{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:16:43Z","timestamp":1781813803697,"version":"3.54.5"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.jaut.2015.06.003","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T15:27:40Z","timestamp":1436023660000},"page":"81-92","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies"],"prefix":"10.1016","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8610-6302","authenticated-orcid":false,"given":"Carin I.M.","family":"Dahlberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda-Liz","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven H.","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa A.P.","family":"Baptista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marton","family":"Keszei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Volpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie K.","family":"Grasset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael C.I.","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolan E.","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott B.","family":"Snapper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi D.","family":"Notarangelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa S.","family":"Westerberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2015.06.003_bib1","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1002\/eji.201040506","article-title":"Functional plasticity and robustness are essential characteristics of biological systems: lessons learned from KLRG1-deficient mice","volume":"40","author":"Jonjic","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jaut.2015.06.003_bib2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0092-8674(00)00078-7","article-title":"Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme","volume":"102","author":"Muramatsu","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2015.06.003_bib3","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.cell.2010.10.032","article-title":"Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter","volume":"143","author":"Victora","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2015.06.003_bib4","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nature13300","article-title":"Clonal selection in the germinal centre by regulated proliferation and hypermutation","volume":"509","author":"Gitlin","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2015.06.003_bib5","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1074-7613(00)80580-4","article-title":"Affinity dependence of the B cell response to antigen: a threshold, a ceiling, and the importance of off-rate","volume":"8","author":"Batista","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2015.06.003_bib6","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ni1100","article-title":"Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5","volume":"5","author":"Allen","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2015.06.003_bib7","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.immuni.2007.04.008","article-title":"Definition of germinal-center B cell migration in\u00a0vivo reveals predominant intrazonal circulation patterns","volume":"26","author":"Hauser","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2015.06.003_bib8","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nri3469","article-title":"How B cells capture, process and present antigens: a crucial role for cell polarity","volume":"13","author":"Yuseff","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2015.06.003_bib9","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/imr.12114","article-title":"Actin cytoskeletal defects in immunodeficiency","volume":"256","author":"Moulding","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jaut.2015.06.003_bib10","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nri2724","article-title":"WASP: a key immunological multitasker","volume":"10","author":"Thrasher","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2015.06.003_bib11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/nyas.12049","article-title":"Wiskott-Aldrich syndrome: a comprehensive review","volume":"1285","author":"Massaad","year":"2013","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.jaut.2015.06.003_bib12","doi-asserted-by":"crossref","first-page":"5326","DOI":"10.1002\/j.1460-2075.1996.tb00917.x","article-title":"N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases","volume":"15","author":"Miki","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.jaut.2015.06.003_bib13","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1038\/ncb1001-897","article-title":"N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility","volume":"3","author":"Snapper","year":"2001","journal-title":"Nat. Cell. Biol."},{"key":"10.1016\/j.jaut.2015.06.003_bib14","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1182\/blood-2010-09-308197","article-title":"Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function","volume":"119","author":"Westerberg","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2015.06.003_bib15","doi-asserted-by":"crossref","first-page":"15424","DOI":"10.1073\/pnas.0706881104","article-title":"Wiskott Aldrich syndrome protein (WASP) and N-WASP are critical for T cell development","volume":"104","author":"Cotta-de-Almeida","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jaut.2015.06.003_bib16","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3389\/fimmu.2012.00209","article-title":"Autoimmunity in Wiskott-Aldrich syndrome: an unsolved enigma","volume":"3","author":"Catucci","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2015.06.003_bib17","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S0022-3476(05)82002-5","article-title":"A\u00a0multiinstitutional survey of the Wiskott-Aldrich syndrome","volume":"125","author":"Sullivan","year":"1994","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.jaut.2015.06.003_bib18","doi-asserted-by":"crossref","first-page":"e622","DOI":"10.1542\/peds.111.5.e622","article-title":"Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients","volume":"111","author":"Dupuis-Girod","year":"2003","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaut.2015.06.003_bib19","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1172\/JCI29539","article-title":"Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis","volume":"117","author":"Humblet-Baron","year":"2007","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.jaut.2015.06.003_bib20","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1084\/jem.20061338","article-title":"The Wiskott-Aldrich syndrome protein is required for the function of CD4(+)CD25(+)Foxp3(+) regulatory T cells","volume":"204","author":"Maillard","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jaut.2015.06.003_bib21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1084\/jem.20061334","article-title":"WASP regulates suppressor activity of human and murine CD4(+)CD25(+)FOXP3(+) natural regulatory T cells","volume":"204","author":"Marangoni","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jaut.2015.06.003_bib22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.clim.2007.02.001","article-title":"Impaired in\u00a0vitro regulatory T cell function associated with Wiskott-Aldrich syndrome","volume":"124","author":"Adriani","year":"2007","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jaut.2015.06.003_bib23","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1084\/jem.20110200","article-title":"WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity","volume":"208","author":"Becker-Herman","year":"2011","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jaut.2015.06.003_bib24","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1182\/blood-2011-09-379412","article-title":"B\u00a0cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice","volume":"119","author":"Recher","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2015.06.003_bib25","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/nri1863","article-title":"Self-tolerance of natural killer cells","volume":"6","author":"Raulet","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2015.06.003_bib26","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jaut.2013.10.006","article-title":"Wiskott-Aldrich syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans","volume":"50","author":"Castiello","year":"2013","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jaut.2015.06.003_bib27","first-page":"340","article-title":"Next generation sequencing reveals skewing of the T and B cell receptor repertoires in patients with wiskott-Aldrich syndrome","volume":"5","author":"O'Connell","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2015.06.003_bib28","doi-asserted-by":"crossref","first-page":"896 e4","DOI":"10.1016\/j.jaci.2013.08.050","article-title":"Molecular and phenotypic abnormalities of B lymphocytes in patients with Wiskott-Aldrich syndrome","volume":"133","author":"Simon","year":"2014","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.jaut.2015.06.003_bib29","doi-asserted-by":"crossref","first-page":"e1001704","DOI":"10.1371\/journal.pbio.1001704","article-title":"N-wasp is essential for the negative regulation of B cell receptor signaling","volume":"11","author":"Liu","year":"2013","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jaut.2015.06.003_bib30","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1084\/jem.20070600","article-title":"Class A scavenger receptors regulate tolerance against apoptotic cells, and autoantibodies against these receptors are predictive of systemic lupus","volume":"204","author":"Wermeling","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jaut.2015.06.003_bib31","first-page":"1362","article-title":"Genetic dissection of SLE pathogenesis. Sle1 on murine chromosome 1 leads to a selective loss of tolerance to H2A\/H2B\/DNA subnucleosomes","volume":"101","author":"Mohan","year":"1998","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.jaut.2015.06.003_bib32","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1182\/blood-2004-03-1003","article-title":"Wiskott-Aldrich syndrome protein deficiency leads to reduced B-cell adhesion, migration, and homing, and a delayed humoral immune response","volume":"105","author":"Westerberg","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2015.06.003_bib33","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1365-2249.2006.03251.x","article-title":"Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes","volume":"147","author":"Li","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jaut.2015.06.003_bib34","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1084\/jem.20080559","article-title":"Repertoire-based selection into the marginal zone compartment during B cell development","volume":"205","author":"Carey","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jaut.2015.06.003_bib35","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1084\/jem.20091927","article-title":"Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in rag-dependent immunodeficiency","volume":"207","author":"Walter","year":"2010","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jaut.2015.06.003_bib36","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/978-1-61779-842-9_32","article-title":"IMGT((R)) tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations: IMGT\/V-QUEST and IMGT\/HighV-QUEST for NGS","volume":"882","author":"Alamyar","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jaut.2015.06.003_bib37","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1084\/jem.20020161","article-title":"The CD8+ dendritic cell subset selectively endocytoses dying cells in culture and in\u00a0vivo","volume":"195","author":"Iyoda","year":"2002","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jaut.2015.06.003_bib38","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1084\/jem.188.12.2313","article-title":"Complement-dependent clearance of apoptotic cells by human macrophages","volume":"188","author":"Mevorach","year":"1998","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jaut.2015.06.003_bib39","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1084\/jem.20122574","article-title":"CXCR4 promotes B cell egress from Peyer's patches","volume":"210","author":"Schmidt","year":"2013","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jaut.2015.06.003_bib40","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/350502a0","article-title":"Molecular characterization of single memory B cells","volume":"350","author":"McHeyzer-Williams","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2015.06.003_bib41","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0092-8674(81)90089-1","article-title":"Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region","volume":"24","author":"Bothwell","year":"1981","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2015.06.003_bib42","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nri1669","article-title":"Structure and function of the spleen","volume":"5","author":"Mebius","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2015.06.003_bib43","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jaut.2007.07.017","article-title":"Innate and adaptive immune response to apoptotic cells","volume":"29","author":"Peng","year":"2007","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jaut.2015.06.003_bib44","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1126\/science.1136736","article-title":"Imaging of germinal center selection events during affinity maturation","volume":"315","author":"Allen","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.jaut.2015.06.003_bib45","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/ni.1820","article-title":"Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production","volume":"10","author":"Randall","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2015.06.003_bib46","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1182\/blood-2008-02-140814","article-title":"Wiskott-Aldrich syndrome protein deficiency in B cells results in impaired peripheral homeostasis","volume":"112","author":"Meyer-Bahlburg","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2015.06.003_bib47","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1182\/blood-2008-02-140715","article-title":"WASP confers selective advantage for specific hematopoietic cell populations and serves a unique role in marginal zone B-cell homeostasis and function","volume":"112","author":"Westerberg","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2015.06.003_bib48","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/88756","article-title":"Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling","volume":"2","author":"Tedford","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2015.06.003_bib49","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/88748","article-title":"Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation","volume":"2","author":"Doody","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2015.06.003_bib50","article-title":"Lentiviral-mediated gene therapy leads to improvement of B-cell functionality in a murine model of Wiskott-Aldrich syndrome","volume":"127","author":"Bosticardo","year":"2011","journal-title":"J.\u00a0Allergy Clin. Immun."},{"key":"10.1016\/j.jaut.2015.06.003_bib51","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1126\/science.1086907","article-title":"Predominant autoantibody production by early human B cell precursors","volume":"301","author":"Wardemann","year":"2003","journal-title":"Science"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841115000852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841115000852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:11:28Z","timestamp":1760256688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841115000852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":51,"alternative-id":["S0896841115000852"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2015.06.003","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2015.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}