{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:16:15Z","timestamp":1791994575242,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI07924"],"award-info":[{"award-number":["AI07924"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["AI40768"],"award-info":[{"award-number":["AI40768"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.jaut.2016.06.019","type":"journal-article","created":{"date-parts":[[2016,7,2]],"date-time":"2016-07-02T22:31:15Z","timestamp":1467498675000},"page":"111-119","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"special_numbering":"C","title":["IgG4 autoantibodies are inhibitory in the autoimmune disease bullous pemphigoid"],"prefix":"10.1016","volume":"73","author":[{"given":"Yagang","family":"Zuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flor","family":"Evangelista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Culton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Guilabert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2016.06.019_bib1","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1182\/blood.V75.6.1211.1211","article-title":"Neutrophil Fc-gamma receptors: a two-way bridge in the immune system","volume":"75","author":"Huizinga","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2016.06.019_bib2","first-page":"57","article-title":"Effector mechanisms activated by human IgG subclass antibodies: clinical and molecular aspects. Review article","volume":"52","author":"Jefferis","year":"1994","journal-title":"Ann. Biol. Clin. Paris"},{"key":"10.1016\/j.jaut.2016.06.019_bib3","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1097\/BOR.0b013e3283412fd4","article-title":"What is IgG4? A review of the biology of a unique immunoglobulin subtype","volume":"23","author":"Nirula","year":"2011","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jaut.2016.06.019_bib4","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.0019-2805.2001.01341.x","article-title":"IgG4 breaking the rules","volume":"105","author":"Aalberse","year":"2002","journal-title":"Immunology"},{"key":"10.1016\/j.jaut.2016.06.019_bib5","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.4049\/jimmunol.1003336","article-title":"Species-specific determinants in the IgG CH3 domain enable Fab-arm exchange by affecting the noncovalent CH3-CH3 interaction strength","volume":"187","author":"Labrijn","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2016.06.019_bib6","doi-asserted-by":"crossref","first-page":"10302","DOI":"10.1021\/ja203638y","article-title":"Mechanism of immunoglobulin G4 Fab-arm exchange","volume":"133","author":"Rispens","year":"2011","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.jaut.2016.06.019_bib7","first-page":"108","article-title":"Development of serum IgG subclass levels in children","volume":"19","author":"Lee","year":"1986","journal-title":"Monogr. Allergy"},{"key":"10.1016\/j.jaut.2016.06.019_bib8","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.4049\/jimmunol.172.5.3252","article-title":"Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity","volume":"172","author":"Nouri-Aria","year":"2004","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2016.06.019_bib9","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40413-015-0063-2","article-title":"Mechanisms of allergen-specific immunotherapy and immune tolerance to allergens","volume":"8","author":"Akdis","year":"2015","journal-title":"World Allergy Organ J."},{"key":"10.1016\/j.jaut.2016.06.019_bib10","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1111\/all.12236","article-title":"Kinetics, cross-reactivity, and specificity of Bet v 1-specific IgG4 antibodies induced by immunotherapy with birch pollen","volume":"68","author":"Subbarayal","year":"2013","journal-title":"Allergy"},{"key":"10.1016\/j.jaut.2016.06.019_bib11","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1056\/NEJM198906013202206","article-title":"The pathogenic effect of IgG4 autoantibodies in endemic pemphigus foliaceus (fogo selvagem)","volume":"320","author":"Rock","year":"1989","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jaut.2016.06.019_bib12","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1046\/j.1523-1747.2003.12017.x","article-title":"The role of subclass switching in the pathogenesis of endemic pemphigus foliaceus","volume":"120","author":"Warren","year":"2003","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.jaut.2016.06.019_bib13","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1111\/j.1538-7836.2009.03568.x","article-title":"IgG subclass distribution of anti-ADAMTS13 antibodies in patients with acquired thrombotic thrombocytopenic purpura","volume":"7","author":"Ferrari","year":"2009","journal-title":"J.\u00a0Thromb. Haemost."},{"key":"10.1016\/j.jaut.2016.06.019_bib14","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/ckj\/sfu077","article-title":"Membranous nephropathy with monoclonal IgG4 deposits and associated IgG4-related lung disease","volume":"7","author":"Omokawa","year":"2014","journal-title":"Clin. Kidney J."},{"key":"10.1016\/j.jaut.2016.06.019_bib15","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/acr.20484","article-title":"Thrombotic thrombocytopenic purpura in IgG4-related disease with severe deficiency of ADAMTS-13 activity and IgG4 autoantibody against ADAMTS-13","volume":"63","author":"Saeki","year":"2011","journal-title":"Arthritis Care Res. Hob."},{"key":"10.1016\/j.jaut.2016.06.019_bib16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1053\/j.semdp.2012.08.002","article-title":"IgG4-related disease: nomenclature, clinical features, and treatment","volume":"29","author":"Stone","year":"2012","journal-title":"Semin. Diagn. Pathol."},{"key":"10.1016\/j.jaut.2016.06.019_bib17","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1002\/art.34593","article-title":"Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations","volume":"64","author":"Stone","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2016.06.019_bib18","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1056\/NEJMra1104650","article-title":"IgG4-related disease","volume":"366","author":"Stone","year":"2012","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.jaut.2016.06.019_bib19","first-page":"642","article-title":"Immunoglobulin G4 and related diseases","volume":"14","author":"Sthoeger","year":"2012","journal-title":"Isr. Med. Assoc. J."},{"key":"10.1016\/j.jaut.2016.06.019_bib20","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.mayocp.2015.03.020","article-title":"Diagnostic approach to the complexity of IgG4-related disease","volume":"90","author":"Stone","year":"2015","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.jaut.2016.06.019_bib21","series-title":"Pemphigus and Pemphigoid","author":"Lever","year":"1965"},{"key":"10.1016\/j.jaut.2016.06.019_bib22","first-page":"733","article-title":"The complement system in bullous pemphigoid. III. Fixation of C1q and C4 by pemphigoid antibody","volume":"86","author":"Jordon","year":"1975","journal-title":"J.\u00a0Lab. Clin. Med."},{"key":"10.1016\/j.jaut.2016.06.019_bib23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0090-1229(75)90017-3","article-title":"The complement system in bullous pemphigoid. II. Immunofluorescent evidence for both classical and alternate-pathway activation","volume":"3","author":"Jordon","year":"1975","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.jaut.2016.06.019_bib24","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1172\/JCI114812","article-title":"Isolation of a human epidermal cDNA corresponding to the 180-kD autoantigen recognized by bullous pemphigoid and herpes gestationis sera. Immunolocalization of this protein to the hemidesmosome","volume":"86","author":"Diaz","year":"1990","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jaut.2016.06.019_bib25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/1523-1747.ep12616580","article-title":"Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180","volume":"99","author":"Giudice","year":"1992","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.jaut.2016.06.019_bib26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1093\/oxfordjournals.jbchem.a124072","article-title":"HD4, a 180 kDa bullous pemphigoid antigen, is a major transmembrane glycoprotein of the hemidesmosome","volume":"113","author":"Nishizawa","year":"1993","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.jaut.2016.06.019_bib27","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.4049\/jimmunol.151.10.5742","article-title":"Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain","volume":"151","author":"Giudice","year":"1993","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2016.06.019_bib28","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/1523-1747.ep12337492","article-title":"Tight clustering of extracellular BP180 epitopes recognized by bullous pemphigoid autoantibodies","volume":"109","author":"Zillikens","year":"1997","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.jaut.2016.06.019_bib29","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1172\/JCI116856","article-title":"A\u00a0passive transfer model of the organ-specific autoimmune disease, bullous pemphigoid, using antibodies generated against the hemidesmosomal antigen, BP180","volume":"92","author":"Liu","year":"1993","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jaut.2016.06.019_bib30","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jaut.2008.08.009","article-title":"Subepidermal blistering induced by human autoantibodies to BP180 requires innate immune players in a humanized bullous pemphigoid mouse model","volume":"31","author":"Liu","year":"2008","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jaut.2016.06.019_bib31","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nm1496","article-title":"Humanization of autoantigen","volume":"13","author":"Nishie","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.jaut.2016.06.019_bib32","first-page":"577","article-title":"IgG4 and IgE are the major immunoglobulins targeting the NC16A domain of BP180 in Bullous pemphigoid: serum levels of these immunoglobulins reflect disease activity","volume":"42","author":"Dopp","year":"2000","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.jaut.2016.06.019_bib33","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1046\/j.1523-1747.2002.19529.x","article-title":"Severity and phenotype of bullous pemphigoid relate to autoantibody profile against the NH2- and COOH-terminal regions of the BP180 ectodomain","volume":"119","author":"Hofmann","year":"2002","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.jaut.2016.06.019_bib34","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1177\/014860719101500160","article-title":"Nonenzymatic glycosylation of immunoglobulin G impairs complement fixation","volume":"15","author":"Hennessey","year":"1991","journal-title":"JPEN J. Parenter. Enter. Nutr."},{"key":"10.1016\/j.jaut.2016.06.019_bib35","series-title":"Current Protocols in Immunology","first-page":"1","article-title":"Complement","author":"Giclas","year":"1994"},{"key":"10.1016\/j.jaut.2016.06.019_bib36","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0092-8674(00)00087-8","article-title":"The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B\/MMP-9 in\u00a0vivo","volume":"102","author":"Liu","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2016.06.019_bib37","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/1523-1747.ep12506462","article-title":"Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker","volume":"78","author":"Bradley","year":"1982","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.jaut.2016.06.019_bib38","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1172\/JCI119639","article-title":"A\u00a0major role for neutrophils in experimental bullous pemphigoid","volume":"100","author":"Liu","year":"1997","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jaut.2016.06.019_bib39","doi-asserted-by":"crossref","first-page":"15003","DOI":"10.1074\/jbc.M111.221036","article-title":"The C5a receptor on mast cells is critical for the autoimmune skin-blistering disease bullous pemphigoid","volume":"286","author":"Heimbach","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.jaut.2016.06.019_bib40","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.4049\/jimmunol.177.5.3398","article-title":"Role of FcRs in animal model of autoimmune bullous pemphigoid","volume":"177","author":"Zhao","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2016.06.019_bib41","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.4049\/jimmunol.1003402","article-title":"Antibodies to pathogenic epitopes on type XVII collagen cause skin fragility in a complement-dependent and -independent manner","volume":"188","author":"Natsuga","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2016.06.019_bib42","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.4049\/jimmunol.1400095","article-title":"Bullous pemphigoid autoantibodies directly induce blister formation without complement activation","volume":"193","author":"Ujiie","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2016.06.019_bib43","doi-asserted-by":"crossref","DOI":"10.1111\/bjd.14411","article-title":"Bullous pemphigoid suggestive of complement-independent blister formation with anti-BP180 IgG4 autoantibodies","author":"Dainichi","year":"2016","journal-title":"Br. J. Dermatol"},{"key":"10.1016\/j.jaut.2016.06.019_bib44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/1523-1747.ep12283737","article-title":"Subclass distribution of IgG autoantibodies in bullous pemphigoid","volume":"86","author":"Bird","year":"1986","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.jaut.2016.06.019_bib45","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/jcla.1860030509","article-title":"Comparison of IgG subclasses and complement binding activity of autoantibodies from patients with bullous pemphigoid and pemphigus","volume":"3","author":"Brooks","year":"1989","journal-title":"J.\u00a0Clin. Lab. Anal."},{"key":"10.1016\/j.jaut.2016.06.019_bib46","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1182\/blood-2008-09-179754","article-title":"Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses","volume":"113","author":"Bruhns","year":"2009","journal-title":"Blood"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089684111630097X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089684111630097X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:13:47Z","timestamp":1760256827000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089684111630097X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":46,"alternative-id":["S089684111630097X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2016.06.019","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IgG4 autoantibodies are inhibitory in the autoimmune disease bullous pemphigoid","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2016.06.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}