{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:04:26Z","timestamp":1792659866128,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.jaut.2014.01.028","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T19:17:28Z","timestamp":1391109448000},"page":"94-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":191,"special_numbering":"C","title":["Diagnosis and classification of granulomatosis with polyangiitis (aka Wegener's granulomatosis)"],"prefix":"10.1016","volume":"48-49","author":[{"given":"Pamela M.K.","family":"Lutalo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P.","family":"D'Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.jaut.2014.01.028_bib1","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1136\/ard.2011.150714","article-title":"Granulomatosis with polyangiitis (Wegener's): an alternative name for Wegener's granulomatosis","volume":"70","author":"Falk","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.jaut.2014.01.028_bib2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/ard.59.3.161","article-title":"Systemic vasculitis: epidemiology, classification and environmental factors","volume":"59","author":"Scott","year":"2000","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"10.1016\/j.jaut.2014.01.028_bib3","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s11926-005-0036-5","article-title":"Epidemiology of systemic vasculitis","volume":"7","author":"Lane","year":"2005","journal-title":"Curr Rheumatol Rep"},{"issue":"6","key":"10.1016\/j.jaut.2014.01.028_bib4","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s11926-012-0286-y","article-title":"Pathogenesis of ANCA-associated vasculitis","volume":"14","author":"Cartin-Ceba","year":"2012","journal-title":"Curr Rheumatol Rep"},{"issue":"1","key":"10.1016\/j.jaut.2014.01.028_bib5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1440-1797.2009.01100.x","article-title":"Review article: drug-induced anti-neutrophil cytoplasmic antibody-associated vasculitis","volume":"14","author":"Gao","year":"2009","journal-title":"Nephrol (Carlton)"},{"issue":"3","key":"10.1016\/j.jaut.2014.01.028_bib6","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1056\/NEJMoa1108735","article-title":"Genetically distinct subsets within ANCA-associated vasculitis","volume":"367","author":"Lyons","year":"2012","journal-title":"N\u00a0Engl J Med"},{"issue":"9","key":"10.1016\/j.jaut.2014.01.028_bib7","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1093\/rheumatology\/kes123","article-title":"Granulomatosis with polyangiitis involves sustained mucosal inflammation that is rich in B-cell survival factors and autoantigen","volume":"51","author":"Zhao","year":"2012","journal-title":"Rheumatol (Oxford)"},{"issue":"3","key":"10.1016\/j.jaut.2014.01.028_bib8","doi-asserted-by":"crossref","first-page":"R70","DOI":"10.1186\/ar4247","article-title":"Increased frequency of circulating IL-21 producing Th-cells in patients with granulomatosis with polyangiitis","volume":"15","author":"Abdulahad","year":"2013","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"10.1016\/j.jaut.2014.01.028_bib9","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0190-9622(94)70224-1","article-title":"Cutaneous Wegener's granulomatosis: clinical, histopathologic, and immunopathologic features of thirty patients","volume":"31","author":"Daoud","year":"1994","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"5","key":"10.1016\/j.jaut.2014.01.028_bib10","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.survophthal.2009.12.003","article-title":"Wegener's granulomatosis: clinical manifestations, differential diagnosis, and management of ocular and systemic disease","volume":"55","author":"Tarabishy","year":"2010","journal-title":"Surv Ophthalmol"},{"issue":"1","key":"10.1016\/j.jaut.2014.01.028_bib11","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.amjmed.2004.02.030","article-title":"The antineutrophil cytoplasmic antibody-associated vasculitides","volume":"117","author":"Seo","year":"2004","journal-title":"Am J Med"},{"issue":"4","key":"10.1016\/j.jaut.2014.01.028_bib12","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1378\/chest.08-3043","article-title":"Antineutrophil cytoplasmic antibody-associated vasculitides and respiratory disease","volume":"136","author":"Gomez-Puerta","year":"2009","journal-title":"Chest"},{"issue":"2","key":"10.1016\/j.jaut.2014.01.028_bib13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/01.md.0000158825.87055.0b","volume":"84","author":"Pagnoux","year":"2005","journal-title":"Med (Baltimore)"},{"issue":"1","key":"10.1016\/j.jaut.2014.01.028_bib14","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/BOR.0b013e32834115f9","article-title":"Neurological involvement in Wegener's granulomatosis","volume":"23","author":"Holle","year":"2011","journal-title":"Curr Opin Rheumatol"},{"issue":"6","key":"10.1016\/j.jaut.2014.01.028_bib15","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/art.23707","article-title":"Assessment of the item selection and weighting in the Birmingham vasculitis activity score for Wegener's granulomatosis","volume":"59","author":"Mahr","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.jaut.2014.01.028_bib16","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1136\/ard.2008.088096","article-title":"EULAR recommendations for the management of primary small and medium vessel vasculitis","volume":"68","author":"Mukhtyar","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"10.1016\/j.jaut.2014.01.028_bib17","doi-asserted-by":"crossref","first-page":"670","DOI":"10.7326\/0003-4819-150-10-200905190-00004","article-title":"Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized trial","volume":"150","author":"de Groot","year":"2009","journal-title":"Ann Intern Med"},{"issue":"3","key":"10.1016\/j.jaut.2014.01.028_bib18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1056\/NEJMoa0909905","article-title":"Rituximab versus cyclophosphamide for ANCA-associated vasculitis","volume":"363","author":"Stone","year":"2010","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.jaut.2014.01.028_bib19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1056\/NEJMoa0909169","article-title":"Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis","volume":"363","author":"Jones","year":"2010","journal-title":"N\u00a0Engl J Med"},{"issue":"7","key":"10.1016\/j.jaut.2014.01.028_bib20","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1136\/ard.2005.044420","article-title":"Lack of efficacy of rituximab in Wegener's granulomatosis with refractory granulomatous manifestations","volume":"65","author":"Aries","year":"2006","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"10.1016\/j.jaut.2014.01.028_bib21","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1002\/art.21142","article-title":"Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis","volume":"52","author":"De Groot","year":"2005","journal-title":"Arthritis Rheum"},{"issue":"10","key":"10.1016\/j.jaut.2014.01.028_bib22","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1002\/art.34547","article-title":"Brief Report: long-term outcome of a randomized clinical trial comparing methotrexate to cyclophosphamide for remission induction in early systemic antineutrophil cytoplasmic antibody-associated vasculitis","volume":"64","author":"Faurschou","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.jaut.2014.01.028_bib23","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1056\/NEJMoa020286","article-title":"A\u00a0randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies","volume":"349","author":"Jayne","year":"2003","journal-title":"N\u00a0Engl J Med"},{"issue":"21","key":"10.1016\/j.jaut.2014.01.028_bib24","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1001\/jama.2010.1658","article-title":"Mycophenolate mofetil vs azathioprine for remission maintenance in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized controlled trial","volume":"304","author":"Hiemstra","year":"2010","journal-title":"J\u00a0Am Med Assoc"},{"issue":"6","key":"10.1016\/j.jaut.2014.01.028_bib25","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0002-9343(03)00077-9","article-title":"Use of a cyclophosphamide-induction methotrexate-maintenance regimen for the treatment of Wegener's granulomatosis: extended follow-up and rate of relapse","volume":"114","author":"Langford","year":"2003","journal-title":"Am J Med"},{"issue":"12","key":"10.1016\/j.jaut.2014.01.028_bib26","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1002\/1529-0131(199912)42:12<2666::AID-ANR24>3.0.CO;2-E","article-title":"A\u00a0staged approach to the treatment of Wegener's granulomatosis: induction of remission with glucocorticoids and daily cyclophosphamide switching to methotrexate for remission maintenance","volume":"42","author":"Langford","year":"1999","journal-title":"Arthritis Rheum"},{"issue":"7","key":"10.1016\/j.jaut.2014.01.028_bib27","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/rheumatology\/kem029","article-title":"Elevated relapse rate under oral methotrexate versus leflunomide for maintenance of remission in Wegener's granulomatosis","volume":"46","author":"Metzler","year":"2007","journal-title":"Rheumatol (Oxford)"},{"issue":"11","key":"10.1016\/j.jaut.2014.01.028_bib28","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1002\/art.34583","article-title":"Rituximab for remission maintenance in relapsing antineutrophil cytoplasmic antibody-associated vasculitis","volume":"64","author":"Smith","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.jaut.2014.01.028_bib29","first-page":"1","article-title":"Treatment of Wegener's granulomatosis: new horizons?","volume":"14","author":"Kallenberg","year":"1996","journal-title":"Clin Exp Rheumatol"},{"issue":"4","key":"10.1016\/j.jaut.2014.01.028_bib30","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/ki.1991.272","article-title":"Plasma exchange in focal necrotizing glomerulonephritis without anti-GBM antibodies","volume":"40","author":"Pusey","year":"1991","journal-title":"Kidney Int"},{"issue":"7","key":"10.1016\/j.jaut.2014.01.028_bib31","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1681\/ASN.2007010090","article-title":"Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis","volume":"18","author":"Jayne","year":"2007","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"6","key":"10.1016\/j.jaut.2014.01.028_bib32","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1053\/j.ajkd.2003.08.015","article-title":"Plasmapheresis therapy for diffuse alveolar hemorrhage in patients with small-vessel vasculitis","volume":"42","author":"Klemmer","year":"2003","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.jaut.2014.01.028_bib33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jaut.2013.03.001","article-title":"B-cell depletion therapy and pregnancy outcome in severe, refractory systemic autoimmune diseases","volume":"43","author":"Sangle","year":"2013","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2014.01.028_bib34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jaut.2012.10.003","article-title":"Progranulin antibodies in autoimmune diseases","volume":"42","author":"Thurner","year":"2013","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2014.01.028_bib35","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.autrev.2013.06.009","article-title":"Performance evaluation of three assays for the detection of PR3-ANCA in granulomatosis with polyangiitis in daily practice","volume":"12","author":"Noel","year":"2013","journal-title":"Autoimmun Rev"},{"issue":"1 Suppl.\u00a075","key":"10.1016\/j.jaut.2014.01.028_bib36","first-page":"S62","article-title":"Progressive multifocal encephalopathy after cyclophosphamide in granulomatosis with polyangiitis (Wegener) patients: case report and review of literature","volume":"31","author":"Pugnet","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.jaut.2014.01.028_bib37","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1136\/annrheumdis-2013-203255","article-title":"Antineutrophil cytoplasmic antibody-associated vasculitides: is it time to split up the group","volume":"72","author":"Millet","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaut.2014.01.028_bib38","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jaut.2010.09.002","article-title":"Wegener's granuloma harbors B lymphocytes with specificities against a proinflammatory transmembrane protein and a tetraspanin","volume":"36","author":"Thurner","year":"2011","journal-title":"J\u00a0Autoimmun"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841114000316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841114000316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:10:49Z","timestamp":1760256649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841114000316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":38,"alternative-id":["S0896841114000316"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2014.01.028","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnosis and classification of granulomatosis with polyangiitis (aka Wegener's granulomatosis)","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2014.01.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}