{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:36:34Z","timestamp":1790922994019,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.jaut.2014.02.001","type":"journal-article","created":{"date-parts":[[2014,2,22]],"date-time":"2014-02-22T14:46:07Z","timestamp":1393080367000},"page":"26-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["Retinoic acid stabilizes antigen-specific regulatory T-cell function in autoimmune hepatitis type 2"],"prefix":"10.1016","volume":"53","author":[{"given":"Beth S.","family":"Holder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte R.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2525-1546","authenticated-orcid":false,"given":"Rodrigo","family":"Liberal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Heneghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8215-4489","authenticated-orcid":false,"given":"Giorgina","family":"Mieli-Vergani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Vergani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Serena","family":"Longhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2014.02.001_bib1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jhep.2004.03.008","article-title":"Impairment of CD4(+)CD25(+) regulatory T-cells in autoimmune liver disease","volume":"41","author":"Longhi","year":"2004","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.jaut.2014.02.001_bib2","doi-asserted-by":"crossref","first-page":"4484","DOI":"10.4049\/jimmunol.176.7.4484","article-title":"Functional study of CD4+CD25+ regulatory T cells in health and autoimmune hepatitis","volume":"176","author":"Longhi","year":"2006","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2014.02.001_bib3","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/hep.23792","article-title":"A\u00a0multifaceted imbalance of T cells with regulatory function characterizes type 1 autoimmune hepatitis","volume":"52","author":"Ferri","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2014.02.001_bib4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1034\/j.1600-065X.2001.1820102.x","article-title":"Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance","volume":"182","author":"Sakaguchi","year":"2001","journal-title":"Immunol Rev"},{"key":"10.1016\/j.jaut.2014.02.001_bib5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","article-title":"Regulatory T cells and immune tolerance","volume":"133","author":"Sakaguchi","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2014.02.001_bib6","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.smim.2011.07.008","article-title":"Clinical perspectives for regulatory T cells in transplantation tolerance","volume":"23","author":"Hippen","year":"2011","journal-title":"Semin Immunol"},{"key":"10.1016\/j.jaut.2014.02.001_bib7","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.2337\/dc12-0038","article-title":"Administration of CD4+CD25highCD127- regulatory T cells preserves beta-cell function in type 1 diabetes in children","volume":"35","author":"Marek-Trzonkowska","year":"2012","journal-title":"Diabetes Care"},{"key":"10.1016\/j.jaut.2014.02.001_bib8","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1084\/jem.20040139","article-title":"In\u00a0vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes","volume":"199","author":"Tang","year":"2004","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaut.2014.02.001_bib9","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1084\/jem.20040180","article-title":"CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes","volume":"199","author":"Tarbell","year":"2004","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaut.2014.02.001_bib10","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/eji.200839073","article-title":"Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg","volume":"39","author":"Stephens","year":"2009","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.jaut.2014.02.001_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002076","article-title":"Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells","volume":"3","author":"Sagoo","year":"2011","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.jaut.2014.02.001_bib12","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1172\/JCI113949","article-title":"Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1","volume":"83","author":"Manns","year":"1989","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.jaut.2014.02.001_bib13","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1136\/gut.46.4.553","article-title":"Liver\/kidney microsomal antibody type 1 targets CYP2D6 on hepatocyte plasma membrane","volume":"46","author":"Muratori","year":"2000","journal-title":"Gut"},{"key":"10.1016\/j.jaut.2014.02.001_bib14","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1053\/j.gastro.2005.12.020","article-title":"Polyclonal T-cell responses to cytochrome P450IID6 are associated with disease activity in autoimmune hepatitis type 2","volume":"130","author":"Ma","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2014.02.001_bib15","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/hep.21658","article-title":"Cytochrome P450IID6-specific CD8 T cell immune responses mirror disease activity in autoimmune hepatitis type 2","volume":"46","author":"Longhi","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2014.02.001_bib16","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/hep.24039","article-title":"Autoantigen-specific regulatory T cells, a potential tool for immune-tolerance reconstitution in type-2 autoimmune hepatitis","volume":"53","author":"Longhi","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2014.02.001_bib17","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.2337\/db05-1576","article-title":"Induction of tolerance in type 1 diabetes via both CD4+CD25+ T regulatory cells and T regulatory type 1 cells","volume":"55","author":"Battaglia","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2014.02.001_bib18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.trim.2007.01.002","article-title":"The effect of immunosuppressive drug rapamycin on regulatory CD4+CD25+Foxp3+T cells in mice","volume":"17","author":"Qu","year":"2007","journal-title":"Transpl Immunol"},{"key":"10.1016\/j.jaut.2014.02.001_bib19","doi-asserted-by":"crossref","first-page":"320","DOI":"10.4049\/jimmunol.178.1.320","article-title":"Selective survival of naturally occurring human CD4+CD25+Foxp3+ regulatory T cells cultured with rapamycin","volume":"178","author":"Strauss","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2014.02.001_bib20","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1182\/blood-2007-06-096438","article-title":"Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3\/Stat-5 independent signaling pathway","volume":"111","author":"Elias","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2014.02.001_bib21","doi-asserted-by":"crossref","first-page":"4119","DOI":"10.4049\/jimmunol.0901065","article-title":"De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid","volume":"183","author":"Wang","year":"2009","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2014.02.001_bib22","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1182\/blood-2005-10-4129","article-title":"Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells","volume":"107","author":"Mennechet","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2014.02.001_bib23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaut.2005.05.001","article-title":"Effect of CD4+ CD25+ regulatory T-cells on CD8 T-cell function in patients with autoimmune hepatitis","volume":"25","author":"Longhi","year":"2005","journal-title":"J\u00a0Autoimmun"},{"key":"10.1016\/j.jaut.2014.02.001_bib24","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1084\/jem.20062512","article-title":"Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression","volume":"204","author":"Deaglio","year":"2007","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.jaut.2014.02.001_bib25","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1053\/j.gastro.2012.02.041","article-title":"Inhibition of Interleukin-17 promotes differentiation of CD25(-) cells into stable t regulatory cells in patients with autoimmune hepatitis","volume":"142","author":"Longhi","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2014.02.001_bib26","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/hep.22071","article-title":"Expansion and de novo generation of potentially therapeutic regulatory T cells in patients with autoimmune hepatitis","volume":"47","author":"Longhi","year":"2008","journal-title":"Hepatology (Baltimore, Md)"},{"key":"10.1016\/j.jaut.2014.02.001_bib27","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1111\/j.1600-6143.2011.03558.x","article-title":"Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease","volume":"11","author":"Hippen","year":"2011","journal-title":"Am J Transplant"},{"key":"10.1016\/j.jaut.2014.02.001_bib28","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/j.intimp.2006.07.025","article-title":"In\u00a0vitro expanded alloantigen-specific CD4+CD25+ regulatory T cell treatment for the induction of donor-specific transplantation tolerance","volume":"6","author":"Jiang","year":"2006","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.jaut.2014.02.001_bib29","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nm1564","article-title":"Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation","volume":"13","author":"Korn","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.jaut.2014.02.001_bib30","series-title":"All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation","first-page":"1765","author":"Benson","year":"2007"},{"key":"10.1016\/j.jaut.2014.02.001_bib31","series-title":"Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3\/Stat-5 independent signaling pathway","first-page":"1013","author":"Elias","year":"2008"},{"key":"10.1016\/j.jaut.2014.02.001_bib32","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1145697","article-title":"Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid","volume":"317","author":"Mucida","year":"2007","journal-title":"Science (New York, NY)"},{"key":"10.1016\/j.jaut.2014.02.001_bib33","series-title":"De novo generation and enhanced suppression of human CD4+CD25+ regulatory T cells by retinoic acid","first-page":"4119","author":"Wang","year":"2009"},{"key":"10.1016\/j.jaut.2014.02.001_bib34","article-title":"Differential effects of rapamycin and retinoic acid on expansion, stability and suppressive qualities of human CD4+CD25+FOXP3+ Treg subpopulations","author":"Scotta","year":"2012","journal-title":"Haematologica"},{"key":"10.1016\/j.jaut.2014.02.001_bib35","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1093\/intimm\/dxg101","article-title":"Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors","volume":"15","author":"Iwata","year":"2003","journal-title":"Int Immunol"},{"key":"10.1016\/j.jaut.2014.02.001_bib36","doi-asserted-by":"crossref","first-page":"146","DOI":"10.2337\/db08-1154","article-title":"All-trans retinoic acid inhibits type 1 Diabetes by T Regulatory (Treg)-Dependent suppression of interferon-\u03b3\u2013producing t-cells without affecting Th17 cells","volume":"58","author":"Van","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2014.02.001_bib37","series-title":"The Pim kinases control rapamycin-resistant T cell survival and activation","first-page":"259","author":"Fox","year":"2005"},{"key":"10.1016\/j.jaut.2014.02.001_bib38","doi-asserted-by":"crossref","first-page":"5794","DOI":"10.4049\/jimmunol.180.9.5794","article-title":"Cutting edge: Foxp3-mediated induction of pim 2 allows human T regulatory cells to preferentially expand in rapamycin","volume":"180","author":"Basu","year":"2008","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2014.02.001_bib39","series-title":"Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells","first-page":"4743","author":"Battaglia","year":"2005"},{"key":"10.1016\/j.jaut.2014.02.001_bib40","doi-asserted-by":"crossref","first-page":"e15868","DOI":"10.1371\/journal.pone.0015868","article-title":"Retinoic acid and rapamycin differentially affect and synergistically promote the ex\u00a0vivo expansion of natural human T regulatory cells","volume":"6","author":"Golovina","year":"2011","journal-title":"PloS one"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841114000407?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841114000407?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:09:28Z","timestamp":1760256568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841114000407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":40,"alternative-id":["S0896841114000407"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2014.02.001","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinoic acid stabilizes antigen-specific regulatory T-cell function in autoimmune hepatitis type 2","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2014.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}