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Lett."},{"key":"10.1016\/j.jaut.2022.102870_bib81","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.immuni.2014.02.005","article-title":"Transcription factor STAT3 and type I interferons are corepressive insulators for differentiation of follicular helper and T helper 1 cells","volume":"40","author":"Ray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2022.102870_bib82","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1172\/JCI81059","article-title":"Interferon-induced mechanosensing defects impede apoptotic cell clearance in lupus","volume":"125","author":"Li","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2022.102870_bib83","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nri2654","article-title":"The functional plasticity of T cell subsets","volume":"9","author":"Bluestone","year":"2009","journal-title":"Nat. Rev. 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Invest."},{"key":"10.1016\/j.jaut.2022.102870_bib90","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.molmed.2022.04.010","article-title":"Therapeutic potential of interleukin-2 in autoimmune diseases","volume":"28","author":"Yuan","year":"2022","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.jaut.2022.102870_bib91","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.4049\/jimmunol.1301843","article-title":"TGF-beta: guardian of T cell function","volume":"191","author":"Oh","year":"2013","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2022.102870_bib92","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1146\/annurev.immunol.26.021607.090357","article-title":"The biology of interleukin-2","volume":"26","author":"Malek","year":"2008","journal-title":"Annu. Rev. 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Rheumatol."},{"key":"10.1016\/j.jaut.2022.102870_bib97","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1074-7613(00)80170-3","article-title":"Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease","volume":"12","author":"Gorelik","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2022.102870_bib98","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1182\/blood.V87.4.1439.bloodjournal8741439","article-title":"Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse","volume":"87","author":"Yaswen","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2022.102870_bib99","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1126\/science.7770771","article-title":"Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta","volume":"268","author":"Suzuki","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.jaut.2022.102870_bib100","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1074-7613(02)00367-9","article-title":"CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. 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Med."},{"key":"10.1016\/j.jaut.2022.102870_bib102","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.immuni.2006.07.011","article-title":"Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms","volume":"25","author":"Li","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2022.102870_bib103","first-page":"218","article-title":"TGF-beta and Eomes control the homeostasis of CD8+ regulatory T cells","author":"Mishra","year":"2021","journal-title":"J. Exp. 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Immunol."},{"key":"10.1016\/j.jaut.2022.102870_bib109","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1172\/JCI22854","article-title":"Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV","volume":"115","author":"Juang","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2022.102870_bib110","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.4049\/jimmunol.182.3.1500","article-title":"Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity","volume":"182","author":"Sunahori","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2022.102870_bib111","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/cmi.2010.78","article-title":"The epigenetics of autoimmunity","volume":"8","author":"Meda","year":"2011","journal-title":"Cell. Mol. 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Clin. Invest."},{"key":"10.1016\/j.jaut.2022.102870_bib120","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.120880","article-title":"Precision DNA demethylation ameliorates disease in lupus-prone mice","volume":"3","author":"Li","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.jaut.2022.102870_bib121","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0129813","article-title":"Genome-wide assessment of differential DNA methylation associated with autoantibody production in systemic lupus erythematosus","volume":"10","author":"Chung","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2022.102870_bib122","first-page":"804","article-title":"Abnormal histone modification patterns in lupus CD4+ T cells","volume":"35","author":"Hu","year":"2008","journal-title":"J. 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Sci."},{"key":"10.1016\/j.jaut.2022.102870_bib125","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature07672","article-title":"Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals","volume":"458","author":"Guttman","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2022.102870_bib126","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/ni.2005","article-title":"The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2","volume":"12","author":"Delgoffe","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2022.102870_bib127","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/ni.3466","article-title":"Immunometabolism of regulatory T cells","volume":"17","author":"Newton","year":"2016","journal-title":"Nat. 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Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jaut.2022.102870_bib132","doi-asserted-by":"crossref","first-page":"4369","DOI":"10.1038\/s41467-018-06686-0","article-title":"Inhibition of glucose metabolism selectively targets autoreactive follicular helper T cells","volume":"9","author":"Choi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2022.102870_bib133","doi-asserted-by":"crossref","first-page":"274ra18","DOI":"10.1126\/scitranslmed.aaa0835","article-title":"Normalization of CD4+ T cell metabolism reverses lupus","volume":"7","author":"Yin","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jaut.2022.102870_bib134","first-page":"132","article-title":"Iron-dependent epigenetic modulation promotes pathogenic T cell differentiation in lupus","author":"Gao","year":"2022","journal-title":"J. Clin. 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