{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:06:56Z","timestamp":1791234416154,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005302","name":"Alexander S. Onassis Public Benefit Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005302","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["75732319"],"award-info":[{"award-number":["75732319"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB834 B12"],"award-info":[{"award-number":["SFB834 B12"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005187","name":"National and Kapodistrian University of Athens","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005187","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["759248"],"award-info":[{"award-number":["759248"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.jaut.2021.102755","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T16:17:39Z","timestamp":1638202659000},"page":"102755","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Adenosine-to-inosine RNA editing contributes to type I interferon responses in systemic sclerosis"],"prefix":"10.1016","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7878-8078","authenticated-orcid":false,"given":"Nikolaos I.","family":"Vlachogiannis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Tual-Chalot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6573-8960","authenticated-orcid":false,"given":"Eleftherios","family":"Zormpas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Bonini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis A.","family":"Ntouros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Pappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2162-1362","authenticated-orcid":false,"given":"Vasiliki-Kalliopi","family":"Bournia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2238-0975","authenticated-orcid":false,"given":"Maria G.","family":"Tektonidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2945-1329","authenticated-orcid":false,"given":"Vassilis L.","family":"Souliotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clio P.","family":"Mavragani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimon","family":"Stamatelopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4144-4305","authenticated-orcid":false,"given":"Aikaterini","family":"Gatsiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros P.","family":"Sfikakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Stellos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2021.102755_bib1","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1056\/NEJMra0806188","article-title":"Scleroderma","volume":"360","author":"Gabrielli","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jaut.2021.102755_bib2","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1136\/ard.2011.150326","article-title":"Patients with systemic lupus erythematosus, myositis, rheumatoid arthritis and scleroderma share activation of a common type I interferon pathway","volume":"70","author":"Higgs","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2021.102755_bib3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/art.27224","article-title":"Systemic sclerosis and lupus: points in an interferon-mediated continuum","volume":"62","author":"Assassi","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2021.102755_bib4","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/art.41610","article-title":"Integrative analysis reveals a molecular stratification of systemic autoimmune diseases","volume":"73","author":"Barturen","year":"2021","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2021.102755_bib5","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/art.27220","article-title":"A four-gene biomarker predicts skin disease in patients with diffuse cutaneous systemic sclerosis","volume":"62","author":"Farina","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2021.102755_bib6","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1002\/art.39287","article-title":"A longitudinal biomarker for the extent of skin disease in patients with diffuse cutaneous systemic sclerosis","volume":"67","author":"Rice","year":"2015","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2021.102755_bib7","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/art.38288","article-title":"Association of interferon- and transforming growth factor \u03b2-regulated genes and macrophage activation with systemic sclerosis-related progressive lung fibrosis: gene expression in SSc-related progressive lung fibrosis","volume":"66","author":"Christmann","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2021.102755_bib8","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1136\/ard.2009.121400","article-title":"Type I interferon system activation and association with disease manifestations in systemic sclerosis","volume":"69","author":"Eloranta","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2021.102755_bib9","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1136\/annrheumdis-2015-207392","article-title":"The interferon type I signature is present in systemic sclerosis before overt fibrosis and might contribute to its pathogenesis through high BAFF gene expression and high collagen synthesis","volume":"75","author":"Brkic","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2021.102755_bib10","doi-asserted-by":"crossref","first-page":"154635","DOI":"10.1016\/j.cyto.2018.12.018","article-title":"Type I interferon dysregulation in systemic sclerosis","volume":"132","author":"Skaug","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.jaut.2021.102755_bib11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/1529-0131(199902)42:2<299::AID-ANR12>3.0.CO;2-R","article-title":"Interferon-alpha does not improve outcome at one year in patients with diffuse cutaneous scleroderma: results of a randomized, double-blind, placebo-controlled trial","volume":"42","author":"Black","year":"1999","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2021.102755_bib12","doi-asserted-by":"crossref","first-page":"R57","DOI":"10.1186\/ar4492","article-title":"others, Dose-escalation of human anti-interferon-alpha receptor monoclonal antibody MEDI-546 in subjects with systemic sclerosis: a phase 1, multicenter, open label study","volume":"16","author":"Goldberg","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2021.102755_bib13","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1038\/jid.2015.188","article-title":"Suppression of T Cell activation and collagen accumulation by an anti-IFNAR1 mAb, anifrolumab, in adult patients with systemic sclerosis","volume":"135","author":"Guo","year":"2015","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.jaut.2021.102755_bib14","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nrrheum.2018.31","article-title":"Type I interferon in rheumatic diseases","volume":"14","author":"Muskardin","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jaut.2021.102755_bib15","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-biochem-060208-105251","article-title":"Functions and regulation of RNA editing by ADAR deaminases","volume":"79","author":"Nishikura","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.jaut.2021.102755_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nrm.2015.4","article-title":"A-to-I editing of coding and non-coding RNAs by ADARs","volume":"17","author":"Nishikura","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jaut.2021.102755_bib17","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1089\/ars.2017.7295","article-title":"Adenosine-to-Inosine RNA editing in health and disease","volume":"29","author":"Gatsiou","year":"2018","journal-title":"Antioxid Redox Signal."},{"key":"10.1016\/j.jaut.2021.102755_bib18","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.celrep.2018.03.036","article-title":"Increased RNA editing may provide a source for autoantigens in systemic lupus erythematosus","volume":"23","author":"Roth","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.jaut.2021.102755_bib19","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1261\/rna.064659.117","article-title":"Decreased A-to-I RNA editing as a source of keratinocytes' dsRNA in psoriasis","volume":"24","author":"Shallev","year":"2018","journal-title":"RNA"},{"key":"10.1016\/j.jaut.2021.102755_bib20","doi-asserted-by":"crossref","first-page":"e391","DOI":"10.1371\/journal.pbio.0020391","article-title":"Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome","volume":"2","author":"Athanasiadis","year":"2004","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jaut.2021.102755_bib21","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1038\/nm.4172","article-title":"Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation","volume":"22","author":"Stellos","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.jaut.2021.102755_bib22","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/nrg798","article-title":"Alu repeats and human genomic diversity","volume":"3","author":"Batzer","year":"2002","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jaut.2021.102755_bib23","doi-asserted-by":"crossref","first-page":"102329","DOI":"10.1016\/j.jaut.2019.102329","article-title":"Increased adenosine-to-inosine RNA editing in rheumatoid arthritis","volume":"106","author":"Vlachogiannis","year":"2020","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2021.102755_bib24","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","article-title":"Classification criteria for systemic sclerosis: an American college of rheumatology\/European league against rheumatism collaborative initiative","volume":"72","author":"van den Hoogen","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2021.102755_bib25","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1002\/art.34473","article-title":"Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus","volume":"64","author":"Petri","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2021.102755_bib26","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.immuni.2012.12.008","article-title":"Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines","volume":"38","author":"Obermoser","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2021.102755_bib27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.clim.2016.10.015","article-title":"Increased frequency of the PTPN22W* variant in primary Sjogren's Syndrome: association with low type I IFN scores","volume":"173","author":"Vlachogiannis","year":"2016","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jaut.2021.102755_bib28","doi-asserted-by":"crossref","first-page":"582401","DOI":"10.3389\/fimmu.2020.582401","article-title":"Association between DNA damage response, fibrosis and type I interferon signature in systemic sclerosis","volume":"11","author":"Vlachogiannis","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2021.102755_bib29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jaut.2015.07.002","article-title":"Type I and II interferon signatures in Sjogren's syndrome pathogenesis: contributions in distinct clinical phenotypes and Sjogren's related lymphomagenesis","volume":"63","author":"Nezos","year":"2015","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2021.102755_bib30","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.yjmcc.2021.07.005","article-title":"Adenosine-to-inosine Alu RNA editing controls the stability of the pro-inflammatory long noncoding RNA NEAT1 in atherosclerotic cardiovascular disease","volume":"160","author":"Vlachogiannis","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.jaut.2021.102755_bib31","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/annrheumdis-2019-215894","article-title":"Global skin gene expression analysis of early diffuse cutaneous systemic sclerosis shows a prominent innate and adaptive inflammatory profile","volume":"79","author":"Skaug","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2021.102755_bib32","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1172\/JCI135439","article-title":"Long noncoding RNA H19X is a key mediator of TGF-\u03b2-driven fibrosis","volume":"130","author":"Pachera","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2021.102755_bib33","author":"Krueger"},{"key":"10.1016\/j.jaut.2021.102755_bib34","author":"Andrews"},{"key":"10.1016\/j.jaut.2021.102755_bib35","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1093\/bioinformatics\/btw354","article-title":"MultiQC: summarize analysis results for multiple tools and samples in a single report","volume":"32","author":"Ewels","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaut.2021.102755_bib36","first-page":"D682","article-title":"Ensembl","volume":"48","author":"Yates","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jaut.2021.102755_bib37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaut.2021.102755_bib38","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.jaut.2021.102755_bib39","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.jaut.2021.102755_bib40","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1748-7188-6-26","article-title":"ViennaRNA package 2.0","volume":"6","author":"Lorenz","year":"2011","journal-title":"Algorithm Mol. Biol."},{"key":"10.1016\/j.jaut.2021.102755_bib41","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1073\/pnas.96.8.4621","article-title":"Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible","volume":"96","author":"George","year":"1999","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.jaut.2021.102755_bib42","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1128\/MCB.15.10.5376","article-title":"Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase","volume":"15","author":"Patterson","year":"1995","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jaut.2021.102755_bib43","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S1074-7613(00)80249-6","article-title":"Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading","volume":"4","author":"Riese","year":"1996","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2021.102755_bib44","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/art.37742","article-title":"Correlation of interferon-inducible chemokine plasma levels with disease severity in systemic sclerosis","volume":"65","author":"Liu","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2021.102755_bib45","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1002\/art.30318","article-title":"Interferon and alternative activation of monocyte\/macrophages in systemic sclerosis-associated pulmonary arterial hypertension","volume":"63","author":"Christmann","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2021.102755_bib46","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1002\/art.41627","article-title":"Predictive significance of serum interferon-inducible protein score for response to treatment in systemic sclerosis-related interstitial lung disease","volume":"73","author":"Assassi","year":"2021","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2021.102755_bib47","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1136\/annrheumdis-2019-215208","article-title":"Interferon regulatory factor 7 (IRF7) represents a link between inflammation and fibrosis in the pathogenesis of systemic sclerosis","volume":"78","author":"Wu","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2021.102755_bib48","doi-asserted-by":"crossref","first-page":"4952","DOI":"10.1074\/jbc.M310162200","article-title":"Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene","volume":"279","author":"Wang","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jaut.2021.102755_bib49","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.aac7049","article-title":"RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself","volume":"349","author":"Liddicoat","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.jaut.2021.102755_bib50","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1016\/j.celrep.2014.10.041","article-title":"The RNA-editing enzyme ADAR1 controls innate immune responses to RNA","volume":"9","author":"Mannion","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.jaut.2021.102755_bib51","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.immuni.2015.11.001","article-title":"Isoforms of RNA-editing enzyme ADAR1 independently control nucleic acid sensor MDA5-driven autoimmunity and multi-organ development","volume":"43","author":"Pestal","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2021.102755_bib52","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/ng.2414","article-title":"Mutations in ADAR1 cause Aicardi-Gouti\u00e8res syndrome associated with a type I interferon signature","volume":"44","author":"Rice","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jaut.2021.102755_bib53","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.celrep.2015.08.080","article-title":"Elevated RNA editing activity is a major contributor to transcriptomic diversity in tumors","volume":"13","author":"Paz-Yaacov","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.jaut.2021.102755_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-018-0271-8","article-title":"Regulation of RNA editing by RNA-binding proteins in human cells","volume":"2","author":"Quinones-Valdez","year":"2019","journal-title":"Commun. Biol."},{"key":"10.1016\/j.jaut.2021.102755_bib55","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/s41592-019-0610-9","article-title":"Genome-wide quantification of ADAR adenosine-to-inosine RNA editing activity","volume":"16","author":"Roth","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jaut.2021.102755_bib56","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nri3787","article-title":"Type I interferons in infectious disease","volume":"15","author":"McNab","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2021.102755_bib57","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3389\/fimmu.2016.00609","article-title":"Type-I interferon responses: from friend to foe in the battle against chronic viral infection","volume":"7","author":"Murira","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2021.102755_bib58","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3389\/fgene.2019.00332","article-title":"Emerging evidence of translational control by AU-rich element-binding proteins","volume":"10","author":"Otsuka","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.jaut.2021.102755_bib59","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2174\/138920312801619394","article-title":"Functional interplay between RNA-binding protein HuR and microRNAs","volume":"13","author":"Srikantan","year":"2012","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.jaut.2021.102755_bib60","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1172\/JCI0214682","article-title":"Cathepsin S inhibitor prevents autoantigen presentation and autoimmunity","volume":"110","author":"Saegusa","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2021.102755_bib61","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/annrheumdis-2013-203717","article-title":"Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming","volume":"74","author":"Rupanagudi","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2021.102755_bib62","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ni.3793","article-title":"Increased Cathepsin S in Prdm1\u2212\/\u2212 dendritic cells alters TFH repertoire and contributes to lupus","volume":"18","author":"Kim","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2021.102755_bib63","doi-asserted-by":"crossref","first-page":"16348","DOI":"10.1038\/s41598-021-94855-5","article-title":"Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-\u03b1 in transgenic mice","volume":"11","author":"Lee","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jaut.2021.102755_bib64","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1210\/jc.2009-1894","article-title":"Cathepsins in human obesity: changes in energy balance predominantly affect cathepsin s in adipose tissue and in circulation","volume":"95","author":"Naour","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.jaut.2021.102755_bib65","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41569-018-0002-3","article-title":"Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials","volume":"15","author":"Liu","year":"2018","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.jaut.2021.102755_bib66","doi-asserted-by":"crossref","first-page":"E2748","DOI":"10.1073\/pnas.1620954114","article-title":"Cathepsin S is the major activator of the psoriasis-associated proinflammatory cytokine IL-36\u03b3","volume":"114","author":"Ainscough","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jaut.2021.102755_bib67","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1002\/art.38633","article-title":"Tear cathepsin S as a candidate biomarker for sj\u00f6gren\u2019s syndrome: tear CTSS as a biomarker for SS","volume":"66","author":"Hamm-Alvarez","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2021.102755_bib68","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12931-020-01381-5","article-title":"Investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics","volume":"21","author":"Brown","year":"2020","journal-title":"Respir. Res."},{"key":"10.1016\/j.jaut.2021.102755_bib69","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/1346-8138.15458","article-title":"Decreased serum cathepsin S levels in patients with systemic sclerosis-associated interstitial lung disease","volume":"47","author":"Toyama","year":"2020","journal-title":"J. Dermatol."},{"key":"10.1016\/j.jaut.2021.102755_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109178","article-title":"ELAVL1 primarily couples mRNA stability with the 3\u2019 UTRs of interferon-stimulated genes","volume":"35","author":"Rothamel","year":"2021","journal-title":"Cell Rep."}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841121001633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841121001633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T20:18:53Z","timestamp":1777580333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841121001633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":70,"alternative-id":["S0896841121001633"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2021.102755","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adenosine-to-inosine RNA editing contributes to type I interferon responses in systemic sclerosis","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2021.102755","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102755"}}