{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:21:44Z","timestamp":1788618104408,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012295","name":"Newcastle NIHR Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012295","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012295","name":"Newcastle Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012295","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000774","name":"Newcastle University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.jaut.2019.06.009","type":"journal-article","created":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T10:06:13Z","timestamp":1562234773000},"page":"102298","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"special_numbering":"C","title":["Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study"],"prefix":"10.1016","volume":"105","author":[{"given":"Kenneth F.","family":"Baker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Skelton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis W.","family":"Lendrem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Scadeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur G.","family":"Pratt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Isaacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2019.06.009_bib1","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1136\/annrheumdis-2016-210715","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update","volume":"76","author":"Smolen","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2019.06.009_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/annrheumdis-2015-207524","article-title":"Treating rheumatoid arthritis to target: 2014 update of the recommendations of an international task force","volume":"75","author":"Smolen","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2019.06.009_bib3","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1093\/rheumatology\/kew479","article-title":"BSR and BHPR guideline for the prescription and monitoring of non-biologic disease-modifying anti-rheumatic drugs","volume":"56","author":"Ledingham","year":"2017","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2019.06.009_bib4","first-page":"1","article-title":"2015 American College of rheumatology guideline for the treatment of rheumatoid arthritis","volume":"68","author":"Singh","year":"2016","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2019.06.009_bib5","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/art.24661","article-title":"Prevalence of and predictive factors for sustained disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: Results from two large early arthritis cohorts","volume":"60","author":"van der Woude","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2019.06.009_bib6","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1136\/annrheumdis-2014-207080","article-title":"Disease-modifying antirheumatic drug-free sustained remission in rheumatoid arthritis: An increasingly achievable outcome with subsidence of disease symptoms","volume":"75","author":"Ajeganova","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2019.06.009_bib7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1136\/ard.2010.136556","article-title":"Discontinuing treatment in patients with rheumatoid arthritis in sustained clinical remission: Exploratory analyses from the BeSt study","volume":"70","author":"Klarenbeek","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2019.06.009_bib8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1136\/annrheumdis-2014-206439","article-title":"Relapse rates in patients with rheumatoid arthritis in stable remission tapering or stopping antirheumatic therapy: Interim results from the prospective randomised controlled RETRO study","volume":"75","author":"Haschka","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2019.06.009_bib9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0140-6736(96)90535-8","article-title":"Randomised placebo-controlled study of stopping second-line drugs in rheumatoid arthritis","volume":"347","author":"ten Wolde","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2019.06.009_bib10","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1093\/rheumatology\/ket416","article-title":"It's like a juggling act: Rheumatoid arthritis patient perspectives on daily life and flare while on current treatment regimes","volume":"53","author":"Flurey","year":"2014","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2019.06.009_bib11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/rheumatology\/keq455","article-title":"'I'm hurting, I want to kill myself': Rheumatoid arthritis flare is more than a high joint count--an international patient perspective on flare where medical help is sought","volume":"51","author":"Hewlett","year":"2012","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2019.06.009_bib12","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s13075-015-0730-2","article-title":"Disease flares in rheumatoid arthritis are associated with joint damage progression and disability: 10-year results from the BeSt study","volume":"17","author":"Markusse","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2019.06.009_bib13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13075-016-0986-1","article-title":"Self-reported flares are predictors of radiographic progression in rheumatoid arthritis patients in 28-joint disease activity score remission: A 24-month observational study","volume":"18","author":"Ometto","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2019.06.009_bib14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/art.30129","article-title":"American College of Rheumatology\/European League against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials","volume":"63","author":"Felson","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2019.06.009_bib15","first-page":"10","article-title":"Development and validation of the DAS28 using CRP","volume":"62","author":"Fransen","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2019.06.009_bib16","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1136\/annrheumdis-2013-204920","article-title":"How much does Disease Activity Score in 28 joints ESR and CRP calculations underestimate disease activity compared with the Simplified Disease Activity Index?","volume":"74","author":"Fleischmann","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2019.06.009_bib17","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/art.24646","article-title":"Evaluation of a novel 7-joint ultrasound score in daily rheumatologic practice: A pilot project","volume":"61","author":"Backhaus","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2019.06.009_bib18","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/art.20939","article-title":"A novel ultrasonographic synovitis scoring system suitable for analyzing finger joint inflammation in rheumatoid arthritis","volume":"52","author":"Scheel","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2019.06.009_bib19","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/art.10877","article-title":"Interobserver agreement in ultrasonography of the finger and toe joints in rheumatoid arthritis","volume":"48","author":"Szkudlarek","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2019.06.009_bib20","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1136\/ard.2011.152926","article-title":"Examination of intra and interrater reliability with a new ultrasonographic reference atlas for scoring of synovitis in patients with rheumatoid arthritis","volume":"70","author":"Hammer","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2019.06.009_bib21","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1136\/annrheumdis-2011-200968","article-title":"A CD4 T cell gene signature for early rheumatoid arthritis implicates interleukin 6-mediated STAT3 signalling, particularly in anti-citrullinated peptide antibody-negative disease","volume":"71","author":"Pratt","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2019.06.009_bib22","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jaut.2019.06.009_bib23","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.jaut.2019.06.009_bib24","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1101\/gr.135350.111","article-title":"GENCODE: The reference human genome annotation for the ENCODE Project","volume":"22","author":"Harrow","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.jaut.2019.06.009_bib25","series-title":"A Language and Environment for Statistical Computing","year":"2016"},{"key":"10.1016\/j.jaut.2019.06.009_bib26","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.12688\/f1000research.7563.1","article-title":"Differential analyses for RNA-seq: Transcript-level estimates improve gene-level inferences","volume":"4","author":"Soneson","year":"2015","journal-title":"F1000Res"},{"key":"10.1016\/j.jaut.2019.06.009_bib27","doi-asserted-by":"crossref","first-page":"D710","DOI":"10.1093\/nar\/gkv1157","article-title":"Ensembl 2016","volume":"44","author":"Yates","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jaut.2019.06.009_bib28","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/nprot.2009.97","article-title":"Mapping identifiers for the integration of genomic datasets with the R\/Bioconductor package biomaRt","volume":"4","author":"Durinck","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.jaut.2019.06.009_bib29","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"voom: Precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.jaut.2019.06.009_bib30","author":"Therneau"},{"key":"10.1016\/j.jaut.2019.06.009_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/oxfordjournals.aje.a115101","article-title":"The impact of confounder selection criteria on effect estimation","volume":"129","author":"Mickey","year":"1989","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.jaut.2019.06.009_bib32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/ije\/7.4.373","article-title":"An improper use of statistical significance testing in studying covariables","volume":"7","author":"Dales","year":"1978","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.jaut.2019.06.009_bib33","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: An open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.jaut.2019.06.009_bib34","author":"Kassambara"},{"key":"10.1016\/j.jaut.2019.06.009_bib35","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2019.06.009_bib36","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1136\/annrheumdis-2016-209201","article-title":"Tapering biologic and conventional DMARD therapy in rheumatoid arthritis: Current evidence and future directions","volume":"75","author":"Schett","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2019.06.009_bib37","first-page":"S4","article-title":"Can we discontinue synthetic disease-modifying anti-rheumatic drugs in rheumatoid arthritis?","volume":"31","author":"Scott","year":"2013","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.jaut.2019.06.009_bib38","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.semarthrit.2018.09.008","article-title":"Therapeutic tolerance in autoimmune disease","volume":"48","author":"Rayner","year":"2018","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.jaut.2019.06.009_bib39","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1136\/annrheumdis-2016-209272","article-title":"Tapering conventional synthetic DMARDs in patients with early arthritis in sustained remission: 2-year follow-up of the tREACH trial","volume":"75","author":"Kuijper","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2019.06.009_bib40","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.3899\/jrheum.111341","article-title":"Remission in early rheumatoid arthritis -- a comparison of new ACR\/EULAR remission criteria to established criteria","volume":"39","author":"Kuriya","year":"2012","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.jaut.2019.06.009_bib41","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3899\/jrheum.111543","article-title":"Validity and reliability problems with patient global as a component of the ACR\/EULAR remission criteria as used in clinical practice","volume":"39","author":"Masri","year":"2012","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.jaut.2019.06.009_bib42","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1136\/annrheumdis-2012-201519","article-title":"Near misses of ACR\/EULAR criteria for remission: Effects of patient global assessment in Boolean and index-based definitions","volume":"71","author":"Studenic","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2019.06.009_bib43","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1093\/rheumatology\/ker425","article-title":"The provisional ACR\/EULAR definition of remission in RA: A comment on the patient global assessment criterion","volume":"51","author":"Vermeer","year":"2012","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2019.06.009_bib44","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-003554","article-title":"Long-term sustained remission in a cohort study of patients with rheumatoid arthritis: Choice of remission criteria","volume":"3","author":"Svensson","year":"2013","journal-title":"BMJ Open"},{"key":"10.1016\/j.jaut.2019.06.009_bib45","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1136\/annrheumdis-2012-201821","article-title":"Performance of the 2011 ACR\/EULAR preliminary remission criteria compared with DAS28 remission in unselected patients with rheumatoid arthritis","volume":"72","author":"Thiele","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2019.06.009_bib46","first-page":"e12","article-title":"Let's not fool ourselves","volume":"vol. 76","author":"Baker","year":"2017"},{"key":"10.1016\/j.jaut.2019.06.009_bib47","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/annrheumdis-2014-206106","article-title":"Evaluating drug-free remission with abatacept in early rheumatoid arthritis: Results from the phase 3b, multicentre, randomised, active-controlled AVERT study of 24 months, with a 12-month, double-blind treatment period","volume":"74","author":"Emery","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2019.06.009_bib48","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1007\/s10067-016-3413-8","article-title":"Optimizing therapy in inflammatory arthritis: Prediction of relapse after tapering or stopping treatment for rheumatoid arthritis patients achieving clinical and radiological remission","volume":"35","author":"El Miedany","year":"2016","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.jaut.2019.06.009_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060635","article-title":"Development of a multi-biomarker disease activity test for rheumatoid arthritis","volume":"8","author":"Centola","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2019.06.009_bib50","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1136\/annrheumdis-2015-207900","article-title":"Prediction of disease relapses by multibiomarker disease activity and autoantibody status in patients with rheumatoid arthritis on tapering DMARD treatment","volume":"75","author":"Rech","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2019.06.009_bib51","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/sji.12209","article-title":"Association of single nucleotide polymorphisms in the IL27 gene with rheumatoid arthritis","volume":"80","author":"Paradowska-Gorycka","year":"2014","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.jaut.2019.06.009_bib52","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/art.30180","article-title":"Increased levels of interleukin-27 in patients with rheumatoid arthritis","volume":"63","author":"Shen","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2019.06.009_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21111565","article-title":"Circulating IL-27 is elevated in rheumatoid arthritis patients","volume":"21","author":"Lai","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.jaut.2019.06.009_bib54","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cyto.2011.04.020","article-title":"IL-27-producing CD14(+) cells infiltrate inflamed joints of rheumatoid arthritis and regulate inflammation and chemotactic migration","volume":"55","author":"Tanida","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.jaut.2019.06.009_bib55","doi-asserted-by":"crossref","DOI":"10.1186\/ar3067","article-title":"Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis","volume":"12","author":"Wong","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2019.06.009_bib56","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1136\/ard.2007.083360","article-title":"Interleukin 27 attenuates collagen-induced arthritis","volume":"67","author":"Niedbala","year":"2008","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2019.06.009_bib57","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1084\/jem.20132307","article-title":"Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis","volume":"212","author":"Jones","year":"2015","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jaut.2019.06.009_bib58","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1210\/me.2003-0202","article-title":"Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1","volume":"18","author":"Wang","year":"2004","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.jaut.2019.06.009_bib59","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/cr.2013.33","article-title":"Early estrogen-induced gene 1, a novel RANK signaling component, is essential for osteoclastogenesis","volume":"23","author":"Choi","year":"2013","journal-title":"Cell Res."},{"key":"10.1016\/j.jaut.2019.06.009_bib60","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.gene.2010.08.006","article-title":"Identification of novel families and classification of the C2 domain superfamily elucidate the origin and evolution of membrane targeting activities in eukaryotes","volume":"469","author":"Zhang","year":"2010","journal-title":"Gene"},{"key":"10.1016\/j.jaut.2019.06.009_bib61","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/BF00201545","article-title":"Two human genes encoding zinc finger proteins, ZNF 12 (KOX 3) and ZNF 26 (KOX 20), map to chromosome 7p22-p21 and 12q24.33, respectively","volume":"86","author":"Seite","year":"1991","journal-title":"Hum. Genet."},{"key":"10.1016\/j.jaut.2019.06.009_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2016.10.017","article-title":"A functional Genomics approach to understand variation in cytokine production in humans","volume":"167","author":"Li","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2019.06.009_bib63","doi-asserted-by":"crossref","first-page":"D754","DOI":"10.1093\/nar\/gkx1098","article-title":"Ensembl 2018","volume":"46","author":"Zerbino","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jaut.2019.06.009_bib64","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s13075-017-1378-x","article-title":"Identification of differential co-expressed gene networks in early rheumatoid arthritis achieving sustained drug-free remission after treatment with a tocilizumab-based or methotrexate-based strategy","volume":"19","author":"Teitsma","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2019.06.009_bib65","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1136\/annrheumdis-2018-eular.2775","article-title":"OP0043\u2005Predictors of drug-free remission in rheumatoid arthritis: Results from the prospective biomarkers of remission in rheumatoid arthritis(BIORRA) study [abstract]","volume":"77","author":"Baker","year":"2018","journal-title":"Ann. Rheum. Dis."}],"updated-by":[{"DOI":"10.1016\/j.jaut.2022.102913","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000}}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841119301969?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841119301969?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:24:20Z","timestamp":1760257460000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841119301969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":65,"alternative-id":["S0896841119301969"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2019.06.009","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predicting drug-free remission in rheumatoid arthritis: A prospective interventional cohort study","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2019.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102298"}}