{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:30:12Z","timestamp":1790771412487,"version":"4.1.0"},"reference-count":213,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jaut.2020.102526","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T02:26:59Z","timestamp":1595557619000},"page":"102526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":56,"special_numbering":"C","title":["Bi-directional communication: Conversations between fibroblasts and immune cells in systemic sclerosis"],"prefix":"10.1016","volume":"113","author":[{"given":"Julie C.","family":"Worrell","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"O'Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2020.102526_bib1","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy","year":"1988","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.jaut.2020.102526_bib2","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/ard.2006.066068","article-title":"Changes in causes of death in systemic sclerosis, 1972-2002","volume":"66","author":"Steen","year":"2007","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib3","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2147\/CLEP.S191418","article-title":"Epidemiology of systemic sclerosis and systemic sclerosis-associated interstitial lung disease","volume":"11","author":"Bergamasco","year":"2019","journal-title":"Clin. Epidemiol."},{"key":"10.1016\/j.jaut.2020.102526_bib4","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1136\/jcp.2004.019224","article-title":"Alterations of mononuclear inflammatory cells, CD4\/CD8+ T cells, interleukin 1beta, and tumour necrosis factor alpha in the bronchoalveolar lavage fluid, peripheral blood, and skin of patients with systemic sclerosis","volume":"58","author":"Hussein","year":"2005","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.jaut.2020.102526_bib5","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1159\/000163933","article-title":"Mononuclear cellular infiltrates in clinically involved skin from patients with systemic sclerosis of recent onset predominantly consist of monocytes\/macrophages. Pathobiology","volume":"63","author":"Kr\u00e4ling","year":"1995","journal-title":"journal of immunopathology, molecular and cellular biology"},{"key":"10.1016\/j.jaut.2020.102526_bib6","doi-asserted-by":"crossref","DOI":"10.1186\/ar4352","article-title":"B lymphocytes and B-cell activating factor promote collagen and profibrotic markers expression by dermal fibroblasts in systemic sclerosis","volume":"15","author":"Fran\u00e7ois","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2020.102526_bib7","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s10067-011-1686-5","article-title":"Serum IL-33 levels are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis","volume":"30","author":"Yanaba","year":"2011","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.jaut.2020.102526_bib8","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/art.1780200410","article-title":"Cellular infiltrates in scleroderma skin","volume":"20","author":"Fleischmajer","year":"1977","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/path.1711660307","article-title":"Sequential dermal microvascular and perivascular changes in the development of scleroderma","volume":"166","author":"Prescott","year":"1992","journal-title":"J. Pathol."},{"key":"10.1016\/j.jaut.2020.102526_bib10","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1093\/rheumatology\/kes090","article-title":"T cells in systemic sclerosis: a reappraisal","volume":"51","author":"O'Reilly","year":"2012","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2020.102526_bib11","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0021-9258(17)36143-4","article-title":"Increased collagen biosynthesis and increased expression of type I and type III procollagen genes in tight skin (TSK) mouse fibroblasts","volume":"261","author":"Jimenez","year":"1986","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jaut.2020.102526_bib12","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1172\/JCI107827","article-title":"Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast","volume":"54","author":"LeRoy","year":"1974","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2020.102526_bib13","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1172\/JCI31139","article-title":"Systemic sclerosis: a prototypic multisystem fibrotic disorder","volume":"117","author":"Varga","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2020.102526_bib14","first-page":"21","article-title":"Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Laboratory investigation","volume":"63","author":"Darby","year":"1990","journal-title":"a journal of technical methods and pathology"},{"key":"10.1016\/j.jaut.2020.102526_bib15","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.it.2005.09.004","article-title":"Scleroderma: from cell and molecular mechanisms to disease models","volume":"26","author":"Abraham","year":"2005","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib16","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00281-015-0503-7","article-title":"Role of innate immune system in systemic sclerosis","volume":"37","author":"Fullard","year":"2015","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.jaut.2020.102526_bib17","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1002\/1529-0131(200011)43:11<2437::AID-ANR10>3.0.CO;2-U","article-title":"Severe organ involvement in systemic sclerosis with diffuse scleroderma","volume":"43","author":"Steen","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib18","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1164\/rccm.2106012","article-title":"Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome","volume":"165","author":"Bouros","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jaut.2020.102526_bib19","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1164\/rccm.200607-912OC","article-title":"Prognosis of fibrotic interstitial pneumonia: idiopathic versus collagen vascular disease-related subtypes","volume":"175","author":"Park","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.jaut.2020.102526_bib20","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1172\/JCI31487","article-title":"Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases","volume":"117","author":"Wynn","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2020.102526_bib21","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1002\/art.22847","article-title":"B cell infiltration in systemic sclerosis-associated interstitial lung disease","volume":"56","author":"Lafyatis","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib22","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/0140-6736(91)91235-M","article-title":"Immunogenetic prediction of pulmonary fibrosis in systemic sclerosis","volume":"338","author":"Briggs","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2020.102526_bib23","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1056\/NEJMra0806188","volume":"360","author":"Gabrielli","year":"2009","journal-title":"Scleroderma. The New England journal of medicine"},{"key":"10.1016\/j.jaut.2020.102526_bib24","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1136\/ard.2008.104299","article-title":"Antifibroblast antibodies from systemic sclerosis patients bind to {alpha}-enolase and are associated with interstitial lung disease","volume":"69","author":"Terrier","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.1780260101","article-title":"Anticentromere antibody. Clinical Correlations and association with favorable prognosis in patients with scleroderma variants","volume":"26","author":"McCarty","year":"1983","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib26","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1183\/09031936.94.07040779","article-title":"From granuloma to fibrosis in interstitial lung diseases: molecular and cellular interactions","volume":"7","author":"Mornex","year":"1994","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jaut.2020.102526_bib27","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1346-8138.2009.00764.x","article-title":"Animal model of systemic sclerosis","volume":"37","author":"Yamamoto","year":"2010","journal-title":"J. Dermatol."},{"key":"10.1016\/j.jaut.2020.102526_bib28","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.0906-6705.2005.00280.x","article-title":"Cellular and molecular mechanisms of bleomycin-induced murine scleroderma: current update and future perspective","volume":"14","author":"Yamamoto","year":"2005","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.jaut.2020.102526_bib29","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9440(10)63289-0","article-title":"Targeted disruption of TGF-beta\/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma","volume":"165","author":"Lakos","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jaut.2020.102526_bib30","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1159\/000082331","article-title":"Upregulation of interleukin-13 and its receptor in a murine model of bleomycin-induced scleroderma","volume":"135","author":"Matsushita","year":"2004","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib31","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1046\/j.1523-1747.2003.12408.x","article-title":"Role of monocyte chemoattractant protein-1 and its receptor,CCR-2, in the pathogenesis of bleomycin-induced scleroderma","volume":"121","author":"Yamamoto","year":"2003","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jaut.2020.102526_bib32","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s40248-017-0089-0","article-title":"Longitudinal assessment of bleomycin-induced lung fibrosis by Micro-CT correlates with histological evaluation in mice","volume":"12","author":"Ruscitti","year":"2017","journal-title":"Multidisciplinary respiratory medicine"},{"key":"10.1016\/j.jaut.2020.102526_bib33","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1172\/JCI0215078","article-title":"CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse","volume":"109","author":"Saito","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2020.102526_bib34","doi-asserted-by":"crossref","first-page":"8570","DOI":"10.1200\/JCO.2005.02.4729","article-title":"Kinetics of response to long-term treatment combining pentoxifylline and tocopherol in patients with superficial radiation-induced fibrosis","volume":"23","author":"Delanian","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.jaut.2020.102526_bib35","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1002\/art.23994","article-title":"A CD40-CD154 interaction in tissue fibrosis","volume":"58","author":"Kawai","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib36","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1136\/annrheumdis-2015-208213","article-title":"Treatment with abatacept prevents experimental dermal fibrosis and induces regression of established inflammation-driven fibrosis","volume":"75","author":"Ponsoye","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib37","doi-asserted-by":"crossref","first-page":"15136","DOI":"10.1073\/pnas.1520997112","article-title":"Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis","volume":"112","author":"Saigusa","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jaut.2020.102526_bib38","first-page":"493","article-title":"Tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton","volume":"82","author":"Green","year":"1976","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jaut.2020.102526_bib39","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1093\/cvr\/27.6.1061","article-title":"Increased collagen synthesis and increased content of type VI collagen in myocardium of tight skin mice","volume":"27","author":"Bashey","year":"1993","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.jaut.2020.102526_bib40","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.1002\/art.24934","article-title":"A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis","volume":"60","author":"Hasegawa","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib41","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/ncomms1734","article-title":"Activation of canonical Wnt signalling is required for TGF-\u03b2-mediated fibrosis","volume":"3","author":"Akhmetshina","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2020.102526_bib42","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/art.1780340512","article-title":"Evidence for autoimmunity in the tight skin mouse model of systemic sclerosis","volume":"34","author":"Bocchieri","year":"1991","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib43","doi-asserted-by":"crossref","first-page":"954","DOI":"10.2353\/ajpath.2006.060205","article-title":"B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis","volume":"169","author":"Hasegawa","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jaut.2020.102526_bib44","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/eji.1830240634","article-title":"A role for CD4+ T cells in the pathogenesis of skin fibrosis in tight skin mice","volume":"24","author":"Wallace","year":"1994","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib45","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1006\/jaut.1993.1059","article-title":"Induction of skin fibrosis and autoantibodies by infusion of immunocompetent cells from tight skin mice into C57BL\/6 Pa\/Pa mice","volume":"6","author":"Phelps","year":"1993","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2020.102526_bib46","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.matbio.2014.05.002","article-title":"Tight skin 2 mice exhibit a novel time line of events leading to increased extracellular matrix deposition and dermal fibrosis","volume":"38","author":"Long","year":"2014","journal-title":"Matrix Biol."},{"key":"10.1016\/j.jaut.2020.102526_bib47","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3109\/08916939809008039","article-title":"T cells infiltrating the skin of Tsk2 scleroderma-like mice exhibit T cell receptor bias","volume":"27","author":"Wooley","year":"1998","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jaut.2020.102526_bib48","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1161\/CIRCULATIONAHA.109.855114","article-title":"Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis","volume":"120","author":"Maurer","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.jaut.2020.102526_bib49","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/art.25056","article-title":"The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis","volume":"62","author":"Reich","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib50","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.3389\/fimmu.2018.02018","article-title":"Fra2 overexpression in mice leads to non-allergic asthma development in an IL-13 dependent manner","volume":"9","author":"Gungl","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib51","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1084\/jem.20160514","article-title":"Fra-2 regulates B cell development by enhancing IRF4 and Foxo1 transcription","volume":"214","author":"Ubieta","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jaut.2020.102526_bib52","first-page":"54","article-title":"IL-1 receptor blockade skews inflammation towards Th2 in a mouse model of systemic sclerosis","author":"Birnhuber","year":"2019","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jaut.2020.102526_bib53","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s13075-018-1694-9","article-title":"T-cell costimulation blockade is effective in experimental digestive and lung tissue fibrosis","author":"Boleto","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2020.102526_bib54","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0002-9440(10)63685-1","article-title":"Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin","volume":"163","author":"Kubo","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jaut.2020.102526_bib55","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1128\/MCB.01278-08","article-title":"Transcription factor Fli1 regulates collagen fibrillogenesis in mouse skin","volume":"29","author":"Asano","year":"2009","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jaut.2020.102526_bib56","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13075-018-1521-3","article-title":"Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells","volume":"20","author":"Saigusa","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2020.102526_bib57","doi-asserted-by":"crossref","first-page":"5797","DOI":"10.1038\/ncomms6797","article-title":"Simultaneous downregulation of KLF5 and Fli1 is a key feature underlying systemic sclerosis","volume":"5","author":"Noda","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2020.102526_bib58","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/rheumatology\/kei244","article-title":"Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients","volume":"45","author":"Tan","year":"2006","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2020.102526_bib59","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/art.22382","article-title":"A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists","volume":"56","author":"York","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib60","first-page":"10","article-title":"Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis","author":"Maugeri","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jaut.2020.102526_bib61","first-page":"70","article-title":"Higher neutrophil count predicts more severe skin\/lung disease and increased mortality in early systemic sclerosis [abstract]","author":"Taherian","year":"2018","journal-title":"Arthritis & rheumatology (Hoboken, NJ)"},{"key":"10.1016\/j.jaut.2020.102526_bib62","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/annrheumdis-2015-207388","article-title":"Type 2 innate lymphoid cell counts are increased in patients with systemic sclerosis and correlate with the extent of fibrosis","volume":"75","author":"Wohlfahrt","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib63","first-page":"78","article-title":"Predictive value OF innate lymphoid cells IN systemic sclerosis","author":"Saore","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib64","first-page":"169","article-title":"Increased frequencies of circulating CXCL10-, CXCL8- and CCL4-producing monocytes and Siglec-3-expressing myeloid dendritic cells in systemic sclerosis patients. Inflammation research","volume":"67","author":"Carvalheiro","year":"2018","journal-title":"official journal of the European Histamine Research Society [et al]"},{"key":"10.1016\/j.jaut.2020.102526_bib65","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.immuni.2019.08.008","article-title":"Single-cell analysis of human mononuclear phagocytes reveals subset-defining markers and identifies circulating inflammatory dendritic cells","volume":"51","author":"Dutertre","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2020.102526_bib66","first-page":"3","article-title":"pDCs in lung and skin fibrosis in a bleomycin-induced model and patients with systemic sclerosis","author":"Kafaja","year":"2018","journal-title":"JCI insight"},{"key":"10.1016\/j.jaut.2020.102526_bib67","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1136\/annrheumdis-2018-214991","article-title":"Low RUNX3 expression alters dendritic cell function in patients with systemic sclerosis and contributes to enhanced fibrosis","volume":"78","author":"Affandi","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib68","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12931-018-0891-z","article-title":"A circulating cell population showing both M1 and M2 monocyte\/macrophage surface markers characterizes systemic sclerosis patients with lung involvement","volume":"19","author":"Trombetta","year":"2018","journal-title":"Respir. Res."},{"key":"10.1016\/j.jaut.2020.102526_bib69","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1136\/annrheumdis-2017-212454","article-title":"Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk","volume":"77","author":"Moreno-Moral","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib70","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4049\/jimmunol.202.Supp.180.9","article-title":"Blood monocyte subsets are dysregulated and respond with high IL-6 secretion in patients with systemic sclerosis","volume":"202","author":"Friedrich","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib71","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1136\/annrheumdis-2018-213648","article-title":"Increase in circulating cells coexpressing M1 and M2 macrophage surface markers in patients with systemic sclerosis","volume":"77","author":"Soldano","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib72","doi-asserted-by":"crossref","first-page":"5670","DOI":"10.1038\/s41467-019-13636-x","article-title":"Trained immunity modulates inflammation-induced fibrosis","volume":"10","author":"Jeljeli","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2020.102526_bib73","first-page":"224","article-title":"Pro-fibrotic activation of human macrophages in systemic sclerosis","volume":"204","author":"Bhandari","year":"2020","journal-title":"Arthritis & rheumatology (Hoboken, NJ)"},{"key":"10.1016\/j.jaut.2020.102526_bib74","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nri2781","article-title":"Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity","volume":"10","author":"Bonneville","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib75","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1136\/ard.54.1.69","article-title":"Natural killer cells and gamma delta T cells in scleroderma: relationship to disease duration and anti-Scl-70 antibodies","volume":"54","author":"Holcombe","year":"1995","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib76","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/j.1365-4632.2008.03805.x","article-title":"Effect of gammadelta T cell supernatant on human skin fibroblast proliferation and collagen production\u2013possible role of transforming growth factor-beta and basic fibroblast growth factor","volume":"47","author":"Ohtsuka","year":"2008","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.jaut.2020.102526_bib77","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.ajpath.2010.11.055","article-title":"\u03b3\u03b4 T cells attenuate bleomycin-induced fibrosis through the production of CXCL10","volume":"178","author":"Pociask","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jaut.2020.102526_bib78","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.3389\/fimmu.2018.01360","article-title":"Activation and regulation of B cell responses by invariant natural killer T cells","volume":"9","author":"Doherty","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib79","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-019-1991-y","article-title":"Invariant natural killer T cells are functionally impaired in patients with systemic sclerosis","volume":"21","author":"Pecher","year":"2019","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2020.102526_bib80","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.autrev.2010.09.016","article-title":"Fibrosis and immune dysregulation in systemic sclerosis","volume":"10","author":"Chizzolini","year":"2011","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jaut.2020.102526_bib81","doi-asserted-by":"crossref","first-page":"6635","DOI":"10.4049\/jimmunol.165.11.6635","article-title":"Quantitative genetic variation in CD19 expression correlates with autoimmunity","volume":"165","author":"Sato","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib82","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/rheumatology\/kev331","article-title":"Decreased levels of regulatory B cells in patients with systemic sclerosis: association with autoantibody production and disease activity","volume":"55","author":"Matsushita","year":"2016","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2020.102526_bib83","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1159\/000053816","article-title":"Microchimerism and systemic sclerosis","volume":"125","author":"Scaletti","year":"2001","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib84","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1001\/archderm.1996.03890310088013","article-title":"Expression of interleukin-4 in scleroderma skin specimens and scleroderma fibroblast cultures. Potential role in fibrosis","volume":"132","author":"Salmon-Ehr","year":"1996","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.jaut.2020.102526_bib85","first-page":"1751","article-title":"Type 2 helper T-cell predominance and high CD30 expression in systemic sclerosis","volume":"151","author":"Mavalia","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jaut.2020.102526_bib86","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/jlb.61.5.539","article-title":"In vivo CD30 expression in human diseases with predominant activation of Th2-like T cells","volume":"61","author":"D'Elios","year":"1997","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jaut.2020.102526_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005903","article-title":"The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes","volume":"4","author":"Radstake","year":"2009","journal-title":"PloS One"},{"key":"10.1016\/j.jaut.2020.102526_bib88","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1172\/JCI131700","article-title":"Cytotoxic CD4+ T lymphocytes may induce endothelial cell apoptosis in systemic sclerosis","volume":"130","author":"Maehara","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2020.102526_bib89","first-page":"10","article-title":"T follicular helper-like cells contribute to skin fibrosis","author":"Taylor","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jaut.2020.102526_bib90","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1001\/archdermatol.2009.225","article-title":"Detection of clonal T cells in the circulation of patients with nephrogenic systemic fibrosis","volume":"145","author":"Kreuter","year":"2009","journal-title":"Arch. Dermatol."},{"key":"10.1016\/j.jaut.2020.102526_bib91","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.3389\/fimmu.2018.01702","article-title":"Innate immunity in systemic sclerosis fibrosis: recent advances","volume":"9","author":"Laurent","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib92","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/sji.12585","article-title":"Mucosal-associated invariant cells are deficient in systemic sclerosis","volume":"86","author":"Mekinian","year":"2017","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib93","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1002\/1529-0131(199811)41:11<2039::AID-ART20>3.0.CO;2-1","article-title":"Inhibition of type I collagen production by dermal fibroblasts upon contact with activated T cells: different sensitivity to inhibition between systemic sclerosis and control fibroblasts","volume":"41","author":"Chizzolini","year":"1998","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib94","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/biof.1117","article-title":"Role of interleukin-13 in fibrosis, particularly systemic sclerosis","volume":"39","author":"O'Reilly","year":"2013","journal-title":"Biofactors"},{"key":"10.1016\/j.jaut.2020.102526_bib95","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/art.37738","article-title":"Tumor necrosis factor-costimulated T lymphocytes from patients with systemic sclerosis trigger collagen production in fibroblasts","volume":"65","author":"H\u00fcgle","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib96","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.3892\/ijmm.2015.2146","article-title":"Toll-like receptor family members in skin fibroblasts are functional and have a higher expression compared to skin keratinocytes","volume":"35","author":"Yao","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.jaut.2020.102526_bib97","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.imlet.2017.09.001","article-title":"Toll like Receptors in systemic sclerosis: an emerging target","volume":"195","author":"O'Reilly","year":"2018","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jaut.2020.102526_bib98","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ajpath.2012.09.007","article-title":"Toll-like receptor 4 signaling augments transforming growth factor-\u03b2 responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma","volume":"182","author":"Bhattacharyya","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.jaut.2020.102526_bib99","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/imm.12260","article-title":"Serum amyloid A induces interleukin-6 in dermal fibroblasts via Toll-like receptor 2, interleukin-1 receptor-associated kinase 4 and nuclear factor-\u03baB","volume":"143","author":"O'Reilly","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.jaut.2020.102526_bib100","first-page":"3","article-title":"TLR4-dependent fibroblast activation drives persistent organ fibrosis in skin and lung","author":"Bhattacharyya","year":"2018","journal-title":"JCI insight"},{"key":"10.1016\/j.jaut.2020.102526_bib101","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.3389\/fimmu.2018.02434","article-title":"Pharmacological inhibition of toll-like receptor-4 signaling by TAK242 prevents and induces regression of experimental organ fibrosis","volume":"9","author":"Bhattacharyya","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib102","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/path.4768","article-title":"Fibroblast growth factor-1 attenuates TGF-\u03b21-induced lung fibrosis","volume":"240","author":"Shimbori","year":"2016","journal-title":"J. Pathol."},{"key":"10.1016\/j.jaut.2020.102526_bib103","doi-asserted-by":"crossref","first-page":"28261","DOI":"10.1038\/srep28261","article-title":"Fibroblasts profiling in scarring trachoma identifies IL-6 as a functional component of a fibroblast-macrophage pro-fibrotic and pro-inflammatory feedback loop","volume":"6","author":"Kechagia","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jaut.2020.102526_bib104","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3389\/fphar.2014.00123","article-title":"Fibroblasts in fibrosis: novel roles and mediators","volume":"5","author":"Kendall","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jaut.2020.102526_bib105","doi-asserted-by":"crossref","first-page":"490","DOI":"10.4049\/jimmunol.1100123","article-title":"Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis","volume":"187","author":"Lin","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib106","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.1002\/eji.200324088","article-title":"Increased CD40 expression in skin fibroblasts from patients with systemic sclerosis (SSc): role of CD40-CD154 in the phenotype of SSc fibroblasts","volume":"33","author":"Fukasawa","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib107","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/jlb.58.2.209","article-title":"Ligation of CD40 on fibroblasts induces CD54 (ICAM-1) and CD106 (VCAM-1) up-regulation and IL-6 production and proliferation","volume":"58","author":"Yellin","year":"1995","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jaut.2020.102526_bib108","doi-asserted-by":"crossref","DOI":"10.1186\/ar2823","article-title":"Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis","volume":"11","author":"Nanki","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2020.102526_bib109","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1002\/(SICI)1521-4141(199903)29:03<1041::AID-IMMU1041>3.0.CO;2-#","article-title":"Interferon-beta mediates stromal cell rescue of T cells from apoptosis","volume":"29","author":"Pilling","year":"1999","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib110","first-page":"807230","article-title":"CXCL4 links inflammation and fibrosis through transcriptional and epigenetic reprogramming of monocyte-derived cells","author":"Silva-Cardoso","year":"2019","journal-title":"bioRxiv"},{"key":"10.1016\/j.jaut.2020.102526_bib111","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/1523-1747.ep12560826","article-title":"Identification of fibroblasts responsible for increased collagen production in localized scleroderma by in situ hybridization","volume":"90","author":"K\u00e4h\u00e4ri","year":"1988","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jaut.2020.102526_bib112","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1002\/art.22927","article-title":"Presence of CD4+CD8+ double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic sclerosis","volume":"56","author":"Parel","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib113","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1182\/blood-2003-12-4395","article-title":"Peripheral CD4(+)CD8(+) T cells are differentiated effector memory cells with antiviral functions","volume":"104","author":"Nascimbeni","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2020.102526_bib114","doi-asserted-by":"crossref","first-page":"11612","DOI":"10.1038\/s41598-017-11926-2","article-title":"Peripheral human CD4(+)CD8(+) T lymphocytes exhibit a memory phenotype and enhanced responses to IL-2, IL-7 and IL-15","volume":"7","author":"Cl\u00e9net","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jaut.2020.102526_bib115","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/rheumatology\/kev335","article-title":"Local skin gene expression reflects both local and systemic skin disease in patients with systemic sclerosis","volume":"55","author":"Rice","year":"2016","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2020.102526_bib116","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1002\/art.24435","article-title":"Regulation of pulmonary inflammation and fibrosis through expression of integrins alphaVbeta3 and alphaVbeta5 on pulmonary T lymphocytes","volume":"60","author":"Luzina","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib117","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/art.37706","article-title":"Interleukin-13-producing CD8+ T cells mediate dermal fibrosis in patients with systemic sclerosis","volume":"65","author":"Fuschiotti","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib118","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.jid.2016.11.037","article-title":"Skin-resident effector memory CD8(+)CD28(-) T cells exhibit a profibrotic phenotype in patients with systemic sclerosis","volume":"137","author":"Li","year":"2017","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jaut.2020.102526_bib119","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.imlet.2017.10.002","article-title":"Current perspectives on the role of CD8+ T cells in systemic sclerosis","volume":"195","author":"Fuschiotti","year":"2018","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.jaut.2020.102526_bib120","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1080\/08916934.2016.1217997","article-title":"Contribution of CD8+ T cells to inflammatory cytokine production in systemic sclerosis (SSc)","volume":"49","author":"Klein","year":"2016","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jaut.2020.102526_bib121","doi-asserted-by":"crossref","first-page":"892","DOI":"10.4049\/jimmunol.1403046","article-title":"Increased CD226 expression on CD8+ T cells is associated with upregulated cytokine production and endothelial cell injury in patients with systemic sclerosis","volume":"195","author":"Ayano","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib122","doi-asserted-by":"crossref","first-page":"101","DOI":"10.5114\/aoms.2015.47877","article-title":"Aberrant expression of cytokine interleukin 9 along with interleukin 4 and interferon \u03b3 in connective tissue disease-associated interstitial lung disease: association with severity of pulmonary fibrosis","volume":"12","author":"Jiang","year":"2016","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.jaut.2020.102526_bib123","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nri3824","article-title":"The development and in vivo function of T helper 9 cells","volume":"15","author":"Kaplan","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib124","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/art.37859","article-title":"Thymic stromal lymphopoietin is up-regulated in the skin of patients with systemic sclerosis and induces profibrotic genes and intracellular signaling that overlap with those induced by interleukin-13 and transforming growth factor \u03b2","volume":"65","author":"Christmann","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib125","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.3899\/jrheum.110268","article-title":"Serum interleukin 9 levels are increased in patients with systemic sclerosis: association with lower frequency and severity of pulmonary fibrosis","volume":"38","author":"Yanaba","year":"2011","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.jaut.2020.102526_bib126","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/cei.13009","article-title":"Interleukin-9 over-expression and T helper 9 polarization in systemic sclerosis patients","volume":"190","author":"Guggino","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib127","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/s41586-019-0896-x","article-title":"PU.1 controls fibroblast polarization and tissue fibrosis","volume":"566","author":"Wohlfahrt","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2020.102526_bib128","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1136\/annrheumdis-2015-207477","article-title":"IL-22 capacitates dermal fibroblast responses to TNF in scleroderma","volume":"75","author":"Brembilla","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib129","doi-asserted-by":"crossref","DOI":"10.1186\/ar3486","article-title":"Increased frequency of circulating Th22 in addition to Th17 and Th2 lymphocytes in systemic sclerosis: association with interstitial lung disease","volume":"13","author":"Truchetet","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2020.102526_bib130","doi-asserted-by":"crossref","first-page":"209179","DOI":"10.1155\/2013\/209179","article-title":"Interleukin-22 inhibits bleomycin-induced pulmonary fibrosis","volume":"2013","author":"Liang","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jaut.2020.102526_bib131","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1136\/annrheumdis-2011-200709","article-title":"Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions","volume":"71","author":"Mathian","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib132","first-page":"765","article-title":"Frequency of Th1, Th2 and Th17 producing T lymphocytes in bronchoalveolar lavage of patients with systemic sclerosis","volume":"27","author":"Meloni","year":"2009","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.jaut.2020.102526_bib133","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1002\/1529-0131(200011)43:11<2455::AID-ANR12>3.0.CO;2-K","article-title":"Increased interleukin-17 production in patients with systemic sclerosis","volume":"43","author":"Kurasawa","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib134","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.4049\/jimmunol.1004081","article-title":"Blocking IL-17A promotes the resolution of pulmonary inflammation and fibrosis via TGF-beta1-dependent and -independent mechanisms","volume":"187","author":"Mi","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib135","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1002\/art.34643","article-title":"Potential roles of interleukin-17A in the development of skin fibrosis in mice","volume":"64","author":"Okamoto","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib136","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2014.08.003","article-title":"B cell activating factor is central to bleomycin- and IL-17-mediated experimental pulmonary fibrosis","volume":"56","author":"Fran\u00e7ois","year":"2015","journal-title":"J. Autoimmun."},{"issue":"Suppl 100","key":"10.1016\/j.jaut.2020.102526_bib137","first-page":"14","article-title":"Th17 cells and IL-17 promote the skin and lung inflammation and fibrosis process in a bleomycin-induced murine model of systemic sclerosis","volume":"34","author":"Lei","year":"2016","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.jaut.2020.102526_bib138","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.3389\/fimmu.2018.01611","article-title":"IL-1-IL-17 signaling Axis contributes to fibrosis and inflammation in two different murine models of systemic sclerosis","volume":"9","author":"Park","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib139","doi-asserted-by":"crossref","DOI":"10.1186\/ar4334","article-title":"Th17 cells favor inflammatory responses while inhibiting type I collagen deposition by dermal fibroblasts: differential effects in healthy and systemic sclerosis fibroblasts","volume":"15","author":"Brembilla","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2020.102526_bib140","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.4049\/jimmunol.1100591","article-title":"Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts","volume":"188","author":"Nakashima","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib141","doi-asserted-by":"crossref","DOI":"10.1186\/ar4430","article-title":"Increased frequency of Th17 cells in systemic sclerosis is related to disease activity and collagen overproduction","volume":"16","author":"Yang","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2020.102526_bib142","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3389\/fimmu.2020.00220","article-title":"T-cell proapoptotic and antifibrotic activity against autologous skin fibroblasts in vitro is associated with IL-17a Axis upregulation in systemic sclerosis","author":"Vettori","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib143","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/art.37860","article-title":"Interleukin-17A+ cell counts are increased in systemic sclerosis skin and their number is inversely correlated with the extent of skin involvement","volume":"65","author":"Truchetet","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib144","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.3389\/fimmu.2018.01865","article-title":"Interleukin-6 and type-I collagen production by systemic sclerosis fibroblasts are differentially regulated by interleukin-17a in the presence of transforming growth factor-beta 1","author":"Dufour","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib145","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jid.2019.05.026","article-title":"IL-17A dissociates inflammation from fibrogenesis in systemic sclerosis","volume":"140","author":"Dufour","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jaut.2020.102526_bib146","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.clim.2011.01.013","article-title":"Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis","volume":"139","author":"Fenoglio","year":"2011","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib147","article-title":"Elevated levels of CD4(+)CD25(+)FoxP3(+) T cells in systemic sclerosis patients contribute to the secretion of IL-17 and immunosuppression dysfunction","volume":"8","author":"Liu","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.jaut.2020.102526_bib148","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1111\/j.1365-2133.2010.09633.x","article-title":"Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea","volume":"162","author":"Antiga","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.jaut.2020.102526_bib149","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/bmt.2013.202","article-title":"Peripheral blood regulatory T cells in patients with diffuse systemic sclerosis (SSc) before and after autologous hematopoietic SCT: a pilot study","volume":"49","author":"Baraut","year":"2014","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.jaut.2020.102526_bib150","doi-asserted-by":"crossref","first-page":"3557","DOI":"10.3760\/cma.j.issn.0366-6999.20141395","article-title":"Correlation of Th17 cells and CD4\u207aCD25\u207a regulatory T cells with clinical parameters in patients with systemic sclerosis","volume":"127","author":"Jiang","year":"2014","journal-title":"Chinese Med J"},{"key":"10.1016\/j.jaut.2020.102526_bib151","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.clim.2010.06.004","article-title":"Analyses of T cell phenotype and function reveal an altered T cell homeostasis in systemic sclerosis. Correlations with disease severity and phenotypes","volume":"137","author":"Giovannetti","year":"2010","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib152","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2014.12.1932","article-title":"Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis","volume":"135","author":"MacDonald","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib153","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1136\/ard.2009.119321","article-title":"The IL1-like cytokine IL33 and its receptor ST2 are abnormally expressed in the affected skin and visceral organs of patients with systemic sclerosis","volume":"69","author":"Manetti","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib154","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1146\/annurev.immunol.26.021607.090344","article-title":"T follicular helper (TFH) cells in normal and dysregulated immune responses","volume":"26","author":"King","year":"2008","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib155","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/rheumatology\/kes258","article-title":"Augmented ICOS expression in patients with early diffuse cutaneous systemic sclerosis","volume":"52","author":"Hasegawa","year":"2013","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2020.102526_bib156","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00403-012-1292-7","article-title":"Increased production of soluble inducible costimulator in patients with diffuse cutaneous systemic sclerosis","volume":"305","author":"Yanaba","year":"2013","journal-title":"Arch. Dermatol. Res."},{"key":"10.1016\/j.jaut.2020.102526_bib157","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.immuni.2010.12.012","article-title":"Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion","volume":"34","author":"Morita","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2020.102526_bib158","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1136\/annrheumdis-2018-214382","article-title":"Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib","volume":"78","author":"Ricard","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib159","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/art.20883","article-title":"Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis","volume":"52","author":"Distler","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib160","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1002\/art.27428","article-title":"Inducible costimulator ligand regulates bleomycin-induced lung and skin fibrosis in a mouse model independently of the inducible costimulator\/inducible costimulator ligand pathway","volume":"62","author":"Tanaka","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib161","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13075-018-1569-0","article-title":"Characterization of inflammatory cell infiltrate of scleroderma skin: B cells and skin score progression","volume":"20","author":"Bosello","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2020.102526_bib162","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1002\/eji.201041194","article-title":"Synovial fibroblasts promote immunoglobulin class switching by a mechanism involving BAFF","volume":"41","author":"Alsaleh","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib163","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/s41598-020-57772-7","article-title":"Positive and negative cooperativity of TNF and Interferon-\u03b3 in regulating synovial fibroblast function and B cell survival in fibroblast\/B cell co-cultures","volume":"10","author":"Lowin","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jaut.2020.102526_bib164","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1182\/blood-2010-07-294249","article-title":"Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells","volume":"117","author":"Iwata","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2020.102526_bib165","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1002\/art.39437","article-title":"Breg cells are numerically decreased and functionally impaired in patients with systemic sclerosis","volume":"68","author":"Mavropoulos","year":"2016","journal-title":"Arthritis & rheumatology (Hoboken, NJ)"},{"key":"10.1016\/j.jaut.2020.102526_bib166","doi-asserted-by":"crossref","first-page":"3274","DOI":"10.1182\/blood-2012-11-465658","article-title":"Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease","volume":"121","author":"Le Huu","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2020.102526_bib167","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aas9944","article-title":"BAFF inhibition attenuates fibrosis in scleroderma by modulating the regulatory and effector B cell balance","volume":"4","author":"Matsushita","year":"2018","journal-title":"Science advances"},{"key":"10.1016\/j.jaut.2020.102526_bib168","first-page":"69","article-title":"GM-CSF-producing B cells: a novel B cell subset involved in the pathogenesis of systemic sclerosis [abstract].","author":"Higashioka","year":"2017","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib169","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1002\/art.20274","article-title":"Altered blood B lymphocyte homeostasis in systemic sclerosis: expanded naive B cells and diminished but activated memory B cells","volume":"50","author":"Sato","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib170","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/art.40016","article-title":"Scleroderma peripheral B lymphocytes secrete interleukin-6 and transforming growth factor \u03b2 and activate fibroblasts","volume":"69","author":"Dumoitier","year":"2017","journal-title":"Arthritis & rheumatology (Hoboken, NJ)"},{"key":"10.1016\/j.jaut.2020.102526_bib171","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13075-020-02153-8","article-title":"Inhibition of effector B cells by ibrutinib in systemic sclerosis","author":"Einhaus","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2020.102526_bib172","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1093\/intimm\/dxv046","article-title":"Regulatory B10 cell development and function","volume":"27","author":"Lykken","year":"2015","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib173","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.4049\/jimmunol.1403246","article-title":"IL-10+ innate-like B cells are part of the skin immune system and require \u03b14\u03b21 integrin to migrate between the peritoneum and inflamed skin","volume":"196","author":"Geherin","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2020.102526_bib174","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10067-009-1286-9","article-title":"Non-Hodgkin's lymphoma in systemic sclerosis: case and literature review","volume":"29","author":"Vettori","year":"2010","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.jaut.2020.102526_bib175","doi-asserted-by":"crossref","first-page":"6230138","DOI":"10.1155\/2017\/6230138","article-title":"Haematological malignancies in systemic sclerosis patients: case reports and review of the world literature","volume":"2017","author":"Colaci","year":"2017","journal-title":"Case reports in rheumatology"},{"key":"10.1016\/j.jaut.2020.102526_bib176","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/leu.2008.266","article-title":"Lymphoma cell adhesion-induced expression of B cell-activating factor of the TNF family in bone marrow stromal cells protects non-Hodgkin's B lymphoma cells from apoptosis","volume":"23","author":"Lwin","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.jaut.2020.102526_bib177","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0046-8177(94)90293-3","article-title":"Immunosuppression, autoimmunity, and lymphoproliferative disorders","volume":"25","author":"Frizzera","year":"1994","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.jaut.2020.102526_bib178","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/rheumatology\/kep093","article-title":"Experience with rituximab in scleroderma: results from a 1-year, proof-of-principle study","volume":"49","author":"Daoussis","year":"2010","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2020.102526_bib179","first-page":"S17","article-title":"Effect of long-term treatment with rituximab on pulmonary function and skin fibrosis in patients with diffuse systemic sclerosis","volume":"30","author":"Daoussis","year":"2012","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.jaut.2020.102526_bib180","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.semarthrit.2014.09.002","article-title":"Long-term efficacy of B cell depletion therapy on lung and skin involvement in diffuse systemic sclerosis","volume":"44","author":"Bosello","year":"2015","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.jaut.2020.102526_bib181","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1136\/annrheumdis-2018-214816","article-title":"Outcomes of patients with systemic sclerosis treated with rituximab in contemporary practice: a prospective cohort study","volume":"78","author":"Elhai","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib182","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1186\/s13104-018-3994-1","article-title":"Effects of treatment with rituximab on microcirculation in patients with long-term systemic sclerosis","author":"Vilela","year":"2018","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.jaut.2020.102526_bib183","doi-asserted-by":"crossref","DOI":"10.1186\/ar3879","article-title":"B-cell depletion therapy in patients with diffuse systemic sclerosis associates with a significant decrease in PDGFR expression and activation in spindle-like cells in the skin","volume":"14","author":"Daoussis","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2020.102526_bib184","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13075-016-1017-y","article-title":"B cell depletion therapy upregulates Dkk-1 skin expression in patients with systemic sclerosis: association with enhanced resolution of skin fibrosis","author":"Daoussis","year":"2016","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2020.102526_bib185","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1007\/s00296-019-04350-4","article-title":"B cell depletion treatment decreases CD4+IL4+ and CD4+CD40L+ T cells in patients with systemic sclerosis","volume":"39","author":"Antonopoulos","year":"2019","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.jaut.2020.102526_bib186","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-510X(02)00309-X","article-title":"Expression of the costimulatory molecule BB-1 and its receptors in patients with scleroderma-polymyositis overlap syndrome","volume":"205","author":"Murata","year":"2002","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.jaut.2020.102526_bib187","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/s13075-018-1652-6","article-title":"Effects of CTLA4-Ig treatment on circulating fibrocytes and skin fibroblasts from the same systemic sclerosis patients: an in vitro assay","author":"Cutolo","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2020.102526_bib188","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s13075-015-0669-3","article-title":"Gene expression changes reflect clinical response in a placebo-controlled randomized trial of abatacept in patients with diffuse cutaneous systemic sclerosis","volume":"17","author":"Chakravarty","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2020.102526_bib189","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3109\/03009742.2013.812238","article-title":"Abatacept induces clinical improvement in patients with severe systemic sclerosis","volume":"43","author":"de Paoli","year":"2014","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.jaut.2020.102526_bib190","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/art.41055","article-title":"Abatacept in early diffuse cutaneous systemic sclerosis: results of a phase II investigator-initiated, multicenter, double-blind, randomized, placebo-controlled trial","volume":"72","author":"Khanna","year":"2020","journal-title":"Arthritis & rheumatology (Hoboken, NJ)"},{"key":"10.1016\/j.jaut.2020.102526_bib191","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/1346-8138.13827","article-title":"Critical contribution of the interleukin-6\/signal transducer and activator of transcription 3 axis to vasculopathy associated with systemic sclerosis","volume":"44","author":"Taniguchi","year":"2017","journal-title":"J. Dermatol."},{"key":"10.1016\/j.jaut.2020.102526_bib192","doi-asserted-by":"crossref","first-page":"9952","DOI":"10.1074\/jbc.M113.545822","article-title":"Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-\u03b2 (TGF-\u03b2) signaling promoting SMAD3 activation and fibrosis via Gremlin protein","volume":"289","author":"O'Reilly","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jaut.2020.102526_bib193","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1172\/JCI4304","article-title":"Endogenous IL-1alpha from systemic sclerosis fibroblasts induces IL-6 and PDGF-A","volume":"103","author":"Kawaguchi","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2020.102526_bib194","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3899\/jrheum.120725","article-title":"Serum interleukin 6 is predictive of early functional decline and mortality in interstitial lung disease associated with systemic sclerosis","volume":"40","author":"De Lauretis","year":"2013","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.jaut.2020.102526_bib195","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2147\/OARRR.S17118","article-title":"Tocilizumab, a humanized anti-interleukin-6 receptor antibody, for treatment of rheumatoid arthritis","author":"Mihara","year":"2011","journal-title":"Open Access Rheumatol"},{"key":"10.1016\/j.jaut.2020.102526_bib196","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1016\/S0140-6736(16)00232-4","article-title":"Safety and efficacy of subcutaneous tocilizumab in adults with systemic sclerosis (faSScinate): a phase 2, randomised, controlled trial","volume":"387","author":"Khanna","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2020.102526_bib197","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1136\/annrheumdis-2018-213031","article-title":"Therapeutic interleukin-6 blockade reverses transforming growth factor-beta pathway activation in dermal fibroblasts: insights from the faSScinate clinical trial in systemic sclerosis","volume":"77","author":"Denton","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib198","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2147\/CE.S76549","article-title":"Pirfenidone in the treatment of idiopathic pulmonary fibrosis: an evidence-based review of its place in therapy","volume":"11","author":"Margaritopoulos","year":"2016","journal-title":"Core Evid."},{"key":"10.1016\/j.jaut.2020.102526_bib199","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.lfs.2007.11.003","article-title":"Pirfenidone inhibits the expression of HSP47 in TGF-beta1-stimulated human lung fibroblasts","volume":"82","author":"Nakayama","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.jaut.2020.102526_bib200","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1465-9921-15-16","article-title":"Pirfenidone inhibits fibrocyte accumulation in the lungs in bleomycin-induced murine pulmonary fibrosis","volume":"15","author":"Inomata","year":"2014","journal-title":"Respir. Res."},{"key":"10.1016\/j.jaut.2020.102526_bib201","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ejphar.2008.06.046","article-title":"Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis","volume":"590","author":"Oku","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.jaut.2020.102526_bib202","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejps.2014.02.014","article-title":"Effect of pirfenidone on proliferation, TGF-\u03b2-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts","volume":"58","author":"Conte","year":"2014","journal-title":"Eur. J. Pharmaceut. Sci. : official journal of the European Federation for Pharmaceutical Sciences"},{"key":"10.1016\/j.jaut.2020.102526_bib203","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.3899\/jrheum.151322","article-title":"An open-label, phase II study of the safety and tolerability of pirfenidone in patients with scleroderma-associated interstitial lung disease: the LOTUSS trial","volume":"43","author":"Khanna","year":"2016","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.jaut.2020.102526_bib204","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00296-020-04565-w","article-title":"Efficacy and safety of pirfenidone in systemic sclerosis-related interstitial lung disease-a randomised controlled trial","volume":"40","author":"Acharya","year":"2020","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.jaut.2020.102526_bib205","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1056\/NEJMoa1402584","article-title":"Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis","volume":"370","author":"Richeldi","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jaut.2020.102526_bib206","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1136\/annrheumdis-2014-207109","article-title":"Nintedanib inhibits fibroblast activation and ameliorates fibrosis in preclinical models of systemic sclerosis","volume":"75","author":"Huang","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib207","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1183\/09031936.00152106","article-title":"Inhibition of PDGF, VEGF and FGF signalling attenuates fibrosis","volume":"29","author":"Chaudhary","year":"2007","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.jaut.2020.102526_bib208","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1056\/NEJMoa1903076","article-title":"Nintedanib for systemic sclerosis-associated interstitial lung disease","volume":"380","author":"Distler","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jaut.2020.102526_bib209","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1016\/j.bmc.2014.04.062","article-title":"Ultrapure ajulemic acid has improved CB2 selectivity with reduced CB1 activity","volume":"22","author":"Tepper","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.jaut.2020.102526_bib210","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1093\/rheumatology\/kep189","article-title":"Cannabinoids inhibit fibrogenesis in diffuse systemic sclerosis fibroblasts","volume":"48","author":"Garcia-Gonzalez","year":"2009","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2020.102526_bib211","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12931-016-0373-0","article-title":"Ajulemic acid exerts potent anti-fibrotic effect during the fibrogenic phase of bleomycin lung","volume":"17","author":"Lucattelli","year":"2016","journal-title":"Respir. Res."},{"key":"10.1016\/j.jaut.2020.102526_bib212","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1136\/annrheumdis-2011-200314","article-title":"Synthetic cannabinoid ajulemic acid exerts potent antifibrotic effects in experimental models of systemic sclerosis","volume":"71","author":"Gonzalez","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2020.102526_bib213","doi-asserted-by":"crossref","DOI":"10.1002\/art.41294","article-title":"Safety and efficacy of lenabasum in a phase 2 randomized, placebo-controlled trial in adults with systemic sclerosis","author":"Spiera","year":"2020","journal-title":"Arthritis & rheumatology (Hoboken, NJ)"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841120301505?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841120301505?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:25:10Z","timestamp":1760257510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841120301505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":213,"alternative-id":["S0896841120301505"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2020.102526","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bi-directional communication: Conversations between fibroblasts and immune cells in systemic sclerosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2020.102526","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102526"}}