{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T23:41:08Z","timestamp":1793662868102,"version":"4.5.1"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:00:00Z","timestamp":1718409600000},"content-version":"am","delay-in-days":411,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.jaut.2023.102992","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T15:36:11Z","timestamp":1673537771000},"page":"102992","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"special_numbering":"C","title":["Influence of X chromosome in sex-biased autoimmune diseases"],"prefix":"10.1016","volume":"137","author":[{"given":"Charles-Henry","family":"Miquel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berenice","family":"Faz-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Gu\u00e9ry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2023.102992_bib1","series-title":"Progress in Autoimmune Diseases Research: Report to Congress","author":"Committe","year":"2005"},{"key":"10.1016\/j.jaut.2023.102992_bib2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cophys.2018.03.010","article-title":"The evolution of greater humoral immunity in females than males: implications for vaccine efficacy","volume":"6","author":"Fink","year":"2018","journal-title":"Current Opinion in Physiology"},{"key":"10.1016\/j.jaut.2023.102992_bib3","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/s41577-020-0348-8","article-title":"Considering how biological sex impacts immune responses and COVID-19 outcomes","volume":"20","author":"Scully","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1126\/science.abe7199","article-title":"Sex differences in immune responses","volume":"371","author":"Takahashi","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.jaut.2023.102992_bib5","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/BOR.0000000000000564","article-title":"Sex bias in autoimmunity","volume":"31","author":"Billi","year":"2019","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jaut.2023.102992_bib6","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/ni0901-777","article-title":"Sex differences in autoimmune disease","volume":"2","author":"Whitacre","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2019.108274","article-title":"Juvenile-onset systemic lupus erythematosus: update on clinical presentation, pathophysiology and treatment options","volume":"209","author":"Smith","year":"2019","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib8","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12979-021-00214-3","article-title":"Sex- and age-dependent alterations of splenic immune cell profile and NK cell phenotypes and function in C57BL\/6J mice","volume":"18","author":"Menees","year":"2021","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.jaut.2023.102992_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000267","article-title":"The sicker sex","volume":"5","author":"Zuk","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.jaut.2023.102992_bib11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fimmu.2017.00108","article-title":"Estrogen receptor-dependent regulation of dendritic cell development and function","volume":"8","author":"Laffont","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/bs.ai.2019.04.001","article-title":"Deconstructing the sex bias in allergy and autoimmunity: from sex hormones and beyond","volume":"142","author":"Laffont","year":"2019","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1146\/annurev-immunol-101320-125133","article-title":"Sex differences in immunity","volume":"40","author":"Wilkinson","year":"2022","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22031114","article-title":"Escape from X Chromosome inactivation and the female predominance in autoimmune diseases","volume":"22","author":"Youness","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.jaut.2023.102992_bib15","first-page":"219","article-title":"The X in seX-biased immunity and autoimmune rheumatic disease","author":"Jiwrajka","year":"2022","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jaut.2023.102992_bib16","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/art.39560","article-title":"X chromosome dose and sex bias in autoimmune diseases: increased prevalence of 47,XXX in systemic lupus erythematosus and sjogren's syndrome","volume":"68","author":"Liu","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.jaut.2023.102992_bib17","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1590\/abd1806-4841.20154066","article-title":"Systemic lupus erythematosus in a patient with Turner syndrome","volume":"90","author":"Bai","year":"2015","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.jaut.2023.102992_bib18","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/s41580-021-00438-7","article-title":"Gene regulation in time and space during X-chromosome inactivation","volume":"23","author":"Loda","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.jaut.2023.102992_bib19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nature11049","article-title":"Spatial partitioning of the regulatory landscape of the X-inactivation centre","volume":"485","author":"Nora","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2023.102992_bib20","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1016\/j.cell.2014.11.021","article-title":"A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping","volume":"159","author":"Rao","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2023.102992_bib21","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/nature18589","article-title":"Structural organization of the inactive X chromosome in the mouse","volume":"535","author":"Giorgetti","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2023.102992_bib22","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nature24265","article-title":"Landscape of X chromosome inactivation across human tissues","volume":"550","author":"Tukiainen","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2023.102992_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2013-14-11-r122","article-title":"Analysis of expressed SNPs identifies variable extents of expression from the human inactive X chromosome","volume":"14","author":"Cotton","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.jaut.2023.102992_bib24","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1093\/hmg\/ddu564","article-title":"Landscape of DNA methylation on the X chromosome reflects CpG density, functional chromatin state and X-chromosome inactivation","volume":"24","author":"Cotton","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jaut.2023.102992_bib25","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1073\/pnas.0810683106","article-title":"Dynamic changes in paternal X-chromosome activity during imprinted X-chromosome inactivation in mice","volume":"106","author":"Patrat","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jaut.2023.102992_bib26","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1101\/gr.103200.109","article-title":"Global survey of escape from X inactivation by RNA-sequencing in mouse","volume":"20","author":"Yang","year":"2010","journal-title":"Genome Res."},{"key":"10.1016\/j.jaut.2023.102992_bib27","doi-asserted-by":"crossref","first-page":"789","DOI":"10.4049\/jimmunol.1800931","article-title":"Cutting edge: CXCR3 escapes X chromosome inactivation in T cells during infection: potential implications for sex differences in immune responses","volume":"203","author":"Oghumu","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib28","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1002\/art.23701","article-title":"Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: support for the notion of a gene-dose effect from the X chromosome","volume":"58","author":"Scofield","year":"2008","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2023.102992_bib29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.clim.2016.04.002","article-title":"Klinefelter's syndrome (47,XXY) is in excess among men with Sj\u00f6gren's syndrome","volume":"168","author":"Harris","year":"2016","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3109\/08916934.2014.968918","article-title":"Associations between Klinefelter's syndrome and autoimmune diseases: English national record linkage studies","volume":"48","author":"Seminog","year":"2015","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jaut.2023.102992_bib31","series-title":"47XXY and 47XXX in Scleroderma and Myositis","author":"Scofield","year":"2022"},{"key":"10.1016\/j.jaut.2023.102992_bib32","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1084\/jem.20070850","article-title":"A role for sex chromosome complement in the female bias in autoimmune disease","volume":"205","author":"Smith-Bouvier","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jaut.2023.102992_bib33","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.tem.2003.11.001","article-title":"Are XX and XY brain cells intrinsically different?","volume":"15","author":"Arnold","year":"2004","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.jaut.2023.102992_bib34","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1136\/annrheumdis-2011-201246","article-title":"The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY","volume":"71","author":"Sasidhar","year":"2012","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2023.102992_bib35","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1172\/JCI126250","article-title":"The X-linked histone demethylase Kdm6a in CD4+ T lymphocytes modulates autoimmunity","volume":"130","author":"Itoh","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2023.102992_bib36","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/bies.201400032","article-title":"Variable escape from X-chromosome inactivation: identifying factors that tip the scales towards expression","volume":"36","author":"Peeters","year":"2014","journal-title":"Bioessays"},{"key":"10.1016\/j.jaut.2023.102992_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005079","article-title":"Escape from X inactivation varies in mouse tissues","volume":"11","author":"Berletch","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jaut.2023.102992_bib38","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12772","article-title":"Metformin directly targets the H3K27me3 demethylase KDM6A\/UTX","volume":"17","author":"Cuyas","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.jaut.2023.102992_bib39","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.immuni.2015.09.002","article-title":"T follicular helper cell-dependent clearance of a persistent virus infection requires T cell expression of the histone demethylase UTX","volume":"43","author":"Cook","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2023.102992_bib40","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.cell.2017.07.026","article-title":"Clonal evolution of autoreactive germinal centers","volume":"170","author":"Degn","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2023.102992_bib41","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1038\/s41590-019-0490-2","article-title":"Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells","volume":"20","author":"Schwickert","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib42","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.immuni.2020.04.015","article-title":"Plasmacytoid dendritic cells and type I interferon promote extrafollicular B cell responses to extracellular self-DNA","volume":"52","author":"Soni","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2023.102992_bib43","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41586-022-04642-z","article-title":"TLR7 gain-of-function genetic variation causes human lupus","volume":"605","author":"Brown","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2023.102992_bib44","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/ni.3731","article-title":"The multiple pathways to autoimmunity","volume":"18","author":"Theofilopoulos","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib45","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41584-020-00544-4","article-title":"Toll-like receptor signalling in B cells during systemic lupus erythematosus","volume":"17","author":"Fillatreau","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.jaut.2023.102992_bib46","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1126\/science.1124978","article-title":"Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication","volume":"312","author":"Pisitkun","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.jaut.2023.102992_bib47","doi-asserted-by":"crossref","first-page":"9970","DOI":"10.1073\/pnas.0603912103","article-title":"A Tlr7 translocation accelerates systemic autoimmunity in murine lupus","volume":"103","author":"Subramanian","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jaut.2023.102992_bib48","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aap8855","article-title":"TLR7 escapes X chromosome inactivation in immune cells","volume":"3","author":"Souyris","year":"2018","journal-title":"Sci Immunol"},{"key":"10.1016\/j.jaut.2023.102992_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108485","article-title":"Heterogeneous escape from X chromosome inactivation results in sex differences in type I IFN responses at the single human pDC level","volume":"33","author":"Hagen","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.jaut.2023.102992_bib50","series-title":"HIV-1 Infection Enhances Innate Function and TLR7 Expression in Female Plasmacytoid Dendritic Cells","volume":"vol. 5","author":"Abbas","year":"2022"},{"key":"10.1016\/j.jaut.2023.102992_bib51","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nri2358","article-title":"Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases","volume":"8","author":"Gilliet","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib52","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1084\/jem.20132522","article-title":"Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus","volume":"211","author":"Sisirak","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jaut.2023.102992_bib53","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1084\/jem.20132620","article-title":"Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model","volume":"211","author":"Rowland","year":"2014","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jaut.2023.102992_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104047","article-title":"Monocytes are the main source of STING-mediated IFN-a production","volume":"80","author":"Congy-Jolivet","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jaut.2023.102992_bib55","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.4049\/jimmunol.177.4.2088","article-title":"TLR7 ligands induce higher IFN-alpha production in females","volume":"177","author":"Berghofer","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib56","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/nm.2004","article-title":"Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1","volume":"15","author":"Meier","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.jaut.2023.102992_bib57","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1182\/blood-2011-08-371831","article-title":"The TLR-mediated response of plasmacytoid dendritic cells is positively regulated by estradiol in vivo through cell-intrinsic estrogen receptor alpha signaling","volume":"119","author":"Seillet","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2023.102992_bib58","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nri2815","article-title":"The X chromosome in immune functions: when a chromosome makes the difference","volume":"10","author":"Libert","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib59","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.4049\/jimmunol.1303400","article-title":"X-Chromosome complement and estrogen receptor signaling independently contribute to the enhanced TLR7-mediated IFN-alpha production of plasmacytoid dendritic cells from women","volume":"193","author":"Laffont","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib60","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41586-020-2282-0","article-title":"TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9","volume":"581","author":"Heinz","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2023.102992_bib61","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s11926-017-0695-z","article-title":"Updates in lupus genetics","volume":"19","author":"Deng","year":"2017","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.jaut.2023.102992_bib62","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1038\/s41467-019-10106-2","article-title":"Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus","volume":"10","author":"Odhams","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2023.102992_bib63","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2016-000159","article-title":"Molecular signatures in systemic lupus erythematosus: distinction between disease flare and infection","volume":"3","author":"Mackay","year":"2016","journal-title":"Lupus Sci. Med."},{"key":"10.1016\/j.jaut.2023.102992_bib64","doi-asserted-by":"crossref","first-page":"5327","DOI":"10.4049\/jimmunol.1501684","article-title":"Sex differences in plasmacytoid dendritic cell levels of IRF5 drive higher IFN-alpha production in women","volume":"195","author":"Griesbeck","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib65","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.3389\/fimmu.2018.03167","article-title":"Sex and pubertal differences in the type 1 interferon pathway associate with both X chromosome number and serum sex hormone concentration","volume":"9","author":"Webb","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib66","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/eji.201343806","article-title":"Self-priming determines high type I IFN production by plasmacytoid dendritic cells","volume":"44","author":"Kim","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib67","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1038\/s41467-018-05784-3","article-title":"Single-cell analysis reveals that stochasticity and paracrine signaling control interferon-alpha production by plasmacytoid dendritic cells","volume":"9","author":"Wimmers","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2023.102992_bib68","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1182\/blood-2011-01-330530","article-title":"A B-cell subset uniquely responsive to innate stimuli accumulates in aged mice","volume":"118","author":"Hao","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2023.102992_bib69","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1182\/blood-2011-01-331462","article-title":"Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c(+) B-cell population is important for the development of autoimmunity","volume":"118","author":"Rubtsov","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.jaut.2023.102992_bib70","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.coi.2019.01.002","article-title":"T-bet(+) B cells: a common denominator in protective and autoreactive antibody responses?","volume":"57","author":"Myles","year":"2019","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2018.08.015","article-title":"Distinct effector B cells induced by unregulated toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus","volume":"49","author":"Jenks","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.jaut.2023.102992_bib72","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1038\/s41467-018-03750-7","article-title":"IL-21 drives expansion and plasma cell differentiation of autoreactive CD11c(hi)T-bet(+) B cells in SLE","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2023.102992_bib73","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.41641","article-title":"IFNgamma induces epigenetic programming of human T-bet(hi) B cells and promotes TLR7\/8 and IL-21 induced differentiation","volume":"8","author":"Zumaquero","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.jaut.2023.102992_bib74","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1172\/JCI91250","article-title":"B cells expressing the transcription factor T-bet drive lupus-like autoimmunity","volume":"127","author":"Rubtsova","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2023.102992_bib75","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cellimm.2014.12.002","article-title":"IFNgamma, and T-bet: their roles in the development of ABCs in female-biased autoimmunity","volume":"294","author":"Rubtsova","year":"2015","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib76","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1038\/s41467-021-25102-8","article-title":"Altered function and differentiation of age-associated B cells contribute to the female bias in lupus mice","volume":"12","author":"Ricker","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2023.102992_bib77","doi-asserted-by":"crossref","first-page":"E3216","DOI":"10.1073\/pnas.1312348110","article-title":"T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance","volume":"110","author":"Rubtsova","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jaut.2023.102992_bib78","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41590-018-0056-8","article-title":"Regulation of age-associated B cells by IRF5 in systemic autoimmunity","volume":"19","author":"Manni","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib79","doi-asserted-by":"crossref","first-page":"16276","DOI":"10.1073\/pnas.1209372109","article-title":"Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity","volume":"109","author":"Walsh","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jaut.2023.102992_bib80","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.4049\/jimmunol.1401720","article-title":"B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers","volume":"193","author":"Soni","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib81","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.136047","article-title":"TLR7 dosage polymorphism shapes interferogenesis and HIV-1 acute viremia in women","volume":"5","author":"Azar","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.jaut.2023.102992_bib82","doi-asserted-by":"crossref","first-page":"7779","DOI":"10.4049\/jimmunol.178.12.7779","article-title":"TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses","volume":"178","author":"Genestier","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib83","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.gde.2019.04.012","article-title":"Enjoy the silence: X-chromosome inactivation diversity in somatic cells","volume":"55","author":"Sierra","year":"2019","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.jaut.2023.102992_bib84","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3389\/fcell.2019.00219","article-title":"X inactivation and escape: epigenetic and structural features","volume":"7","author":"Fang","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.jaut.2023.102992_bib85","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/368154a0","article-title":"The human X-inactivation centre is not required for maintenance of X-chromosome inactivation","volume":"368","author":"Brown","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2023.102992_bib86","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/366362a0","article-title":"Role for DNA methylation in genomic imprinting","volume":"366","author":"Li","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2023.102992_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007050","article-title":"Loss of Xist RNA from the inactive X during B cell development is restored in a dynamic YY1-dependent two-step process in activated B cells","volume":"13","author":"Syrett","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jaut.2023.102992_bib88","doi-asserted-by":"crossref","first-page":"7167","DOI":"10.1128\/MCB.00810-06","article-title":"Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation","volume":"26","author":"Savarese","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.jaut.2023.102992_bib89","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.126751","article-title":"Altered X-chromosome inactivation in T cells may promote sex-biased autoimmune diseases","volume":"4","author":"Syrett","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.jaut.2023.102992_bib90","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/JLB.6RI0319-094R","article-title":"When the balance is broken: X-linked gene dosage from two X chromosomes and female-biased autoimmunity","volume":"106","author":"Syrett","year":"2019","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jaut.2023.102992_bib91","first-page":"118","article-title":"The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients","author":"Pyfrom","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jaut.2023.102992_bib92","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1016\/j.jaci.2018.02.010","article-title":"CD40LG duplication-associated autoimmune disease is silenced by nonrandom X-chromosome inactivation","volume":"141","author":"Le Coz","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.jaut.2023.102992_bib93","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1101\/gad.380906","article-title":"A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced","volume":"20","author":"Chaumeil","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.jaut.2023.102992_bib94","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.cell.2010.04.042","article-title":"LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation","volume":"141","author":"Chow","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2023.102992_bib95","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13072-018-0219-8","article-title":"Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after Xist deletion","volume":"11","author":"Adrianse","year":"2018","journal-title":"Epigenet. Chromatin"},{"key":"10.1016\/j.jaut.2023.102992_bib96","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.cell.2013.01.034","article-title":"Xist RNA is a potent suppressor of hematologic cancer in mice","volume":"152","author":"Yildirim","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2023.102992_bib97","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1016\/j.cell.2021.02.015","article-title":"B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells","volume":"184","author":"Yu","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.jaut.2023.102992_bib98","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature03479","article-title":"X-inactivation profile reveals extensive variability in X-linked gene expression in females","volume":"434","author":"Carrel","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2023.102992_bib99","first-page":"E2029","article-title":"Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X","volume":"113","author":"Wang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.jaut.2023.102992_bib100","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/hmg\/7.4.737","article-title":"The UTX gene escapes X inactivation in mice and humans","volume":"7","author":"Greenfield","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.jaut.2023.102992_bib101","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/hmg\/3.6.879","article-title":"A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human","volume":"3","author":"Agulnik","year":"1994","journal-title":"Hum. Mol. Genet."}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089684112300001X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089684112300001X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:31:49Z","timestamp":1760257909000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089684112300001X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":101,"alternative-id":["S089684112300001X"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2023.102992","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of X chromosome in sex-biased autoimmune diseases","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2023.102992","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102992"}}