{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T05:42:34Z","timestamp":1792474954330,"version":"4.5.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.jaut.2023.103047","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T17:31:25Z","timestamp":1683826285000},"page":"103047","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Effects of fecal microbiota transplant on DNA methylation in patients with systemic lupus erythematosus"],"prefix":"10.1016","volume":"141","author":[{"given":"Bo","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianmei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cancan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianjin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2023.103047_bib1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/s41423-018-0010-6","article-title":"Type I interferons promote the survival and proinflammatory properties of transitional B cells in systemic lupus erythematosus patients","volume":"16","author":"Liu","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jaut.2023.103047_bib2","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1136\/annrheumdis-2021-220687","article-title":"Metagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese","volume":"80","author":"Tomofuji","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2023.103047_bib3","series-title":"Disordered Intestinal Microbes Are Associated with the Activity of Systemic Lupus Erythematosus","first-page":"821","volume":"133","author":"Li","year":"2019"},{"key":"10.1016\/j.jaut.2023.103047_bib4","volume":"233","author":"Ma","year":"2021"},{"key":"10.1016\/j.jaut.2023.103047_bib5","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1001\/jama.2018.20046","article-title":"Effect of fecal microbiota transplantation on 8-week remission in patients with ulcerative colitis: a randomized clinical trial","volume":"321","author":"Costello","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.jaut.2023.103047_bib6","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1136\/annrheumdis-2020-219511","article-title":"Safety and efficacy of faecal microbiota transplantation for active peripheral psoriatic arthritis: an exploratory randomised placebo-controlled trial","volume":"80","author":"Kragsnaes","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2023.103047_bib7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1136\/gutjnl-2020-322630","article-title":"Faecal microbiota transplantation halts progression of human new-onset type 1 diabetes in a randomised controlled trial","volume":"70","author":"de Groot","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.jaut.2023.103047_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102844","article-title":"Safety and efficacy of fecal microbiota transplantation for treatment of systemic lupus erythematosus: an explorer trial","volume":"130","author":"Huang","year":"2022","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2023.103047_bib9","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.4049\/jimmunol.179.9.6352","article-title":"Demethylation of CD40LG on the inactive X in T cells from women with lupus","volume":"179","author":"Lu","year":"2007","journal-title":"Journal of immunology (Baltimore, Md"},{"key":"10.1016\/j.jaut.2023.103047_bib10","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1002\/art.20255","article-title":"Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors","volume":"50","author":"Oelke","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2023.103047_bib11","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jaut.2016.06.020","article-title":"The critical role of epigenetics in systemic lupus erythematosus and autoimmunity","volume":"74","author":"Long","year":"2016","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2023.103047_bib12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jdermsci.2013.04.022","article-title":"Ultraviolet B enhances DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus via inhibiting DNMT1 catalytic activity","volume":"71","author":"Wu","year":"2013","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.jaut.2023.103047_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-981-15-3449-2_7","article-title":"The epigenetics of lupus erythematosus","volume":"1253","author":"Wu","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jaut.2023.103047_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106355","article-title":"Gut microbiota induces DNA methylation via SCFAs predisposing obesity-prone individuals to diabetes","volume":"182","author":"Guo","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jaut.2023.103047_bib15","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1993513","article-title":"Effects of fecal microbiota transplant on DNA methylation in subjects with metabolic syndrome","volume":"13","author":"van der Vossen","year":"2021","journal-title":"Gut Microb."},{"key":"10.1016\/j.jaut.2023.103047_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/nu14142825","article-title":"Vitamin B12 regulates the transcriptional, metabolic, and epigenetic programing in human ileal epithelial cells","volume":"14","author":"Ge","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jaut.2023.103047_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102844","article-title":"Safety and efficacy of fecal microbiota transplantation for treatment of systemic lupus erythematosus: an explorer trial","volume":"130","author":"Huang","year":"2022","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2023.103047_bib18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.jaut.2023.103047_bib19","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.1038\/s41467-022-32015-7","article-title":"Oral administration of Blautia wexlerae ameliorates obesity and type 2 diabetes via metabolic remodeling of the gut microbiota","volume":"13","author":"Hosomi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2023.103047_bib20","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1365-4632.2010.04804.x","article-title":"Analysis of associations between the patterns of global DNA hypomethylation and expression of DNA methyltransferase in patients with systemic lupus erythematosus","volume":"50","author":"Zhu","year":"2011","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.jaut.2023.103047_bib21","first-page":"99","article-title":"Induction by isoniazid and hydrallazine of antinuclear factors in mice","volume":"3","author":"Cannat","year":"1968","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jaut.2023.103047_bib22","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jaut.2018.09.007","article-title":"Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: identifying DNA methylation signatures associated with interferon-related genes based on ethnicity and SLEDAI","volume":"96","author":"Joseph","year":"2019","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2023.103047_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003678","article-title":"Genome-wide DNA methylation analysis of systemic lupus erythematosus reveals persistent hypomethylation of interferon genes and compositional changes to CD4+ T-cell populations","volume":"9","author":"Absher","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jaut.2023.103047_bib24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/978-981-15-3449-2_7","article-title":"The epigenetics of lupus erythematosus","volume":"1253","author":"Wu","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.jaut.2023.103047_bib25","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/nrc3139","article-title":"TRIM proteins and cancer","volume":"11","author":"Hatakeyama","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.jaut.2023.103047_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.655126","article-title":"Silencing of the TRIM58 gene by aberrant promoter methylation is associated with a poor patient outcome and promotes cell proliferation and migration in clear cell renal cell carcinoma","volume":"8","author":"Gan","year":"2021","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.jaut.2023.103047_bib27","first-page":"218","article-title":"A crucial role for Jagunal homolog 1 in humoral immunity and antibody glycosylation in mice and humans","author":"Hagelkruys","year":"2021","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jaut.2023.103047_bib28","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/s41423-021-00661-4","article-title":"Gut microbiota-derived metabolites in the regulation of host immune responses and immune-related inflammatory diseases","volume":"18","author":"Yang","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.jaut.2023.103047_bib29","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/s41564-019-0659-3","article-title":"The microbiota programs DNA methylation to control intestinal homeostasis and inflammation","volume":"5","author":"Ansari","year":"2020","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.jaut.2023.103047_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106355","article-title":"Gut microbiota induces DNA methylation via SCFAs predisposing obesity-prone individuals to diabetes","volume":"182","author":"Guo","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jaut.2023.103047_bib31","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1017\/S0007114518001526","article-title":"Effects of SCFA on the DNA methylation pattern of adiponectin and resistin in high-fat-diet-induced obese male mice","volume":"120","author":"Lu","year":"2018","journal-title":"Br. J. Nutr."}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841123000562?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841123000562?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T08:36:02Z","timestamp":1760258162000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841123000562"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":31,"alternative-id":["S0896841123000562"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2023.103047","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of fecal microbiota transplant on DNA methylation in patients with systemic lupus erythematosus","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2023.103047","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103047"}}