{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:42:34Z","timestamp":1790808154143,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004756","name":"Emil Aaltosen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004756","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003756","name":"Biomedicum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003756","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007797","name":"University of Helsinki","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Finnish Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007798","name":"University of Helsinki Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007798","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.jaut.2021.102616","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T08:45:24Z","timestamp":1614415524000},"page":"102616","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Generation of self-reactive, shared T-cell receptor \u03b1 chains in the human thymus"],"prefix":"10.1016","volume":"119","author":[{"given":"Nelli","family":"Heikkil\u00e4","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silja","family":"Sormunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joonatan","family":"Mattila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taina","family":"H\u00e4rk\u00f6nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Knip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmi-Leena","family":"Ihantola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuure","family":"Kinnunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka P.","family":"Mattila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jari","family":"Saram\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Petteri","family":"Arstila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2021.102616_bib1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/334395a0","article-title":"T-cell antigen receptor genes and T-cell recognition","volume":"334","author":"Davis","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2021.102616_bib2","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1126\/science.286.5441.958","article-title":"A direct estimate of the human alphabeta T cell receptor diversity","volume":"286","author":"Arstila","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.jaut.2021.102616_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1126\/scitranslmed.3001442","article-title":"Overlap and effective size of the human CD8+ T cell receptor repertoire","volume":"2","author":"Robins","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jaut.2021.102616_bib4","doi-asserted-by":"crossref","first-page":"13139","DOI":"10.1073\/pnas.1409155111","article-title":"Diversity and clonal selection in the human T-cell repertoire","volume":"111","author":"Qi","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jaut.2021.102616_bib5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.molimm.2016.07.002","article-title":"T cell receptor diversity in the human thymus","volume":"76","author":"Vanhanen","year":"2016","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.immunol.23.021704.115658","article-title":"How TCRs bind MHCs, peptides, and coreceptors","volume":"24","author":"Rudolph","year":"2006","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nri2260","article-title":"The molecular basis for public T-cell responses?","volume":"8","author":"Venturi","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/cr.2012.1","article-title":"Determinants of public T cell responses","volume":"22","author":"Li","year":"2012","journal-title":"Cell Res."},{"key":"10.1016\/j.jaut.2021.102616_bib9","doi-asserted-by":"crossref","first-page":"7853","DOI":"10.4049\/jimmunol.181.11.7853","article-title":"TCR beta-chain sharing in human CD8+ T cell responses to cytomegalovirus and EBV","volume":"181","author":"Venturi","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib10","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1101\/gr.170753.113","article-title":"T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity","volume":"24","author":"Madi","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.jaut.2021.102616_bib11","doi-asserted-by":"crossref","first-page":"37543","DOI":"10.1038\/srep37543","article-title":"Autoimmune susceptibility imposed by public TCRbeta chains","volume":"6","author":"Zhao","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jaut.2021.102616_bib12","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1172\/JCI83792","article-title":"Public T cell receptors confer high-avidity CD4 responses to HIV controllers","volume":"126","author":"Benati","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2021.102616_bib13","doi-asserted-by":"crossref","first-page":"5980","DOI":"10.1073\/pnas.1319389111","article-title":"Distinctive properties of identical twins' TCR repertoires revealed by high-throughput sequencing","volume":"111","author":"Zvyagin","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jaut.2021.102616_bib14","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.molimm.2020.09.003","article-title":"Human thymic T cell repertoire is imprinted with strong convergence to shared sequences","volume":"127","author":"Heikkil\u00e4","year":"2020","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib15","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/eji.201948404","article-title":"Identifying the inheritable component of human thymic T cell repertoire generation in monozygous twins","volume":"50","author":"Heikkil\u00e4","year":"2020","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1530\/EJE-13-0089","article-title":"Extended family history of autoimmune diseases and phenotype and genotype of children with newly diagnosed type 1 diabetes","volume":"169","author":"Parkkola","year":"2013","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.jaut.2021.102616_bib17","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1093\/bioinformatics\/btx286","article-title":"McPAS-TCR: a manually curated catalogue of pathology-associated T cell receptor sequences","volume":"33","author":"Tickotsky","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaut.2021.102616_bib18","doi-asserted-by":"crossref","first-page":"D1057","DOI":"10.1093\/nar\/gkz874","article-title":"VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium","volume":"48","author":"Bagaev","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jaut.2021.102616_bib19","doi-asserted-by":"crossref","first-page":"10732","DOI":"10.1073\/pnas.1809208115","article-title":"Proinsulin C-peptide is an autoantigen in people with type 1 diabetes","volume":"115","author":"So","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jaut.2021.102616_bib20","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.1901079","article-title":"Characterization of proinsulin T cell epitopes restricted by type 1 diabetes-associated HLA class II molecules","author":"Ihantola","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.4049\/jimmunol.1700172","article-title":"Single-cell RNA sequencing reveals expanded clones of islet antigen-reactive CD4+ T cells in peripheral blood of subjects with type 1 diabetes","volume":"199","author":"Cerosaletti","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib22","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/ni.3271","article-title":"T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex","volume":"16","author":"Beringer","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108658","article-title":"Assessing T cell clonal size distribution: a non-parametric approach","volume":"9","author":"Bolkhovskaya","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.jaut.2021.102616_bib24","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s11892-011-0223-x","article-title":"Genetics of the HLA region in the prediction of type 1 diabetes","volume":"11","author":"Noble","year":"2011","journal-title":"Curr. Diabetes Rep."},{"key":"10.1016\/j.jaut.2021.102616_bib25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/nri3667","article-title":"Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)","volume":"14","author":"Klein","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/ng0397-293","article-title":"The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes","volume":"15","author":"Pugliese","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jaut.2021.102616_bib27","doi-asserted-by":"crossref","first-page":"5918","DOI":"10.4049\/jimmunol.161.11.5918","article-title":"Transcription of a broad range of self-antigens in human thymus suggests a role for central mechanisms in tolerance toward peripheral antigens","volume":"161","author":"Sospedra","year":"1998","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1084\/jem.20031677","article-title":"Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters","volume":"199","author":"Gotter","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jaut.2021.102616_bib29","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jaut.2019.01.011","article-title":"Primary immunodeficiency and autoimmunity: a comprehensive review","volume":"99","author":"Amaya-Uribe","year":"2019","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2021.102616_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S146239940501015X","article-title":"Molecular pathogenesis of rheumatic fever and rheumatic heart disease","volume":"7","author":"Guilherme","year":"2005","journal-title":"Expet Rev. Mol. Med."},{"key":"10.1016\/j.jaut.2021.102616_bib31","first-page":"863","article-title":"Reactive arthritis","volume":"19","author":"Petersel","year":"2005","journal-title":"Infect. Dis. Clin."},{"key":"10.1016\/j.jaut.2021.102616_bib32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nrrheum.2015.133","article-title":"Genetics of ankylosing spondylitis--insights into pathogenesis","volume":"12","author":"Brown","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jaut.2021.102616_bib33","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.molmed.2019.11.003","article-title":"Epstein-barr virus in multiple sclerosis: theory and emerging immunotherapies","volume":"26","author":"Bar-Or","year":"2020","journal-title":"Trends Mol. Med."},{"issue":"Suppl","key":"10.1016\/j.jaut.2021.102616_bib34","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jaut.2005.09.024","article-title":"Infections and autoimmune diseases","volume":"25","author":"Bach","year":"2005","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2021.102616_bib35","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1097\/QAD.0000000000001603","article-title":"The Dat\u2019AIDS study group, Epidemiology of autoimmune and inflammatory diseases in a French nationwide HIV cohort","volume":"31","author":"Lebrun","year":"2017","journal-title":"AIDS"},{"key":"10.1016\/j.jaut.2021.102616_bib36","article-title":"Incidence of autoimmune diseases in people living with HIV compared to a matched population: a cohort study","author":"Damba","year":"2020","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.jaut.2021.102616_bib37","doi-asserted-by":"crossref","first-page":"102506","DOI":"10.1016\/j.jaut.2020.102506","article-title":"Autoinflammatory and autoimmune conditions at the crossroad of COVID-19","volume":"114","author":"Rodr\u00edguez","year":"2020","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2021.102616_bib38","doi-asserted-by":"crossref","first-page":"102592","DOI":"10.1016\/j.jaut.2020.102592","article-title":"The JANUS of chronic inflammatory and autoimmune diseases onset during COVID-19 - a systematic review of the literature","volume":"117","author":"Novelli","year":"2020","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2021.102616_bib39","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s00125-018-4561-y","article-title":"Coxsackievirus B1 infections are associated with the initiation of insulin-driven autoimmunity that progresses to type 1 diabetes","volume":"61","author":"Sioofy-Khojine","year":"2018","journal-title":"Diabetologia"},{"key":"10.1016\/j.jaut.2021.102616_bib40","doi-asserted-by":"crossref","first-page":"446","DOI":"10.2337\/db13-0619","article-title":"Coxsackievirus B1 is associated with induction of \u03b2-cell autoimmunity that portends type 1 diabetes","volume":"63","author":"Laitinen","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2021.102616_bib41","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/pedi.12545","article-title":"Primary islet autoantibody at initial seroconversion and autoantibodies at diagnosis of type 1 diabetes as markers of disease heterogeneity","volume":"19","author":"Ilonen","year":"2018","journal-title":"Pediatr. Diabetes"},{"key":"10.1016\/j.jaut.2021.102616_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/v11080762","article-title":"Viruses and autoimmunity: a review on the potential interaction and molecular mechanisms","volume":"11","author":"Smatti","year":"2019","journal-title":"Viruses"},{"key":"10.1016\/j.jaut.2021.102616_bib43","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.3389\/fimmu.2020.01821","article-title":"Clinical use of schistosoma mansoni antigens as novel immunotherapies for autoimmune disorders","volume":"11","author":"Cleenewerk","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib44","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1146\/annurev-immunol-042718-041757","article-title":"Using T cell receptor repertoires to understand the principles of adaptive immune recognition","volume":"37","author":"Bradley","year":"2019","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib45","doi-asserted-by":"crossref","first-page":"11112","DOI":"10.1038\/ncomms11112","article-title":"Individual heritable differences result in unique cell lymphocyte receptor repertoires of naive and antigen-experienced cells","volume":"7","author":"Rubelt","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2021.102616_bib46","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature03523","article-title":"Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice","volume":"435","author":"Nakayama","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2021.102616_bib47","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1073\/pnas.1915008117","article-title":"Determinants governing T cell receptor \u03b1\/\u03b2-chain pairing in repertoire formation of identical twins","volume":"117","author":"Tanno","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.jaut.2021.102616_bib48","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.4049\/jimmunol.1401717","article-title":"Specific roles of each TCR hemichain in generating functional chain-centric TCR","volume":"194","author":"Nakatsugawa","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib49","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.4049\/jimmunol.1400007","article-title":"Identification of multiple public TCR repertoires in chronic beryllium disease","volume":"192","author":"Bowerman","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib50","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/BJ20080850","article-title":"Conformational changes and flexibility in T-cell receptor recognition of peptide-MHC complexes","volume":"415","author":"Armstrong","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.jaut.2021.102616_bib51","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/nri3279","article-title":"Why must T cells be cross-reactive?","volume":"12","author":"Sewell","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib52","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.4049\/jimmunol.1403031","article-title":"High diversity in the TCR repertoire of GAD65 autoantigen-specific human CD4+ T cells","volume":"194","author":"Eugster","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2021.102616_bib53","doi-asserted-by":"crossref","first-page":"44661","DOI":"10.1038\/srep44661","article-title":"CD8(+) T cells specific for the islet autoantigen IGRP are restricted in their T cell receptor chain usage","volume":"7","author":"Fuchs","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jaut.2021.102616_bib54","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aao4013","article-title":"Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors","volume":"3","author":"Culina","year":"2018","journal-title":"Sci Immunol"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089684112100024X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089684112100024X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:27:51Z","timestamp":1760257671000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089684112100024X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":54,"alternative-id":["S089684112100024X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2021.102616","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Generation of self-reactive, shared T-cell receptor \u03b1 chains in the human thymus","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2021.102616","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102616"}}