{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T15:36:06Z","timestamp":1790004966314,"version":"4.0.1"},"reference-count":183,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.jaut.2020.102438","type":"journal-article","created":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T08:35:55Z","timestamp":1584174955000},"page":"102438","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":106,"special_numbering":"C","title":["Clinical significance of miRNAs in autoimmunity"],"prefix":"10.1016","volume":"109","author":[{"given":"Lian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianjin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2020.102438_bib1","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-Y","article-title":"The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14","volume":"75","author":"Lee","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2020.102438_bib2","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1471-4159.2012.07925.x","article-title":"Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin","volume":"123","author":"Jin","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.jaut.2020.102438_bib3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/1471-2105-15-255","article-title":"Inferring the perturbed microRNA regulatory networks from gene expression data using a network propagation based method","volume":"15","author":"Wang","year":"2014","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.jaut.2020.102438_bib4","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1177\/0300985813502820","article-title":"MicroRNAs: history, biogenesis, and their evolving role in animal development and disease","volume":"51","author":"Bhaskaran","year":"2014","journal-title":"Veterinary pathology"},{"key":"10.1016\/j.jaut.2020.102438_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2015.05.001","article-title":"An overview of microRNAs","volume":"87","author":"Hammond","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jaut.2020.102438_bib6","doi-asserted-by":"crossref","first-page":"D140","DOI":"10.1093\/nar\/gkj112","article-title":"miRBase: microRNA sequences, targets and gene nomenclature","volume":"34","author":"Griffiths-Jones","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jaut.2020.102438_bib7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nri.2016.40","article-title":"MicroRNAs as regulatory elements in immune system logic","volume":"16","author":"Mehta","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib8","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12943-018-0765-5","article-title":"Nuclear functions of mammalian MicroRNAs in gene regulation, immunity and cancer","volume":"17","author":"Liu","year":"2018","journal-title":"Mol. Canc."},{"key":"10.1016\/j.jaut.2020.102438_bib9","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/cmi.2017.7","article-title":"miRNAs: Novel regulators of autoimmunity-mediated pancreatic beta-cell destruction in type 1 diabetes","volume":"14","author":"Zheng","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib10","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1136\/ard.2010.139857","article-title":"Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression","volume":"70","author":"Stagakis","year":"2011","journal-title":"Ann. Rheumatic Dis."},{"key":"10.1016\/j.jaut.2020.102438_bib11","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1136\/annrheumdis-2013-204377","article-title":"Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis","volume":"74","author":"Zhou","year":"2015","journal-title":"Ann. Rheumatic Dis."},{"key":"10.1016\/j.jaut.2020.102438_bib12","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/s41423-019-0319-9","article-title":"Exosomal microRNA in autoimmunity","volume":"16","author":"Duan","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib13","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s12016-015-8502-y","article-title":"Epigenetics and primary biliary cirrhosis: a comprehensive review and implications for autoimmunity","volume":"50","author":"Xie","year":"2016","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/rheumatology\/kex412","article-title":"Unchanging premature mortality trends in systemic lupus erythematosus: a general population-based study (1999-2014)","volume":"57","author":"Jorge","year":"2018","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2020.102438_bib15","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.jaci.2016.10.055","article-title":"Shared genetic variants suggest common pathways in allergy and autoimmune diseases","volume":"140","author":"Kreiner","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib16","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/cmi.2018.7","article-title":"The microbiome and autoimmunity: a paradigm from the gut-liver axis","volume":"15","author":"Li","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s12016-009-8169-3","article-title":"The role of epigenetics in aging and autoimmunity","volume":"39","author":"Grolleau-Julius","year":"2010","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib18","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1053\/j.gastro.2014.04.022","article-title":"Genome-wide association study identifies variants associated with autoimmune hepatitis type 1","volume":"147","author":"de Boer","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2020.102438_bib19","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1136\/annrheumdis-2012-202675","article-title":"Ethnic specificity of lupus-associated loci identified in a genome-wide association study in Korean women","volume":"73","author":"Lee","year":"2014","journal-title":"Ann. Rheumatic Dis."},{"key":"10.1016\/j.jaut.2020.102438_bib20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jaut.2017.04.003","article-title":"The epigenetic mechanism for discordance of autoimmunity in monozygotic twins","volume":"83","author":"Xiang","year":"2017","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2020.102438_bib21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s12016-016-8592-1","article-title":"Beyond genetics: what causes type 1 diabetes","volume":"52","author":"Wang","year":"2017","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib22","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1126\/science.1063206","article-title":"Nuclear cloning and epigenetic reprogramming of the genome","volume":"293","author":"Rideout","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.jaut.2020.102438_bib23","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S1470-2045(09)70343-2","article-title":"Relation between microRNA expression and progression and prognosis of gastric cancer: a microRNA expression analysis","volume":"11","author":"Ueda","year":"2010","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.jaut.2020.102438_bib24","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1007\/s00018-016-2167-4","article-title":"Contribution of MicroRNAs to autoimmune diseases","volume":"73","author":"Garo","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jaut.2020.102438_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2013.01.010","article-title":"The critical importance of epigenetics in autoimmunity","volume":"41","author":"Lu","year":"2013","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2020.102438_bib26","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41586-018-0253-5","article-title":"Induction of innate immune memory via microRNA targeting of chromatin remodelling factors","volume":"559","author":"Seeley","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2020.102438_bib27","doi-asserted-by":"crossref","first-page":"ra29","DOI":"10.1126\/scisignal.2000594","article-title":"Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation","volume":"3","author":"Poliseno","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.jaut.2020.102438_bib28","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.cell.2008.02.019","article-title":"Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters","volume":"132","author":"Ventura","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2020.102438_bib29","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature01957","article-title":"The nuclear RNase III Drosha initiates microRNA processing","volume":"425","author":"Lee","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2020.102438_bib30","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1126\/science.1178705","article-title":"A high-resolution structure of the pre-microRNA nuclear export machinery","volume":"326","author":"Okada","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jaut.2020.102438_bib31","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/s41556-019-0345-y","article-title":"An ARF6-Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles","volume":"21","author":"Clancy","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.jaut.2020.102438_bib32","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.cell.2012.09.027","article-title":"Dicer partner proteins tune the length of mature miRNAs in flies and mammals","volume":"151","author":"Fukunaga","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2020.102438_bib33","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.cell.2018.02.051","article-title":"Phase transitions in the assembly and function of human miRISC","volume":"173","author":"Sheu-Gruttadauria","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2020.102438_bib34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev-biophys-083012-130404","article-title":"Molecular mechanisms of RNA interference","volume":"42","author":"Wilson","year":"2013","journal-title":"Annu. Rev. Biophys."},{"key":"10.1016\/j.jaut.2020.102438_bib35","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1093\/nar\/gkt1318","article-title":"Discovery and visualization of miRNA-mRNA functional modules within integrated data using bicluster analysis","volume":"42","author":"Bryan","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jaut.2020.102438_bib36","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1101\/gad.1706508","article-title":"Chromatin structure analyses identify miRNA promoters","volume":"22","author":"Ozsolak","year":"2008","journal-title":"Genes Dev."},{"key":"10.1016\/j.jaut.2020.102438_bib37","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1261\/rna.1947110","article-title":"Systematic comparison of microarray profiling, real-time PCR, and next-generation sequencing technologies for measuring differential microRNA expression","volume":"16","author":"Git","year":"2010","journal-title":"RNA (New York, N.Y.)"},{"key":"10.1016\/j.jaut.2020.102438_bib38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ygeno.2013.03.008","article-title":"Next-generation sequencing and microarray-based interrogation of microRNAs from formalin-fixed, paraffin-embedded tissue: preliminary assessment of cross-platform concordance","volume":"102","author":"Kelly","year":"2013","journal-title":"Genomics"},{"key":"10.1016\/j.jaut.2020.102438_bib39","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/978-1-61779-427-8_15","article-title":"Profiling of short RNAs using Helicos single-molecule sequencing","volume":"822","author":"Kapranov","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jaut.2020.102438_bib40","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-1-60761-663-4_5","article-title":"Profiling microRNA expression with the Illumina BeadChip platform","volume":"632","author":"Tsao","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jaut.2020.102438_bib41","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1261\/rna.036475.112","article-title":"Differences in microRNA detection levels are technology and sequence dependent","volume":"19","author":"Leshkowitz","year":"2013","journal-title":"RNA (New York, N.Y.)"},{"key":"10.1016\/j.jaut.2020.102438_bib42","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/s12859-019-3050-8","article-title":"Automatic discovery of 100-miRNA signature for cancer classification using ensemble feature selection","volume":"20","author":"Lopez-Rincon","year":"2019","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.jaut.2020.102438_bib43","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nrg3198","article-title":"MicroRNA profiling: approaches and considerations","volume":"13","author":"Pritchard","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jaut.2020.102438_bib44","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/14737159.2017.1268533","article-title":"NanoString, a novel digital color-coded barcode technology: current and future applications in molecular diagnostics","volume":"17","author":"Tsang","year":"2017","journal-title":"Expert Rev. Mol. Diagn."},{"key":"10.1016\/j.jaut.2020.102438_bib45","doi-asserted-by":"crossref","DOI":"10.3390\/ncrna3030022","article-title":"miR-146 and miR-155: two key modulators of immune response and tumor development","volume":"3","author":"Testa","year":"2017","journal-title":"Non-coding RNA"},{"key":"10.1016\/j.jaut.2020.102438_bib46","first-page":"376","article-title":"The role of miR-146a on NF-kappaB expression level in human umbilical vein endothelial cells under hyperglycemic condition","volume":"117","author":"Kamali","year":"2016","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.jaut.2020.102438_bib47","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1182\/blood-2016-02-697003","article-title":"miR-125b controls monocyte adaptation to inflammation through mitochondrial metabolism and dynamics","volume":"128","author":"Duroux-Richard","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2020.102438_bib48","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jneuroim.2018.06.010","article-title":"MicroRNA-150 targets PU.1 and regulates macrophage differentiation and function in experimental autoimmune encephalomyelitis","volume":"323","author":"Shakerian","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jaut.2020.102438_bib49","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1080\/14728222.2018.1535594","article-title":"Let-7 microRNA as a potential therapeutic target with implications for immunotherapy","volume":"22","author":"Gilles","year":"2018","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.jaut.2020.102438_bib50","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1182\/blood-2008-09-179150","article-title":"MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation","volume":"114","author":"Hashimi","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2020.102438_bib51","doi-asserted-by":"crossref","first-page":"4373","DOI":"10.1038\/onc.2008.72","article-title":"MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene","volume":"27","author":"Lu","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.jaut.2020.102438_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106153","article-title":"MicroRNA-29b modulates innate and antigen-specific immune responses in mouse models of autoimmunity","volume":"9","author":"Salama","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.jaut.2020.102438_bib53","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.4049\/jimmunol.0903021","article-title":"miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation","volume":"184","author":"Jurkin","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib54","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1073\/pnas.0811073106","article-title":"MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells","volume":"106","author":"Ceppi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jaut.2020.102438_bib55","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1002\/JLB.3MR0218-079R","article-title":"MicroRNA miR-223 as regulator of innate immunity","volume":"104","author":"Yuan","year":"2018","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jaut.2020.102438_bib56","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1016\/j.celrep.2018.10.074","article-title":"Activation of miR-21-regulated pathways in immune aging selects against signatures characteristic of memory T cells","volume":"25","author":"Kim","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jaut.2020.102438_bib57","doi-asserted-by":"crossref","first-page":"18561","DOI":"10.1073\/pnas.1905221116","article-title":"Phenotypical microRNA screen reveals a noncanonical role of CDK2 in regulating neutrophil migration","volume":"116","author":"Hsu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jaut.2020.102438_bib58","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fimmu.2019.00085","article-title":"Cell type-specific roles of NF-kappaB linking inflammation and thrombosis","volume":"10","author":"Mussbacher","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib59","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.1073\/pnas.0902636106","article-title":"Inositol phosphatase SHIP1 is a primary target of miR-155","volume":"106","author":"O'Connell","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jaut.2020.102438_bib60","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/imm.12227","article-title":"Role of miR-155 in the regulation of lymphocyte immune function and disease","volume":"142","author":"Seddiki","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.jaut.2020.102438_bib61","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/imr.12061","article-title":"MicroRNA regulation of T-cell differentiation and function","volume":"253","author":"Jeker","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jaut.2020.102438_bib62","doi-asserted-by":"crossref","first-page":"12207","DOI":"10.1038\/ncomms12207","article-title":"Regulation of B-cell development and tolerance by different members of the miR-17 approximately 92 family microRNAs","volume":"7","author":"Lai","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2020.102438_bib63","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nri3494","article-title":"MicroRNA-mediated regulation of T helper cell differentiation and plasticity","volume":"13","author":"Baumjohann","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib64","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.immuni.2011.07.009","article-title":"MicroRNA-29 regulates T-box transcription factors and interferon-gamma production in helper T cells","volume":"35","author":"Steiner","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2020.102438_bib65","doi-asserted-by":"crossref","first-page":"e406","DOI":"10.1038\/bcj.2016.10","article-title":"miR-203 and miR-221 regulate SOCS1 and SOCS3 in essential thrombocythemia","volume":"6","author":"Navarro","year":"2016","journal-title":"Blood Canc. J."},{"key":"10.1016\/j.jaut.2020.102438_bib66","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1172\/JCI97426","article-title":"MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation","volume":"128","author":"Wu","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2020.102438_bib67","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1038\/s41467-018-05196-3","article-title":"Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b","volume":"9","author":"Cho","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2020.102438_bib68","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1182\/blood-2011-12-398099","article-title":"miR-155 regulates IFN-gamma production in natural killer cells","volume":"119","author":"Trotta","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2020.102438_bib69","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.immuni.2016.01.003","article-title":"MicroRNAs 24 and 27 suppress allergic inflammation and target a network of regulators of T helper 2 cell-associated cytokine production","volume":"44","author":"Pua","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2020.102438_bib70","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.cell.2010.08.012","article-title":"Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses","volume":"142","author":"Lu","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2020.102438_bib71","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1182\/blood-2017-06-789321","article-title":"MicroRNA-17-92 is required for T-cell and B-cell pathogenicity in chronic graft-versus-host disease in mice","volume":"131","author":"Wu","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2020.102438_bib72","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3389\/fimmu.2018.01377","article-title":"Anti-inflammatory MicroRNAs and their potential for inflammatory diseases treatment","volume":"9","author":"Tahamtan","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib73","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.immuni.2016.05.015","article-title":"The MicroRNA-183-96-182 cluster promotes T helper 17 cell pathogenicity by negatively regulating transcription factor Foxo1 expression","volume":"44","author":"Ichiyama","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2020.102438_bib74","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1038\/ni.1798","article-title":"MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis","volume":"10","author":"Du","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib75","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.immuni.2014.03.014","article-title":"miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression","volume":"40","author":"Escobar","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2020.102438_bib76","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.39479","article-title":"miR-34a is a microRNA safeguard for Citrobacter-induced inflammatory colon oncogenesis","volume":"7","author":"Wang","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.jaut.2020.102438_bib77","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.clim.2016.10.017","article-title":"The expression of Bcl-6 in circulating follicular helper-like T cells positively correlates with the disease activity in systemic lupus erythematosus","volume":"173","author":"Huang","year":"2016","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib78","doi-asserted-by":"crossref","first-page":"38115","DOI":"10.1038\/srep38115","article-title":"Artemisinin analogue SM934 attenuate collagen-induced arthritis by suppressing T follicular helper cells and T helper 17 cells","volume":"6","author":"Lin","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jaut.2020.102438_bib79","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.immuni.2014.09.015","article-title":"miR-155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation","volume":"41","author":"Hu","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2020.102438_bib80","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.00537","article-title":"MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice","volume":"2","author":"Zhao","year":"2013","journal-title":"eLife"},{"key":"10.1016\/j.jaut.2020.102438_bib81","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/gene.2011.77","article-title":"Molecular mechanisms underlying the regulation and functional plasticity of FOXP3(+) regulatory T cells","volume":"13","author":"Gao","year":"2012","journal-title":"Gene Immun."},{"key":"10.1016\/j.jaut.2020.102438_bib82","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fimmu.2018.00057","article-title":"Effects of MicroRNA on regulatory T cells and implications for adoptive cellular therapy to ameliorate graft-versus-host disease","volume":"9","author":"Hippen","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib83","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/embor.2008.224","article-title":"miR-142-3p restricts cAMP production in CD4+CD25- T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA","volume":"10","author":"Huang","year":"2009","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jaut.2020.102438_bib84","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1172\/JCI78090","article-title":"MicroRNA regulation of lymphocyte tolerance and autoimmunity","volume":"125","author":"Simpson","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2020.102438_bib85","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4161\/15384101.2014.977112","article-title":"miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression","volume":"14","author":"Sun","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.jaut.2020.102438_bib86","doi-asserted-by":"crossref","first-page":"21629","DOI":"10.1073\/pnas.1016299107","article-title":"Dicer controls CD8+ T-cell activation, migration, and survival","volume":"107","author":"Zhang","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jaut.2020.102438_bib87","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.immuni.2012.12.006","article-title":"MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer","volume":"38","author":"Dudda","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2020.102438_bib88","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1038\/s41467-019-09882-8","article-title":"miR-155 harnesses Phf19 to potentiate cancer immunotherapy through epigenetic reprogramming of CD8(+) T cell fate","volume":"10","author":"Ji","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2020.102438_bib89","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.smim.2015.11.006","article-title":"Enhancing adoptive T cell immunotherapy with microRNA therapeutics","volume":"28","author":"Ji","year":"2016","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib90","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.3389\/fimmu.2018.02148","article-title":"Control of immunoregulatory molecules by miRNAs in T cell activation","volume":"9","author":"Rodriguez-Galan","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib91","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/cr.2014.121","article-title":"Tumor-secreted miR-214 induces regulatory T cells: a major link between immune evasion and tumor growth","volume":"24","author":"Yin","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.jaut.2020.102438_bib92","doi-asserted-by":"crossref","first-page":"3702","DOI":"10.1172\/JCI94012","article-title":"miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity","volume":"127","author":"Li","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2020.102438_bib93","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nri.2016.15","article-title":"Immune memory: sequential evolution of B cell memory","volume":"16","author":"Leavy","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib94","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2017.495","article-title":"Alternative mechanisms of miR-34a regulation in cancer","volume":"8","author":"Slabakova","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.jaut.2020.102438_bib95","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4049\/jimmunol.1101563","article-title":"BLIMP-1 and STAT3 counterregulate microRNA-21 during plasma cell differentiation","volume":"189","author":"Barnes","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib96","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1093\/intimm\/dxq042","article-title":"MicroRNA 125b inhibition of B cell differentiation in germinal centers","volume":"22","author":"Gururajan","year":"2010","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib97","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1002\/eji.201444633","article-title":"miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim","volume":"45","author":"Haftmann","year":"2015","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib98","article-title":"MicroRNA-155-at the critical interface of innate and adaptive immunity in arthritis","volume":"8","author":"Alivernini","year":"1932","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib99","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.immuni.2010.06.013","article-title":"MicroRNA-34a perturbs B lymphocyte development by repressing the forkhead box transcription factor Foxp1","volume":"33","author":"Rao","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2020.102438_bib100","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.cell.2007.07.021","article-title":"MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb","volume":"131","author":"Xiao","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2020.102438_bib101","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.4049\/jimmunol.0901278","article-title":"Hemokinin-1 activates the MAPK pathway and enhances B cell proliferation and antibody production","volume":"184","author":"Wang","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib102","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1182\/blood-2011-05-355412","article-title":"The RNase III enzyme Dicer is essential for germinal center B-cell formation","volume":"119","author":"Xu","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2020.102438_bib103","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12929-019-0558-1","article-title":"Regulatory mechanisms of B cell responses and the implication in B cell-related diseases","volume":"26","author":"Tsai","year":"2019","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.jaut.2020.102438_bib104","doi-asserted-by":"crossref","first-page":"936","DOI":"10.3389\/fimmu.2018.00936","article-title":"The function of MicroRNAs in B-cell development, lymphoma, and their potential in clinical practice","volume":"9","author":"Zheng","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib105","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1016\/S0140-6736(19)30237-5","article-title":"Management strategies and future directions for systemic lupus erythematosus in adults","volume":"393","author":"Durcan","year":"2019","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.jaut.2020.102438_bib106","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s12016-017-8640-5","article-title":"Unmet needs in the pathogenesis and treatment of systemic lupus erythematosus","volume":"55","author":"Bakshi","year":"2018","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib107","article-title":"Platelets and IgE: shaping the innate immune response in systemic lupus erythematosus","author":"Brilland","year":"2019","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib108","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/nm.2815","article-title":"The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-alpha","volume":"18","author":"Zhu","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.jaut.2020.102438_bib109","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1002\/art.10234","article-title":"Demethylation of ITGAL (CD11a) regulatory sequences in systemic lupus erythematosus","volume":"46","author":"Lu","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102438_bib110","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.4049\/jimmunol.179.9.6352","article-title":"Demethylation of CD40LG on the inactive X in T cells from women with lupus","volume":"179","author":"Lu","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib111","first-page":"4126106","article-title":"The involvement of MicroRNAs in modulation of innate and adaptive immunity in systemic lupus erythematosus and lupus nephritis","author":"Honarpisheh","year":"2018","journal-title":"Journal of immunology research"},{"key":"10.1016\/j.jaut.2020.102438_bib112","doi-asserted-by":"crossref","first-page":"6773","DOI":"10.4049\/jimmunol.0904060","article-title":"MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1","volume":"184","author":"Pan","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib113","doi-asserted-by":"crossref","first-page":"23910","DOI":"10.3390\/ijms141223910","article-title":"Rheumatoid arthritis-associated microRNA-155 targets SOCS1 and upregulates TNF-alpha and IL-1beta in PBMCs","volume":"14","author":"Li","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jaut.2020.102438_bib114","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/art.37912","article-title":"MicroRNA-30a promotes B cell hyperactivity in patients with systemic lupus erythematosus by direct interaction with Lyn","volume":"65","author":"Liu","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102438_bib115","first-page":"419","article-title":"Targeting E2F1 and c-Myc expression by microRNA-17-5p represses interferon-stimulated gene MxA in peripheral blood mononuclear cells of pediatric systemic lupus erythematosus patients","volume":"19","author":"Sarhan","year":"2015","journal-title":"Discov. Med."},{"key":"10.1016\/j.jaut.2020.102438_bib116","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1177\/0961203319829853","article-title":"Downregulation of miR-633 activated AKT\/mTOR pathway by targeting AKT1 in lupus CD4(+) T cells","volume":"28","author":"Chen","year":"2019","journal-title":"Lupus"},{"key":"10.1016\/j.jaut.2020.102438_bib117","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/nrrheum.2018.10","article-title":"The B cell response to citrullinated antigens in the development of rheumatoid arthritis","volume":"14","author":"Scherer","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jaut.2020.102438_bib118","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jaut.2019.02.004","article-title":"J. 'RA and the microbiome: do host genetic factors provide the link?","volume":"99","author":"Wells","year":"2019","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2020.102438_bib119","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/s41423-018-0037-8","article-title":"Cystathionine-gamma-lyase ameliorates the histone demethylase JMJD3-mediated autoimmune response in rheumatoid arthritis","volume":"16","author":"Wu","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib120","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1111\/1756-185X.13338","article-title":"MiR-146a levels in rheumatoid arthritis and their correlation with disease activity: a meta-analysis","volume":"21","author":"Bae","year":"2018","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102438_bib121","doi-asserted-by":"crossref","first-page":"11193","DOI":"10.1073\/pnas.1019536108","article-title":"MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis","volume":"108","author":"Kurowska-Stolarska","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jaut.2020.102438_bib122","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/art.38142","article-title":"A novel p53\/microRNA-22\/Cyr61 axis in synovial cells regulates inflammation in rheumatoid arthritis","volume":"66","author":"Lin","year":"2014","journal-title":"Arthritis & rheumatology"},{"key":"10.1016\/j.jaut.2020.102438_bib123","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/jcmm.13312","article-title":"Down-regulation of miR-10a-5p in synoviocytes contributes to TBX5-controlled joint inflammation","volume":"22","author":"Hussain","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.jaut.2020.102438_bib124","doi-asserted-by":"crossref","first-page":"E7140","DOI":"10.1073\/pnas.1706833114","article-title":"miR-146a-Traf6 regulatory axis controls autoimmunity and myelopoiesis, but is dispensable for hematopoietic stem cell homeostasis and tumor suppression","volume":"114","author":"Magilnick","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jaut.2020.102438_bib125","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/art.30115","article-title":"Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation","volume":"63","author":"Stanczyk","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102438_bib126","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.humimm.2009.11.008","article-title":"miR-223 is overexpressed in T-lymphocytes of patients affected by rheumatoid arthritis","volume":"71","author":"Fulci","year":"2010","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib127","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jaut.2014.08.002","article-title":"Breaking peripheral immune tolerance to CNS antigens in neurodegenerative diseases: boosting autoimmunity to fight-off chronic neuroinflammation","volume":"54","author":"Schwartz","year":"2014","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2020.102438_bib128","article-title":"Multiple sclerosis, the microbiome, TLR2, and the hygiene hypothesis","volume":"102430","author":"Wasko","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jaut.2020.102438_bib129","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s12016-016-8595-y","article-title":"Role of mast cells in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis","volume":"52","author":"Elieh-Ali-Komi","year":"2017","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib130","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.3389\/fimmu.2018.01256","article-title":"Dysregulated MicroRNA involvement in multiple sclerosis by induction of T helper 17 cell differentiation","volume":"9","author":"Chen","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib131","doi-asserted-by":"crossref","first-page":"5972","DOI":"10.4049\/jimmunol.1300351","article-title":"MicroRNA-155 confers encephalogenic potential to Th17 cells by promoting effector gene expression","volume":"190","author":"Hu","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib132","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1093\/brain\/awr262","article-title":"Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity","volume":"134","author":"Guerau-de-Arellano","year":"2011","journal-title":"Brain : J. Neurol."},{"key":"10.1016\/j.jaut.2020.102438_bib133","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jneuroim.2014.11.004","article-title":"MMP-9 expression is increased in B lymphocytes during multiple sclerosis exacerbation and is regulated by microRNA-320a","volume":"278","author":"Aung","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jaut.2020.102438_bib134","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1212\/WNL.0b013e3182759621","article-title":"Regulated microRNAs in the CSF of patients with multiple sclerosis: a case-control study","volume":"79","author":"Haghikia","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.jaut.2020.102438_bib135","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1523\/JNEUROSCI.0851-16.2016","article-title":"miR-142-3p is a key regulator of IL-1beta-dependent synaptopathy in neuroinflammation","volume":"37","author":"Mandolesi","year":"2017","journal-title":"J. Neurosci. : Off. J. Soc. Neurosci."},{"key":"10.1016\/j.jaut.2020.102438_bib136","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.gene.2014.04.069","article-title":"miR-326 and miR-26a, two potential markers for diagnosis of relapse and remission phases in patient with relapsing-remitting multiple sclerosis","volume":"544","author":"Honardoost","year":"2014","journal-title":"Gene"},{"key":"10.1016\/j.jaut.2020.102438_bib137","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1093\/brain\/awp300","article-title":"MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47","volume":"132","author":"Junker","year":"2009","journal-title":"Brain : J. Neurol."},{"key":"10.1016\/j.jaut.2020.102438_bib138","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jaut.2019.04.005","article-title":"Therapeutic trials of biologics in primary biliary cholangitis: an open label study of abatacept and review of the literature","volume":"101","author":"Bowlus","year":"2019","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2020.102438_bib139","article-title":"Clinical management of primary biliary cholangitis-strategies and evolving trends","author":"Gao","year":"2019","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib140","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s12016-014-8449-4","article-title":"Women and primary biliary cirrhosis","volume":"48","author":"Sun","year":"2015","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib141","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jaut.2009.02.022","article-title":"Primary biliary cirrhosis is associated with altered hepatic microRNA expression","volume":"32","author":"Padgett","year":"2009","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2020.102438_bib142","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3892\/ijmm.2016.2610","article-title":"Altered expression of miR-92a correlates with Th17 cell frequency in patients with primary biliary cirrhosis","volume":"38","author":"Liang","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jaut.2020.102438_bib143","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/hep.25691","article-title":"Up-regulation of microRNA 506 leads to decreased Cl-\/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis","volume":"56","author":"Banales","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2020.102438_bib144","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nrgastro.2013.87","article-title":"MicroRNAs in liver disease","volume":"10","author":"Szabo","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jaut.2020.102438_bib145","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jaut.2012.12.013","article-title":"Overexpression of microRNA-21 is associated with elevated pro-inflammatory cytokines in dominant-negative TGF-beta receptor type II mouse","volume":"41","author":"Ando","year":"2013","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2020.102438_bib146","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12016-011-8283-x","article-title":"Cutting-edge issues in organ-specific autoimmunity","volume":"41","author":"Gershwin","year":"2011","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib147","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s12016-015-8493-8","article-title":"Environmental basis of autoimmunity","volume":"50","author":"Floreani","year":"2016","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib148","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s12016-011-8259-x","article-title":"Autoimmunity and environment: am I at risk?","volume":"42","author":"Smyk","year":"2012","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib149","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/s12016-007-8051-0","article-title":"X chromosome inactivation and female predisposition to autoimmunity","volume":"34","author":"Ozcelik","year":"2008","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib150","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1261\/rna.2258506","article-title":"RAKE and LNA-ISH reveal microRNA expression and localization in archival human brain","volume":"12","author":"Nelson","year":"2006","journal-title":"RNA (New York, N.Y.)"},{"key":"10.1016\/j.jaut.2020.102438_bib151","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-1-60761-811-9_8","article-title":"MicroRNA-profiling in formalin-fixed paraffin-embedded specimens","volume":"667","author":"Lehmann","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jaut.2020.102438_bib152","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143321","article-title":"Towards clinical applications of blood-borne miRNA signatures: the influence of the anticoagulant EDTA on miRNA abundance","volume":"10","author":"Leidinger","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.jaut.2020.102438_bib153","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13148-018-0492-1","article-title":"Circulating microRNAs as potential cancer biomarkers: the advantage and disadvantage","volume":"10","author":"Wang","year":"2018","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.jaut.2020.102438_bib154","doi-asserted-by":"crossref","first-page":"623","DOI":"10.2217\/bmm.13.44","article-title":"Stability of miRNA in human urine supports its biomarker potential","volume":"7","author":"Mall","year":"2013","journal-title":"Biomarkers Med."},{"key":"10.1016\/j.jaut.2020.102438_bib155","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/jcb.24745","article-title":"Standardizing analysis of circulating microRNA: clinical and biological relevance","volume":"115","author":"Farina","year":"2014","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.jaut.2020.102438_bib156","first-page":"638","article-title":"Human salivary microRNAs in Cancer","volume":"9","author":"Rapado-Gonzalez","year":"2018","journal-title":"J. Canc."},{"key":"10.1016\/j.jaut.2020.102438_bib157","doi-asserted-by":"crossref","first-page":"9557","DOI":"10.3390\/ijms16059557","article-title":"miRNAs in the pathogenesis of systemic lupus erythematosus","volume":"16","author":"Qu","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jaut.2020.102438_bib158","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.3389\/fimmu.2018.01473","article-title":"B cell-related circulating MicroRNAs with the potential value of biomarkers in the differential diagnosis, and distinguishment between the disease activity and lupus nephritis for systemic lupus erythematosus","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib159","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1186\/s12967-018-1739-5","article-title":"NovelmiRNA-25 inhibits AMPD2 in peripheral blood mononuclear cells of patients with systemic lupus erythematosus and represents a promising novel biomarker","volume":"16","author":"Guo","year":"2018","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.jaut.2020.102438_bib160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069118","article-title":"Comprehensive microRNA analysis identifies miR-24 and miR-125a-5p as plasma biomarkers for rheumatoid arthritis","volume":"8","author":"Murata","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jaut.2020.102438_bib161","doi-asserted-by":"crossref","first-page":"e491","DOI":"10.1212\/NXI.0000000000000491","article-title":"Identification of MS-specific serum miRNAs in an international multicenter study","volume":"5","author":"Regev","year":"2018","journal-title":"Neurology(R) neuroimmunology & neuroinflammation"},{"key":"10.1016\/j.jaut.2020.102438_bib162","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41576-018-0074-2","article-title":"Clinical epigenetics: seizing opportunities for translation","volume":"20","author":"Berdasco","year":"2019","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jaut.2020.102438_bib163","article-title":"MicroRNA expression profiles identify disease-specific alterations in systemic lupus erythematosus and primary Sjogren's syndrome","volume":"12","author":"Chen","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.jaut.2020.102438_bib164","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19082293","article-title":"The micro-RNA expression profiles of autoimmune arthritis reveal novel biomarkers of the disease and therapeutic response","volume":"19","author":"Dudics","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jaut.2020.102438_bib165","doi-asserted-by":"crossref","first-page":"E189","DOI":"10.1111\/hepr.12198","article-title":"Expression of micro-RNAs in peripheral blood mononuclear cells from primary biliary cirrhosis patients","volume":"44","author":"Katsushima","year":"2014","journal-title":"Hepatol. Res. : the official journal of the Japan Society of Hepatology"},{"key":"10.1016\/j.jaut.2020.102438_bib166","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024604","article-title":"Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis","volume":"6","author":"Waschbisch","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.jaut.2020.102438_bib167","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/acn3.152","article-title":"Natalizumab restores aberrant miRNA expression profile in multiple sclerosis and reveals a critical role for miR-20b","volume":"2","author":"Ingwersen","year":"2015","journal-title":"Annals of clinical and translational neurology"},{"key":"10.1016\/j.jaut.2020.102438_bib168","first-page":"114","article-title":"How close are miRNAs from clinical practice? A perspective on the diagnostic and therapeutic market","volume":"30","author":"Bonneau","year":"2019","journal-title":"Ejifcc"},{"key":"10.1016\/j.jaut.2020.102438_bib169","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1158\/1078-0432.CCR-12-2728","article-title":"Clinical significance and prognostic value of microRNA expression signatures in hepatocellular carcinoma","volume":"19","author":"Wei","year":"2013","journal-title":"Clin. Canc. Res. : Off. J. Am. Assoc. Can. Res."},{"key":"10.1016\/j.jaut.2020.102438_bib170","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s13075-016-1054-6","article-title":"miR-155 in the progression of lung fibrosis in systemic sclerosis","volume":"18","author":"Christmann","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2020.102438_bib171","doi-asserted-by":"crossref","first-page":"3905","DOI":"10.4049\/jimmunol.1200822","article-title":"The downregulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized scleroderma","volume":"190","author":"Makino","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102438_bib172","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jaut.2017.03.009","article-title":"Integration of microbiome and epigenome to decipher the pathogenesis of autoimmune diseases","volume":"83","author":"Chen","year":"2017","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2020.102438_bib173","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1089\/nat.2018.0727","article-title":"Intracellular trafficking and endosomal release of oligonucleotides: what we know and what we don't","volume":"28","author":"Juliano","year":"2018","journal-title":"Nucleic Acid Therapeut."},{"key":"10.1016\/j.jaut.2020.102438_bib174","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1080\/15476286.2018.1445959","article-title":"Anti-miRNA oligonucleotides: a comprehensive guide for design","volume":"15","author":"Lima","year":"2018","journal-title":"RNA Biol."},{"key":"10.1016\/j.jaut.2020.102438_bib175","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.4155\/fmc.14.116","article-title":"J. miRNA-based therapies: strategies and delivery platforms for oligonucleotide and non-oligonucleotide agents","volume":"6","author":"Baumann","year":"2014","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.jaut.2020.102438_bib176","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd.2016.246","article-title":"MicroRNA therapeutics: towards a new era for the management of cancer and other diseases","volume":"16","author":"Rupaimoole","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jaut.2020.102438_bib177","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nrc3166","article-title":"Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy","volume":"11","author":"Kasinski","year":"2011","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.jaut.2020.102438_bib178","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.jacc.2015.06.1315","article-title":"Precision medicine in patients with resistant hypertension and obstructive sleep apnea: blood pressure response to continuous positive airway pressure treatment","volume":"66","author":"Sanchez-de-la-Torre","year":"2015","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.jaut.2020.102438_bib179","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.addr.2014.10.030","article-title":"Contribution of bioinformatics prediction in microRNA-based cancer therapeutics","volume":"81","author":"Banwait","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.jaut.2020.102438_bib180","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1053\/j.semdp.2008.07.007","article-title":"Old activity or young discipline?","volume":"25","author":"Morente","year":"2008","journal-title":"Semin. Diagn. Pathol."},{"key":"10.1016\/j.jaut.2020.102438_bib181","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.tig.2016.12.003","article-title":"Single-cell multiomics: multiple measurements from single cells","volume":"33","author":"Macaulay","year":"2017","journal-title":"Trends Genet. : TIG (Trends Genet.)"},{"key":"10.1016\/j.jaut.2020.102438_bib182","doi-asserted-by":"crossref","first-page":"11310","DOI":"10.1038\/ncomms11310","article-title":"Dynamic and flexible H3K9me3 bridging via HP1beta dimerization establishes a plastic state of condensed chromatin","volume":"7","author":"Hiragami-Hamada","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2020.102438_bib183","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/cmi.2017.164","article-title":"miR-125b-5p and miR-99a-5p downregulate human gammadelta T-cell activation and cytotoxicity","volume":"16","author":"Zhu","year":"2019","journal-title":"Cell. Mol. Immunol."}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841120300512?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841120300512?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:24:38Z","timestamp":1760257478000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841120300512"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":183,"alternative-id":["S0896841120300512"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2020.102438","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical significance of miRNAs in autoimmunity","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2020.102438","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102438"}}