{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T11:12:58Z","timestamp":1780657978412,"version":"3.54.1"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"am","delay-in-days":362,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 104-2320-B-002-033-MY3"],"award-info":[{"award-number":["MOST 104-2320-B-002-033-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes, Taiwan","doi-asserted-by":"crossref","award":["NHRI-EX103-10027SC"],"award-info":[{"award-number":["NHRI-EX103-10027SC"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006477","name":"National Taiwan University","doi-asserted-by":"publisher","award":["NTU-CDP-104R7880"],"award-info":[{"award-number":["NTU-CDP-104R7880"]}],"id":[{"id":"10.13039\/501100006477","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health, United States","doi-asserted-by":"publisher","award":["DK067003"],"award-info":[{"award-number":["DK067003"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.jaut.2018.09.009","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T09:39:56Z","timestamp":1538127596000},"page":"159-170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Endogenous IL-10 maintains immune tolerance but IL-10 gene transfer exacerbates autoimmune cholangitis"],"prefix":"10.1016","volume":"95","author":[{"given":"Yu-Hsin","family":"Hsueh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-Jhen","family":"Syu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-I.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick S.C.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Eric","family":"Gershwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Hui","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2018.09.009_bib1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev-pathol-020712-164014","article-title":"The immunobiology and pathophysiology of primary biliary cirrhosis","volume":"8","author":"Hirschfield","year":"2013","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.jaut.2018.09.009_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jaut.2016.10.003","article-title":"Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis","volume":"77","author":"Chung","year":"2017","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2018.09.009_bib3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s12016-015-8482-y","article-title":"Animal models of primary biliary cirrhosis","volume":"48","author":"Katsumi","year":"2015","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib4","doi-asserted-by":"crossref","first-page":"34884","DOI":"10.1038\/srep34884","article-title":"Dual roles of IFN-gamma and IL-4 in the natural history of murine autoimmune cholangitis: IL-30 and implications for precision medicine","volume":"6","author":"Syu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jaut.2018.09.009_bib5","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.4049\/jimmunol.1001597","article-title":"CD8 T cells mediate direct biliary ductule damage in nonobese diabetic autoimmune biliary disease","volume":"186","author":"Yang","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib6","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1002\/hep.28122","article-title":"Natural killer cells regulate T cell immune responses in primary biliary cirrhosis","volume":"62","author":"Shimoda","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.09.009_bib7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s12016-014-8456-5","article-title":"New therapies for primary biliary cirrhosis","volume":"48","author":"Floreani","year":"2015","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1111\/cei.12415","article-title":"Successful immunotherapy of autoimmune cholangitis by adoptive transfer of forkhead box protein 3(+) regulatory T cells","volume":"178","author":"Tanaka","year":"2014","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib9","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1056\/NEJMe1804945","article-title":"Progress in primary biliary cholangitis","volume":"378","author":"Carey","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jaut.2018.09.009_bib10","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1111\/liv.13880","article-title":"Novel and emerging therapies for cholestatic liver diseases","volume":"38","author":"Goldstein","year":"2018","journal-title":"Liver Int."},{"key":"10.1016\/j.jaut.2018.09.009_bib11","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1586\/1744666X.2016.1147956","article-title":"Chemokine and chemokine receptors in autoimmunity: the case of primary biliary cholangitis","volume":"12","author":"Choi","year":"2016","journal-title":"Expet Rev. Clin. Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jaut.2018.05.001","article-title":"Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice","volume":"91","author":"Hintermann","year":"2018","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2018.09.009_bib13","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.1038\/s41598-018-25214-0","article-title":"Pilot study with IBAT inhibitor A4250 for the treatment of cholestatic pruritus in primary biliary cholangitis","volume":"8","author":"Al-Dury","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jaut.2018.09.009_bib14","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nrgastro.2016.201","article-title":"Primary biliary cholangitis in 2016: high-definition PBC: biology, models and therapeutic advances","volume":"14","author":"Webb","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jaut.2018.09.009_bib15","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jaut.2016.08.006","article-title":"Hydrophobic bile acids suppress expression of AE2 in biliary epithelial cells and induce bile duct inflammation in primary biliary cholangitis","volume":"75","author":"Hisamoto","year":"2016","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2018.09.009_bib16","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jaut.2018.01.007","article-title":"The immunobiology of mucosal-associated invariant T cell (MAIT) function in primary biliary cholangitis: regulation by cholic acid-induced Interleukin-7","volume":"90","author":"Jiang","year":"2018","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2018.09.009_bib17","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/hep.24113","article-title":"Innate immunity and primary biliary cirrhosis: activated invariant natural killer T cells exacerbate murine autoimmune cholangitis and fibrosis","volume":"53","author":"Wu","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.09.009_bib18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-immunol-031210-101312","article-title":"Regulation and functions of the IL-10 family of cytokines in inflammation and disease","volume":"29","author":"Ouyang","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jaut.2018.04.003","article-title":"Characterization of Blimp-1 function in effector regulatory T cells","volume":"91","author":"Cretney","year":"2018","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2018.09.009_bib20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jaut.2017.10.011","article-title":"Signaling via toll-like receptor 4 and CD40 in B cells plays a regulatory role in the pathogenesis of multiple sclerosis through interleukin-10 production","volume":"88","author":"Okada","year":"2018","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2018.09.009_bib21","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the interleukin-10 receptor","volume":"19","author":"Moore","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib22","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","article-title":"The regulation of IL-10 production by immune cells","volume":"10","author":"Saraiva","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib23","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/ni.1791","article-title":"Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis","volume":"10","author":"Murai","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib24","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/1521-4141(200006)30:6<1683::AID-IMMU1683>3.0.CO;2-A","article-title":"IL-10 directly acts on T cells by specifically altering the CD28 co-stimulation pathway","volume":"30","author":"Joss","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib25","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1046\/j.1365-2249.1998.00713.x","article-title":"IL-10 down-regulates T cell activation by antigen-presenting liver sinusoidal endothelial cells through decreased antigen uptake via the mannose receptor and lowered surface expression of accessory molecules","volume":"114","author":"Knolle","year":"1998","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib26","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jaut.2015.08.020","article-title":"Immunity, tolerance and autoimmunity in the liver: a comprehensive review","volume":"66","author":"Doherty","year":"2016","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2018.09.009_bib27","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/lt.21091","article-title":"Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10","volume":"13","author":"Yang","year":"2007","journal-title":"Liver Transplant."},{"key":"10.1016\/j.jaut.2018.09.009_bib28","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1002\/hep.510280621","article-title":"Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice","volume":"28","author":"Louis","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.09.009_bib29","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/hep.21498","article-title":"IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A-induced liver injury in mice","volume":"45","author":"Erhardt","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.09.009_bib30","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nri3169","article-title":"Living in the liver: hepatic infections","volume":"12","author":"Protzer","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib31","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1053\/gast.1997.v112.pm9041256","article-title":"Hepatoprotective role of interleukin 10 in galactosamine\/lipopolysaccharide mouse liver injury","volume":"112","author":"Louis","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2018.09.009_bib32","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.bbrc.2005.08.085","article-title":"Interleukin-10 gene therapy reverses thioacetamide-induced liver fibrosis in mice","volume":"336","author":"Hung","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jaut.2018.09.009_bib33","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1074\/jbc.273.1.302","article-title":"Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells","volume":"273","author":"Wang","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jaut.2018.09.009_bib34","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1053\/j.gastro.2004.04.062","article-title":"Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes","volume":"127","author":"Safadi","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2018.09.009_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2017.02.004","article-title":"Checkpoint-based immunotherapy for autoimmune diseases - opportunities and challenges","volume":"79","author":"He","year":"2017","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2018.09.009_bib36","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jaut.2015.10.005","article-title":"AAV-IL-22 modifies liver chemokine activity and ameliorates portal inflammation in murine autoimmune cholangitis","volume":"66","author":"Hsueh","year":"2016","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2018.09.009_bib37","article-title":"Innate immunity drives the initiation of a murine model of primary biliary cirrhosis","volume":"10","author":"Chang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2018.09.009_bib38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0009-9236(97)90065-5","article-title":"Pharmacodynamics of subcutaneous recombinant human interleukin-10 in healthy volunteers","volume":"62","author":"Huhn","year":"1997","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.jaut.2018.09.009_bib39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1182\/blood-2013-01-306647","article-title":"Immune responses to AAV vectors: overcoming barriers to successful gene therapy","volume":"122","author":"Mingozzi","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2018.09.009_bib40","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1128\/JVI.00254-08","article-title":"In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses","volume":"82","author":"Grimm","year":"2008","journal-title":"J. Virol."},{"key":"10.1016\/j.jaut.2018.09.009_bib41","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1006\/clin.1996.0129","article-title":"Elevations in IFN-gamma, IL-5, and IL-10 in patients with the autoimmune disease primary biliary cirrhosis: association with autoantibodies and soluble CD30","volume":"80","author":"Krams","year":"1996","journal-title":"Clin. Immunol. Immunopathol."},{"key":"10.1016\/j.jaut.2018.09.009_bib42","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3109\/08916939908994050","article-title":"Concanavalin A-induced hepatitis in mice is prevented by interleukin (IL)-10 and exacerbated by endogenous IL-10 deficiency","volume":"31","author":"Di Marco","year":"1999","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jaut.2018.09.009_bib43","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1002\/hep.28641","article-title":"Chronic expression of interferon gamma leads to murine autoimmune cholangitis with a female predominance","volume":"64","author":"Bae","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.09.009_bib44","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12016-015-8514-7","article-title":"Regulator versus effector paradigm: interleukin-10 as indicator of the switching response","volume":"50","author":"Mingomataj","year":"2016","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib45","doi-asserted-by":"crossref","first-page":"3971","DOI":"10.4049\/jimmunol.158.8.3971","article-title":"Attenuation of proinflammatory response by recombinant human IL-10 in human endotoxemia: effect of timing of recombinant human IL-10 administration","volume":"158","author":"Pajkrt","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib46","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0041-1345(96)00412-5","article-title":"High-dose cellular IL-10 exacerbates rejection and reverses effects of cyclosporine and tacrolimus in Mouse cardiac transplantation","volume":"29","author":"Li","year":"1997","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.jaut.2018.09.009_bib47","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1046\/j.1365-2249.2000.01392.x","article-title":"IL-10 stimulates production of platelet-activating factor by monocytes of patients with active systemic lupus erythematosus (SLE)","volume":"122","author":"Bussolati","year":"2000","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib48","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/hep.510310218","article-title":"Repeated concanavalin A challenge in mice induces an interleukin 10-producing phenotype and liver fibrosis","volume":"31","author":"Louis","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2018.09.009_bib49","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.hepres.2006.05.002","article-title":"Repeated administrations of concanavalin A induce Th1 to Th2 cytokine shift and tolerance against liver injury in mice","volume":"35","author":"Tamaki","year":"2006","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.jaut.2018.09.009_bib50","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/gut.50.2.191","article-title":"Treatment of Crohn's disease with recombinant human interleukin 10 induces the proinflammatory cytokine interferon gamma","volume":"50","author":"Tilg","year":"2002","journal-title":"Gut"},{"key":"10.1016\/j.jaut.2018.09.009_bib51","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1189\/jlb.0408249","article-title":"Comprehensive biomarker monitoring in cytokine therapy: heterogeneous, time-dependent, and persisting immune effects of interleukin-10 application in psoriasis","volume":"85","author":"Docke","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jaut.2018.09.009_bib52","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.ccr.2011.11.003","article-title":"IL-10 elicits IFNgamma-dependent tumor immune surveillance","volume":"20","author":"Mumm","year":"2011","journal-title":"Canc. Cell"},{"key":"10.1016\/j.jaut.2018.09.009_bib53","doi-asserted-by":"crossref","first-page":"3570","DOI":"10.1158\/0008-5472.CAN-12-0721","article-title":"IL-10 directly activates and expands tumor-resident CD8(+) T cells without de novo infiltration from secondary lymphoid organs","volume":"72","author":"Emmerich","year":"2012","journal-title":"Canc. Res."},{"key":"10.1016\/j.jaut.2018.09.009_bib54","doi-asserted-by":"crossref","first-page":"L841","DOI":"10.1152\/ajplung.00329.2004","article-title":"Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles","volume":"288","author":"Barbarin","year":"2005","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.jaut.2018.09.009_bib55","doi-asserted-by":"crossref","first-page":"L341","DOI":"10.1152\/ajplung.00122.2010","article-title":"New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2\/CCR2 axis","volume":"300","author":"Sun","year":"2011","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.jaut.2018.09.009_bib56","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.4049\/jimmunol.161.8.4283","article-title":"Immunoregulatory roles of IL-10 in innate immunity: IL-10 inhibits macrophage production of IFN-gamma-inducing factors but enhances NK cell production of IFN-gamma","volume":"161","author":"Shibata","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib57","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1182\/blood-2006-03-005595","article-title":"TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activation","volume":"108","author":"Qian","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2018.09.009_bib58","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1084\/jem.181.3.839","article-title":"Role of interleukin 10 in the B lymphocyte hyperactivity and autoantibody production of human systemic lupus erythematosus","volume":"181","author":"Llorente","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jaut.2018.09.009_bib59","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jaut.2016.06.002","article-title":"A proliferation inducing ligand (APRIL) promotes IL-10 production and regulatory functions of human B cells","volume":"73","author":"Hua","year":"2016","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2018.09.009_bib60","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jaut.2016.09.005","article-title":"Identification of tonsillar CD4(+)CD25(-)LAG3(+) T cells as naturally occurring IL-10-producing regulatory T cells in human lymphoid tissue","volume":"76","author":"Sumitomo","year":"2017","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2018.09.009_bib61","first-page":"191","article-title":"The molecular basis of IL-10 function: from receptor structure to the onset of signaling","volume":"380","author":"Walter","year":"2014","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.jaut.2018.09.009_bib62","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.jaut.2017.06.006","article-title":"Small molecules to the rescue: inhibition of cytokine signaling in immune-mediated diseases","volume":"85","author":"Gadina","year":"2017","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2018.09.009_bib63","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/gut.2005.088690","article-title":"Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis","volume":"56","author":"Inagaki","year":"2007","journal-title":"Gut"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841118304359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841118304359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:20:40Z","timestamp":1760257240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841118304359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":63,"alternative-id":["S0896841118304359"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2018.09.009","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endogenous IL-10 maintains immune tolerance but IL-10 gene transfer exacerbates autoimmune cholangitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2018.09.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}