{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T19:40:04Z","timestamp":1789501204698,"version":"build-2803163510"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81325002"],"award-info":[{"award-number":["81325002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81620108002"],"award-info":[{"award-number":["81620108002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK39588"],"award-info":[{"award-number":["DK39588"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.jaut.2018.01.007","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T02:52:44Z","timestamp":1519181564000},"page":"64-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"special_numbering":"C","title":["The immunobiology of mucosal-associated invariant T cell (MAIT) function in primary biliary cholangitis: Regulation by cholic acid-induced Interleukin-7"],"prefix":"10.1016","volume":"90","author":[{"given":"Xiang","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weici","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qixia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiran","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaolian","family":"Bian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dekai","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0409-2777","authenticated-orcid":false,"given":"Jingyuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aftab A.","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S.C.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross L.","family":"Coppel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruqi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Eric","family":"Gershwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2018.01.007_bib1","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1002\/hep.22226","article-title":"Adoptive transfer of CD8(+) T cells from transforming growth factor beta receptor type II (dominant negative form) induces autoimmune cholangitis in mice","volume":"47","author":"Yang","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.01.007_bib2","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.jhep.2015.06.031","article-title":"Changing nomenclature for PBC: from 'cirrhosis' to 'cholangitis'","volume":"63","author":"Beuers","year":"2015","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.jaut.2018.01.007_bib3","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/hep.29059","article-title":"The fingerprint of antimitochondrial antibodies and the etiology of primary biliary cholangitis","volume":"65","author":"Shuai","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.01.007_bib4","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.autrev.2014.01.041","article-title":"The diagnosis of primary biliary cirrhosis","volume":"13","author":"Bowlus","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jaut.2018.01.007_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jaut.2016.12.012","article-title":"Chemokine receptor CXCR3 deficiency exacerbates murine autoimmune cholangitis by promoting pathogenic CD8+ T cell activation","volume":"78","author":"Ma","year":"2017","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jaut.2018.01.007_bib6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jaut.2017.07.003","article-title":"Development of autoantibodies precedes clinical manifestations of autoimmune diseases: a comprehensive review","volume":"83","author":"Ma","year":"2017","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jaut.2018.01.007_bib7","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/hep4.1044","article-title":"Toward solving the etiological mystery of primary biliary cholangitis","volume":"1","author":"Tanakaa","year":"2017","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.jaut.2018.01.007_bib8","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1586\/14737159.2016.1164038","article-title":"A\u00a0contemporary perspective on the molecular characteristics of mitochondrial autoantigens and diagnosis in primary biliary cholangitis","volume":"16","author":"Leung","year":"2016","journal-title":"Expert. Rev. Mol. Diagn."},{"key":"10.1016\/j.jaut.2018.01.007_bib9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrgastro.2015.12","article-title":"Novel therapeutic targets in primary biliary cirrhosis","volume":"12","author":"Dyson","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jaut.2018.01.007_bib10","doi-asserted-by":"crossref","DOI":"10.1080\/1744666X.2017.1391093","article-title":"From pathogenesis to novel therapies in the treatment of primary biliary cholangitis","author":"Ronca","year":"2017","journal-title":"Expet Rev. Clin. Immunol."},{"key":"10.1016\/j.jaut.2018.01.007_bib11","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/liv.13344","article-title":"Finding the cure for primary biliary cholangitis - still waiting","volume":"37","author":"Tanaka","year":"2017","journal-title":"Liver Int."},{"key":"10.1016\/j.jaut.2018.01.007_bib12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hep.28359","article-title":"Ustekinumab for patients with primary biliary cholangitis who have an inadequate response to ursodeoxycholic acid: a proof-of-concept study,","volume":"64","author":"Hirschfield","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.01.007_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1586\/17512433.2015.1092381","article-title":"Obeticholic acid for the treatment of primary biliary cirrhosis","volume":"9","author":"Trivedi","year":"2016","journal-title":"Expet Rev. Clin. Pharmacol."},{"key":"10.1016\/j.jaut.2018.01.007_bib14","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jhep.2014.09.010","article-title":"Unmet clinical need in autoimmune liver diseases","volume":"62","author":"Dyson","year":"2015","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.jaut.2018.01.007_bib15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jaut.2015.10.005","article-title":"AAV-IL-22 modifies liver chemokine activity and ameliorates portal inflammation in murine autoimmune cholangitis","volume":"66","author":"Hsueh","year":"2016","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jaut.2018.01.007_bib16","article-title":"The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity","author":"Bae","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.01.007_bib17","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/hep.28641","article-title":"Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance","volume":"64","author":"Bae","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.01.007_bib18","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jaut.2016.08.006","article-title":"Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis","volume":"75","author":"Hisamoto","year":"2016","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jaut.2018.01.007_bib19","doi-asserted-by":"crossref","first-page":"34884","DOI":"10.1038\/srep34884","article-title":"Dual roles of IFN-gamma and IL-4 in the natural history of murine autoimmune cholangitis: IL-30 and implications for precision medicine","volume":"6","author":"Syu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jaut.2018.01.007_bib20","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/cmi.2015.86","article-title":"The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis","volume":"14","author":"Tomiyama","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jaut.2018.01.007_bib21","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/ni.1890","article-title":"Antimicrobial activity of mucosal-associated invariant T cells","volume":"11","author":"Le. Bourhis","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2018.01.007_bib22","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nature11605","article-title":"MR1 presents microbial vitamin B metabolites to MAIT cells","volume":"491","author":"Kjer-Nielsen","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2018.01.007_bib23","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1182\/blood-2010-08-303339","article-title":"Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hiIL-17-secreting T cells","volume":"117","author":"Dusseaux","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2018.01.007_bib24","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.4049\/jimmunol.1203218","article-title":"IL-7 licenses activation of human liver intrasinusoidal mucosal-associated invariant T cells","volume":"190","author":"Tang","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2018.01.007_bib25","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ni1370","article-title":"Invariant V(alpha)19i T cells regulate autoimmune inflammation","volume":"7","author":"Croxford","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2018.01.007_bib26","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1172\/JCI78941","article-title":"Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients","volume":"125","author":"Magalhaes","year":"2015","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.jaut.2018.01.007_bib27","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/cei.12277","article-title":"Innate mucosal-associated invariant T (MAIT) cells are activated in inflammatory bowel diseases","volume":"176","author":"Serriari","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jaut.2018.01.007_bib28","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/intimm\/dxr047","article-title":"Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis","volume":"23","author":"Miyazaki","year":"2011","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jaut.2018.01.007_bib29","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/S0140-6736(10)61965-4","article-title":"Primary biliary cirrhosis","volume":"377","author":"Selmi","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2018.01.007_bib30","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1002\/hep.27313","article-title":"Ongoing activation of autoantigen-specific B cells in primary biliary cirrhosis","volume":"60","author":"Zhang","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.01.007_bib31","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/hep.29245","article-title":"Autoreactive monoclonal antibodies from patients with primary biliary cholangitis recognize environmental xenobiotics","volume":"66","author":"Tanaka","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.01.007_bib32","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/hep.24526","article-title":"Fine phenotypic and functional characterization of effector cluster of differentiation 8 positive T cells in human patients with primary biliary cirrhosis","volume":"54","author":"Tsuda","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.01.007_bib33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jaut.2014.02.010","article-title":"The critical role of myeloid-derived suppressor cells and FXR activation in immune-mediated liver injury","volume":"53","author":"Zhang","year":"2014","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jaut.2018.01.007_bib34","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1084\/jem.20130958","article-title":"Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells","volume":"210","author":"Reantragoon","year":"2013","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.jaut.2018.01.007_bib35","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jaut.2015.07.010","article-title":"Treatment of cholestatic fibrosis by altering gene expression of Cthrc1: implications for autoimmune and non-autoimmune liver disease","volume":"63","author":"Bian","year":"2015","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jaut.2018.01.007_bib36","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/sj.bjc.6603613","article-title":"PTK (protein tyrosine kinase)-6 and HER2 and 4, but not HER1 and 3 predict long-term survival in breast carcinomas","volume":"96","author":"Aubele","year":"2007","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.jaut.2018.01.007_bib37","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13148-015-0098-9","article-title":"PBC Epigenetic Study Group. DNA methylation profiling of the X chromosome reveals an aberrant demethylation on CXCR3 promoter in primary biliary cirrhosis","volume":"7","author":"Lleo","year":"2015","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.jaut.2018.01.007_bib38","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.jhep.2015.12.017","article-title":"Biliary epithelium and liver B cells exposed to bacteria activate intrahepatic MAIT cells through MR1","volume":"64","author":"Jeffery","year":"2016","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.jaut.2018.01.007_bib39","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.4049\/jimmunol.174.2.1055","article-title":"CXC chemokine ligand 16 promotes integrin-mediated adhesion of liver-infiltrating lymphocytes to cholangiocytes and hepatocytes within the inflamed human liver","volume":"174","author":"Heydtmann","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2018.01.007_bib40","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00281-009-0167-2","article-title":"Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis","volume":"31","author":"Borchers","year":"2009","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.jaut.2018.01.007_bib41","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/hep.22428","article-title":"Biochemical response to ursodeoxycholic acid and long-term prognosis in primary biliary cirrhosis","volume":"48","author":"Corpechot","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.01.007_bib42","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1002\/hep.26322","article-title":"Early biochemical response to ursodeoxycholic acid and long-term prognosis of primary biliary cirrhosis: results of a 14-year cohort study","volume":"58","author":"Zhang","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.01.007_bib43","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.immuni.2009.01.007","article-title":"Hepatic interleukin-7 expression regulates T cell responses","volume":"30","author":"Sawa","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2018.01.007_bib44","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/ng.789","article-title":"Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis","volume":"43","author":"Mells","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jaut.2018.01.007_bib45","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.4049\/jimmunol.1202062","article-title":"IL-7 restores lymphocyte functions in septic patients","volume":"189","author":"Venet","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2018.01.007_bib46","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2174\/187152810791292809","article-title":"Biliary innate immunity in the pathogenesis of biliary diseases","volume":"9","author":"Harada","year":"2010","journal-title":"Inflamm. Allergy - Drug Targets"},{"key":"10.1016\/j.jaut.2018.01.007_bib47","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1002\/eji.201545969","article-title":"TLR signalling in human antigen-presenting cells regulates MR1-dependent activation of MAIT cells","volume":"46","author":"Ussher","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jaut.2018.01.007_bib48","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1182\/blood-2012-06-436436","article-title":"Early and nonreversible decrease of CD161++\/MAIT cells in HIV infection","volume":"121","author":"Cosgrove","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2018.01.007_bib49","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.autrev.2017.07.002","article-title":"Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases","volume":"16","author":"Li","year":"2017","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jaut.2018.01.007_bib50","article-title":"Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy","author":"Tang","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.jaut.2018.01.007_bib51","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0002-9440(10)62060-3","article-title":"CXCR 3 activation promotes lymphocyte transendothelial migration across human hepatic endothelium under fluid flow","volume":"167","author":"Curbishley","year":"2005","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jaut.2018.01.007_bib52","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.jhep.2012.07.008","article-title":"CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver","volume":"57","author":"Oo","year":"2012","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.jaut.2018.01.007_bib53","doi-asserted-by":"crossref","first-page":"6236","DOI":"10.4049\/jimmunol.163.11.6236","article-title":"Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver","volume":"163","author":"Shields","year":"1999","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.jaut.2018.01.007_bib54","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1586\/1744666X.2016.1147956","article-title":"Chemokine and chemokine receptors in autoimmunity_ the case of primary biliary cholangitis","volume":"12","author":"Choi","year":"2016","journal-title":"Expet Rev. Clin. Immunol."},{"key":"10.1016\/j.jaut.2018.01.007_bib55","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1002\/hep.26979","article-title":"IL-12\/Th1 and IL-23\/Th17 biliary microenvironment in primary biliary cirrhosis: implications for therapy","volume":"59","author":"Yang","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.01.007_bib56","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jaut.2008.11.001","article-title":"Hepatic IL-17 responses in human and murine primary biliary cirrhosis","volume":"32","author":"Lan","year":"2009","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.jaut.2018.01.007_bib57","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrgastro.2015.200","article-title":"Immunology in the liver \u2014 from homeostasis to disease","volume":"13","author":"Heymann","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jaut.2018.01.007_bib58","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1053\/j.gastro.2005.10.055","article-title":"Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners","volume":"130","author":"Radaeva","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2018.01.007_bib59","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.immuni.2004.07.016","article-title":"Suppression of IL7Ralpha transcription by IL-7 and other prosurvival cytokines: a novel mechanism for maximizing IL-7-dependent T cell survival","volume":"21","author":"Park","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2018.01.007_bib60","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1089\/jir.2013.0075","article-title":"Differential serum levels of eosinophilic eotaxins in primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis","volume":"34","author":"Landi","year":"2014","journal-title":"J.\u00a0Interferon Cytokine Res."},{"key":"10.1016\/j.jaut.2018.01.007_bib61","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S1097-2765(00)80348-2","article-title":"Endogenous bile acids are ligands for the nuclear receptor FXR\/BAR","volume":"3","author":"Wang","year":"1999","journal-title":"Mol. Cell."},{"key":"10.1016\/j.jaut.2018.01.007_bib62","article-title":"Suppressed hepatic bile acid signalling despite elevated production of primary and secondary bile acids in NAFLD","author":"Jiao","year":"2017","journal-title":"Gut"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841117306662?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841117306662?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:16:42Z","timestamp":1760257002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841117306662"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":62,"alternative-id":["S0896841117306662"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2018.01.007","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The immunobiology of mucosal-associated invariant T cell (MAIT) function in primary biliary cholangitis: Regulation by cholic acid-induced Interleukin-7","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2018.01.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}