{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T15:21:45Z","timestamp":1784992905226,"version":"3.55.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Spanish Ministry of Economy, Industry and Competitiveness","award":["GCL2016-79093\/P"],"award-info":[{"award-number":["GCL2016-79093\/P"]}]},{"name":"Basque Government to Research Groups of the Basque University System","award":["IT1138-16"],"award-info":[{"award-number":["IT1138-16"]}]},{"name":"Imanol Mart\u00edn Laza","award":["2014_1_326"],"award-info":[{"award-number":["2014_1_326"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.jaut.2018.07.011","type":"journal-article","created":{"date-parts":[[2018,7,29]],"date-time":"2018-07-29T08:46:18Z","timestamp":1532853978000},"page":"70-82","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Contribution of ancient human remains analysis to the understanding of the variability in HLA-B gene variants in relation to the diagnosis of spondyloarthropathies"],"prefix":"10.1016","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2996-4861","authenticated-orcid":false,"given":"Imanol M.","family":"Laza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3046-4477","authenticated-orcid":false,"given":"Nerea G.","family":"Ventades","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Hervella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4599-0020","authenticated-orcid":false,"given":"Concepci\u00f3n","family":"de-la-R\u00faa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2018.07.011_bib1","article-title":"Update on spondyloarthropathies","volume":"18","author":"Khan","year":"2002","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.jaut.2018.07.011_bib2","series-title":"Kelley & Firestein's Textbook of Rheumatology","first-page":"1256","article-title":"Etiology and pathogenesis of spondyloarthritis","author":"Sikora","year":"2017"},{"issue":"10","key":"10.1016\/j.jaut.2018.07.011_bib3","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1002\/art.1780401015","article-title":"Susceptibility to ankylosing spondylitis in twins: the role of genes, HLA and the environment","volume":"40","author":"Brown","year":"1997","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.jaut.2018.07.011_bib4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/intimm\/dxw002","article-title":"Genetics of autoimmune diseases: perspectives from genome-wide association studies","volume":"28","author":"Kochi","year":"2016","journal-title":"Int. Immunol."},{"issue":"6","key":"10.1016\/j.jaut.2018.07.011_bib5","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s11926-015-0516-1","article-title":"Revisiting MHC genes in spondyloarthritis","volume":"17","author":"Breban","year":"2015","journal-title":"Curr. Rheumatol. Rep."},{"issue":"10","key":"10.1016\/j.jaut.2018.07.011_bib6","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1002\/art.21371","article-title":"Molecular evidence of HLA-B27 in a historical case of ankylosing spondylitis","volume":"52","author":"Haak","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2018.07.011_bib7","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1136\/ard.2008.097121","article-title":"HLA-B27 sequences identified in a mediaeval skeleton with ankylosing spondylitis","volume":"68","author":"Leden","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2018.07.011_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/242121a0","article-title":"Human lymphocyte antigen association in ankylosing spondylitis","volume":"242","author":"Caffrey","year":"1973","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.jaut.2018.07.011_bib9","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.autrev.2011.01.011","article-title":"What is the new role of HLA-B27 in spondyloarthropathies?","volume":"10","author":"Chatzikyriakidou","year":"2011","journal-title":"Autoimmun. Rev."},{"issue":"4","key":"10.1016\/j.jaut.2018.07.011_bib10","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1136\/annrheumdis-2013-204436","article-title":"Prevalence of spondyloarthritis in reference to HLA-B27 in the French population: results of the GAZEL cohort","volume":"74","author":"Costantino","year":"2015","journal-title":"Ann. Rheum. Dis."},{"issue":"2","key":"10.1016\/j.jaut.2018.07.011_bib11","first-page":"210","article-title":"Vitamin D status in spondyloarthritis: results of the ASAS-COMOSPA international study","volume":"36","author":"Fernandes","year":"2018","journal-title":"Clin. Exp. Rheumatol."},{"issue":"2","key":"10.1016\/j.jaut.2018.07.011_bib12","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/ncprheum0989","article-title":"The effect of melanism and vitamin D synthesis on the incidence of autoimmune disease","volume":"5","author":"Shoenfeld","year":"2009","journal-title":"Nat. Clin. Pract. Rheumatol."},{"key":"10.1016\/j.jaut.2018.07.011_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1364-6826(98)00113-8","article-title":"Evaluating sun-climate relationships since the little Ice age","volume":"61","author":"Lean","year":"1999","journal-title":"J. Atmos. Sol. Terr. Phys."},{"issue":"2","key":"10.1016\/j.jaut.2018.07.011_bib14","first-page":"54","article-title":"Revisi\u00f3n de m\u00e9todos de extracci\u00f3n de ADN a partir de restos\u00f3seos en el laboratorio forente","volume":"39","author":"Barrio-Caballero","year":"2013","journal-title":"Rev. Espa\u00f1ola Med. Leg."},{"key":"10.1016\/j.jaut.2018.07.011_bib15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ijpp.2018.01.004","article-title":"A recording form for differential diagnosis of arthropathies","volume":"20","author":"Ventades","year":"2018","journal-title":"Int. J. Paleophatol."},{"key":"10.1016\/j.jaut.2018.07.011_bib16","series-title":"Kelley & Firestein's Textbook of Rheumatology","first-page":"1256","article-title":"Ankylosing spondylitis","author":"van der Linden","year":"2017"},{"issue":"1","key":"10.1016\/j.jaut.2018.07.011_bib17","first-page":"1","article-title":"Differences in the expression of spondyloarthropathy: a comparison between ankylosing spondylitis and psoriatic arthritis","volume":"16","author":"Gladman","year":"1993","journal-title":"Clin. Invest. Med."},{"key":"10.1016\/j.jaut.2018.07.011_bib18","series-title":"Introduction to Forensic Anthropology","author":"Byers","year":"2001"},{"key":"10.1016\/j.jaut.2018.07.011_bib19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/ajpa.22026","article-title":"A new method to estimate adult age at death using the acetabulum","volume":"148","author":"Calce","year":"2012","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.jaut.2018.07.011_bib20","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF02437238","article-title":"Skeletal age determination based on the os pubis: a comparison of the Acs\u00e1di-Nemesk\u00e9ri and Suchey-Brook methods","volume":"5","author":"Brooks","year":"2004","journal-title":"Hum. Evol."},{"key":"10.1016\/j.jaut.2018.07.011_bib21","first-page":"287","article-title":"Estimation of age from cranial suture closure in Basque population","volume":"10","author":"Egu\u00eda","year":"1983","journal-title":"Anthropos"},{"key":"10.1016\/j.jaut.2018.07.011_bib22","series-title":"Human Osteology","author":"White","year":"2011"},{"key":"10.1016\/j.jaut.2018.07.011_bib23","article-title":"Ancient DNA from south-east europe reveals different events during early and middle neolithic influencing the european genetic heritage","volume":"8","author":"Hervella","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2018.07.011_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037022","article-title":"The loss of functional caspase-12 in Europe is a pre-Neolithic event","volume":"7","author":"Hervella","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2018.07.011_bib25","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/ajpa.20148","article-title":"Mitochondrial DNA diversity in 17th-18th century remains from tenerife (canary islands)","volume":"127","author":"Maca-Meyer","year":"2005","journal-title":"Am. J. Phys. Anthropol."},{"issue":"3","key":"10.1016\/j.jaut.2018.07.011_bib26","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3899\/jrheum.151170","article-title":"Genetic markers in a medieval case of ankylosing spondylitis","volume":"43","author":"Laza","year":"2016","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.jaut.2018.07.011_bib27","first-page":"105","article-title":"Polymorphism and evolution of HLA class I and II genes and molecules","volume":"1","author":"Little","year":"1999","journal-title":"Rev. Immunogenet."},{"key":"10.1016\/j.jaut.2018.07.011_bib28","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1053\/berh.2002.0243","article-title":"Genetic aspects of ankylosing spondylitis","volume":"16","author":"Khan","year":"2002","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.jaut.2018.07.011_bib29","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s11926-010-0126-x","article-title":"Remarkable polymorphism of HLA-B27: an ongoing saga","volume":"12","author":"Khan","year":"2010","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.jaut.2018.07.011_bib30","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s11926-013-0362-y","article-title":"Polymorphism of HLA-B27: 105 subtypes currently known","volume":"15","author":"Khan","year":"2013","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.jaut.2018.07.011_bib31","first-page":"277","article-title":"Molecular typing of HLA-B27 alleles","volume":"36","author":"Dominguez","year":"1991","journal-title":"Immunogenetics"},{"key":"10.1016\/j.jaut.2018.07.011_bib32","doi-asserted-by":"crossref","first-page":"D423","DOI":"10.1093\/nar\/gku1161","article-title":"The IPD and IPD-IMGT\/HLA Database: allele variant databases","volume":"43","author":"Robinson","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jaut.2018.07.011_bib33","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1126\/science.289.5482.1139b","article-title":"Ancient DNA: do it right or not at all","volume":"289","author":"Cooper","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.jaut.2018.07.011_bib34","first-page":"353","article-title":"Ancient DNA","volume":"2","author":"Hofreiter","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2018.07.011_bib35","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1146\/annurev.genet.37.110801.143214","article-title":"Genetic analyses from ancient DNA","volume":"38","author":"P\u00e4\u00e4bo","year":"2004","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.jaut.2018.07.011_bib36","first-page":"701","article-title":"Authenticity in ancient DNA studies","volume":"18","author":"Gilbert","year":"2006","journal-title":"Med. Secoli"},{"issue":"3","key":"10.1016\/j.jaut.2018.07.011_bib37","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1093\/genetics\/152.3.1079","article-title":"Estimation of past demographic parameters from the distribution of pairwise differences when the mutation rates vary among sites: application to human mitochondrial DNA","volume":"152","author":"Schneider","year":"1999","journal-title":"Genetics"},{"issue":"9","key":"10.1016\/j.jaut.2018.07.011_bib38","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1002\/anr.1780320912","article-title":"HLA-Bw60 increases susceptibility to ankylosing spondylitis in HLA-B27+ patients","volume":"32","author":"Robinson","year":"1989","journal-title":"Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.jaut.2018.07.011_bib39","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1002\/1529-0131(200006)43:6<1356::AID-ANR20>3.0.CO;2-Y","article-title":"The familial form of spondyloarthropathy: a clinical study of 115 multiplex families. Groupe Fran\u00e7ais d\u00b4Etude G\u00e9n\u00e9tique des Spondyloarthropathies","volume":"43","author":"Said-Nahal","year":"2000","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.jaut.2018.07.011_bib40","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0016-5085(00)70209-5","article-title":"Clinical phenotype is related to HLA genotype in the peripheral arthropathies of inflammatory bowel disease","volume":"118","author":"Orchard","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2018.07.011_bib41","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1136\/ard.2004.021774","article-title":"Radiological sacroiliitis, a hallmark of spondylitis, is linked with CARD15 gene polymorphisms in patient with Crohn's disease","volume":"63","author":"Peeters","year":"2004","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2018.07.011_bib42","article-title":"Role of HLA typing on Crohn's disease pathogenesis","volume":"4","author":"Mahdi","year":"2015","journal-title":"Ann. Med. Surg. (Lond.)"},{"issue":"11","key":"10.1016\/j.jaut.2018.07.011_bib43","first-page":"1658","article-title":"HLA antigens in ankylosing spondylitis associated with Crohn's disease. Increased frequency of the HLA phenotype B27, B44","volume":"15","author":"Purrmann","year":"1988","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.jaut.2018.07.011_bib44","article-title":"Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1","volume":"21","author":"Cortes","year":"2015","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.jaut.2018.07.011_bib45","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s10067-014-2662-7","article-title":"An update on the contribution of the MHC to AS susceptibility","volume":"33","author":"Reveille","year":"2014","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.jaut.2018.07.011_bib46","article-title":"Analysis of HLA-B15 and HLA-B27 in spondyloarthritis with peripheral and axial clinical patterns","volume":"11","author":"Londono","year":"2015","journal-title":"BMJ Open"},{"issue":"8","key":"10.1016\/j.jaut.2018.07.011_bib47","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1136\/ard.61.8.714","article-title":"Effect of HLA-B and HLA-DR genes on susceptibility to and severity of spondyloarthropathies in Mexican patients","volume":"61","author":"Vargas-Alarc\u00f3n","year":"2002","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.jaut.2018.07.011_bib48","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1053\/gast.2002.35396","article-title":"Uveitis and erythema nodosum in inflammatory bowel disease: clinical features and the role of HLA genes","volume":"123","author":"Orchad","year":"2002","journal-title":"Gastreoenterology"},{"issue":"11","key":"10.1016\/j.jaut.2018.07.011_bib49","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1002\/art.1780381120","article-title":"Association of HLA-B39 with HLA-B27-negative ankylosing spondylitis and pauciarticular juvenile rheumatoid arthritis in Japanese patients. Evidence for a role of the peptide-anchoring B pocket","volume":"38","author":"Yamaguchi","year":"1995","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2018.07.011_bib50","article-title":"Concepts of pathogenesis in psoriatic arthritis: genotype determines clinical phenotype","volume":"7","author":"FitzGerald","year":"2015","journal-title":"Arthritis Res. Ther."},{"issue":"3","key":"10.1016\/j.jaut.2018.07.011_bib51","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1399-0039.2012.01944.x","article-title":"Old and new HLA associations with ankylosing spondylitis","volume":"80","author":"D\u00edaz-Pe\u00f1a","year":"2012","journal-title":"Tissue Antigens"},{"issue":"3","key":"10.1016\/j.jaut.2018.07.011_bib52","first-page":"586","article-title":"HLA antigens in psoriatic arthritis","volume":"13","author":"Gladman","year":"1986","journal-title":"J. Rheumatol."},{"issue":"6","key":"10.1016\/j.jaut.2018.07.011_bib53","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/sj.jid.5700357","article-title":"PSORS1: linking genetics and immunology","volume":"126","author":"Elder","year":"2006","journal-title":"J. Invest. Dermatol."},{"issue":"6","key":"10.1016\/j.jaut.2018.07.011_bib54","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1136\/ard.25.6.525","article-title":"Ankylosing spondylitis in a Canadian indian population","volume":"25","author":"Gofton","year":"1966","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2018.07.011_bib55","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/ajpa.1330910302","article-title":"Seronegative spondyloarthropathies and diffuse idiopathic skeletal hyperostosis in ancient northern Chile","volume":"91","author":"Arriaza","year":"1993","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.jaut.2018.07.011_bib56","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.rdc.2012.08.012","article-title":"Pathophysiology and role of the gastrointestinal system in spondyloarthritides","volume":"38","author":"Jacques","year":"2012","journal-title":"Rheum. Dis. Clin. N. Am."}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841118302610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841118302610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:19:24Z","timestamp":1760257164000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841118302610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":56,"alternative-id":["S0896841118302610"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2018.07.011","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Contribution of ancient human remains analysis to the understanding of the variability in HLA-B gene variants in relation to the diagnosis of spondyloarthropathies","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2018.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}