{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:23:30Z","timestamp":1792895010152,"version":"4.5.0"},"reference-count":180,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["11221280"],"award-info":[{"award-number":["11221280"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1190830"],"award-info":[{"award-number":["1190830"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["ACE 210015"],"award-info":[{"award-number":["ACE 210015"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["ICN09_016\/ICN 2021_045"],"award-info":[{"award-number":["ICN09_016\/ICN 2021_045"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["SA77210051"],"award-info":[{"award-number":["SA77210051"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013928","name":"Millennium Institute on Immunology and Immunotherapy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020884","name":"Agencia Nacional de Investigaci\u00f3n y Desarrollo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020884","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.jaut.2022.102956","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T01:35:04Z","timestamp":1671068104000},"page":"102956","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["Involvement of trained immunity during autoimmune responses"],"prefix":"10.1016","volume":"137","author":[{"given":"Valentina P.","family":"Mora","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo A.","family":"Loaiza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Soto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Bohmwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis M.","family":"Kalergis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2022.102956_bib1","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/S0140-6736(00)04904-7","article-title":"An overview of the immune system","volume":"357","author":"Parkin","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2022.102956_bib2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.chom.2011.04.006","article-title":"Trained immunity: a memory for innate host defense","volume":"9","author":"Netea","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jaut.2022.102956_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2009.12.980","article-title":"Overview of the immune response","volume":"125","author":"Chaplin","year":"2010","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.chom.2018.12.006","article-title":"Innate and adaptive immune memory: an evolutionary continuum in the host's response to pathogens","volume":"25","author":"Netea","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jaut.2022.102956_bib5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/JLB.MR0318-104R","article-title":"Long-term reprogramming of the innate immune system","volume":"105","author":"Dominguez-Andres","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jaut.2022.102956_bib6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1515\/bmc-2015-0028","article-title":"The dendritic cell side of the immunological synapse","volume":"7","author":"Verboogen","year":"2016","journal-title":"Biomol. Concepts"},{"key":"10.1016\/j.jaut.2022.102956_bib7","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2217\/imt.11.38","article-title":"Modulation of the dendritic cell-T-cell synapse to promote pathogen immunity and prevent autoimmunity","volume":"3","author":"Carre\u00f1o","year":"2011","journal-title":"Immunotherapy"},{"key":"10.1016\/j.jaut.2022.102956_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4067\/S0716-97602011000100007","article-title":"Contribution of dendritic cell\/T cell interactions to triggering and maintaining autoimmunity","volume":"44","author":"Llanos","year":"2011","journal-title":"Biol. Res."},{"key":"10.1016\/j.jaut.2022.102956_bib9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2174\/138161206775193145","article-title":"The dendritic cell-T cell synapse as a determinant of autoimmune pathogenesis","volume":"12","author":"Iruretagoyena","year":"2006","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.jaut.2022.102956_bib10","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jaut.2018.10.012","article-title":"Molecular mimicry and autoimmunity","volume":"95","author":"Rojas","year":"2018","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2022.102956_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2020.104444","article-title":"Prediction of molecular mimicry between antigens from Leishmania sp. and human: implications for autoimmune response in systemic lupus erythematosus","volume":"148","author":"M\u00fanera","year":"2020","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.jaut.2022.102956_bib12","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/s41598-019-55730-6","article-title":"A possible role for autoimmunity through molecular mimicry in alphavirus mediated arthritis","volume":"10","author":"Venigalla","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jaut.2022.102956_bib13","first-page":"2889","article-title":"Immune evasion and the evolution of molecular mimicry in parasites","volume":"67","author":"Hurford","year":"2013","journal-title":"Evolution"},{"key":"10.1016\/j.jaut.2022.102956_bib14","doi-asserted-by":"crossref","first-page":"432","DOI":"10.3389\/fmicb.2018.00432","article-title":"Intestinal microbiota influences non-intestinal related autoimmune diseases","volume":"9","author":"Opazo","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.jaut.2022.102956_bib15","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/ni.3731","article-title":"The multiple pathways to autoimmunity","volume":"18","author":"Theofilopoulos","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib16","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMra020100","article-title":"The effect of infections on susceptibility to autoimmune and allergic diseases","volume":"347","author":"Bach","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jaut.2022.102956_bib17","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1002\/art.41214","article-title":"Increasing prevalence of antinuclear antibodies in the United States","volume":"72","author":"Dinse","year":"2020","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.jaut.2022.102956_bib18","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/joim.12395","article-title":"Human autoimmune diseases: a comprehensive update","volume":"278","author":"Wang","year":"2015","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.jaut.2022.102956_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.01467","article-title":"Naturally derived heme-oxygenase 1 inducers and their therapeutic application to immune-mediated diseases","volume":"11","author":"Funes","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2567.2008.02964.x","article-title":"Modulation of nuclear factor-kappaB activity can influence the susceptibility to systemic lupus erythematosus","volume":"128","author":"Kalergis","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.jaut.2022.102956_bib21","doi-asserted-by":"crossref","first-page":"218","DOI":"10.2174\/1566523214666140424150308","article-title":"Heme oxygenase-1 as a target for the design of gene and pharmaceutical therapies for autoimmune diseases","volume":"14","author":"Mackern-Oberti","year":"2014","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.jaut.2022.102956_bib22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/imm.12124","article-title":"Carbon monoxide exposure improves immune function in lupus-prone mice","volume":"140","author":"Mackern-Oberti","year":"2013","journal-title":"Immunology"},{"key":"10.1016\/j.jaut.2022.102956_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cei.12657","article-title":"Carbon monoxide inhibits T cell activation in target organs during systemic lupus erythematosus","volume":"182","author":"Mackern-Oberti","year":"2015","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib24","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1365-2567.2012.03598.x","article-title":"Haem oxygenase 1 expression is altered in monocytes from patients with systemic lupus erythematosus","volume":"136","author":"Herrada","year":"2012","journal-title":"Immunology"},{"key":"10.1016\/j.jaut.2022.102956_bib25","doi-asserted-by":"crossref","first-page":"aaf1098","DOI":"10.1126\/science.aaf1098","article-title":"Trained immunity: a program of innate immune memory in health and disease","volume":"352","author":"Netea","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.jaut.2022.102956_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2022.102190","article-title":"Trained immunity: implications for vaccination","volume":"77","author":"Geckin","year":"2022","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib27","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1089\/ars.2017.7310","article-title":"Epigenetics and trained immunity","volume":"29","author":"Van Der Heijden","year":"2018","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.jaut.2022.102956_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2020.100897","article-title":"Immunometabolic control of trained immunity","volume":"77","author":"Riksen","year":"2021","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.jaut.2022.102956_bib29","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.3389\/fimmu.2019.02806","article-title":"BCG-induced cross-protection and development of trained immunity: implication for vaccine design","volume":"10","author":"Covi\u00e1n","year":"2019","journal-title":"Front. Immunol."},{"issue":"20","key":"10.1016\/j.jaut.2022.102956_bib30","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"206","author":"Netea","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib31","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/cr.2007.83","article-title":"JMJD3 is a histone H3K27 demethylase","volume":"17","author":"Xiang","year":"2007","journal-title":"Cell Res."},{"key":"10.1016\/j.jaut.2022.102956_bib32","first-page":"83","volume":"vol. 39","author":"Liu","year":"2020"},{"key":"10.1016\/j.jaut.2022.102956_bib33","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.chom.2020.05.014","article-title":"BCG vaccination in humans elicits trained immunity via the hematopoietic progenitor compartment","volume":"28","author":"Cirovic","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jaut.2022.102956_bib34","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.vaccine.2004.09.006","article-title":"Acute lower respiratory tract infections and respiratory syncytial virus in infants in Guinea-Bissau: a beneficial effect of BCG vaccination for girls","volume":"23","author":"Stensballe","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.jaut.2022.102956_bib35","first-page":"185","article-title":"The efficacy of Bacillus Calmette-Guerin vaccinations for the prevention of acute upper respiratory tract infection in the elderly","volume":"43","author":"Wardhana","year":"2011","journal-title":"Acta Med. Indones."},{"key":"10.1016\/j.jaut.2022.102956_bib36","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMoa1714021","article-title":"Prevention of M. tuberculosis infection with H4:IC31 vaccine or BCG revaccination","volume":"379","author":"Nemes","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jaut.2022.102956_bib37","first-page":"1","article-title":"mTOR\/HIF1\u03b1-mediated aerobic glycolysis as metabolic basis for trained immunity","volume":"345","author":"Kumar","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.jaut.2022.102956_bib38","first-page":"605","article-title":"Beneficial effect of enhanced macrophage function in the trauma patient","volume":"211","author":"Browder","year":"1990","journal-title":"Ann. Surg."},{"key":"10.1016\/j.jaut.2022.102956_bib39","doi-asserted-by":"crossref","first-page":"4175","DOI":"10.1007\/s00394-021-02566-4","article-title":"Effects of yeast \u03b2-glucans for the prevention and treatment of upper respiratory tract infection in healthy subjects: a systematic review and meta-analysis","volume":"60","author":"Zhong","year":"2021","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.jaut.2022.102956_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107634","article-title":"\u03b2-Glucan induces protective trained immunity against Mycobacterium tuberculosis infection: a key role for IL-1","volume":"31","author":"Moorlag","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.jaut.2022.102956_bib41","series-title":"oxLDL-Induced Trained Immunity Is Dependent on Mitochondrial Metabolic Reprogramming Europe PMC Funders Group","author":"Groh","year":"2021"},{"key":"10.1016\/j.jaut.2022.102956_bib42","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1161\/ATVBAHA.120.315452","article-title":"Trained immunity and reactivity of macrophages and endothelial cells","volume":"41","author":"Drummer","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jaut.2022.102956_bib43","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.atherosclerosis.2016.10.019","article-title":"Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo","volume":"254","author":"Bekkering","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.jaut.2022.102956_bib44","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1161\/CIRCRESAHA.119.315800","article-title":"Catecholamines induce trained immunity in monocytes in vitro and in vivo","volume":"127","author":"van der Heijden","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.jaut.2022.102956_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2022.868343","article-title":"Trained immunity contribution to autoimmune and inflammatory disorders","volume":"13","author":"Funes","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib46","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3389\/fimmu.2018.00298","article-title":"The potential role of trained immunity in autoimmune and autoinflammatory disorders","volume":"9","author":"Arts","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib47","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.3389\/fimmu.2020.631743","article-title":"Therapies targeting trained immune cells in inflammatory and autoimmune diseases","volume":"11","author":"Municio","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib48","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41577-020-00487-7","article-title":"Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders","volume":"21","author":"Zengeler","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib49","doi-asserted-by":"crossref","first-page":"5902","DOI":"10.1016\/j.cell.2021.10.013","article-title":"Insular cortex neurons encode and retrieve specific immune responses","volume":"184","author":"Koren","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2022.102956_bib50","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-018-0023-4","article-title":"Innate immune memory in the brain shapes neurological disease hallmarks","volume":"556","author":"Wendeln","year":"2018","journal-title":"Nat"},{"key":"10.1016\/j.jaut.2022.102956_bib51","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.3389\/fimmu.2020.546415","article-title":"Memory-like responses of brain microglia are controlled by developmental state and pathogen dose","volume":"11","author":"Lajqi","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib52","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev-immunol-032713-120240","article-title":"Microglia development and function","volume":"32","author":"Nayak","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2018.02.015","article-title":"The roles of macrophages and microglia in multiple sclerosis and experimental autoimmune encephalomyelitis","volume":"318","author":"Chu","year":"2018","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.jaut.2022.102956_bib54","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbi.2015.03.013","article-title":"Long-lasting pro-inflammatory suppression of microglia by LPS-preconditioning is mediated by RelB-dependent epigenetic silencing","volume":"48","author":"Schaafsma","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jaut.2022.102956_bib55","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.it.2019.02.001","article-title":"Priming microglia for innate immune memory in the brain","volume":"40","author":"Neher","year":"2019","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib56","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1056\/NEJMra1100030","article-title":"Genomics and the multifactorial nature of human autoimmune disease","volume":"365","author":"Cho","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jaut.2022.102956_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102469","article-title":"Understanding the immunopathogenesis of autoimmune diseases by animal studies using gene modulation: a comprehensive review","volume":"19","author":"Lee","year":"2020","journal-title":"Autoimmun. Rev."},{"issue":"15","key":"10.1016\/j.jaut.2022.102956_bib58","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/cmi.2017.137","article-title":"Genetic and epigenetic influences on the loss of tolerance in autoimmunity","volume":"156","author":"Zhang","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib59","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrg1944","article-title":"Genetics of autoimmune diseases \u2014 disorders of immune homeostasis","volume":"7","author":"Gregersen","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.jaut.2022.102956_bib60","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1084\/jem.20102327","article-title":"Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development","volume":"208","author":"Lei","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jaut.2022.102956_bib61","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nri.2016.26","article-title":"T cell receptor signalling in the control of regulatory T cell differentiation and function","volume":"16","author":"Li","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib62","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri.2016.9","article-title":"AIRE expands: new roles in immune tolerance and beyond","volume":"16","author":"Anderson","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib63","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s10875-014-0025-4","article-title":"Natural IgM: beneficial autoantibodies for the control of inflammatory and autoimmune disease","volume":"34","author":"Gr\u00f6nwall","year":"2014","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib64","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1136\/annrheumdis-2013-203863","article-title":"International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies","volume":"73","author":"Agmon-Levin","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2022.102956_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102392","article-title":"An overview of autoantibodies in rheumatoid arthritis","volume":"110","author":"van Delft","year":"2020","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2022.102956_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.533388","article-title":"The role of antibodies in the pathogenesis of multiple sclerosis","volume":"11","author":"Yu","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.jaut.2022.102956_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111892","article-title":"Contribution of dysregulated DNA methylation to autoimmunity","volume":"22","author":"Funes","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jaut.2022.102956_bib68","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.autrev.2018.10.005","article-title":"Innate immune-responses and their role in driving autoimmunity","volume":"18","author":"Toubi","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jaut.2022.102956_bib69","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1128\/CMR.00046-08","article-title":"Pathogen recognition and inflammatory signaling in innate immune defenses","volume":"22","author":"Mogensen","year":"2009","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.jaut.2022.102956_bib70","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.autrev.2019.02.006","article-title":"Immune checkpoints and the regulation of tolerogenicity in dendritic cells: implications for autoimmunity and immunotherapy","volume":"18","author":"Funes","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jaut.2022.102956_bib71","doi-asserted-by":"crossref","first-page":"16381","DOI":"10.3390\/ijms150916381","article-title":"Targeting dendritic cell function during systemic autoimmunity to restore tolerance","volume":"15","author":"Mackern-Oberti","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jaut.2022.102956_bib72","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/978-1-60761-869-0_22","article-title":"Induction of tolerogenic dendritic cells by NF-\u03baB blockade and Fc\u03b3 receptor modulation","volume":"677","author":"Carre\u00f1o","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jaut.2022.102956_bib73","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1111\/imm.12806","article-title":"Autologous tolerogenic dendritic cells derived from monocytes of systemic lupus erythematosus patients and healthy donors show a stable and immunosuppressive phenotype","volume":"152","author":"Obreque","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.jaut.2022.102956_bib74","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.autrev.2014.10.010","article-title":"Role of dendritic cells in the initiation, progress and modulation of systemic autoimmune diseases","volume":"14","author":"Mackern-Oberti","year":"2015","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jaut.2022.102956_bib75","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.clim.2013.04.017","article-title":"Tolerogenic dendritic cells as a therapy for treating lupus","volume":"148","author":"Llanos","year":"2013","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib76","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/imm.13119","article-title":"Tolerogenic dendritic cell transfer ameliorates systemic lupus erythematosus in mice","volume":"158","author":"Funes","year":"2019","journal-title":"Immunology"},{"key":"10.1016\/j.jaut.2022.102956_bib77","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/imm.12910","article-title":"Implications of macrophage polarization in autoimmunity","volume":"154","author":"Funes","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.jaut.2022.102956_bib78","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.it.2004.09.015","article-title":"The chemokine system in diverse forms of macrophage activation and polarization","volume":"25","author":"Mantovani","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib79","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/intimm\/dxv066","article-title":"TLR7 and TLR9 ligands regulate antigen presentation by macrophages","volume":"28","author":"Celhar","year":"2016","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib80","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jaut.2009.11.001","article-title":"Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice","volume":"34","author":"Santiago-Raber","year":"2010","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2022.102956_bib81","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1182\/blood-2006-12-061648","article-title":"Macrophages prevent the differentiation of autoreactive B cells by secreting CD40 ligand and interleukin-6","volume":"110","author":"Kilmon","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2022.102956_bib82","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1007\/s10787-020-00762-y","article-title":"Innate immune response in systemic autoimmune diseases: a potential target of therapy","volume":"28","author":"Hejrati","year":"2020","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.jaut.2022.102956_bib83","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/nri3399","article-title":"Neutrophil recruitment and function in health and inflammation","volume":"13","author":"Kolaczkowska","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib84","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41584-018-0039-z","article-title":"The role of neutrophil extracellular traps in rheumatic diseases","volume":"14","author":"Apel","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jaut.2022.102956_bib85","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/nm.4027","article-title":"Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease","volume":"22","author":"Lood","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.jaut.2022.102956_bib86","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aag3358","article-title":"Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis","volume":"2","author":"Carmona-Rivera","year":"2017","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib87","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.4049\/jimmunol.1700778","article-title":"Netting neutrophils activate autoreactive B cells in lupus","volume":"200","author":"Gestermann","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib88","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.4049\/jimmunol.1003349","article-title":"IFN-\u0391 production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes is promoted by NK cells via MIP-1\u03b2 and LFA-1","volume":"186","author":"Hagberg","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib89","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/imm.12504","article-title":"Contribution of dendritic cells to the autoimmune pathology of systemic lupus erythematosus","volume":"146","author":"Mackern-Oberti","year":"2015","journal-title":"Immunology"},{"key":"10.1016\/j.jaut.2022.102956_bib90","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1471-4906(00)01821-4","article-title":"Innate immunity and autoimmunity: from self-protection to self-destruction","volume":"22","author":"Shi","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib91","first-page":"631","article-title":"Systemic lupus erythematosus. Epidemiology, pathophysiology, manifestations, and management","volume":"57","author":"Fortuna","year":"2013","journal-title":"Dent. Clin."},{"key":"10.1016\/j.jaut.2022.102956_bib92","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s12519-019-00229-3","article-title":"Immunological pathogenesis and treatment of systemic lupus erythematosus","volume":"16","author":"Pan","year":"2020","journal-title":"World J. Pediatr."},{"key":"10.1016\/j.jaut.2022.102956_bib93","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/BOR.0000000000000480","article-title":"Epidemiology of systemic lupus erythematosus: an update","volume":"30","author":"Stojan","year":"2018","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jaut.2022.102956_bib94","doi-asserted-by":"crossref","first-page":"544","DOI":"10.2174\/156652311798192806","article-title":"Genetic and pharmacological modulation of dendritic cell-T cell interactions as a therapeutic strategy for systemic lupus erythematosus","volume":"11","author":"Llanos","year":"2011","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.jaut.2022.102956_bib95","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1365-2567.2009.03138.x","article-title":"Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc\u03b3 receptors and costimulatory molecules on dendritic cells","volume":"128","author":"Carre\u00f1o","year":"2009","journal-title":"Immunology"},{"key":"10.1016\/j.jaut.2022.102956_bib96","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s00005-016-0418-6","article-title":"Hormonal modulation of dendritic cells differentiation, maturation and function: implications for the initiation and progress of systemic autoimmunity","volume":"65","author":"Mackern-Oberti","year":"2017","journal-title":"Arch. Immunol. Ther. Exp."},{"key":"10.1016\/j.jaut.2022.102956_bib97","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111327","article-title":"Cytokines as biomarkers in systemic lupus erythematosus: value for diagnosis and drug therapy","volume":"22","author":"Idborg","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jaut.2022.102956_bib98","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1073\/pnas.85.7.2260","article-title":"Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotype","volume":"85","author":"Mendlovic","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jaut.2022.102956_bib99","first-page":"109","article-title":"IL-1 beta-deficient mice are resistant to induction of experimental SLE","volume":"17","author":"Voronov","year":"2006","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.jaut.2022.102956_bib100","doi-asserted-by":"crossref","first-page":"118","DOI":"10.4049\/jimmunol.141.1.118","article-title":"Novel and enhanced IL-1 gene expression in autoimmune mice with lupus","volume":"141","author":"Boswell","year":"1988","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/385297","article-title":"Effect of proinflammatory cytokines (IL-6, TNF- \u03b1 , and IL-1 \u03b2) on clinical manifestations in Indian SLE patients","volume":"2014","author":"Umare","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.jaut.2022.102956_bib102","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1093\/rheumatology\/ket428","article-title":"The association of cytokines with disease activity and damage scores in systemic lupus erythematosus patients","volume":"53","author":"McCarthy","year":"2014","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2022.102956_bib103","doi-asserted-by":"crossref","DOI":"10.7754\/Clin.Lab.2015.150709","article-title":"Pro-inflammatory cytokines are elevated in pregnant women with systemic lupus erythematosus in association with the activation of TLR4","volume":"62","author":"Qu","year":"2016","journal-title":"Clin. Lab."},{"key":"10.1016\/j.jaut.2022.102956_bib104","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.chom.2017.12.010","article-title":"BCG vaccination protects against experimental viral infection in humans through the induction of cytokines associated with trained immunity","volume":"23","author":"Arts","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.jaut.2022.102956_bib105","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1073\/pnas.85.5.1620","article-title":"A low dose of recombinant interleukin 1 protects granulocytopenic mice from lethal gram-negative infection","volume":"85","author":"van der Meer","year":"1988","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jaut.2022.102956_bib106","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1128\/iai.57.10.3257-3258.1989","article-title":"Efficacy of interleukin-1 beta against systemic Candida albicans infections in normal and immunosuppressed mice","volume":"57","author":"Pecyk","year":"1989","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jaut.2022.102956_bib107","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1128\/iai.55.9.2061-2065.1987","article-title":"Recombinant murine interleukin-1 alpha enhancement of nonspecific antibacterial resistance","volume":"55","author":"Czuprynski","year":"1987","journal-title":"Infect. Immun."},{"key":"10.1016\/j.jaut.2022.102956_bib108","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1177\/0961203314522333","article-title":"Acceleration of SLE-like syndrome development in NZBxNZW F1 mice by beta-glucan","volume":"23","author":"Fagone","year":"2014","journal-title":"Lupus"},{"key":"10.1016\/j.jaut.2022.102956_bib109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/207504","article-title":"Murine models of systemic lupus erythematosus","volume":"2011","author":"Perry","year":"2011","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.jaut.2022.102956_bib110","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.cell.2017.11.034","article-title":"Modulation of myelopoiesis progenitors is an integral component of trained immunity","volume":"172","author":"Mitroulis","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2022.102956_bib111","doi-asserted-by":"crossref","first-page":"17537","DOI":"10.1073\/pnas.1202870109","article-title":"Bacille Calmette-Gu\u00e9rin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes","volume":"109","author":"Kleinnijenhuis","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jaut.2022.102956_bib112","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4172\/2329-9541.1000150","article-title":"Therapeutic action research of bacille calmette guerin (BCG) on a systemic lupus erythematosus mouse model","volume":"5","author":"biao Yu","year":"2016","journal-title":"J. Immunol. Tech. Infect. Dis."},{"key":"10.1016\/j.jaut.2022.102956_bib113","doi-asserted-by":"crossref","first-page":"e2941","DOI":"10.1002\/dmrr.2941","article-title":"TNF, TNF inducers, and TNFR2 agonists: a new path to type 1 diabetes treatment","volume":"34","author":"Faustman","year":"2018","journal-title":"Diabetes. Metab. Res. Rev."},{"key":"10.1016\/j.jaut.2022.102956_bib114","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.semarthrit.2019.04.006","article-title":"Metabolism as a key regulator in the pathogenesis of systemic lupus erythematosus","volume":"48","author":"Takeshima","year":"2019","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.jaut.2022.102956_bib115","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.02658","article-title":"Novel treatments in lupus","volume":"9","author":"Vukelic","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib116","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1002\/art.34502","article-title":"N -acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: a randomized, double-blind, placebo-controlled trial","volume":"64","author":"Lai","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2022.102956_bib117","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/s41467-022-28407-4","article-title":"The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression","volume":"13","author":"Geller","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2022.102956_bib118","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1001\/jama.2018.13103","article-title":"Diagnosis and management of rheumatoid arthritis: a review","volume":"320","author":"Aletaha","year":"2018","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"10.1016\/j.jaut.2022.102956_bib119","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00296-020-04731-0","article-title":"The global prevalence of rheumatoid arthritis: a meta-analysis based on a systematic review","volume":"41","author":"Almutairi","year":"2021","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.jaut.2022.102956_bib120","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2022.102956_bib121","doi-asserted-by":"crossref","DOI":"10.1093\/rheumatology\/keh201","article-title":"The role of interleukin-1 in the pathogenesis of rheumatoid arthritis","volume":"43","author":"Kay","year":"2004","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2022.102956_bib122","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1136\/annrheumdis-2019-216656","article-title":"Efficacy of pharmacological treatment in rheumatoid arthritis: a systematic literature research informing the 2019 update of the EULAR recommendations for management of rheumatoid arthritis","volume":"79","author":"Kerschbaumer","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2022.102956_bib123","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005121.pub3","article-title":"Anakinra for rheumatoid arthritis","author":"Mertens","year":"2009","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.jaut.2022.102956_bib124","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1080\/14740338.2018.1486819","article-title":"Anakinra for the treatment of rheumatoid arthritis: a safety evaluation","volume":"17","author":"Ram\u00edrez","year":"2018","journal-title":"Expet Opin. Drug Saf."},{"key":"10.1016\/j.jaut.2022.102956_bib125","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1699-0463.1989.tb00446.x","article-title":"Collagen induced arthritis as an experimental model for rheumatoid arthritis. Immunogenetics, pathogenesis and autoimmunity","volume":"97","author":"Holmdahl","year":"1989","journal-title":"APMIS"},{"key":"10.1016\/j.jaut.2022.102956_bib126","first-page":"441","article-title":"Suppression of collagen-induced arthritis by lipopolysaccharide in DBA\/1 mice","volume":"20","author":"Zhao","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.jaut.2022.102956_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106642","article-title":"Stigmasterol protects rats from collagen induced arthritis by inhibiting proinflammatory cytokines","volume":"85","author":"Ahmad Khan","year":"2020","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jaut.2022.102956_bib128","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.3389\/fphar.2018.01472","article-title":"Integrating network pharmacology and metabolomics study on anti-rheumatic mechanisms and antagonistic effects against methotrexate-induced toxicity of qing-Luo-yin","volume":"9","author":"Zuo","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jaut.2022.102956_bib129","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.intimp.2019.04.027","article-title":"Curcumin attenuates collagen-induced rat arthritis via anti-inflammatory and apoptotic effects","volume":"72","author":"Wang","year":"2019","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jaut.2022.102956_bib130","article-title":"Collagen-induced arthritis: a model for murine autoimmune","volume":"5","author":"Pietrosimone","year":"2015","journal-title":"Arthritis, BIO-PROTOCOL"},{"key":"10.1016\/j.jaut.2022.102956_bib131","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1084\/jem.20041758","article-title":"A role for fungal \u03b2-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice","volume":"201","author":"Yoshitomi","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jaut.2022.102956_bib132","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jaut.2005.06.002","article-title":"Effect of Candida albicans cell wall glucan as adjuvant for induction of autoimmune arthritis in mice","volume":"25","author":"Hida","year":"2005","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2022.102956_bib133","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1348-0421.2006.tb03814.x","article-title":"\u03b2-Glucan derived from zymosan acts as an adjuvant for collagen-induced arthritis","volume":"50","author":"Hida","year":"2006","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib134","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.biopha.2018.03.057","article-title":"Quercetin attenuates zymosan-induced arthritis in mice","volume":"102","author":"Guazelli","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jaut.2022.102956_bib135","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11926-021-01004-y","article-title":"Reactive arthritis following Bacillus calmette\u2013guerin therapy for bladder cancer: a systematic literature review","volume":"23","author":"Ben Abdelghani","year":"2021","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.jaut.2022.102956_bib136","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1007\/s00296-005-0059-2","article-title":"Reactive arthritis following BCG immunotherapy for urinary bladder carcinoma: a systematic review","volume":"26","author":"Tinazzi","year":"2006","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.jaut.2022.102956_bib137","first-page":"284","article-title":"Reactive arthritis after the intravesical instillation of BCG","volume":"8","author":"Mac\u00eda Villa","year":"2012","journal-title":"Reumatol. Cl\u00ednica (English Ed."},{"key":"10.1016\/j.jaut.2022.102956_bib138","doi-asserted-by":"crossref","first-page":"5117","DOI":"10.1073\/pnas.82.15.5117","article-title":"Arthritis induced by a T-lymphocyte clone that responds to Mycobacterium tuberculosis and to cartilage proteoglycans","volume":"82","author":"van Eden","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jaut.2022.102956_bib139","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/BOR.0000000000000594","article-title":"Pathogenesis and treatment of autoimmune rheumatic diseases","volume":"31","author":"Liu","year":"2019","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jaut.2022.102956_bib140","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa0835","article-title":"Normalization of CD4 + T cell metabolism reverses lupus","volume":"7","author":"Yin","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.jaut.2022.102956_bib141","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01973","article-title":"Inhibition of glycolysis reduces disease severity in an autoimmune model of rheumatoid arthritis","volume":"9","author":"Abboud","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib142","article-title":"2-Deoxy-D-glucose alleviates collagen-induced arthritis of rats and is accompanied by metabolic regulation of the spleen and liver","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2019.108229","article-title":"Dietary oleuropein and its new acyl-derivate attenuate murine lupus nephritis through HO-1\/Nrf2 activation and suppressing JAK\/STAT, NF-\u03baB, MAPK and NLRP3 inflammasome signaling pathways","volume":"74","author":"Castejon","year":"2019","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.jaut.2022.102956_bib144","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3390\/nu13020311","article-title":"A new peracetylated oleuropein derivative ameliorates joint inflammation and destruction in a murine collagen-induced arthritis model via activation of the Nrf-2\/Ho-1 antioxidant pathway and suppression of MAPKs and NF-\u03baB activation","volume":"13","author":"Castej\u00f3n","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.jaut.2022.102956_bib145","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1021\/jf505894b","article-title":"Oleuropein suppresses LPS-induced inflammatory responses in RAW 264.7 cell and Zebrafish","volume":"63","author":"Ryu","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.jaut.2022.102956_bib146","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41573-019-0025-4","article-title":"Therapeutic targeting of trained immunity","volume":"18","author":"Mulder","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.jaut.2022.102956_bib147","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104581","article-title":"Tylophorine-based compounds are therapeutic in rheumatoid arthritis by targeting the caprin-1 ribonucleoprotein complex and inhibiting expression of associated c-Myc and HIF-1\u03b1","volume":"152","author":"Lee","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jaut.2022.102956_bib148","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/B978-0-444-64076-5.00046-6","article-title":"Multiple sclerosis","volume":"148","author":"Cotsapas","year":"2018","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.jaut.2022.102956_bib149","first-page":"527","article-title":"Progressive multiple sclerosis: from pathogenic mechanisms to treatment","volume":"140","author":"Correale","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.jaut.2022.102956_bib150","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S1474-4422(14)70305-9","article-title":"Role of the innate and adaptive immune responses in the course of multiple sclerosis","volume":"14","author":"Hemmer","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.jaut.2022.102956_bib151","first-page":"2021","article-title":"The immune response in multiple sclerosis","volume":"17","author":"Mur\u00faa","year":"2022","journal-title":"Annu. Rev. Pathol. Mech. Dis. Annu. Rev. Pathol. Mech. Dis."},{"key":"10.1016\/j.jaut.2022.102956_bib152","first-page":"1816","volume":"vol. 26","author":"Walton","year":"2020"},{"key":"10.1016\/j.jaut.2022.102956_bib153","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1124\/jpet.104.072512","article-title":"Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse","volume":"312","author":"Iruretagoyena","year":"2005","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.jaut.2022.102956_bib154","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4049\/jimmunol.0802886","article-title":"Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunity","volume":"184","author":"Herrada","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib155","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1476-5381.2011.01302.x","article-title":"Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)","volume":"164","author":"Constantinescu","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jaut.2022.102956_bib156","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2021.104383","article-title":"Glucan particles as a novel adjuvant for the induction of experimental autoimmune encephalomyelitis","volume":"366","author":"Chase Huizar","year":"2021","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib157","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.805302","article-title":"Curdlan, a microbial \u03b2-glucan, has contrasting effects on autoimmune and viral models of multiple sclerosis","volume":"12","author":"Sato","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.jaut.2022.102956_bib158","series-title":"Mouse Models of Multiple Sclerosis: Experimental Autoimmune Encephalomyelitis and Theiler's Virus-Induced Demyelinating Disease","first-page":"381","author":"McCarthy","year":"2012"},{"key":"10.1016\/j.jaut.2022.102956_bib159","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2174\/187152808785748155","article-title":"Therapeutic benefits of regulating inflammation in autoimmunity","volume":"7","author":"Nikoopour","year":"2008","journal-title":"Inflamm. Allergy - Drug Targets"},{"key":"10.1016\/j.jaut.2022.102956_bib160","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1080\/08923973.2021.1878215","article-title":"Mycobacterium bovis BCG-mediated suppression of Th17 response in mouse experimental autoimmune encephalomyelitis","volume":"43","author":"Matsuzaki","year":"2021","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.jaut.2022.102956_bib161","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.53.7.1588","article-title":"Use of bacille calmette-guerin (BCG) in multiple sclerosis","volume":"53","author":"Ristori","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.jaut.2022.102956_bib162","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s12272-020-01278-3","article-title":"Brain energy metabolism and multiple sclerosis: progress and prospects","volume":"43","author":"Park","year":"2020","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jaut.2022.102956_bib163","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jbiotec.2015.02.015","article-title":"Bioenergetics profile of CD4 + T cells in relapsing remitting multiple sclerosis subjects","volume":"202","author":"De Riccardis","year":"2015","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.jaut.2022.102956_bib164","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbacli.2016.10.004","article-title":"Metabolic response to glatiramer acetate therapy in multiple sclerosis patients","volume":"6","author":"De Riccardis","year":"2016","journal-title":"BBA Clin"},{"issue":"15","key":"10.1016\/j.jaut.2022.102956_bib165","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41574-019-0254-y","article-title":"The heterogeneous pathogenesis of type 1 diabetes mellitus","volume":"1511","author":"Ilonen","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jaut.2022.102956_bib166","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0140-6736(13)60591-7","article-title":"Type 1 diabetes","volume":"383","author":"Atkinson","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2022.102956_bib167","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4106518","article-title":"Two to tango: dialogue between adaptive and innate immunity in type 1 diabetes","volume":"2020","author":"Sun","year":"2020","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.jaut.2022.102956_bib168","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/8954125","article-title":"Therapeutic effects of BCG vaccination on type 1 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials","volume":"2020","author":"Chang","year":"2020","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.jaut.2022.102956_bib169","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.3389\/fimmu.2021.669456","article-title":"Glycolysis inhibition induces functional and metabolic exhaustion of CD4+ T cells in type 1 diabetes","volume":"12","author":"Martins","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103150","article-title":"Bacillus Calmette-Guerin \u2019s beneficial impact on glucose metabolism: evidence for broad based applications","volume":"24","author":"Shpilsky","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.jaut.2022.102956_bib171","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.tem.2018.11.006","article-title":"BCG therapy for type 1 diabetes: restoration of balanced immunity and metabolism","volume":"30","author":"K\u00fchtreiber","year":"2019","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.jaut.2022.102956_bib172","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41541-018-0062-8","article-title":"Long-term reduction in hyperglycemia in advanced type 1 diabetes: the value of induced aerobic glycolysis with BCG vaccinations","volume":"3","author":"K\u00fchtreiber","year":"2018","journal-title":"Npj Vaccines"},{"key":"10.1016\/j.jaut.2022.102956_bib173","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0041756","article-title":"Proof-of-Concept, randomized, controlled clinical trial of bacillus-calmette-guerin for treatment of long-term type 1 diabetes","volume":"7","author":"Faustman","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2022.102956_bib174","doi-asserted-by":"crossref","first-page":"13644","DOI":"10.1073\/pnas.0803429105","article-title":"Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism","volume":"105","author":"Ban","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jaut.2022.102956_bib175","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1016\/j.celrep.2016.11.011","article-title":"Immunometabolic pathways in BCG-induced trained immunity","volume":"17","author":"Arts","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.jaut.2022.102956_bib176","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.769341","article-title":"Impact of prebiotic \u03b2-glucan treatment at juvenile age on the gut microbiota composition and the eventual type 1 diabetes onset in non-obese diabetic mice","volume":"8","author":"Taylor","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jaut.2022.102956_bib177","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabres.2020.108464","article-title":"The effect of beta-glucan supplementation on glycemic control and variability in adolescents with type 1 diabetes mellitus","volume":"169","author":"Bozbulut","year":"2020","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.jaut.2022.102956_bib178","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.4049\/jimmunol.1400186","article-title":"Fungal \u03b2-glucan, a dectin-1 ligand, promotes protection from type 1 diabetes by inducing regulatory innate immune response","volume":"193","author":"Karumuthil-Melethil","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib179","doi-asserted-by":"crossref","first-page":"8323","DOI":"10.4049\/jimmunol.181.12.8323","article-title":"Induction of innate immune response through TLR2 and dectin 1 prevents type 1 diabetes","volume":"181","author":"Karumuthil-Melethil","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2022.102956_bib180","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.2337\/db14-1145","article-title":"TLR2- and dectin 1\u2013associated innate immune response modulates T-cell response to pancreatic \u03b2-cell antigen and prevents type 1 diabetes","volume":"64","author":"Karumuthil-Melethil","year":"2015","journal-title":"Diabetes"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841122001640?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841122001640?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:30:54Z","timestamp":1760257854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841122001640"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":180,"alternative-id":["S0896841122001640"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2022.102956","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of trained immunity during autoimmune responses","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2022.102956","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102956"}}