","author":"Sakurai","year":"2007","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib41","doi-asserted-by":"crossref","unstructured":"Venkatesh J, Kawabata D, Kim S, Xu X, Chinnasamy P, Paul E, et\u00a0al. Selective regulation of autoreactive B cells by FcgammaRIIB. J Autoimmun;32:149\u2013157.","DOI":"10.1016\/j.jaut.2009.02.009"},{"key":"10.1016\/j.jaut.2013.12.014_bib42","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nri2762","article-title":"FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications","volume":"10","author":"Smith","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1196\/annals.1405.042","article-title":"CD4+ T cells and cytokines in the pathogenesis of acquired myasthenia gravis","volume":"1132","author":"Conti-Fine","year":"2008","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.jaut.2013.12.014_bib44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1124\/pr.109.002006","article-title":"Therapeutic targeting of B cells for rheumatic autoimmune diseases","volume":"63","author":"Engel","year":"2011","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.jaut.2013.12.014_bib45","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nri2785","article-title":"FOXP3+ regulatory T cells in the human immune system","volume":"10","author":"Sakaguchi","year":"2010","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib46","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.clim.2008.12.001","article-title":"Modulation of dendritic cells using granulocyte-macrophage colony-stimulating factor (GM-CSF) delays type 1 diabetes by enhancing CD4+CD25+ regulatory T cell function","volume":"131","author":"Cheatem","year":"2009","journal-title":"Clin Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib47","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/intimm\/dxn147","article-title":"GM-CSF-induced CD11c+CD8a\u2013dendritic cells facilitate Foxp3+ and IL-10+ regulatory T cell expansion resulting in suppression of autoimmune thyroiditis","volume":"21","author":"Ganesh","year":"2009","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib48","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1084\/jem.20020642","article-title":"Human CD4(+)CD25(+) regulatory, contact-dependent T cells induce interleukin 10-producing, contact-independent type 1-like regulatory T cells","volume":"196","author":"Dieckmann","year":"2002","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaut.2013.12.014_bib49","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.4049\/jimmunol.172.9.5213","article-title":"Natural and induced CD4+CD25+ cells educate CD4+CD25\u2212 cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10","volume":"172","author":"Zheng","year":"2004","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib50","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000092576","article-title":"Type I regulatory T cells in autoimmunity andinflammatory diseases","volume":"140","author":"Veldman","year":"2006","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib51","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/mus.10362","article-title":"Dendritic cells in hyperplastic thymuses from patients with myasthenia gravis","volume":"27","author":"Nagane","year":"2003","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.jaut.2013.12.014_bib52","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0008-8749(03)00118-7","article-title":"Induction of peripheral tolerance to experimental autoimmune myasthenia gravis by acetylcholine receptor- pulsed dendritic cells","volume":"223","author":"Xiao","year":"2003","journal-title":"Cell Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib53","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.4049\/jimmunol.174.3.1729","article-title":"Cathepsin S is required for murine autoimmune myasthenia gravis pathogenesis","volume":"174","author":"Yang","year":"2005","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib54","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1084\/jem.184.2.747","article-title":"Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation","volume":"184","author":"Cella","year":"1996","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaut.2013.12.014_bib55","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/30989","article-title":"A\u00a0conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell","volume":"393","author":"Ridge","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2013.12.014_bib56","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1681\/ASN.V641143","article-title":"T\u00a0cell costimulatory pathways: promising novel targets for immunosuppression and tolerance induction","volume":"6","author":"Sayegh","year":"1995","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.jaut.2013.12.014_bib57","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jdermsci.2007.03.002","article-title":"Tolerogenic dendritic cells and regulatory T cells: a two-way relationship","volume":"46","author":"Mahnke","year":"2007","journal-title":"J\u00a0Dermatol Sci"},{"key":"10.1016\/j.jaut.2013.12.014_bib58","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1172\/JCI24772","article-title":"Activating and inhibitory IgG Fc receptors on human DCs mediate opposing functions","volume":"115","author":"Boruchov","year":"2005","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaut.2013.12.014_bib59","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1073\/pnas.0500014102","article-title":"Selective blockade of inhibitory Fcgamma receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells","volume":"102","author":"Dhodapkar","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaut.2013.12.014_bib60","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1084\/jem.189.2.371","article-title":"Fcgamma receptor-mediated induction of dendritic cell maturation and major histocompatibility complex class I-restricted antigen presentation after immune complex internalization","volume":"189","author":"Regnault","year":"1999","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaut.2013.12.014_bib61","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0952-7915(96)80013-6","article-title":"Manipulation of the Th1\/Th2 balance in autoimmune disease","volume":"8","author":"Nicholson","year":"1996","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib62","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1172\/JCI7121","article-title":"Oral administration of an immunodominant T-cell epitope downregulates Th1\/Th2 cytokines and prevents experimental myasthenia gravis","volume":"104","author":"Baggi","year":"1999","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaut.2013.12.014_bib63","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1084\/jem.186.3.385","article-title":"Interferon gamma (IFN-gamma) is necessary for the genesis of acetylcholine receptor-induced clinical experimental autoimmune myasthenia gravis in mice","volume":"186","author":"Balasa","year":"1997","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaut.2013.12.014_bib64","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties","volume":"7","author":"Mosmann","year":"1989","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib65","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3109\/08916930903555943","article-title":"Antibody effector mechanisms in myasthenia gravis-pathogenesis at the neuromuscular junction","volume":"43","author":"Gomez","year":"2010","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jaut.2013.12.014_bib66","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/(SICI)1097-4598(199705)20:5<543::AID-MUS2>3.0.CO;2-9","article-title":"Cytokines and the pathogenesis of myasthenia gravis","volume":"20","author":"Zhang","year":"1997","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.jaut.2013.12.014_bib67","doi-asserted-by":"crossref","first-page":"5757","DOI":"10.4049\/jimmunol.162.10.5757","article-title":"Mechanisms of nasal tolerance induction in experimental autoimmune myasthenia gravis: identification of regulatory cells","volume":"162","author":"Shi","year":"1999","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib68","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1182\/blood-2006-03-006403","article-title":"Tolerogenic dendritic cells: cytokine modulation comes of age","volume":"108","author":"Rutella","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2013.12.014_bib69","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.immuni.2008.08.005","article-title":"Tuning microenvironments: Induction of regulatory T cells by dendritic cells","volume":"29","author":"Belkaid","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2013.12.014_bib70","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.imbio.2012.07.015","article-title":"The immunoglobulin, IgG Fc receptor and complement triangle in autoimmune diseases","volume":"217","author":"Karsten","year":"2012","journal-title":"Immunobiology"},{"key":"10.1016\/j.jaut.2013.12.014_bib71","doi-asserted-by":"crossref","first-page":"8440","DOI":"10.4049\/jimmunol.177.12.8440","article-title":"Regulated expression of FcgammaR in human dendritic cells controls cross-presentation of antigen-antibody complexes","volume":"177","author":"Liu","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2013.12.014_bib72","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/srep00124","article-title":"Polymeric human Fc-fusion proteins with modified effector functions","volume":"1","author":"Mekhaiel","year":"2011","journal-title":"Sci Rep"}],"updated-by":[{"DOI":"10.1016\/j.jaut.2014.10.004","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000}}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841113001613?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841113001613?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:10:29Z","timestamp":1760256629000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841113001613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8]]},"references-count":72,"alternative-id":["S0896841113001613"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2013.12.014","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2014,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recombinant IgG2a Fc (M045) multimers effectively suppress experimental autoimmune myasthenia gravis","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2013.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}