{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:08:46Z","timestamp":1791461326244,"version":"4.3.4"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":304,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/T028025\/1"],"award-info":[{"award-number":["MR\/T028025\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018952","name":"Birmingham Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203326"],"award-info":[{"award-number":["NIHR203326"]}],"id":[{"id":"10.13039\/501100018952","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007195","name":"Universit\u00e0 degli Studi di Napoli Federico II","doi-asserted-by":"publisher","award":["PNRR DM 118 M4C1"],"award-info":[{"award-number":["PNRR DM 118 M4C1"]}],"id":[{"id":"10.13039\/100007195","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["57875"],"award-info":[{"award-number":["57875"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.jaut.2024.103181","type":"journal-article","created":{"date-parts":[[2024,3,23]],"date-time":"2024-03-23T09:45:23Z","timestamp":1711187123000},"page":"103181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease"],"prefix":"10.1016","volume":"144","author":[{"given":"Anella","family":"Saviano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Schettino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzia","family":"Iaccarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel Abo","family":"Mansour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenefa","family":"Begum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Marigliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Raucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gelsomina","family":"Riccardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Mitidieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"d'Emmanuele di Villa Bianca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Bello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Panza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Smimmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Vellecco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Rimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Cheesbrough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaogong","family":"Zhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq H.","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pieretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo Maria","family":"D'Amore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Marinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"La Pietra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaella","family":"Sorrentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Caso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Scarpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Cirino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Randazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariarosaria","family":"Bucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen Michelle","family":"McGettrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif Jilani","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2280-4299","authenticated-orcid":false,"given":"Francesco","family":"Maione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2024.103181_bib1","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/ecco-jcc\/jjx072","article-title":"Incidence, phenotype, and Mortality of inflammatory bowel disease 'twenty years after","volume":"11","author":"Carbonnel","year":"2017","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jaut.2024.103181_bib2","first-page":"519","article-title":"Incidence and phenotype at diagnosis of very-early-onset compared with later-onset paediatric inflammatory bowel disease: a population-based study [1988-2011]","volume":"11","author":"Bequet","year":"2017","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jaut.2024.103181_bib3","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1053\/j.gastro.2017.05.010","article-title":"Genetic factors interact with tobacco smoke to modify risk for inflammatory bowel disease in humans and mice","volume":"153","author":"Yadav","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2024.103181_bib4","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1124\/jpet.109.160838","article-title":"Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitis","volume":"332","author":"Singh","year":"2010","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.jaut.2024.103181_bib5","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.3389\/fimmu.2017.01271","article-title":"Intestinal epithelial cell endoplasmic reticulum stress and inflammatory bowel disease pathogenesis: an update review","volume":"8","author":"Ma","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2024.103181_bib6","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jaut.2017.12.004","article-title":"Th17 plasticity and its relevance to inflammatory bowel disease","volume":"87","author":"Ueno","year":"2018","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2024.103181_bib7","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1093\/ecco-jcc\/jjw106","article-title":"IBD: in food we trust","volume":"10","author":"Marion-Letellier","year":"2016","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jaut.2024.103181_bib8","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/MIB.0000000000000585","article-title":"Dietary practices and beliefs in patients with inflammatory bowel disease","volume":"22","author":"Limdi","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jaut.2024.103181_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/nu14122469","article-title":"Nutrition and supplementation in ulcerative colitis","volume":"14","author":"Radziszewska","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.jaut.2024.103181_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.794169","article-title":"Nutraceuticals for the treatment of IBD: current progress and future directions","volume":"9","author":"Ban","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.jaut.2024.103181_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25246016","volume":"vol. 25","author":"Saviano","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.jaut.2024.103181_bib12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1586\/egh.11.29","article-title":"Existing dietary guidelines for Crohn's disease and ulcerative colitis","volume":"5","author":"Brown","year":"2011","journal-title":"Expet Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jaut.2024.103181_bib13","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/S2468-1253(22)00021-8","article-title":"Lifestyle, behaviour, and environmental modification for the management of patients with inflammatory bowel diseases: an International Organization for Study of Inflammatory Bowel Diseases consensus","volume":"7","author":"Ananthakrishnan","year":"2022","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.jaut.2024.103181_bib14","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/689492","article-title":"The central role of the gut microbiota in chronic inflammatory diseases","volume":"2014","author":"Ferreira","year":"2014","journal-title":"J Immunol Res"},{"key":"10.1016\/j.jaut.2024.103181_bib15","article-title":"Mango (Mangifera indica L.) polyphenols: anti-inflammatory intestinal microbial health benefits, and associated mechanisms of actions","volume":"26","author":"Kim","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.jaut.2024.103181_bib16","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.intimp.2016.03.004","article-title":"Mangiferin corrects the imbalance of Th17\/Treg cells in mice with TNBS-induced colitis","volume":"34","author":"Lim","year":"2016","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jaut.2024.103181_bib17","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1159\/000494654","article-title":"Mangiferin attenuates murine lupus nephritis by inducing CD4+Foxp3+ regulatory T cells via suppression of mTOR signaling","volume":"50","author":"Liang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.jaut.2024.103181_bib18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.intimp.2014.08.025","article-title":"Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-\u03baB and MAPK signaling inactivation","volume":"23","author":"Dou","year":"2014","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.jaut.2024.103181_bib19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cbi.2016.04.033","article-title":"Mangiferin attenuates DSS colitis in mice: molecular docking and in vivo approach","volume":"253","author":"Somani","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.jaut.2024.103181_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106283","article-title":"Anti-inflammatory and immunomodulatory activity of Mangifera indica L. reveals the modulation of COX-2\/mPGES-1 axis and Th17\/Treg ratio","volume":"182","author":"Saviano","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jaut.2024.103181_bib21","doi-asserted-by":"crossref","first-page":"G135","DOI":"10.1152\/ajpgi.90462.2008","article-title":"T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade","volume":"296","author":"Ostanin","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.jaut.2024.103181_bib22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12944-017-0449-y","article-title":"Mangiferin: a natural miracle bioactive compound against lifestyle related disorders","volume":"16","author":"Imran","year":"2017","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.jaut.2024.103181_bib23","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1136\/ard-2023-224479","article-title":"New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A\/F function","volume":"82","author":"Saviano","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2024.103181_bib24","doi-asserted-by":"crossref","first-page":"827","DOI":"10.4049\/jimmunol.1303484","article-title":"Opposing roles of prostaglandin D2 receptors in ulcerative colitis","volume":"193","author":"Sturm","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2024.103181_bib25","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1136\/gutjnl-2015-309940","article-title":"Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD","volume":"66","author":"Lee","year":"2017","journal-title":"Gut"},{"key":"10.1016\/j.jaut.2024.103181_bib26","first-page":"1069","article-title":"Adrenergic effect on cytokine release after ex vivo healthy volunteers' whole blood LPS stimulation","volume":"39","author":"Papandreou","year":"2016","journal-title":"Inflammation"},{"key":"10.1016\/j.jaut.2024.103181_bib27","doi-asserted-by":"crossref","DOI":"10.1080\/19420862.2020.1813962","article-title":"A minimal physiologically based pharmacokinetic model to characterize colon TNF suppression and treatment effects of an anti-TNF monoclonal antibody in a mouse inflammatory bowel disease model","volume":"12","author":"Zheng","year":"2020","journal-title":"mAbs"},{"key":"10.1016\/j.jaut.2024.103181_bib28","doi-asserted-by":"crossref","first-page":"6005","DOI":"10.4049\/jimmunol.164.11.6005","article-title":"Prevention of experimental colitis in SCID mice reconstituted with CD45RBhigh CD4+ T cells by blocking the CD40-CD154 interactions","volume":"164","author":"Liu","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2024.103181_bib29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-1-4939-1212-4_18","article-title":"Experimental mouse models of T cell-dependent inflammatory bowel disease","volume":"1193","author":"Song-Zhao","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jaut.2024.103181_bib30","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.4049\/jimmunol.172.3.1515","article-title":"Expression of dual TCR on DO11.10 T cells allows for ovalbumin-induced oral tolerance to prevent T cell-mediated colitis directed against unrelated enteric bacterial antigens","volume":"172","author":"Zhou","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2024.103181_bib31","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1002\/eji.201040379","article-title":"Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis","volume":"40","author":"Mikami","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jaut.2024.103181_bib32","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1053\/j.gastro.2012.07.019","article-title":"An oral CD3-specific antibody suppresses T-cell-induced colitis and alters cytokine responses to T-cell activation in mice","volume":"143","author":"Forster","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2024.103181_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102872","article-title":"ETS-1 facilitates Th1 cell-mediated mucosal inflammation in inflammatory bowel diseases through upregulating CIRBP","volume":"132","author":"He","year":"2022","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2024.103181_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0226154","article-title":"Amiselimod (MT-1303), a novel sphingosine 1-phosphate receptor-1 functional antagonist, inhibits progress of chronic colitis induced by transfer of CD4+CD45RBhigh T cells","volume":"14","author":"Shimano","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2024.103181_bib35","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.phrs.2008.04.004","article-title":"New insights of dimethyl sulphoxide effects (DMSO) on experimental in vivo models of nociception and inflammation","volume":"57","author":"Colucci","year":"2008","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jaut.2024.103181_bib36","article-title":"Pharmacological evaluation of the SCID T cell transfer model of colitis: as a model of Crohn's disease","volume":"2012","author":"Lindebo Holm","year":"2012","journal-title":"Int. J. Inflamm."},{"key":"10.1016\/j.jaut.2024.103181_bib37","doi-asserted-by":"crossref","first-page":"3023","DOI":"10.1038\/s41598-018-21004-w","article-title":"Inactivation of TRPM7 kinase in mice results in enlarged spleens, reduced T-cell proliferation and diminished store-operated calcium entry","volume":"8","author":"Beesetty","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jaut.2024.103181_bib38","doi-asserted-by":"crossref","first-page":"4804","DOI":"10.1038\/s41467-022-32505-8","article-title":"Mannose ameliorates experimental colitis by protecting intestinal barrier integrity","volume":"13","author":"Dong","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2024.103181_bib39","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.4049\/jimmunol.0803684","article-title":"Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis","volume":"183","author":"Nemoto","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2024.103181_bib40","doi-asserted-by":"crossref","first-page":"959","DOI":"10.3389\/fphar.2017.00959","article-title":"Traditional herbal medicine-derived sulforaphene LFS-01 reverses colitis in mice by selectively altering the gut microbiota and promoting intestinal gamma-delta T cells","volume":"8","author":"Li","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jaut.2024.103181_bib41","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1016\/j.apsb.2021.03.011","article-title":"Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation","volume":"11","author":"Lv","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jaut.2024.103181_bib42","doi-asserted-by":"crossref","first-page":"5197","DOI":"10.1172\/JCI138697","article-title":"Inactivation of paracellular cation-selective claudin-2 channels attenuates immune-mediated experimental colitis in mice","volume":"130","author":"Raju","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2024.103181_bib43","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1136\/gutjnl-2014-307311","article-title":"Protective effects of Fc-fused PD-L1 on two different animal models of colitis","volume":"64","author":"Song","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.jaut.2024.103181_bib44","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.apsb.2021.04.007","article-title":"Targeting PDE4 as a promising therapeutic strategy in chronic ulcerative colitis through modulating mucosal homeostasis","volume":"12","author":"Li","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jaut.2024.103181_bib45","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jconrel.2021.05.027","article-title":"New strategy for MS treatment with autoantigen-modified liposomes and their therapeutic effect","volume":"335","author":"Shimizu","year":"2021","journal-title":"J. Contr. Release"},{"key":"10.1016\/j.jaut.2024.103181_bib46","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/bph.15413","article-title":"IL-17-induced inflammation modulates the mPGES-1\/PPAR-\u03b3 pathway in monocytes\/macrophages","volume":"179","author":"Raucci","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jaut.2024.103181_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104351","article-title":"IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation","volume":"147","author":"Raucci","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jaut.2024.103181_bib48","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1016\/j.apsb.2020.07.019","article-title":"Lactoferrin-mediated macrophage targeting delivery and patchouli alcohol-based therapeutic strategy for inflammatory bowel diseases","volume":"10","author":"Zhao","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jaut.2024.103181_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.dib.2019.104381","article-title":"In-depth immunophenotyping data relating to IL-17Ab modulation of circulating Treg\/Th17 cells and of in situ infiltrated inflammatory monocytes in the onset of gouty inflammation","volume":"25","author":"Raucci","year":"2019","journal-title":"Data Brief"},{"key":"10.1016\/j.jaut.2024.103181_bib50","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1002\/eji.202170126","article-title":"Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)","volume":"51","author":"Cossarizza","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jaut.2024.103181_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112148","article-title":"Immunomodulatory assessment of Portulaca oleracea L. extract in a mouse model of colitis","volume":"143","author":"Alfwuaires","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jaut.2024.103181_bib52","doi-asserted-by":"crossref","first-page":"R1013","DOI":"10.1152\/ajpregu.2001.281.3.R1013","article-title":"Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice","volume":"281","author":"Wang","year":"2001","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.jaut.2024.103181_bib53","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.apsb.2021.03.043","article-title":"DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS\u2012STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis","volume":"12","author":"Wang","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.jaut.2024.103181_bib54","doi-asserted-by":"crossref","first-page":"9546","DOI":"10.1021\/acs.analchem.0c00606","article-title":"Human faecal (1)H NMR metabolomics: evaluation of solvent and sample processing on coverage and reproducibility of signature metabolites","volume":"92","author":"Cui","year":"2020","journal-title":"Anal. Chem."},{"issue":"Suppl 1","key":"10.1016\/j.jaut.2024.103181_bib55","first-page":"S36","article-title":"NMR-based metabonomics analysis of mouse urine and fecal extracts following oral treatment with the broad-spectrum antibiotic enrofloxacin (Baytril)","volume":"47","author":"Romick-Rosendale","year":"2009","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.jaut.2024.103181_bib56","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s12272-010-0716-1","article-title":"1H NMR-based metabonomic assessment of probiotic effects in a colitis mouse model","volume":"33","author":"Hong","year":"2010","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.jaut.2024.103181_bib57","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jmr.2009.11.012","article-title":"A versatile tool for the rapid alignment of 1D NMR spectra","volume":"202","author":"Savorani","year":"2010","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.jaut.2024.103181_bib58","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1111\/bph.14586","article-title":"Neutralization of IL-17 rescues amyloid-\u03b2-induced neuroinflammation and memory impairment","volume":"176","author":"Cristiano","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jaut.2024.103181_bib59","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1038\/s41467-021-22764-2","article-title":"PPAR\u0263 drives IL-33-dependent ILC2 pro-tumoral functions","volume":"12","author":"Ercolano","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2024.103181_bib60","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-59745-353-0_4","article-title":"Analysis of leukocyte migration through monolayers of cultured endothelial cells","volume":"370","author":"McGettrick","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.jaut.2024.103181_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000177","article-title":"Omega-3 Fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment","volume":"7","author":"Tull","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.jaut.2024.103181_bib62","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1189\/jlb.0508301","article-title":"Direct observations of the kinetics of migrating T cells suggest active retention by endothelial cells with continual bidirectional migration","volume":"85","author":"McGettrick","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.jaut.2024.103181_bib63","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.4049\/jimmunol.1100299","article-title":"Prostaglandin D2 regulates CD4+ memory T cell trafficking across blood vascular endothelium and primes these cells for clearance across lymphatic endothelium","volume":"187","author":"Ahmed","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2024.103181_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113171","article-title":"Galectin-9 supports primary T cell transendothelial migration in a glycan and integrin dependent manner","volume":"151","author":"Mansour","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jaut.2024.103181_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111579","article-title":"Supplementation with ribonucleotide-based ingredient (Ribodiet\u00ae) lessens oxidative stress, brain inflammation, and amyloid pathology in a murine model of Alzheimer","volume":"139","author":"Saviano","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.jaut.2024.103181_bib66","doi-asserted-by":"crossref","DOI":"10.3390\/biom12010099","article-title":"Silico, in vitro, and in vivo analysis of tanshinone IIA and cryptotanshinone from salvia miltiorrhiza as modulators of cyclooxygenase-2\/mPGES-1\/endothelial prostaglandin EP3 pathway","volume":"12","author":"Saviano","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.jaut.2024.103181_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2022.103207","article-title":"Analysis of rheumatoid- vs psoriatic arthritis synovial fluid reveals differential macrophage (CCR2) and T helper subsets (STAT3\/4 and FOXP3) activation","volume":"21","author":"Caso","year":"2022","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jaut.2024.103181_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106595","article-title":"Interleukin-17 (IL-17) triggers systemic inflammation, peripheral vascular dysfunction, and related prothrombotic state in a mouse model of Alzheimer's disease","volume":"187","author":"Vellecco","year":"2023","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jaut.2024.103181_bib69","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bcp.2008.11.011","article-title":"Interleukin 17 sustains rather than induces inflammation","volume":"77","author":"Maione","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jaut.2024.103181_bib70","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.3389\/fimmu.2018.02752","article-title":"Repetitive exposure of IL-17 into the murine air pouch favors the recruitment of inflammatory monocytes and the release of IL-16 and TREM-1 in the inflammatory fluids","volume":"9","author":"Maione","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2024.103181_bib71","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.molcel.2018.08.009","article-title":"Structures of the human PGD(2) receptor CRTH2 reveal novel mechanisms for ligand recognition","volume":"72","author":"Wang","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.jaut.2024.103181_bib72","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1002\/jcc.20292","article-title":"Integrated modeling program, applied chemical theory (IMPACT)","volume":"26","author":"Banks","year":"2005","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.jaut.2024.103181_bib73","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1021\/jm051256o","article-title":"Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes","volume":"49","author":"Friesner","year":"2006","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jaut.2024.103181_bib74","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1021\/jm030644s","article-title":"Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening","volume":"47","author":"Halgren","year":"2004","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.jaut.2024.103181_bib75","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1016\/S0140-6736(16)31711-1","article-title":"Crohn's disease","volume":"389","author":"Torres","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2024.103181_bib76","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1172\/JCI121668","article-title":"IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease","volume":"129","author":"Belarif","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2024.103181_bib77","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.crohns.2010.04.004","article-title":"Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: definitions, frequency and pharmacological aspects","volume":"4","author":"Allez","year":"2010","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jaut.2024.103181_bib78","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1053\/gast.2002.34755","article-title":"Use of surrogate markers of inflammation and Rome criteria to distinguish organic from nonorganic intestinal disease","volume":"123","author":"Tibble","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.jaut.2024.103181_bib79","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00394-014-0760-6","article-title":"Sicilian pistachio (Pistacia vera L.) nut inhibits expression and release of inflammatory mediators and reverts the increase of paracellular permeability in IL-1\u03b2-exposed human intestinal epithelial cells","volume":"54","author":"Gentile","year":"2015","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.jaut.2024.103181_bib80","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/ecco-jcc\/jjx075","article-title":"Genetic mouse models with intestinal-specific tight junction deletion resemble an ulcerative colitis phenotype","volume":"11","author":"Stremmel","year":"2017","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jaut.2024.103181_bib81","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/00365529950172835","article-title":"Correlation between faecal excretion of indium-111-labelled granulocytes and calprotectin, a granulocyte marker protein, in patients with inflammatory bowel disease","volume":"34","author":"R\u00f8seth","year":"1999","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.jaut.2024.103181_bib82","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41575-020-00399-w","article-title":"The intestinal barrier, an arbitrator turned provocateur in IBD","volume":"18","author":"Mehandru","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.jaut.2024.103181_bib83","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/s41564-019-0442-5","article-title":"Author Correction: gut microbiome structure and metabolic activity in inflammatory bowel disease","volume":"4","author":"Franzosa","year":"2019","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.jaut.2024.103181_bib84","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.cmet.2020.03.003","article-title":"Microbiota-derived metabolites suppress arthritis by amplifying aryl-hydrocarbon receptor activation in regulatory B cells","volume":"31","author":"Rosser","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.jaut.2024.103181_bib85","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/ecco-jcc\/jjab202","article-title":"Efficacy and outcomes of faecal microbiota transplantation for recurrent clostridioides difficile infection in children with inflammatory bowel disease","volume":"16","author":"Nicholson","year":"2022","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.jaut.2024.103181_bib86","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1093\/ibd\/izad160","article-title":"Exploring colitis through dynamic T cell adoptive transfer models","volume":"29","author":"Yang","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.jaut.2024.103181_bib87","doi-asserted-by":"crossref","DOI":"10.3390\/cells10081847","article-title":"Translating Treg therapy for inflammatory bowel disease in humanized mice","volume":"10","author":"Negi","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.jaut.2024.103181_bib88","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nri1057","article-title":"Anatomical basis of tolerance and immunity to intestinal antigens","volume":"3","author":"Mowat","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2024.103181_bib89","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1136\/gut.2003.023671","article-title":"Modulating the intestinal immune system: the role of lymphotoxin and GALT organs","volume":"53","author":"Spahn","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.jaut.2024.103181_bib90","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/path.2269","article-title":"The highway code of T cell trafficking","volume":"214","author":"Marelli-Berg","year":"2008","journal-title":"J. Pathol."},{"key":"10.1016\/j.jaut.2024.103181_bib91","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1365-2567.2010.03278.x","article-title":"Memory T-cell trafficking: new directions for busy commuters","volume":"130","author":"Marelli-Berg","year":"2010","journal-title":"Immunology"},{"key":"10.1016\/j.jaut.2024.103181_bib92","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/intimm\/dxq047","article-title":"Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses","volume":"22","author":"Pereira","year":"2010","journal-title":"Int. Immunol."},{"key":"10.1016\/j.jaut.2024.103181_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104807","article-title":"The functional link between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3) in the onset of inflammation","volume":"157","author":"Maione","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.jaut.2024.103181_bib94","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1161\/ATVBAHA.109.188540","article-title":"COX-2 limits prostanoid production in activated HUVECs and is a source of PGH2 for transcellular metabolism to PGE2 by tumor cells","volume":"29","author":"Salvado","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.jaut.2024.103181_bib95","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.mvr.2011.01.006","article-title":"Tumor cells induce COX-2 and mPGES-1 expression in microvascular endothelial cells mainly by means of IL-1 receptor activation","volume":"81","author":"Cas\u00f3s","year":"2011","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.jaut.2024.103181_bib96","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1161\/01.RES.87.6.504","article-title":"Human vascular smooth muscle cells but not endothelial cells express prostaglandin E synthase","volume":"87","author":"Soler","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.jaut.2024.103181_bib97","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1172\/JCI111509","article-title":"Prostaglandin I2 is not a major metabolite of arachidonic acid in cultured endothelial cells from human foreskin microvessels","volume":"74","author":"Charo","year":"1984","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2024.103181_bib98","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1021\/acsmedchemlett.7b00157","article-title":"Discovery of fevipiprant (NVP-QAW039), a potent and selective DP(2) receptor antagonist for treatment of asthma","volume":"8","author":"Sandham","year":"2017","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.jaut.2024.103181_bib99","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1124\/jpet.102.046748","article-title":"An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro","volume":"305","author":"Sugimoto","year":"2003","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.jaut.2024.103181_bib100","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/nature13479","article-title":"Pro-resolving lipid mediators are leads for resolution physiology","volume":"510","author":"Serhan","year":"2014","journal-title":"Nature"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841124000155?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841124000155?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T18:42:35Z","timestamp":1738435355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841124000155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":100,"alternative-id":["S0896841124000155"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2024.103181","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A reverse translational approach reveals the protective roles of Mangifera indica in inflammatory bowel disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2024.103181","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103181"}}