{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:58:38Z","timestamp":1773403118011,"version":"3.50.1"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Thousand Talents Program"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81322047"],"award-info":[{"award-number":["81322047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673525"],"award-info":[{"award-number":["81673525"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"J\u00e9r\u00f4me Honnorat from Agence Nationale de la Recherche","award":["ANR-14-CE15-0001-MECANO"],"award-info":[{"award-number":["ANR-14-CE15-0001-MECANO"]}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DQ20170336751"],"award-info":[{"award-number":["DQ20170336751"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.jaut.2018.09.012","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T20:08:25Z","timestamp":1539634105000},"page":"168-177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Structural mapping of hot spots within human CASPR2 discoidin domain for autoantibody recognition"],"prefix":"10.1016","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6341-9277","authenticated-orcid":false,"given":"Wenjun","family":"Liang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaux","family":"Saint-Martin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelly","family":"Noraz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Honnorat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2018.09.012_bib1","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nrneurol.2017.43","article-title":"The value of LGI1, Caspr2 and voltage-gated potassium channel antibodies in encephalitis","volume":"13","author":"Van Sonderen","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jaut.2018.09.012_bib2","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1111\/ejn.13212","article-title":"Neuronal central nervous system syndromes probably mediated by autoantibodies","volume":"43","author":"Chefdeville","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jaut.2018.09.012_bib3","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1055\/s-0034-1390394","article-title":"Neuronal surface antibody-mediated autoimmune encephalitis","volume":"34","author":"Linnoila","year":"2014","journal-title":"Semin. Neurol."},{"key":"10.1016\/j.jaut.2018.09.012_bib4","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1093\/brain\/awq213","article-title":"Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia","volume":"133","author":"Irani","year":"2010","journal-title":"Brain"},{"key":"10.1016\/j.jaut.2018.09.012_bib5","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S1474-4422(10)70137-X","article-title":"Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series","volume":"9","author":"Lai","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jaut.2018.09.012_bib6","doi-asserted-by":"crossref","first-page":"S277","DOI":"10.1097\/JTO.0b013e3181f23f04","article-title":"Caspr2 antibodies in patients with thymomas","volume":"5","author":"Vincent","year":"2010","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.jaut.2018.09.012_bib7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/jnnp-2011-301506","article-title":"Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia","volume":"83","author":"Becker","year":"2012","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jaut.2018.09.012_bib8","doi-asserted-by":"crossref","first-page":"e371","DOI":"10.1212\/NXI.0000000000000371","article-title":"Autoimmune episodic ataxia in patients with anti-CASPR2 antibody-associated encephalitis","volume":"4","author":"Joubert","year":"2017","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.jaut.2018.09.012_bib9","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1212\/WNL.0b013e3182698cab","article-title":"Chronic pain as a manifestation of potassium channel-complex autoimmunity","volume":"79","author":"Klein","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.jaut.2018.09.012_bib10","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/jns.12089","article-title":"Guillain-Barre syndrome associated with CASPR2 antibodies: two paediatric cases","volume":"19","author":"Rosch","year":"2014","journal-title":"J. Peripher. Nerv. Syst."},{"key":"10.1016\/j.jaut.2018.09.012_bib11","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1038\/mp.2016.165","article-title":"Caspr2-reactive antibody cloned from a mother of an ASD child mediates an ASD-like phenotype in mice","volume":"21","author":"Brimberg","year":"2016","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.jaut.2018.09.012_bib12","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1212\/WNL.0000000000002547","article-title":"Orthostatic myoclonus associated with Caspr2 antibodies","volume":"86","author":"Govert","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.jaut.2018.09.012_bib13","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1111\/epi.12405","article-title":"Autoantibodies to neuronal antigens in children with new-onset seizures classified according to the revised ILAE organization of seizures and epilepsies","volume":"54","author":"Suleiman","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.jaut.2018.09.012_bib14","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/epi.13356","article-title":"Neuronal antibodies in pediatric epilepsy: clinical features and long-term outcomes of a historical cohort not treated with immunotherapy","volume":"57","author":"Wright","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.jaut.2018.09.012_bib15","doi-asserted-by":"crossref","first-page":"344","DOI":"10.5152\/npa.2016.15932","article-title":"Brain infiltration of immune cells in CASPR2-antibody associated mesial temporal lobe epilepsy with hippocampal sclerosis","volume":"53","author":"Unverengil","year":"2016","journal-title":"Noro Psikiyatr Ars"},{"key":"10.1016\/j.jaut.2018.09.012_bib16","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jocn.2017.02.063","article-title":"Isaacs syndrome with CASPR2 antibody: a series of three cases","volume":"41","author":"Song","year":"2017","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.jaut.2018.09.012_bib17","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.eplepsyres.2016.12.006","article-title":"Investigation of neuronal auto-antibodies in systemic lupus erythematosus patients with epilepsy","volume":"129","author":"Karaaslan","year":"2017","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.jaut.2018.09.012_bib18","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1001\/jamaneurol.2016.1585","article-title":"Characterization of a subtype of autoimmune encephalitis with anti-contactin-associated protein-like 2 antibodies in the cerebrospinal fluid, prominent limbic symptoms, and seizures","volume":"73","author":"Joubert","year":"2016","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.jaut.2018.09.012_bib19","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0896-6273(00)81049-1","article-title":"Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels","volume":"24","author":"Poliak","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.jaut.2018.09.012_bib20","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cell.2017.10.024","article-title":"Synaptic neurexin complexes: a molecular code for the logic of neural circuits","volume":"171","author":"Sudhof","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2018.09.012_bib21","doi-asserted-by":"crossref","first-page":"18120","DOI":"10.1073\/pnas.1216398109","article-title":"Candidate autism gene screen identifies critical role for cell-adhesion molecule CASPR2 in dendritic arborization and spine development","volume":"109","author":"Anderson","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jaut.2018.09.012_bib22","doi-asserted-by":"crossref","first-page":"6176","DOI":"10.1073\/pnas.1423205112","article-title":"Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2\/Caspr2 knockout neurons","volume":"112","author":"Varea","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jaut.2018.09.012_bib23","article-title":"The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: an In Vivo Mouse Study","volume":"10","author":"Gdalyahu","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.jaut.2018.09.012_bib24","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1056\/NEJMoa052773","article-title":"Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2","volume":"354","author":"Strauss","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jaut.2018.09.012_bib25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ajhg.2007.09.017","article-title":"Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders","volume":"82","author":"Bakkaloglu","year":"2008","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.jaut.2018.09.012_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0888-7543(03)00097-1","article-title":"CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder","volume":"82","author":"Verkerk","year":"2003","journal-title":"Genomics"},{"key":"10.1016\/j.jaut.2018.09.012_bib27","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1111\/ejn.14081","article-title":"Contactin-associated protein-like 2, a protein of the neurexin family involved in several human diseases","volume":"48","author":"Saint-Martin","year":"2018","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.jaut.2018.09.012_bib28","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.cell.2011.08.040","article-title":"Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits","volume":"147","author":"Penagarikano","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2018.09.012_bib29","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1093\/emboj\/16.5.978","article-title":"Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions","volume":"16","author":"Peles","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.jaut.2018.09.012_bib30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000371594","article-title":"Connecting the CNTNAP2 networks with neurodevelopmental disorders","volume":"6","author":"Poot","year":"2015","journal-title":"Mol. Syndromol."},{"key":"10.1016\/j.jaut.2018.09.012_bib31","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s12974-016-0678-4","article-title":"Mapping autoantigen epitopes: molecular insights into autoantibody-associated disorders of the nervous system","volume":"13","author":"Sinmaz","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.jaut.2018.09.012_bib32","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3389\/fncel.2015.00265","article-title":"Inhibitory axons are targeted in hippocampal cell culture by anti-Caspr2 autoantibodies associated with limbic encephalitis","volume":"9","author":"Pinatel","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.jaut.2018.09.012_bib33","doi-asserted-by":"crossref","first-page":"e127","DOI":"10.1212\/NXI.0000000000000127","article-title":"Caspr2 autoantibodies target multiple epitopes","volume":"2","author":"Olsen","year":"2015","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.jaut.2018.09.012_bib34","doi-asserted-by":"crossref","first-page":"24133","DOI":"10.1074\/jbc.M116.748236","article-title":"Molecular architecture of contactin-associated protein-like 2 (CNTNAP2) and its interaction with contactin 2 (CNTN2)","volume":"291","author":"Lu","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jaut.2018.09.012_bib35","doi-asserted-by":"crossref","first-page":"5788","DOI":"10.1074\/jbc.M115.705681","article-title":"Structural characterization of the extracellular domain of CASPR2 and insights into its association with the novel ligand Contactin1","volume":"291","author":"Rubio-Marrero","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jaut.2018.09.012_bib36","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.pep.2008.08.004","article-title":"BacMam system for high-level expression of recombinant soluble and membrane glycoproteins for structural studies","volume":"62","author":"Dukkipati","year":"2008","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.jaut.2018.09.012_bib37","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.cell.2010.07.040","article-title":"Structural basis of semaphorin-plexin recognition and viral mimicry from Sema7A and A39R complexes with PlexinC1","volume":"142","author":"Liu","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2018.09.012_bib38","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.jaut.2018.09.012_bib39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1107\/S0907444906045975","article-title":"Solving structures of protein complexes by molecular replacement with phaser","volume":"63","author":"McCoy","year":"2007","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.jaut.2018.09.012_bib40","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/46594","article-title":"Crystal structures of the membrane-binding C2 domain of human coagulation factor V","volume":"402","author":"Macedo-Ribeiro","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2018.09.012_bib41","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: a comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.jaut.2018.09.012_bib42","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.jaut.2018.09.012_bib43","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1107\/S0907444909042073","article-title":"MolProbity: all-atom structure validation for macromolecular crystallography","volume":"66","author":"Chen","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.jaut.2018.09.012_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002829","article-title":"Reliable B cell epitope predictions: impacts of method development and improved benchmarking","volume":"8","author":"Kringelum","year":"2012","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.jaut.2018.09.012_bib45","doi-asserted-by":"crossref","first-page":"W545","DOI":"10.1093\/nar\/gkq366","article-title":"Dali server: conservation mapping in 3D","volume":"38","author":"Holm","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jaut.2018.09.012_bib46","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"Clustal W and clustal X version 2.0","volume":"23","author":"Larkin","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaut.2018.09.012_bib47","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1093\/bioinformatics\/15.4.305","article-title":"ESPript: analysis of multiple sequence alignments in PostScript","volume":"15","author":"Gouet","year":"1999","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaut.2018.09.012_bib48","doi-asserted-by":"crossref","first-page":"W344","DOI":"10.1093\/nar\/gkw408","article-title":"ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules","volume":"44","author":"Ashkenazy","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jaut.2018.09.012_bib49","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1107\/S0907444910045749","article-title":"Overview of the CCP4 suite and current developments","volume":"67","author":"Winn","year":"2011","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.jaut.2018.09.012_bib50","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1093\/hmg\/dds320","article-title":"Inherited genetic variants in autism-related CNTNAP2 show perturbed trafficking and ATF6 activation","volume":"21","author":"Falivelli","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jaut.2018.09.012_bib51","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0022-2836(68)90205-2","article-title":"Solvent content of protein crystals","volume":"33","author":"Matthews","year":"1968","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.jaut.2018.09.012_bib52","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1016\/j.str.2009.10.012","article-title":"Crystallographic insight into collagen recognition by discoidin domain receptor 2","volume":"17","author":"Carafoli","year":"2009","journal-title":"Structure"},{"key":"10.1016\/j.jaut.2018.09.012_bib53","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1182\/blood.V98.1.13","article-title":"Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII","volume":"98","author":"Spiegel","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2018.09.012_bib54","doi-asserted-by":"crossref","first-page":"416","DOI":"10.9734\/BJMMR\/2014\/6135","article-title":"Potential autoepitope within the extracellular region of contactin-associated protein-like 2 in mice","volume":"4","author":"Obregon","year":"2014","journal-title":"Br. J. Med. Med. Res."},{"key":"10.1016\/j.jaut.2018.09.012_bib55","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41467-017-02414-2","article-title":"Structural basis of SALM5-induced PTP\u00ce' dimerization for synaptic differentiation","volume":"9","author":"Lin","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2018.09.012_bib56","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.1546293","article-title":"Structural evidence for induced fit as a mechanism for antibody-antigen recognition","volume":"255","author":"Rini","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.jaut.2018.09.012_bib57","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nri976","article-title":"The autoantibody repertoire: searching for order","volume":"3","author":"Plotz","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2018.09.012_bib58","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.molimm.2009.08.022","article-title":"Structural determinants of GAD antigenicity","volume":"47","author":"Arafat","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jaut.2018.09.012_bib59","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1136\/jnnp-2016-315251","article-title":"CASPR2 autoantibodies are raised during pregnancy in mothers of children with mental retardation and disorders of psychological development but not autism","volume":"88","author":"Coutinho","year":"2017","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jaut.2018.09.012_bib60","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.bbapap.2015.02.008","article-title":"Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes","volume":"1854","author":"Chen","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.jaut.2018.09.012_bib61","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1083\/jcb.200305078","article-title":"Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers","volume":"162","author":"Traka","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.jaut.2018.09.012_bib62","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/ana.25120","article-title":"Mechanisms of Caspr2 antibodies in autoimmune encephalitis and neuromyotonia","volume":"83","author":"Patterson","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jaut.2018.09.012_bib63","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.nrl.2013.12.007","article-title":"Clinical spectrum and diagnostic value of antibodies against the potassium channel related protein complex","volume":"30","author":"Montojo","year":"2015","journal-title":"Neurologia"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841118302944?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841118302944?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:19:52Z","timestamp":1760257192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841118302944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":63,"alternative-id":["S0896841118302944"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2018.09.012","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural mapping of hot spots within human CASPR2 discoidin domain for autoantibody recognition","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2018.09.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}