{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:47:06Z","timestamp":1784119626575,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF-2021R1A4A5032185"],"award-info":[{"award-number":["NRF-2021R1A4A5032185"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.jaut.2022.102940","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T06:37:53Z","timestamp":1666852673000},"page":"102940","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Caspase-10 affects the pathogenesis of primary biliary cholangitis by regulating inflammatory cell death"],"prefix":"10.1016","volume":"133","author":[{"given":"Minjeong","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Hee","family":"Dho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeam","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeongun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonjung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Jong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hoon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-A","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5983-4470","authenticated-orcid":false,"given":"Lark Kyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2022.102940_bib1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41575-019-0226-7","article-title":"Primary biliary cholangitis: pathogenesis and therapeutic opportunities","volume":"17","author":"Gulamhusein","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jaut.2022.102940_bib2","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.cgh.2018.12.028","article-title":"Effects of age and sex of response to ursodeoxycholic acid and transplant-free survival in patients with primary biliary cholangitis","volume":"17","author":"Cheung","year":"2019","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"Suppl 2","key":"10.1016\/j.jaut.2022.102940_bib3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000440754","article-title":"Genetic and environmental risk factors for PBC","volume":"33","author":"Zhang","year":"2015","journal-title":"Dig. Dis."},{"key":"10.1016\/j.jaut.2022.102940_bib4","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/cmi.2016.4","article-title":"Adaptive immunity in the liver","volume":"13","author":"Shuai","year":"2016","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jaut.2022.102940_bib5","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/hep.23783","article-title":"Biliary apotopes and anti-mitochondrial antibodies activate innate immune responses in primary biliary cirrhosis","volume":"52","author":"Lleo","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2022.102940_bib6","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/hep.20859","article-title":"Altered monocyte responses to defined TLR ligands in patients with primary biliary cirrhosis","volume":"42","author":"Mao","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2022.102940_bib7","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1002\/hep.26429","article-title":"Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice","volume":"58","author":"Pradere","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2022.102940_bib8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1055\/s-0034-1383725","article-title":"Genetics and epigenetics of primary biliary cirrhosis","volume":"34","author":"Bianchi","year":"2014","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.jaut.2022.102940_bib9","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1055\/s-0035-1567831","article-title":"Genome-wide association studies in primary biliary cirrhosis","volume":"35","author":"Gulamhusein","year":"2015","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.jaut.2022.102940_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14828","article-title":"A genome-wide association study identifies six novel risk loci for primary biliary cholangitis","volume":"8","author":"Qiu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2022.102940_bib11","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/hep.23041","article-title":"Keratin variants are overrepresented in primary biliary cirrhosis and associate with disease severity","volume":"50","author":"Zhong","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2022.102940_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004369","article-title":"Recent mitochondrial DNA mutations increase the risk of developing common late-onset human diseases","volume":"10","author":"Hudson","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jaut.2022.102940_bib13","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.clinre.2016.05.011","article-title":"The epigenetics of PBC: the link between genetic susceptibility and environment","volume":"40","author":"Marzorati","year":"2016","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.1016\/j.jaut.2022.102940_bib14","doi-asserted-by":"crossref","first-page":"7391","DOI":"10.1073\/pnas.1403477111","article-title":"Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death","volume":"111","author":"Weng","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jaut.2022.102940_bib15","doi-asserted-by":"crossref","first-page":"E10888","DOI":"10.1073\/pnas.1809548115","article-title":"Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection","volume":"115","author":"Sarhan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jaut.2022.102940_bib16","doi-asserted-by":"crossref","first-page":"8307","DOI":"10.1021\/bi100968m","article-title":"Activation and specificity of human caspase-10","volume":"49","author":"Wachmann","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.jaut.2022.102940_bib17","doi-asserted-by":"crossref","first-page":"7191","DOI":"10.3748\/wjg.v23.i39.7191","article-title":"Evidence from a familial case suggests maternal inheritance of primary biliary cholangitis","volume":"23","author":"Shin","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jaut.2022.102940_bib18","doi-asserted-by":"crossref","first-page":"W272","DOI":"10.1093\/nar\/gkw398","article-title":"CHOPCHOP v2: a web tool for the next generation of CRISPR genome engineering","volume":"44","author":"Labun","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.jaut.2022.102940_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102617","article-title":"The IL-1 family cytokines and receptors in autoimmune diseases","volume":"19","author":"Migliorini","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jaut.2022.102940_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2015.05.001","article-title":"Inflammasomes and human autoimmunity: a comprehensive review","volume":"61","author":"Yang","year":"2015","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2022.102940_bib21","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jaut.2009.09.010","article-title":"Serum inflammatory cytokines, complement components, and soluble interleukin 2 receptor in primary biliary cirrhosis","volume":"33","author":"Barak","year":"2009","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2022.102940_bib22","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.1073\/pnas.82.15.4939","article-title":"Differentiation-enhanced binding of the amino-terminal fragment of human urokinase plasminogen activator to a specific receptor on U937 monocytes","volume":"82","author":"Stoppelli","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jaut.2022.102940_bib23","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1182\/blood-2009-12-256446","article-title":"KLF4 is a tumor suppressor in B-cell non-Hodgkin lymphoma and in classic Hodgkin lymphoma","volume":"116","author":"Guan","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2022.102940_bib24","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/embor.2012.156","article-title":"Mammalian proapoptotic factor ChaC1 and its homologues function as gamma-glutamyl cyclotransferases acting specifically on glutathione","volume":"13","author":"Kumar","year":"2012","journal-title":"EMBO Rep."},{"key":"10.1016\/j.jaut.2022.102940_bib25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nature18629","article-title":"Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores","volume":"535","author":"Liu","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2022.102940_bib26","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/s41586-019-1770-6","article-title":"Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis","volume":"575","author":"Fritsch","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2022.102940_bib27","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/cdd.2017.65","article-title":"Initiation and execution mechanisms of necroptosis: an overview","volume":"24","author":"Grootjans","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.jaut.2022.102940_bib28","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1038\/s41467-019-12194-6","article-title":"Caspase-10 inhibits ATP-citrate lyase-mediated metabolic and epigenetic reprogramming to suppress tumorigenesis","volume":"10","author":"Kumari","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2022.102940_bib29","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/19709","article-title":"The CED-4-homologous protein FLASH is involved in Fas-mediated activation of caspase-8 during apoptosis","volume":"398","author":"Imai","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2022.102940_bib30","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S1097-2765(03)00051-0","article-title":"A unified model for apical caspase activation","volume":"11","author":"Boatright","year":"2003","journal-title":"Mol. Cell."},{"key":"10.1016\/j.jaut.2022.102940_bib31","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1128\/MCB.00692-15","article-title":"RIP1 cleavage in the kinase domain regulates TRAIL-induced NF-kappaB activation and lymphoma survival","volume":"35","author":"Zhang","year":"2015","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jaut.2022.102940_bib32","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1002\/hep.25828","article-title":"Human antigen R contributes to hepatic stellate cell activation and liver fibrosis","volume":"56","author":"Woodhoo","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.jaut.2022.102940_bib33","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1056\/NEJM199105303242204","article-title":"A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis. UDCA-PBC Study Group","volume":"324","author":"Poupon","year":"1991","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jaut.2022.102940_bib34","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.immuni.2016.09.008","article-title":"Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome","volume":"45","author":"Guo","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2022.102940_bib35","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1053\/j.gastro.2013.05.042","article-title":"Efficacy and safety of the farnesoid X receptor agonist obeticholic acid in patients with type 2 diabetes and nonalcoholic fatty liver disease","volume":"145","author":"Mudaliar","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2022.102940_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s12016-015-8466-y","article-title":"Updated understanding of autoimmune lymphoproliferative syndrome (ALPS)","volume":"50","author":"Li","year":"2016","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"10.1016\/j.jaut.2022.102940_bib37","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1182\/blood.V99.11.4094","article-title":"Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas","volume":"99","author":"Shin","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2022.102940_bib38","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1038\/sj.onc.1205394","article-title":"Inactivating mutations of the caspase-10 gene in gastric cancer","volume":"21","author":"Park","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.jaut.2022.102940_bib39","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1042\/BJ20041142","article-title":"The protein structures that shape caspase activity, specificity, activation and inhibition","volume":"384","author":"Fuentes-Prior","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.jaut.2022.102940_bib40","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0092-8674(00)80605-4","article-title":"Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II","volume":"98","author":"Wang","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2022.102940_bib41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181874","article-title":"Clinical impact of a targeted next-generation sequencing gene panel for autoinflammation and vasculitis","volume":"12","author":"Omoyinmi","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2022.102940_bib42","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.immuni.2019.05.020","article-title":"Caspases in cell death, inflammation, and disease","volume":"50","author":"Van Opdenbosch","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2022.102940_bib43","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ceb.2020.02.004","article-title":"New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8","volume":"63","author":"Schwarzer","year":"2020","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.jaut.2022.102940_bib44","doi-asserted-by":"crossref","first-page":"27084","DOI":"10.1074\/jbc.273.42.27084","article-title":"Pro-caspase-3 is a major physiologic target of caspase-8","volume":"273","author":"Stennicke","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jaut.2022.102940_bib45","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41586-019-1548-x","article-title":"Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis","volume":"574","author":"Newton","year":"2019","journal-title":"Nature"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841122001482?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841122001482?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:32:56Z","timestamp":1760257976000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841122001482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":45,"alternative-id":["S0896841122001482"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2022.102940","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Caspase-10 affects the pathogenesis of primary biliary cholangitis by regulating inflammatory cell death","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2022.102940","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"102940"}}