{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T23:17:54Z","timestamp":1780442274066,"version":"3.54.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jaut.2015.10.005","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T08:34:54Z","timestamp":1446626094000},"page":"89-97","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["AAV-IL-22 modifies liver chemokine activity and ameliorates portal inflammation in murine autoimmune cholangitis"],"prefix":"10.1016","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9775-1876","authenticated-orcid":false,"given":"Yu-Hsin","family":"Hsueh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Ning","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5925-1547","authenticated-orcid":false,"given":"Chia-En","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Eric","family":"Gershwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Hui","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2015.10.005_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-immunol-031210-101312","article-title":"Regulation and functions of the IL-10 family of cytokines in inflammation and disease","volume":"29","author":"Ouyang","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jaut.2015.10.005_bib2","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1146\/annurev-immunol-032414-112123","article-title":"Interleukin-22: immunobiology and pathology","volume":"33","author":"Dudakov","year":"2015","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jaut.2015.10.005_bib3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.immuni.2004.07.007","article-title":"IL-22 increases the innate immunity of tissues","volume":"21","author":"Wolk","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2015.10.005_bib4","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/hep.20184","article-title":"Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation","volume":"39","author":"Radaeva","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2015.10.005_bib5","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.immuni.2007.07.023","article-title":"Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation","volume":"27","author":"Zenewicz","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2015.10.005_bib6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/hep.24339","article-title":"In\u00a0vivo consequences of liver-specific interleukin-22 expression in mice: implications for human liver disease progression","volume":"54","author":"Park","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2015.10.005_bib7","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/hep.23837","article-title":"Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3","volume":"52","author":"Ki","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2015.10.005_bib8","doi-asserted-by":"crossref","first-page":"7891","DOI":"10.4049\/jimmunol.181.11.7891","article-title":"Protective immunity to systemic infection with attenuated Salmonella enterica serovar enteritidis in the absence of IL-12 is associated with IL-23-dependent IL-22, but not IL-17","volume":"181","author":"Schulz","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2015.10.005_bib9","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1097\/TP.0b013e3182449136","article-title":"Interleukin-22: implications for liver ischemia-reperfusion injury","volume":"93","author":"Chestovich","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.jaut.2015.10.005_bib10","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/hep.25744","article-title":"Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice","volume":"56","author":"Kong","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2015.10.005_bib11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10238-011-0134-9","article-title":"Expressions of IL-22 in circulating CD4+\/CD8+ T cells and their correlation with disease activity in SLE patients","volume":"11","author":"Qin","year":"2011","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.jaut.2015.10.005_bib12","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/art.20965","article-title":"Expression of interleukin-22 in rheumatoid arthritis: potential role as a proinflammatory cytokine","volume":"52","author":"Ikeuchi","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2015.10.005_bib13","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/art.24220","article-title":"Proinflammatory role of the Th17 cytokine interleukin-22 in collagen-induced arthritis in C57BL\/6 mice","volume":"60","author":"Geboes","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2015.10.005_bib14","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-3083.2011.02583.x","article-title":"Expression of interleukin-22 in Sjogren's syndrome: significant correlation with disease parameters","volume":"74","author":"Lavoie","year":"2011","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.jaut.2015.10.005_bib15","first-page":"597","article-title":"IL-22 is required for Th17 cell-mediated pathology in a mouse model of psoriasis-like skin inflammation","volume":"118","author":"Ma","year":"2008","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jaut.2015.10.005_bib16","doi-asserted-by":"crossref","first-page":"462","DOI":"10.4049\/jimmunol.1102224","article-title":"IL-22 is required for imiquimod-induced psoriasiform skin inflammation in mice","volume":"188","author":"Van Belle","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2015.10.005_bib17","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.4049\/jimmunol.1100482","article-title":"IL-22-induced regulatory CD11b+ APCs suppress experimental autoimmune uveitis","volume":"187","author":"Ke","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2015.10.005_bib18","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.4049\/jimmunol.177.6.3635","article-title":"Hydrodynamic-based delivery of an interleukin-22-Ig fusion gene ameliorates experimental autoimmune myocarditis in rats","volume":"177","author":"Chang","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2015.10.005_bib19","doi-asserted-by":"crossref","first-page":"e93279","DOI":"10.1371\/journal.pone.0093279","article-title":"Endogenous IL-22 plays a dual role in arthritis: regulation of established arthritis via IFN-gamma responses","volume":"9","author":"Justa","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2015.10.005_bib20","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1002\/art.37849","article-title":"Interleukin-22 reduces the severity of collagen-induced arthritis in association with increased levels of interleukin-10","volume":"65","author":"Sarkar","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2015.10.005_bib21","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/hep.24113","article-title":"Innate immunity and primary biliary cirrhosis: activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosis","volume":"53","author":"Wu","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2015.10.005_bib22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/cei.12298","article-title":"Innate immunity drives xenobiotic-induced murine autoimmune cholangitis","volume":"177","author":"Chang","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jaut.2015.10.005_bib23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1182\/blood-2013-01-306647","article-title":"Immune responses to AAV vectors: overcoming barriers to successful gene therapy","volume":"122","author":"Mingozzi","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2015.10.005_bib24","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1128\/JVI.00254-08","article-title":"In\u00a0vitro and in\u00a0vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses","volume":"82","author":"Grimm","year":"2008","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.jaut.2015.10.005_bib25","doi-asserted-by":"crossref","first-page":"e0121320","DOI":"10.1371\/journal.pone.0121320","article-title":"Innate immunity drives the initiation of a murine model of primary biliary cirrhosis","volume":"10","author":"Chang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2015.10.005_bib26","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.4049\/jimmunol.138.10.3525","article-title":"Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis","volume":"138","author":"Gershwin","year":"1987","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2015.10.005_bib27","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s12016-015-8482-y","article-title":"Animal models of primary biliary cirrhosis","volume":"48","author":"Katsumi","year":"2015","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2015.10.005_bib28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jaut.2015.01.011","article-title":"Systems biologic analysis of T regulatory cells genetic pathways in murine primary biliary cirrhosis","volume":"59","author":"Wang","year":"2015","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jaut.2015.10.005_bib29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jaut.2015.08.016","article-title":"Using GWAS to identify genetic predisposition in hepatic autoimmunity","volume":"66","author":"Webb","year":"2016","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jaut.2015.10.005_bib30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jaut.2015.07.004","article-title":"The immunogenetics of primary biliary cirrhosis: a comprehensive review","volume":"64","author":"Webb","year":"2015","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jaut.2015.10.005_bib31","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/hep.22042","article-title":"The causes of primary biliary cirrhosis: convenient and inconvenient truths","volume":"47","author":"Gershwin","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2015.10.005_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellimm.2006.04.006","article-title":"New insights to the immunopathology and autoimmune responses in primary biliary cirrhosis","volume":"239","author":"He","year":"2006","journal-title":"Cell Immunol."},{"key":"10.1016\/j.jaut.2015.10.005_bib33","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.cld.2008.02.008","article-title":"Treatment of primary biliary cirrhosis: therapy with choleretic and immunosuppressive agents","volume":"12","author":"Silveira","year":"2008","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.jaut.2015.10.005_bib34","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1053\/j.gastro.2010.09.004","article-title":"Pathogenesis of cholestatic liver disease and therapeutic approaches","volume":"139","author":"Hirschfield","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2015.10.005_bib35","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jaut.2013.06.014","article-title":"Clinical management of autoimmune biliary diseases","volume":"46","author":"Imam","year":"2013","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jaut.2015.10.005_bib36","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s12016-014-8456-5","article-title":"New therapies for primary biliary cirrhosis","volume":"48","author":"Floreani","year":"2015","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2015.10.005_bib37","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1002\/hep.27313","article-title":"Ongoing activation of autoantigen-specific B cells in primary biliary cirrhosis","volume":"60","author":"Zhang","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2015.10.005_bib38","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/hep.27306","article-title":"CXCR5+ CD4+ T follicular helper cells participate in the pathogenesis of primary biliary cirrhosis","volume":"61","author":"Wang","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2015.10.005_bib39","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/hep.27725","article-title":"Chemokine (C-X-C motif) ligand 13 promotes intrahepatic chemokine (C-X-C motif) receptor 5+ lymphocyte homing and aberrant B-cell immune responses in primary biliary cirrhosis","volume":"61","author":"Li","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2015.10.005_bib40","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.immuni.2009.04.010","article-title":"Mechanisms of foxp3+ T regulatory cell-mediated suppression","volume":"30","author":"Shevach","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2015.10.005_bib41","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nri2138","article-title":"Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans","volume":"7","author":"Roncarolo","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2015.10.005_bib42","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000282062","article-title":"The role of chemokines in the recruitment of lymphocytes to the liver","volume":"28","author":"Oo","year":"2010","journal-title":"Dig. Dis."},{"key":"10.1016\/j.jaut.2015.10.005_bib43","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1172\/JCI6642","article-title":"Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease","volume":"104","author":"Murai","year":"1999","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jaut.2015.10.005_bib44","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0002-9440(10)62060-3","article-title":"CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow","volume":"167","author":"Curbishley","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jaut.2015.10.005_bib45","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.4049\/jimmunol.174.2.1055","article-title":"CXC chemokine ligand 16 promotes integrin-mediated adhesion of liver-infiltrating lymphocytes to cholangiocytes and hepatocytes within the inflamed human liver","volume":"174","author":"Heydtmann","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2015.10.005_bib46","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/hep.20582","article-title":"Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts","volume":"41","author":"Isse","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2015.10.005_bib47","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jaut.2005.08.009","article-title":"Increased levels of chemokine receptor CXCR3 and chemokines IP-10 and MIG in patients with primary biliary cirrhosis and their first degree relatives","volume":"25","author":"Chuang","year":"2005","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jaut.2015.10.005_bib48","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s10620-013-2920-6","article-title":"Chemokine-chemokine receptor CCL2-CCR2 and CX3CL1-CX3CR1 axis may play a role in the aggravated inflammation in primary biliary cirrhosis","volume":"59","author":"Sasaki","year":"2014","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.jaut.2015.10.005_bib49","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1002\/hep.26916","article-title":"Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment","volume":"59","author":"Zhao","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2015.10.005_bib50","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1053\/j.gastro.2011.06.051","article-title":"A\u00a0proinflammatory role for interleukin-22 in the immune response to hepatitis B virus","volume":"141","author":"Zhang","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2015.10.005_bib51","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2012.03.044","article-title":"Interleukin-22 promotes proliferation of liver stem\/progenitor cells in mice and patients with chronic hepatitis B virus infection","volume":"143","author":"Feng","year":"2012","journal-title":"Gastroenterology"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841115300500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841115300500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:12:22Z","timestamp":1760256742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841115300500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":51,"alternative-id":["S0896841115300500"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2015.10.005","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AAV-IL-22 modifies liver chemokine activity and ameliorates portal inflammation in murine autoimmune cholangitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2015.10.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}