{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:00:23Z","timestamp":1792839623462,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"MRC Stratified Medicine award"},{"name":"NIHR Birmingham Biomedical Research Centre","id":[{"id":"https:\/\/ror.org\/05ccjmp23","id-type":"ROR","asserted-by":"crossref"}]},{"name":"MRC Stratified Medicine, PSC Partners"},{"name":"NIHR Birmingham Biomedical Research Centre","id":[{"id":"https:\/\/ror.org\/05ccjmp23","id-type":"ROR","asserted-by":"crossref"}]},{"name":"NIHR\/Wellcome Trust Birmingham Clinical Research Facility","id":[{"id":"https:\/\/ror.org\/029chgv08","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.jaut.2018.07.020","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T10:17:09Z","timestamp":1534241829000},"page":"143-155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":65,"special_numbering":"C","title":["Increased sensitivity of Treg cells from patients with PBC to low dose IL-12 drives their differentiation into IFN-\u03b3 secreting cells"],"prefix":"10.1016","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9820-4698","authenticated-orcid":false,"given":"Evaggelia","family":"Liaskou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samita R.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0710-5644","authenticated-orcid":false,"given":"Gwilym","family":"Webb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danai","family":"Bagkou Dimakou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Akiror","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Krishna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Mells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave E.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon J.","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Barone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4631-549X","authenticated-orcid":false,"given":"Benjamin A.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon M.","family":"Hirschfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2018.07.020_bib1","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jaut.2012.06.002","article-title":"Genetic variations in interleukin-12 related genes in immune-mediated diseases","volume":"39","author":"van Wanrooij","year":"2012","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2018.07.020_bib2","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1056\/NEJMoa0810440","article-title":"Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants","volume":"360","author":"Hirschfield","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jaut.2018.07.020_bib3","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/gene.2010.29","article-title":"STAT4 is a confirmed genetic risk factor for Sjogren's syndrome and could be involved in type 1 interferon pathway signaling","volume":"11","author":"Gestermann","year":"2010","journal-title":"Gene Immun."},{"key":"10.1016\/j.jaut.2018.07.020_bib4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/gene.2010.28","article-title":"International Multiple Sclerosis Genetics C. IL12A, MPHOSPH9\/CDK2AP1 and RGS1 are novel multiple sclerosis susceptibility loci","volume":"11","year":"2010","journal-title":"Gene Immun."},{"key":"10.1016\/j.jaut.2018.07.020_bib5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-pathol-020712-164014","article-title":"The immunobiology and pathophysiology of primary biliary cirrhosis","volume":"8","author":"Hirschfield","year":"2013","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.jaut.2018.07.020_bib6","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1002\/hep.26979","article-title":"IL-12\/Th1 and IL-23\/Th17 biliary microenvironment in primary biliary cirrhosis: implications for therapy","volume":"59","author":"Yang","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.07.020_bib7","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/hep.21123","article-title":"Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis","volume":"43","author":"Lan","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.07.020_bib8","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-2249.2009.03898.x","article-title":"Imbalance between T helper type 17 and T regulatory cells in patients with primary biliary cirrhosis: the serum cytokine profile and peripheral cell population","volume":"156","author":"Rong","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jaut.2018.07.020_bib9","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.4049\/jimmunol.0901216","article-title":"Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver","volume":"184","author":"Oo","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2018.07.020_bib10","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/hep.28517","article-title":"Human intrahepatic regulatory T cells are functional, require IL-2 from effector cells for survival, and are susceptible to Fas ligand-mediated apoptosis","volume":"64","author":"Chen","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.07.020_bib11","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.2792","article-title":"Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjogren's syndrome","volume":"45","author":"Lessard","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jaut.2018.07.020_bib12","doi-asserted-by":"crossref","first-page":"243723","DOI":"10.1155\/2015\/243723","article-title":"T Regulatory and T Helper 17 cells in primary Sjogren's syndrome: facts and perspectives","volume":"2015","author":"Alunno","year":"2015","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jaut.2018.07.020_bib13","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nm.2389","article-title":"Identification of T helper type 1-like, Foxp3+ regulatory T cells in human autoimmune disease","volume":"17","author":"Dominguez-Villar","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.jaut.2018.07.020_bib14","article-title":"Differential effects of IL-12 on Tregs and non-Treg T cells: roles of IFN-gamma, IL-2 and IL-2R","volume":"7","author":"Zhao","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2018.07.020_bib15","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/ni.2366","article-title":"IL-12 family cytokines: immunological playmakers","volume":"13","author":"Vignali","year":"2012","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2018.07.020_bib16","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10238-015-0381-2","article-title":"Elevated circulating CD14(low)CD16(+) monocyte subset in primary biliary cirrhosis correlates with liver injury and promotes Th1 polarization","volume":"16","author":"Peng","year":"2016","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.jaut.2018.07.020_bib17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1053\/j.gastro.2014.04.003","article-title":"Loss of CD28 expression by liver-infiltrating T cells contributes to pathogenesis of primary sclerosing cholangitis","volume":"147","author":"Liaskou","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2018.07.020_bib18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/1471-2105-7-85","article-title":"Statistical analysis of real-time PCR data","volume":"7","author":"Yuan","year":"2006","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.jaut.2018.07.020_bib19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4049\/jimmunol.172.1.61","article-title":"Sustained IL-12 signaling is required for Th1 development","volume":"172","author":"Athie-Morales","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2018.07.020_bib20","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.1074\/jbc.M115.681833","article-title":"Nicotinic acid adenine dinucleotide phosphate plays a critical role in naive and effector murine T cells but not natural regulatory T cells","volume":"291","author":"Ali","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jaut.2018.07.020_bib21","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/eji.201343617","article-title":"Activation of human basophils by combined toll-like receptor- and FcepsilonRI-triggering can promote Th2 skewing of naive T helper cells","volume":"44","author":"Suurmond","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jaut.2018.07.020_bib22","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1089\/jir.2013.0075","article-title":"Differential serum levels of eosinophilic eotaxins in primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis","volume":"34","author":"Landi","year":"2014","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.jaut.2018.07.020_bib23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jlb.64.1.2","article-title":"Regulation of T helper cell differentiation by STAT molecules","volume":"64","author":"Kaplan","year":"1998","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jaut.2018.07.020_bib24","doi-asserted-by":"crossref","first-page":"6435","DOI":"10.4049\/jimmunol.172.10.6435","article-title":"CD4+CD25bright regulatory T cells actively regulate inflammation in the joints of patients with the remitting form of juvenile idiopathic arthritis","volume":"172","author":"de Kleer","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2018.07.020_bib25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jhep.2004.03.008","article-title":"Impairment of CD4(+)CD25(+) regulatory T-cells in autoimmune liver disease","volume":"41","author":"Longhi","year":"2004","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jaut.2018.07.020_bib26","doi-asserted-by":"crossref","first-page":"R335","DOI":"10.1186\/ar1192","article-title":"CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease","volume":"6","author":"Cao","year":"2004","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2018.07.020_bib27","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/hep.28641","article-title":"Chronic expression of interferon-gamma leads to murine autoimmune cholangitis with a female predominance","volume":"64","author":"Bae","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.07.020_bib28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.trsl.2006.04.007","article-title":"Gene expression profiling in biliary epithelial cells of primary biliary cirrhosis using laser capture microdissection and cDNA microarray","volume":"148","author":"Baba","year":"2006","journal-title":"Transl. Res. : J. Lab. Clin. Med."},{"key":"10.1016\/j.jaut.2018.07.020_bib29","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1111\/j.1572-0241.2005.41662.x","article-title":"Differential gene expression profiles in stage I primary biliary cirrhosis","volume":"100","author":"Honda","year":"2005","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.jaut.2018.07.020_bib30","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1136\/gut.49.4.565","article-title":"Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expression","volume":"49","author":"Shackel","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.jaut.2018.07.020_bib31","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jaut.2015.07.004","article-title":"The immunogenetics of primary biliary cirrhosis: a comprehensive review","volume":"64","author":"Webb","year":"2015","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2018.07.020_bib32","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/hep.29524","article-title":"The interplay of type I and type II interferons in murine autoimmune cholangitis as a basis for sex-biased autoimmunity","volume":"67","author":"Bae","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.07.020_bib33","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/hep.20859","article-title":"Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis","volume":"42","author":"Mao","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.07.020_bib34","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/rheumatology\/kel270","article-title":"Clinical and immunological characteristics of patients with Sjogren's syndrome in relation to alpha-fodrin antibodies","volume":"46","author":"Willeke","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.jaut.2018.07.020_bib35","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1016\/j.febslet.2009.10.036","article-title":"Correlation of mRNA and protein in complex biological samples","volume":"583","author":"Maier","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.jaut.2018.07.020_bib36","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.jhep.2016.12.001","article-title":"Dysfunction of hepatic regulatory T cells in experimental sclerosing cholangitis is related to IL-12 signaling","volume":"66","author":"Schwinge","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.jaut.2018.07.020_bib37","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1002\/hep.23132","article-title":"Deletion of interleukin-12p40 suppresses autoimmune cholangitis in dominant negative transforming growth factor beta receptor type II mice","volume":"50","author":"Yoshida","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.07.020_bib38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jaut.2014.02.009","article-title":"Distinct from its canonical effects, deletion of IL-12p40 induces cholangitis and fibrosis in interleukin-2Ralpha(-\/-) mice","volume":"51","author":"Yao","year":"2014","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2018.07.020_bib39","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/hep.25829","article-title":"Deletion of interleukin (IL)-12p35 induces liver fibrosis in dominant-negative TGFbeta receptor type II mice","volume":"57","author":"Tsuda","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.07.020_bib40","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/hep.28359","article-title":"Ustekinumab for patients with primary biliary cholangitis who have an inadequate response to ursodeoxycholic acid: a proof-of-concept study","volume":"64","author":"Hirschfield","year":"2016","journal-title":"Hepatology"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841118303032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841118303032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:19:02Z","timestamp":1760257142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841118303032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":40,"alternative-id":["S0896841118303032"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2018.07.020","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased sensitivity of Treg cells from patients with PBC to low dose IL-12 drives their differentiation into IFN-\u03b3 secreting cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2018.07.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}