{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:20:01Z","timestamp":1790806801303,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100013290","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2017YFA0105801"],"award-info":[{"award-number":["2017YFA0105801"]}],"id":[{"id":"10.13039\/501100013290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Science Funds of China","doi-asserted-by":"publisher","award":["81671611 to F. H, 81871224"],"award-info":[{"award-number":["81671611 to F. H, 81871224"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Science Funds of China","doi-asserted-by":"publisher","award":["F. H, 81870481 to A.X"],"award-info":[{"award-number":["F. H, 81870481 to A.X"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR059103"],"award-info":[{"award-number":["R01 AR059103"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R61 AR073447 409"],"award-info":[{"award-number":["R61 AR073447 409"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jaut.2020.102491","type":"journal-article","created":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T07:51:38Z","timestamp":1592466698000},"page":"102491","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"special_numbering":"C","title":["Human gingiva-derived mesenchymal stem cells are therapeutic in lupus nephritis through targeting of CD39\u2212CD73 signaling pathway"],"prefix":"10.1016","volume":"113","author":[{"given":"Junlong","family":"Dang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenjian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingling","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangying","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boqing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Bellanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umadevi","family":"Kandalam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hany A.","family":"Emam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Jarjour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song Guo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2020.102491_bib1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.molmed.2017.05.006","article-title":"Pathogenesis of human systemic lupus erythematosus: a cellular perspective","volume":"23","author":"Moulton","year":"2017","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jaut.2020.102491_bib2","first-page":"258","article-title":"Imaging B lymphocytes in autoimmune inflammatory diseases","volume":"58","author":"Iodice","year":"2014","journal-title":"Q. J. Nucl. Med. Mol. Imag. : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the So"},{"key":"10.1016\/j.jaut.2020.102491_bib3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cellimm.2017.05.008","article-title":"Role of CD11c(+) T-bet(+) B cells in human health and disease","volume":"321","author":"Karnell","year":"2017","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.jaut.2020.102491_bib4","doi-asserted-by":"crossref","first-page":"R210","DOI":"10.1186\/ar3187","article-title":"Therapeutic potential of human umbilical cord mesenchymal stem cells in the treatment of rheumatoid arthritis","volume":"12","author":"Liu","year":"2010","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2020.102491_bib5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s12026-013-8466-z","article-title":"B-lymphocyte tolerance and effector function in immunity and autoimmunity","volume":"57","author":"Khan","year":"2013","journal-title":"Immunol. Res."},{"key":"10.1016\/j.jaut.2020.102491_bib6","first-page":"1245","article-title":"B cell-targeted therapy in autoimmune disease: rationale, mechanisms, and clinical application","volume":"35","author":"Mease","year":"2008","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.jaut.2020.102491_bib7","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/cmi.2016.59","article-title":"Mesenchymal stem cells ameliorate B-cell-mediated immune responses and increase IL-10-expressing regulatory B cells in an EBI3-dependent manner","volume":"14","author":"Cho","year":"2017","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jaut.2020.102491_bib8","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.3324\/haematol.12857","article-title":"The effect of mesenchymal stem cells on the viability, proliferation and differentiation of B-lymphocytes","volume":"93","author":"Tabera","year":"2008","journal-title":"Haematologica"},{"key":"10.1016\/j.jaut.2020.102491_bib9","doi-asserted-by":"crossref","first-page":"15249","DOI":"10.1038\/s41598-017-14979-5","article-title":"Human gingiva-derived mesenchymal stem cells ameliorate streptozoticin-induced T1DM in mice via suppression of T effector cells and up-regulating treg subsets","volume":"7","author":"Zhang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jaut.2020.102491_bib10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2174\/1574888X13666180220141114","article-title":"Updates on GMSCs treatment for autoimmune diseases","volume":"13","author":"Huang","year":"2018","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.jaut.2020.102491_bib11","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.bbrc.2010.01.126","article-title":"Human gingiva-derived mesenchymal stem cells are superior to bone marrow-derived mesenchymal stem cells for cell therapy in regenerative medicine","volume":"393","author":"Tomar","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.jaut.2020.102491_bib12","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1002\/art.37894","article-title":"Adoptive transfer of human gingiva-derived mesenchymal stem cells ameliorates collagen-induced arthritis via suppression of Th1 and Th17 cells and enhancement of regulatory T cell differentiation","volume":"65","author":"Chen","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102491_bib13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fimmu.2017.00068","article-title":"Human gingiva-derived mesenchymal stem cells inhibit xeno-graft-versus-host disease via CD39-CD73-adenosine and Ido signals","volume":"8","author":"Huang","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102491_bib14","doi-asserted-by":"crossref","first-page":"878","DOI":"10.3389\/fimmu.2018.00878","article-title":"Human gingiva-derived mesenchymal stem cells modulate monocytes\/macrophages and alleviate atherosclerosis","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102491_bib15","doi-asserted-by":"crossref","first-page":"7787","DOI":"10.4049\/jimmunol.0902318","article-title":"Mesenchymal stem cells derived from human gingiva are capable of immunomodulatory functions and ameliorate inflammation-related tissue destruction in experimental colitis","volume":"183","author":"Zhang","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102491_bib16","first-page":"1167","article-title":"Erratum: human gingiva tissue-derived MSC ameliorates immune-mediated bone marrow failure of aplastic anemia via suppression of Th1 and Th17 cells and enhancement of CD4+Foxp3+ regulatory T cells differentiation","volume":"12","author":"Zhao","year":"2020","journal-title":"Am. J. Tourism Res."},{"key":"10.1016\/j.jaut.2020.102491_bib17","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.ebiom.2019.04.058","article-title":"Human gingival tissue-derived MSC suppress osteoclastogenesis and bone erosion via CD39-adenosine signal pathway in autoimmune arthritis","volume":"43","author":"Luo","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jaut.2020.102491_bib18","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1016\/j.ymthe.2020.04.003","article-title":"CD39 produced from human GMSCs regulates the balance of osteoclasts and osteoblasts through the wnt\/\u03b2-catenin pathway in osteoporosis","volume":"28","author":"Wu","year":"2020","journal-title":"Mol. Ther."},{"key":"10.1016\/j.jaut.2020.102491_bib19","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1365-2249.2006.03251.x","article-title":"Protein array autoantibody profiles for insights into systemic lupus erythematosus and incomplete lupus syndromes","volume":"147","author":"Li","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jaut.2020.102491_bib20","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1172\/JCI23587","article-title":"Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays","volume":"115","author":"Li","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2020.102491_bib21","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1006\/clim.2001.5079","article-title":"NZM2328: a new mouse model of systemic lupus erythematosus with unique genetic susceptibility loci","volume":"100","author":"Waters","year":"2001","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jaut.2020.102491_bib22","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.4049\/jimmunol.0802948","article-title":"Accelerated pathological and clinical nephritis in systemic lupus erythematosus-prone New Zealand Mixed 2328 mice doubly deficient in TNF receptor 1 and TNF receptor 2 via a Th17-associated pathway","volume":"182","author":"Jacob","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102491_bib23","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.4049\/jimmunol.1501740","article-title":"TGF-beta-Induced regulatory T cells directly suppress B cell responses through a noncytotoxic mechanism","volume":"196","author":"Xu","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102491_bib24","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/qjmed\/hcu033","article-title":"Mesenchymal stem cells, autoimmunity and rheumatoid arthritis","volume":"107","author":"El-Jawhari","year":"2014","journal-title":"QJM"},{"key":"10.1016\/j.jaut.2020.102491_bib25","doi-asserted-by":"crossref","first-page":"269","DOI":"10.4067\/S0716-97602012000300008","article-title":"Mesenchymal stem cell treatment for autoimmune diseases: a critical review","volume":"45","author":"Figueroa","year":"2012","journal-title":"Biol. Res."},{"key":"10.1016\/j.jaut.2020.102491_bib26","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jcyt.2015.10.011","article-title":"Mesenchymal stromal cells and immunomodulation: a gathering of regulatory immune cells","volume":"18","author":"Najar","year":"2016","journal-title":"Cytotherapy"},{"key":"10.1016\/j.jaut.2020.102491_bib27","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1002\/stem.738","article-title":"Human gingiva-derived mesenchymal stromal cells attenuate contact hypersensitivity via prostaglandin E2-dependent mechanisms","volume":"29","author":"Su","year":"2011","journal-title":"Stem Cell."},{"key":"10.1016\/j.jaut.2020.102491_bib28","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jaci.2014.12.1926","article-title":"Culture medium from TNF-alpha-stimulated mesenchymal stem cells attenuates allergic conjunctivitis through multiple antiallergic mechanisms","volume":"136","author":"Su","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jaut.2020.102491_bib29","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1084\/jem.20151722","article-title":"IFN-gamma receptor and STAT1 signaling in B cells are central to spontaneous germinal center formation and autoimmunity","volume":"213","author":"Domeier","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jaut.2020.102491_bib30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1089\/scd.2014.0155","article-title":"Inhibition of B-cell proliferation and antibody production by mesenchymal stromal cells is mediated by T cells","volume":"24","author":"Rosado","year":"2015","journal-title":"Stem Cell. Dev."},{"key":"10.1016\/j.jaut.2020.102491_bib31","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1182\/blood-2004-09-3740","article-title":"B-cell kinetics in humans: rapid turnover of peripheral blood memory cells","volume":"105","author":"Macallan","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2020.102491_bib32","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.cell.2013.04.033","article-title":"Global regulation of promoter melting in naive lymphocytes","volume":"153","author":"Kouzine","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2020.102491_bib33","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/ni.3519","article-title":"Plasma cell differentiation is coupled to division-dependent DNA hypomethylation and gene regulation","volume":"17","author":"Barwick","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2020.102491_bib34","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1182\/blood-2005-11-4502","article-title":"Activated CD4+CD25+ T cells selectively kill B lymphocytes","volume":"107","author":"Zhao","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2020.102491_bib35","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.4049\/jimmunol.1302897","article-title":"Regulatory CD4+ T cells promote B cell anergy in murine lupus","volume":"192","author":"Liu","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102491_bib36","doi-asserted-by":"crossref","first-page":"4183","DOI":"10.4049\/jimmunol.169.8.4183","article-title":"Generation ex vivo of TGF-beta-producing regulatory T cells from CD4+CD25- precursors","volume":"169","author":"Zheng","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102491_bib37","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fimmu.2018.00035","article-title":"TGF-beta-Induced CD8(+)CD103(+) regulatory T cells show potent therapeutic effect on chronic graft-versus-host disease lupus by suppressing B cells","volume":"9","author":"Zhong","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102491_bib38","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.3389\/fimmu.2017.01334","article-title":"Vivo attenuation of antibody-mediated acute renal allograft rejection by ex vivo TGF-beta-induced CD4(+)Foxp3(+) regulatory T cells","volume":"8","author":"Liao","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102491_bib39","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1002\/stem.503","article-title":"Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing","volume":"28","author":"Zhang","year":"2010","journal-title":"Stem Cell."},{"key":"10.1016\/j.jaut.2020.102491_bib40","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.3389\/fimmu.2018.01322","article-title":"Ectonucleotidase-mediated suppression of lupus autoimmunity and vascular dysfunction","volume":"9","author":"Knight","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102491_bib41","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s12026-016-8870-2","article-title":"The role of adenosinergic pathway in human autoimmune diseases","volume":"64","author":"Dong","year":"2016","journal-title":"Immunol. Res."},{"key":"10.1016\/j.jaut.2020.102491_bib42","first-page":"4017","article-title":"Progress and prospect of mesenchymal stem cell-based therapy in atherosclerosis","volume":"8","author":"Zhang","year":"2016","journal-title":"Am. J. Tourism Res."},{"key":"10.1016\/j.jaut.2020.102491_bib43","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-019-1262-5","article-title":"A preclinical study\u2014systemic evaluation of safety on mesenchymal stem cells derived from human gingiva tissue","volume":"10","author":"Zhao","year":"2019","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.jaut.2020.102491_bib44","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1002\/art.24698","article-title":"Novel evidence-based systemic lupus erythematosus responder index","volume":"61","author":"Furie","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102491_bib45","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/art.27233","article-title":"Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: the randomized, double-blind, phase II\/III systemic lupus erythematosus evaluation of rituximab trial","volume":"62","author":"Merrill","year":"2010","journal-title":"Arthritis Rheum."}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841120301098?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841120301098?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:25:47Z","timestamp":1760257547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841120301098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":45,"alternative-id":["S0896841120301098"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2020.102491","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Human gingiva-derived mesenchymal stem cells are therapeutic in lupus nephritis through targeting of CD39\u2212CD73 signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2020.102491","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102491"}}