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Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib67","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.immuni.2015.11.008","article-title":"T-Box transcription factors combine with the cytokines TGF-\u03b2 and IL-15 to control tissue-resident memory T cell fate","volume":"43","author":"Mackay","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2022.102950_bib68","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1126\/science.aad2035","article-title":"Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes","volume":"352","author":"Mackay","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jaut.2022.102950_bib69","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nature24993","article-title":"Runx3 programs CD8(+) T cell residency in non-lymphoid tissues and tumours","volume":"552","author":"Milner","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2022.102950_bib70","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.immuni.2020.04.007","article-title":"Heterogenous populations of tissue-resident CD8(+) T cells are generated in response to infection and malignancy","volume":"52","author":"Milner","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2022.102950_bib71","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nri3442","article-title":"The integration of T cell migration, differentiation and function","volume":"13","author":"Masopust","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib72","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-94-017-9153-3_7","article-title":"Integrin \u03b1E\u03b27: molecular features and functional significance in the immune system","volume":"819","author":"Hadley","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jaut.2022.102950_bib73","doi-asserted-by":"crossref","first-page":"17872","DOI":"10.1073\/pnas.1010201107","article-title":"Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residence","volume":"107","author":"Wakim","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jaut.2022.102950_bib74","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.4049\/jimmunol.1400003","article-title":"Cutting edge: resident memory CD8 T cells occupy frontline niches in secondary lymphoid organs","volume":"192","author":"Schenkel","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib75","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.4049\/jimmunol.1200402","article-title":"Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues","volume":"188","author":"Casey","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib76","doi-asserted-by":"crossref","first-page":"16741","DOI":"10.1073\/pnas.1107200108","article-title":"E-cadherin promotes accumulation of a unique memory CD8 T-cell population in murine salivary glands","volume":"108","author":"Hofmann","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jaut.2022.102950_bib77","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/nature12110","article-title":"Immune surveillance by CD8\u03b1\u03b1+ skin-resident T cells in human herpes virus infection","volume":"497","author":"Zhu","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2022.102950_bib78","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev-immunol-020711-075011","article-title":"Sphingosine-1-phosphate and lymphocyte egress from lymphoid organs","volume":"30","author":"Cyster","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib79","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nature04606","article-title":"CD69 acts downstream of interferon-alpha\/beta to inhibit S1P1 and lymphocyte egress from lymphoid organs","volume":"440","author":"Shiow","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2022.102950_bib80","doi-asserted-by":"crossref","first-page":"7632","DOI":"10.4049\/jimmunol.178.12.7632","article-title":"Kruppel-like factor 2 controls T cell trafficking by activating L-selectin (CD62L) and sphingosine-1-phosphate receptor 1 transcription","volume":"178","author":"Bai","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib81","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.jaci.2015.12.1339","article-title":"Sphingosine-1-phosphate\/sphingosine-1-phosphate receptor 1 signaling is required for migration of naive human T cells from the thymus to the periphery","volume":"138","author":"Resop","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib82","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/ni.2745","article-title":"Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells","volume":"14","author":"Skon","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib83","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/ni1238","article-title":"Chemokine receptor CCR7 required for T lymphocyte exit from peripheral tissues","volume":"6","author":"Debes","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib84","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/mi.2017.101","article-title":"IL-15 supports the generation of protective lung-resident memory CD4 T cells","volume":"11","author":"Strutt","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib85","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1002\/art.41652","article-title":"Tissue-resident memory CD8+ T cells from skin differentiate psoriatic arthritis from psoriasis","volume":"73","author":"Leijten","year":"2021","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.jaut.2022.102950_bib86","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/eji.202048737","article-title":"Circulating memory CD8(+) T cells are limited in forming CD103(+) tissue-resident memory T cells at mucosal sites after reinfection","volume":"51","author":"Behr","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib87","first-page":"1467","article-title":"Programs for the persistence, vigilance and control of human CD8(+) lung-resident memory T cells, Nat","volume":"17","author":"Hombrink","year":"2016","journal-title":"Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib88","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.1007\/s00018-021-03877-9","article-title":"The molecular basis and cellular effects of distinct CD103 expression on CD4 and CD8 T cells","volume":"78","author":"Keller","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.jaut.2022.102950_bib89","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s40425-018-0399-6","article-title":"Resident memory T cells, critical components in tumor immunology","volume":"6","author":"Mami-Chouaib","year":"2018","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.jaut.2022.102950_bib90","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1093\/infdis\/jiu281","article-title":"The chemokine receptor CXCR6 is required for the maintenance of liver memory CD8\u207a T cells specific for infectious pathogens","volume":"210","author":"Tse","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.jaut.2022.102950_bib91","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1084\/jem.20181308","article-title":"CXCR6 regulates localization of tissue-resident memory CD8 T cells to the airways","volume":"216","author":"Wein","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jaut.2022.102950_bib92","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/s41385-022-00491-1","article-title":"Regulation of tissue-resident memory T cells by the Microbiota","volume":"15","author":"Overacre-Delgoffe","year":"2022","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib93","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1126\/science.1177486","article-title":"Bacterial community variation in human body habitats across space and time","volume":"326","author":"Costello","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jaut.2022.102950_bib94","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41586-019-0878-z","article-title":"A defined commensal consortium elicits CD8 T cells and anti-cancer immunity","volume":"565","author":"Tanoue","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2022.102950_bib95","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41385-020-0315-5","article-title":"CD4(+) T cells persist for years in the human small intestine and display a T(H)1 cytokine profile","volume":"14","author":"Bartolom\u00e9-Casado","year":"2021","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib96","article-title":"Functionally competent, PD-1(+) CD8(+) trm cells populate the brain following local antigen encounter","volume":"11","author":"Sch\u00f8ller","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib97","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/s41577-019-0162-3","article-title":"T cells and the skin: from protective immunity to inflammatory skin disorders","volume":"19","author":"Ho","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib98","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.867962","article-title":"HSV-2-Specific human female reproductive tract tissue resident memory T cells recognize diverse HSV antigens","volume":"13","author":"Koelle","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib99","doi-asserted-by":"crossref","first-page":"e1140","DOI":"10.1002\/cti2.1140","article-title":"Synovial fluid CD69(+)CD8(+) T cells with tissue-resident phenotype mediate perforin-dependent citrullination in rheumatoid arthritis","volume":"9","author":"Jung","year":"2020","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib100","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41584-021-00730-y","article-title":"Erasing the memory of arthritis in joints","volume":"18","author":"Onuora","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jaut.2022.102950_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102400","article-title":"The etiology of rheumatoid arthritis","volume":"110","author":"Scherer","year":"2020","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2022.102950_bib102","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3389\/fimmu.2016.00461","article-title":"A critical reappraisal of neutrophil extracellular traps and NETosis mimics based on differential requirements for protein citrullination","volume":"7","author":"Konig","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib103","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/imr.12834","article-title":"Insights into the study and origin of the citrullinome in rheumatoid arthritis","volume":"294","author":"Fert-Bober","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.jaut.2022.102950_bib104","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3389\/fimmu.2016.00485","article-title":"NETosis as source of autoantigens in rheumatoid arthritis","volume":"7","author":"Corsiero","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib105","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/s41584-019-0244-4","article-title":"The structure, specificity and function of anti-citrullinated protein antibodies","volume":"15","author":"Ge","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jaut.2022.102950_bib106","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41590-020-00816-x","article-title":"The immunology of rheumatoid arthritis","volume":"22","author":"Weyand","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib107","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3389\/fmed.2019.00072","article-title":"Synovial tissue biopsy research","volume":"6","author":"Veale","year":"2019","journal-title":"Front. Med."},{"key":"10.1016\/j.jaut.2022.102950_bib108","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.berh.2004.08.002","article-title":"The different stages of synovitis: acute vs chronic, early vs late and non-erosive vs erosive","volume":"19","author":"Tarner","year":"2005","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.jaut.2022.102950_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102868","article-title":"Emerging role of Tissue Resident Memory T cells in vitiligo: from pathogenesis to therapeutics","volume":"20","author":"Shah","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jaut.2022.102950_bib110","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.immuni.2017.01.009","article-title":"CD49a expression defines tissue-resident CD8(+) T cells poised for cytotoxic function in human skin","volume":"46","author":"Cheuk","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2022.102950_bib111","first-page":"288","article-title":"Hobit- and Blimp-1-driven CD4(+) tissue-resident memory T cells control chronic intestinal inflammation, Nat","volume":"20","author":"Zundler","year":"2019","journal-title":"Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib112","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.joca.2017.10.013","article-title":"Hierarchical, imbalanced pro-inflammatory cytokine networks govern the pathogenesis of chronic arthropathies","volume":"26","author":"Livshits","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.jaut.2022.102950_bib113","first-page":"657","article-title":"Juvenile idiopathic arthritis: oligoarthritis and polyarthritis, pediatr","volume":"65","author":"Crayne","year":"2018","journal-title":"Clin. North America"},{"key":"10.1016\/j.jaut.2022.102950_bib114","first-page":"135","article-title":"Juvenile idiopathic arthritis: from aetiopathogenesis to therapeutic approaches, Pediatric Rheumatol","volume":"19","author":"Zaripova","year":"2021","journal-title":"Online J"},{"key":"10.1016\/j.jaut.2022.102950_bib115","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12969-021-00521-5","article-title":"Growth and puberty in children with juvenile idiopathic arthritis","volume":"19","author":"d'Angelo","year":"2021","journal-title":"Pediatric Rheumatol. Online J."},{"key":"10.1016\/j.jaut.2022.102950_bib116","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/eji.202048797","article-title":"Antigen-driven PD-1(+) TOX(+) BHLHE40(+) and PD-1(+) TOX(+) EOMES(+) T lymphocytes regulate juvenile idiopathic arthritis in situ","volume":"51","author":"Maschmeyer","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib117","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102827","article-title":"Gut microbiota-microRNA interactions in ankylosing spondylitis","volume":"20","author":"Tavasolian","year":"2021","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jaut.2022.102950_bib118","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s40265-019-01075-3","article-title":"Secukinumab: a review in ankylosing spondylitis","volume":"79","author":"Blair","year":"2019","journal-title":"Drugs"},{"key":"10.1016\/j.jaut.2022.102950_bib119","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s13075-018-1784-8","article-title":"Factors related to health-related quality of life in ankylosing spondylitis, overall and stratified by sex","volume":"20","author":"Law","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2022.102950_bib120","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/S0140-6736(07)60635-7","article-title":"Ankylosing spondylitis","volume":"369","author":"Braun","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2022.102950_bib121","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1053\/j.gastro.2021.07.042","article-title":"Extraintestinal manifestations of inflammatory bowel disease: current concepts, treatment, and implications for disease management","volume":"161","author":"Rogler","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2022.102950_bib122","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1136\/annrheumdis-2019-215349","article-title":"Integrin and transcriptomic profiles identify a distinctive synovial CD8+ T cell subpopulation in spondyloarthritis","volume":"78","author":"Qaiyum","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2022.102950_bib123","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.3748\/wjg.v25.i18.2162","article-title":"Inflammatory bowel diseases and spondyloarthropathies: from pathogenesis to treatment","volume":"25","author":"Fragoulis","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.jaut.2022.102950_bib124","doi-asserted-by":"crossref","first-page":"e174","DOI":"10.1136\/annrheumdis-2019-216456","article-title":"Gut-derived CD8(+) tissue-resident memory T cells are expanded in the peripheral blood and synovia of SpA patients","volume":"80","author":"Guggino","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2022.102950_bib125","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/S0140-6736(18)30830-4","article-title":"The pathogenesis of psoriatic arthritis","volume":"391","author":"Veale","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2022.102950_bib126","first-page":"957","volume":"376","author":"Ritchlin","year":"2017","journal-title":"Psoriatic Arthritis, N. Engl. J. Med."},{"key":"10.1016\/j.jaut.2022.102950_bib127","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/1346-8138.15954","article-title":"Psoriatic arthritis","volume":"48","author":"Umezawa","year":"2021","journal-title":"J. Dermatol."},{"key":"10.1016\/j.jaut.2022.102950_bib128","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/s41584-018-0091-8","article-title":"Effects of the IL-23-IL-17 pathway on bone in spondyloarthritis","volume":"14","author":"Gravallese","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jaut.2022.102950_bib129","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1056\/NEJMoa1412679","article-title":"Secukinumab inhibition of interleukin-17a in patients with psoriatic arthritis","volume":"373","author":"Mease","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jaut.2022.102950_bib130","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1002\/art.38376","article-title":"Interleukin-17+CD8+ T cells are enriched in the joints of patients with psoriatic arthritis and correlate with disease activity and joint damage progression","volume":"66","author":"Menon","year":"2014","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.jaut.2022.102950_bib131","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/art.41156","article-title":"Tissue-resident memory phenotype and function of synovial interleukin-17a+cd8+ T cells in psoriatic arthritis","volume":"72","author":"Steel","year":"2020","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.jaut.2022.102950_bib132","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/1346-8138.14097","article-title":"Clinical characteristics of Japanese patients with psoriatic arthritis: comparison with East Asian countries","volume":"45","author":"Yamamoto","year":"2018","journal-title":"J. Dermatol."},{"key":"10.1016\/j.jaut.2022.102950_bib133","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jaad.2018.06.027","article-title":"Prevalence of psoriatic arthritis in patients with psoriasis: a systematic review and meta-analysis of observational and clinical studies","volume":"80","author":"Alinaghi","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.jaut.2022.102950_bib134","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41584-019-0175-0","article-title":"Preventing psoriatic arthritis: focusing on patients with psoriasis at increased risk of transition","volume":"15","author":"Scher","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jaut.2022.102950_bib135","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1146\/annurev-immunol-042617-053214","article-title":"Tissue-resident T cells and other resident leukocytes","volume":"37","author":"Masopust","year":"2019","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib136","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.immuni.2018.01.015","article-title":"T cells in nonlymphoid tissues give rise to lymph-node-resident memory T cells","volume":"48","author":"Beura","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2022.102950_bib137","first-page":"412","article-title":"Developmental plasticity allows outside-in immune responses by resident memory T cells, Nat","volume":"21","author":"Fonseca","year":"2020","journal-title":"Immunol."},{"key":"10.1016\/j.jaut.2022.102950_bib138","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aav8995","article-title":"Human CD4(+)CD103(+) cutaneous resident memory T cells are found in the circulation of healthy individuals","volume":"4","author":"Klicznik","year":"2019","journal-title":"Sci. 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Med."},{"key":"10.1016\/j.jaut.2022.102950_bib141","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and management of rheumatoid arthritis: a review","volume":"320","author":"Aletaha","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.jaut.2022.102950_bib142","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102425","article-title":"Insights into the treatment of rheumatoid arthritis: a paradigm in medicine","volume":"110","author":"Smolen","year":"2020","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2022.102950_bib143","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1136\/ard.2010.141234","article-title":"The impact of four dynamic, goal-steered treatment strategies on the 5-year outcomes of rheumatoid arthritis patients in the BeSt study","volume":"70","author":"Klarenbeek","year":"2011","journal-title":"Ann. Rheum. 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