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Immunopharm."},{"key":"10.1016\/j.jaut.2017.12.006_bib73","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nm.3085","article-title":"Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis","volume":"19","author":"Nie","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.jaut.2017.12.006_bib74","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1084\/jem.20061531","article-title":"Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta","volume":"204","author":"Nadkarni","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jaut.2017.12.006_bib75","doi-asserted-by":"crossref","first-page":"R115","DOI":"10.1186\/ar4567","article-title":"Type 1 regulatory T cells specific for collagen type II as an efficient cell-based therapy in arthritis","volume":"16","author":"Asnagli","year":"2014","journal-title":"Arthritis Res. 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Med."},{"key":"10.1016\/j.jaut.2017.12.006_bib86","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1002\/art.24329","article-title":"GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis","volume":"60","author":"van Hamburg","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2017.12.006_bib87","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/nm1585","article-title":"Th17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27\/STAT1","volume":"13","author":"Amadi-Obi","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.jaut.2017.12.006_bib88","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.immuni.2007.02.009","article-title":"Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation","volume":"26","author":"Laurence","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2017.12.006_bib89","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1074\/jbc.M207577200","article-title":"Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17","volume":"278","author":"Aggarwal","year":"2003","journal-title":"J.\u00a0Biol. 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Dis."},{"key":"10.1016\/j.jaut.2017.12.006_bib107","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1126\/science.1135245","article-title":"A\u00a0genome-wide association study identifies IL23R as an inflammatory bowel disease gene","volume":"314","author":"Duerr","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jaut.2017.12.006_bib108","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057553","article-title":"IL-23 dependent and independent stages of experimental arthritis: no clinical effect of therapeutic IL-23p19 inhibition in collagen-induced arthritis","volume":"8","author":"Cornelissen","year":"2013","journal-title":"PLos One"},{"key":"10.1016\/j.jaut.2017.12.006_bib109","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1136\/annrheumdis-2016-209831","article-title":"A\u00a0randomised phase II study evaluating the efficacy and safety of subcutaneously administered ustekinumab and guselkumab in patients with active rheumatoid arthritis despite treatment with methotrexate","volume":"76","author":"Smolen","year":"2017","journal-title":"Ann. 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Immunol."},{"key":"10.1016\/j.jaut.2017.12.006_bib118","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jaut.2016.11.003","article-title":"Interleukin-7 and -15 maintain pathogenic memory Th17 cells in autoimmunity","volume":"77","author":"Chen","year":"2017","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jaut.2017.12.006_bib119","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1084\/jem.20102516","article-title":"Cytokine signals through PI-3 kinase pathway modulate Th17 cytokine production by CCR6+ human memory T cells","volume":"208","author":"Wan","year":"2011","journal-title":"J.\u00a0Exp. 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