{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:33:46Z","timestamp":1761129226373,"version":"build-2065373602"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T00:00:00Z","timestamp":1427846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005010","name":"AIRC","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Italian Ministry of Health"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1016\/j.jaut.2015.01.005","type":"journal-article","created":{"date-parts":[[2015,1,23]],"date-time":"2015-01-23T23:47:18Z","timestamp":1422056838000},"page":"78-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Autoantibodies specific to D4GDI modulate Rho GTPase mediated cytoskeleton remodeling and induce autophagy in T lymphocytes"],"prefix":"10.1016","volume":"58","author":[{"given":"Cristiana","family":"Barbati","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano","family":"Alessandri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Vomero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Vona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Colasanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Vacirca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Camerini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Crescenzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Pendolino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Truglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Conti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Garofalo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Sorice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Pierdominici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Valesini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Malorni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Ortona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2015.01.005_bib1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJMra071297","article-title":"Systemic lupus erythematosus","volume":"358","author":"Rahman","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.jaut.2015.01.005_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.autrev.2010.09.007","article-title":"Updating on the pathogenesis of systemic lupus erythematosus","volume":"10","author":"Gualtierotti","year":"2010","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaut.2015.01.005_bib3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.autrev.2011.10.010","article-title":"Macrophages and neutrophils in SLE-an online molecular catalog","volume":"11","author":"Orme","year":"2012","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaut.2015.01.005_bib4","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1177\/0961203308098191","article-title":"Lupus and T cells","volume":"18","author":"La Cava","year":"2009","journal-title":"Lupus"},{"key":"10.1016\/j.jaut.2015.01.005_bib5","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.autrev.2008.07.041","article-title":"Metabolic control of T cell activation and death in SLE","volume":"8","author":"Fernandez","year":"2009","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaut.2015.01.005_bib6","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2174\/138161208783413310","article-title":"Apoptosis in the homeostasis of the immune system and in human immune mediated diseases","volume":"14","author":"Giovannetti","year":"2008","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.jaut.2015.01.005_bib7","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/ng.81","article-title":"Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci","volume":"40","author":"Harley","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaut.2015.01.005_bib8","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/ng.468","article-title":"A\u00a0large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus","volume":"41","author":"Gateva","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaut.2015.01.005_bib9","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/ng.472","article-title":"Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus","volume":"41","author":"Han","year":"2009","journal-title":"Nat Genet"},{"key":"10.1016\/j.jaut.2015.01.005_bib10","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3109\/08916930903374774","article-title":"Systems biology of lupus: mapping the impact of genomic and environmental factors on gene expression signatures, cellular signaling, metabolic pathways, hormonal and cytokine imbalance, and selecting targets for treatment","volume":"3","author":"Perl","year":"2010","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jaut.2015.01.005_bib11","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1136\/ard.2010.140111","article-title":"Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population","volume":"70","author":"Zhou","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.jaut.2015.01.005_bib12","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.4161\/auto.20275","article-title":"Macroautophagy is deregulated in murine and human lupus T lymphocytes","volume":"8","author":"Gros","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.jaut.2015.01.005_bib13","first-page":"173","article-title":"mTOR signaling: a central pathway to pathogenesis in systemic lupus erythematosus?","volume":"9","author":"Fernandez","year":"2010","journal-title":"Discov Med"},{"key":"10.1016\/j.jaut.2015.01.005_bib14","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1096\/fj.11-194175","article-title":"Role of autophagy in immunity and autoimmunity, with a special focus on systemic lupus erythematosus","volume":"26","author":"Pierdominici","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.jaut.2015.01.005_bib15","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1002\/art.22085","article-title":"Rapamycin reduces disease activity and normalizes T cell activation-induced calcium fluxing in patients with systemic lupus erythematosus","volume":"54","author":"Fernandez","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2015.01.005_bib16","doi-asserted-by":"crossref","first-page":"4722","DOI":"10.1096\/fj.12-206060","article-title":"T\u00a0lymphocytes from patients with systemic lupus erythematosus are resistant to induction of autophagy","volume":"26","author":"Alessandri","year":"2012","journal-title":"FASEB J"},{"key":"10.1016\/j.jaut.2015.01.005_bib17","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.4049\/jimmunol.138.6.1750","article-title":"IgG anti-lymphocyte antibodies in systemic lupus erythematosus react with surface molecules shared by peripheral T cells and a primitive T cell line","volume":"138","author":"Minota","year":"1987","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2015.01.005_bib18","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1096\/fj.08-124891","article-title":"Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor","volume":"23","author":"Liao","year":"2009","journal-title":"FASEB J"},{"key":"10.1016\/j.jaut.2015.01.005_bib19","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1002\/art.1780400928","article-title":"Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus","volume":"40","author":"Hochberg","year":"1997","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2015.01.005_bib20","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/art.1780350606","article-title":"Derivation of the SLEDAI disease activity index for lupus patients. The committee on prognosis studies in SLE","volume":"35","author":"Bombardieri","year":"1992","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2015.01.005_bib21","first-page":"581","article-title":"Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee","volume":"23","author":"Preliminary criteria for the classification of systemic sclerosis (scleroderma)","year":"1980","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2015.01.005_bib22","first-page":"1078","article-title":"Criteria for diagnosis of Behcet's disease. International Study Group for Behcet's disease","volume":"335","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2015.01.005_bib23","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1002\/art.33400","article-title":"Autoantibodies to estrogen receptor alpha interfere with T lymphocyte homeostasis and are associated with disease activity in systemic lupus erythematosus","volume":"64","author":"Colasanti","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2015.01.005_bib24","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1002\/art.22802","article-title":"Anti-beta2-glycoprotein I antibodies induce monocyte release of tumor necrosis factor alpha and tissue factor by signal transduction pathways involving lipid rafts","volume":"56","author":"Sorice","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.jaut.2015.01.005_bib25","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1021\/ac950914h","article-title":"Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels","volume":"68","author":"Shevchenko","year":"1996","journal-title":"Anal Chem"},{"key":"10.1016\/j.jaut.2015.01.005_bib26","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1021\/pr3000199","article-title":"Interaction network of the 14-3-3 protein in the ancient protozoan parasite Giardia duodenalis","volume":"11","author":"Lalle","year":"2012","journal-title":"J\u00a0Proteome Res"},{"key":"10.1016\/j.jaut.2015.01.005_bib27","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1021\/ac00104a020","article-title":"Method to correlate tandem mass spectra of modified peptides to amino acid sequences in the protein database","volume":"67","author":"Yates","year":"1995","journal-title":"Anal Chem"},{"key":"10.1016\/j.jaut.2015.01.005_bib28","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1182\/blood-2007-05-092825","article-title":"Autoantibodies to the C-terminal subunit of RLIP76 induce oxidative stress and endothelial cell apoptosis in immune-mediated vascular diseases and atherosclerosis","volume":"111","author":"Margutti","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2015.01.005_bib29","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.4049\/jimmunol.178.6.3932","article-title":"Unravelling the complexity of T cell abnormalities in common variable immunodeficiency","volume":"178","author":"Giovannetti","year":"2007","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.jaut.2015.01.005_bib30","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/sj.cdd.4400616","article-title":"The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly","volume":"7","author":"Matarrese","year":"2000","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.jaut.2015.01.005_bib31","doi-asserted-by":"crossref","first-page":"7568","DOI":"10.1073\/pnas.90.16.7568","article-title":"Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes","volume":"90","author":"Scherle","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaut.2015.01.005_bib32","doi-asserted-by":"crossref","first-page":"50121","DOI":"10.1074\/jbc.M204299200","article-title":"Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways","volume":"277","author":"Groysman","year":"2002","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.jaut.2015.01.005_bib33","doi-asserted-by":"crossref","first-page":"e863","DOI":"10.1038\/cddis.2013.389","article-title":"Constitutive localization of DR4 in lipid rafts is mandatory for TRAIL-induced apoptosis in B-cell hematologic malignancies","volume":"4","author":"Marconi","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.jaut.2015.01.005_bib34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.autrev.2008.07.044","article-title":"Rho GTPase-mediated pathways in mature CD4+ T cells","volume":"8","author":"Pernis","year":"2009","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jaut.2015.01.005_bib35","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1096\/fj.05-4706hyp","article-title":"Is the Rac GTPase-activating toxin CNF1 a smart hijacker of host cell fate?","volume":"20","author":"Malorni","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.jaut.2015.01.005_bib36","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.4161\/auto.21459","article-title":"The actin cytoskeleton participates in the early events of autophagosome formation upon starvation induced autophagy","volume":"8","author":"Aguilera","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.jaut.2015.01.005_bib37","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4161\/auto.19496","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"8","author":"Klionsky","year":"2012","journal-title":"Autophagy"},{"key":"10.1016\/j.jaut.2015.01.005_bib38","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1038\/ncomms3189","article-title":"Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress","volume":"4","author":"Gurkar","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.jaut.2015.01.005_bib39","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0898-6568(98)00063-1","article-title":"Rho guanine dissociation inhibitors: pivotal molecules in cellular signalling","volume":"11","author":"Olofsson","year":"1999","journal-title":"Cell Signal"},{"key":"10.1016\/j.jaut.2015.01.005_bib40","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/nrm3153","article-title":"The \u2018invisible hand\u2019: regulation of RHO GTPases by RHOGDIs","volume":"12","author":"Garcia-Mata","year":"2011","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.jaut.2015.01.005_bib41","doi-asserted-by":"crossref","first-page":"e44879","DOI":"10.1371\/journal.pone.0044879","article-title":"Evaluating caveolin interactions: do proteins interact with the caveolin scaffolding domain through a widespread aromatic residue-rich motif?","volume":"7","author":"Byrne","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2015.01.005_bib42","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1242\/jcs.112.18.3081","article-title":"Ezrin regulates cell-cell and cell-matrix adhesion, a possible role with E-cadherin\/beta-catenin","volume":"112","author":"Hiscox","year":"1999","journal-title":"J\u00a0Cell Sci"},{"issue":"111","key":"10.1016\/j.jaut.2015.01.005_bib43","first-page":"47","article-title":"Long-range and selective autoregulation of cell-cell or cell-matrix adhesions by cadherin or integrin ligands","volume":"1998","author":"Levenberg","year":"1998","journal-title":"J\u00a0Cell Sci"},{"key":"10.1016\/j.jaut.2015.01.005_bib44","doi-asserted-by":"crossref","first-page":"6532","DOI":"10.1073\/pnas.100023397","article-title":"Regulation of the actin cycle in\u00a0vivo by actin filament severing","volume":"97","author":"McGrath","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaut.2015.01.005_bib45","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1615\/CritRevImmunol.v25.i2.30","article-title":"T- and B-cell abnormalities in systemic lupus erythematosus","volume":"25","author":"Nagy","year":"2005","journal-title":"Crit Rev Immunol"},{"key":"10.1016\/j.jaut.2015.01.005_bib46","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/ar3251","article-title":"Abnormalities of T cell signaling in systemic lupus erythematosus","volume":"13","author":"Moulton","year":"2011","journal-title":"Arthritis Res Ther"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841115000062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841115000062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:11:11Z","timestamp":1760256671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841115000062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":46,"alternative-id":["S0896841115000062"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2015.01.005","relation":{},"ISSN":["0896-8411"],"issn-type":[{"type":"print","value":"0896-8411"}],"subject":[],"published":{"date-parts":[[2015,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autoantibodies specific to D4GDI modulate Rho GTPase mediated cytoskeleton remodeling and induce autophagy in T lymphocytes","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2015.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}