{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:27:27Z","timestamp":1790184447301,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100013105","name":"Shanghai Rising-Star Program","doi-asserted-by":"publisher","award":["14QA1404600"],"award-info":[{"award-number":["14QA1404600"]}],"id":[{"id":"10.13039\/501100013105","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2013CB530502"],"award-info":[{"award-number":["2013CB530502"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81422021"],"award-info":[{"award-number":["81422021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31270924"],"award-info":[{"award-number":["31270924"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31390431"],"award-info":[{"award-number":["31390431"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31270943"],"award-info":[{"award-number":["31270943"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81123006"],"award-info":[{"award-number":["81123006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.jaut.2016.05.012","type":"journal-article","created":{"date-parts":[[2016,6,5]],"date-time":"2016-06-05T15:45:01Z","timestamp":1465141501000},"page":"42-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Rb selectively inhibits innate IFN-\u03b2 production by enhancing deacetylation of IFN-\u03b2 promoter through HDAC1 and HDAC8"],"prefix":"10.1016","volume":"73","author":[{"given":"Jun","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingguang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanwan","family":"Huai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanxing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuetao","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2016.05.012_bib1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.ccr.2013.03.022","article-title":"Mutant p53 prolongs NF-kappaB activation and promotes chronic inflammation and inflammation-associated colorectal cancer","volume":"23","author":"Cooks","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.jaut.2016.05.012_bib2","first-page":"2","article-title":"Modulation of immune responses by the tumor suppressor p53","volume":"8","author":"Lowe","year":"2013","journal-title":"Biodiscovery"},{"key":"10.1016\/j.jaut.2016.05.012_bib3","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nri3446","article-title":"The history of Toll-like receptors - redefining innate immunity","volume":"13","author":"O\u2019Neill","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2016.05.012_bib4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2016.05.012_bib5","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1146\/annurev-immunol-031210-101340","article-title":"Nucleic acid recognition by the innate immune system","volume":"29","author":"Barbalat","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jaut.2016.05.012_bib6","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nri1900","article-title":"IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors","volume":"6","author":"Honda","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2016.05.012_bib7","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.immuni.2013.05.007","article-title":"Cytosolic sensing of viruses","volume":"38","author":"Goubau","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2016.05.012_bib8","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2016.05.012_bib9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nri.2015.8","article-title":"Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease","volume":"16","author":"Cao","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2016.05.012_bib10","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1146\/annurev-immunol-032713-120156","article-title":"Innate immune sensing and signaling of cytosolic nucleic acids","volume":"32","author":"Wu","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jaut.2016.05.012_bib11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.cell.2013.01.011","article-title":"Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation","volume":"152","author":"Chen","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2016.05.012_bib12","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/nature05732","article-title":"TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity","volume":"446","author":"Gack","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2016.05.012_bib13","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.cell.2010.01.037","article-title":"Selective transcription in response to an inflammatory stimulus","volume":"140","author":"Smale","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2016.05.012_bib14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/ni.1876","article-title":"The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway","volume":"11","author":"Yang","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2016.05.012_bib15","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/ni.1897","article-title":"The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3","volume":"11","author":"Kim","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2016.05.012_bib16","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nrm3567","article-title":"Molecular mechanisms underlying RB protein function","volume":"14","author":"Dick","year":"2013","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.jaut.2016.05.012_bib17","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1084\/jem.20121716","article-title":"Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression","volume":"210","author":"Garfin","year":"2013","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jaut.2016.05.012_bib18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jcp.24137","article-title":"Understanding the targeting of the RB family proteins by viral oncoproteins to defeat their oncogenic machinery","volume":"228","author":"Bellacchio","year":"2013","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.jaut.2016.05.012_bib19","doi-asserted-by":"crossref","first-page":"12319","DOI":"10.1128\/JVI.75.24.12319-12330.2001","article-title":"Altered cellular mRNA levels in human cytomegalovirus-infected fibroblasts: viral block to the accumulation of antiviral mRNAs","volume":"75","author":"Browne","year":"2001","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.jaut.2016.05.012_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003664","article-title":"HIV-1 activates macrophages independent of Toll-like receptors","volume":"3","author":"Brown","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2016.05.012_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005210","article-title":"Phagocytosis of Staphylococcus aureus by macrophages exerts cytoprotective effects manifested by the upregulation of antiapoptotic factors","volume":"4","author":"Koziel","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2016.05.012_bib22","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/ni1576","article-title":"TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes","volume":"9","author":"Yarilina","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2016.05.012_bib23","doi-asserted-by":"crossref","first-page":"2793","DOI":"10.4049\/jimmunol.0900695","article-title":"Interactions between innate antiviral and atopic immunoinflammatory pathways precipitate and sustain asthma exacerbations in children","volume":"183","author":"Subrata","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2016.05.012_bib24","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1084\/jem.20101974","article-title":"Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice","volume":"209","author":"Han","year":"2012","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jaut.2016.05.012_bib25","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/ni.2015","article-title":"Intracellular MHC class II molecules promote TLR-triggered innate immune responses by maintaining activation of the kinase Btk","volume":"12","author":"Liu","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2016.05.012_bib26","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/ni.3132","article-title":"Senataxin suppresses the antiviral transcriptional response and controls viral biogenesis","volume":"16","author":"Miller","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2016.05.012_bib27","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1096\/fj.05-4530fje","article-title":"Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice","volume":"20","author":"Boesten","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.jaut.2016.05.012_bib28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"Clausen","year":"1999","journal-title":"Transgenic. Res."},{"key":"10.1016\/j.jaut.2016.05.012_bib29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nri3845","article-title":"Type I interferons in anticancer immunity","volume":"15","author":"Zitvogel","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2016.05.012_bib30","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.immuni.2006.08.009","article-title":"Type I interferon gene induction by the interferon regulatory factor family of transcription factors","volume":"25","author":"Honda","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2016.05.012_bib31","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd4360","article-title":"Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders","volume":"13","author":"Falkenberg","year":"2014","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.jaut.2016.05.012_bib32","doi-asserted-by":"crossref","first-page":"22154","DOI":"10.1074\/jbc.272.35.22154","article-title":"Synergism between multiple virus-induced factor-binding elements involved in the differential expression of interferon A genes","volume":"272","author":"Braganca","year":"1997","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jaut.2016.05.012_bib33","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/jcb.20352","article-title":"Transcriptional enhancers: intelligent enhanceosomes or flexible billboards?","volume":"94","author":"Arnosti","year":"2005","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.jaut.2016.05.012_bib34","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.cell.2007.05.019","article-title":"An atomic model of the interferon-beta enhanceosome","volume":"129","author":"Panne","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2016.05.012_bib35","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.it.2011.04.001","article-title":"Histone deacetylases as regulators of inflammation and immunity","volume":"32","author":"Shakespear","year":"2011","journal-title":"Trends. Immunol."},{"key":"10.1016\/j.jaut.2016.05.012_bib36","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1002\/hep.27217","article-title":"Retinoblastoma protein potentiates the innate immune response in hepatocytes: significance for hepatocellular carcinoma","volume":"60","author":"Hutcheson","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2016.05.012_bib37","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.2337\/diabetes.54.5.1423","article-title":"Tumor suppressor p53 inhibits autoimmune inflammation and macrophage function","volume":"54","author":"Zheng","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2016.05.012_bib38","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri3581","article-title":"Regulation of type I interferon responses","volume":"14","author":"Ivashkiv","year":"2014","journal-title":"Nat. Rev. Immunol."}],"updated-by":[{"DOI":"10.1016\/j.jaut.2019.102380","type":"correction","label":"Correction","source":"retraction-watch","updated":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"record-id":"29299"},{"DOI":"10.1016\/j.jaut.2019.102380","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000}}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841116300737?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841116300737?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:14:02Z","timestamp":1760256842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841116300737"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":38,"alternative-id":["S0896841116300737"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2016.05.012","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rb selectively inhibits innate IFN-\u03b2 production by enhancing deacetylation of IFN-\u03b2 promoter through HDAC1 and HDAC8","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2016.05.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}