{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:44:45Z","timestamp":1778827485867,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007924","name":"Bengbu Medical College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007924","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.jaut.2024.103231","type":"journal-article","created":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T21:41:30Z","timestamp":1714513290000},"page":"103231","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Autoimmune diseases and the risk of bladder cancer: A Mendelian randomization analysis"],"prefix":"10.1016","volume":"146","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8560-9306","authenticated-orcid":false,"given":"Jun","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cui","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiajun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.jaut.2024.103231_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21654","article-title":"Cancer statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA A Cancer J. Clin."},{"issue":"12","key":"10.1016\/j.jaut.2024.103231_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2022.103210","article-title":"Mendelian randomization as a tool to gain insights into the mosaic causes of autoimmune diseases","volume":"21","author":"Chen","year":"2022","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jaut.2024.103231_bib3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/bs.ai.2019.09.002","article-title":"Autoimmune diseases in China","volume":"144","author":"Li","year":"2019","journal-title":"Adv. Immunol."},{"issue":"11","key":"10.1016\/j.jaut.2024.103231_bib4","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1681\/ASN.2016010098","article-title":"Mendelian randomization as an approach to assess causality using observational data","volume":"27","author":"Sekula","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"issue":"6","key":"10.1016\/j.jaut.2024.103231_bib5","doi-asserted-by":"crossref","first-page":"7552","DOI":"10.1002\/cam4.5498","article-title":"Causal associations between gastroesophageal reflux disease and lung cancer risk: a Mendelian randomization study","volume":"12","author":"Li","year":"2023","journal-title":"Cancer Med."},{"issue":"2","key":"10.1016\/j.jaut.2024.103231_bib6","doi-asserted-by":"crossref","first-page":"67","DOI":"10.12997\/jla.2019.8.2.67","article-title":"Mendelian randomization analysis in observational epidemiology","volume":"8","author":"Lee","year":"2019","journal-title":"J Lipid Atheroscler"},{"issue":"10","key":"10.1016\/j.jaut.2024.103231_bib7","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s41588-021-00931-x","article-title":"A cross-population atlas of genetic associations for 220 human phenotypes","volume":"53","author":"Sakaue","year":"2021","journal-title":"Nat. Genet."},{"issue":"7863","key":"10.1016\/j.jaut.2024.103231_bib8","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/s41586-021-03552-w","article-title":"Interpreting type 1 diabetes risk with genetics and single-cell epigenomics","volume":"594","author":"Chiou","year":"2021","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.jaut.2024.103231_bib9","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1038\/ng.2770","article-title":"Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis","volume":"45","author":"Beecham","year":"2013","journal-title":"Nat. Genet."},{"issue":"9","key":"10.1016\/j.jaut.2024.103231_bib10","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ng.3359","article-title":"Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations","volume":"47","author":"Liu","year":"2015","journal-title":"Nat. Genet."},{"issue":"5","key":"10.1016\/j.jaut.2024.103231_bib11","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2108672119","article-title":"Identification of genetic risk loci and prioritization of genes and pathways for myasthenia gravis: a genome-wide association study","volume":"119","author":"Chia","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.jaut.2024.103231_bib12","first-page":"a041302","article-title":"Mendelian randomization","volume":"12","author":"Birney","year":"2022","journal-title":"Cold Spring Harb Perspect Med."},{"key":"10.1016\/j.jaut.2024.103231_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.861885","article-title":"Multiple sclerosis and the risk of cardiovascular diseases: a mendelian randomization study","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.jaut.2024.103231_bib14","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s00125-023-05886-8","article-title":"Altered blood gene expression in the obesity-related type 2 diabetes cluster may be causally involved in lipid metabolism:a Mendelian randomization study","volume":"66","author":"de Klerk","year":"2023","journal-title":"Diabetologia"},{"issue":"6","key":"10.1016\/j.jaut.2024.103231_bib15","first-page":"1961","article-title":"Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic","volume":"45","author":"Bowden","year":"2016","journal-title":"Int. J. Epidemiol."},{"issue":"5","key":"10.1016\/j.jaut.2024.103231_bib16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur. J. Epidemiol."},{"issue":"2","key":"10.1016\/j.jaut.2024.103231_bib17","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int. J. Epidemiol."},{"issue":"5","key":"10.1016\/j.jaut.2024.103231_bib18","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat. Genet."},{"issue":"11","key":"10.1016\/j.jaut.2024.103231_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007081","article-title":"Orienting the causal relationship between imprecisely measured traits using GWAS summary data","volume":"13","author":"Hemani","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jaut.2024.103231_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.750533","article-title":"Six autoimmune disorders are associated with increased incidence of gastric cancer: a systematic review and meta-analysis of half a million patients","volume":"12","author":"Z\u00e1dori","year":"2021","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.jaut.2024.103231_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102882","article-title":"Autoimmunity and cancer","volume":"20","author":"Masetti","year":"2021","journal-title":"Autoimmun. Rev."},{"issue":"1","key":"10.1016\/j.jaut.2024.103231_bib22","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s12016-018-8721-0","article-title":"Regulatory T cell plasticity and stability and autoimmune diseases","volume":"58","author":"Qiu","year":"2020","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"3","key":"10.1016\/j.jaut.2024.103231_bib23","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/intimm\/dxaa078","article-title":"IL-6 in inflammation, autoimmunity and cancer","volume":"33","author":"Hirano","year":"2021","journal-title":"Int. Immunol."},{"issue":"3","key":"10.1016\/j.jaut.2024.103231_bib24","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/0961203319899986","article-title":"Hematological malignancies in connective tissue diseases","volume":"29","author":"Noureldine","year":"2020","journal-title":"Lupus"},{"issue":"7","key":"10.1016\/j.jaut.2024.103231_bib25","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1172\/JCI97953","article-title":"Role of prostanoids in gastrointestinal cancer","volume":"128","author":"Wang","year":"2018","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.jaut.2024.103231_bib26","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/j.immuni.2020.10.020","article-title":"Antagonistic inflammatory phenotypes dictate tumor fate and response to immune checkpoint blockade","volume":"53","author":"Bonavita","year":"2020","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.jaut.2024.103231_bib27","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/j.semarthrit.2021.09.009","article-title":"Risk of malignancy in patients with systemic lupus erythematosus: systematic review and meta-analysis","volume":"51","author":"Clarke","year":"2021","journal-title":"Semin. Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.jaut.2024.103231_bib28","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/cac2.12283","article-title":"The five major autoimmune diseases increase the risk of cancer: epidemiological data from a large-scale cohort study in China","volume":"42","author":"Zhou","year":"2022","journal-title":"Cancer Commun."},{"issue":"681","key":"10.1016\/j.jaut.2024.103231_bib29","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abq4419","article-title":"Additive efficacy of a bispecific anti-TNF\/IL-6 nanobody compound in translational models of rheumatoid arthritis","volume":"15","author":"Biesemann","year":"2023","journal-title":"Sci. Transl. Med."},{"issue":"7","key":"10.1016\/j.jaut.2024.103231_bib30","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/art.41666","article-title":"Characterization and function of tumor necrosis factor and interleukin-6-induced osteoclasts in rheumatoid arthritis","volume":"73","author":"Yokota","year":"2021","journal-title":"Arthritis Rheumatol."},{"issue":"2","key":"10.1016\/j.jaut.2024.103231_bib31","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1586\/1744666X.2015.983082","article-title":"Immunological basis in the pathogenesis and treatment of bladder cancer","volume":"11","author":"Thompson","year":"2015","journal-title":"Expet Rev. Clin. Immunol."},{"issue":"4","key":"10.1016\/j.jaut.2024.103231_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061901","article-title":"IL-6 expression regulates tumorigenicity and correlates with prognosis in bladder cancer","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.jaut.2024.103231_bib33","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/sj.bjc.6601165","article-title":"Polymorphisms in tumour necrosis factor (TNF) are associated with risk of bladder cancer and grade of tumour at presentation","volume":"89","author":"Marsh","year":"2003","journal-title":"Br. J. Cancer"},{"issue":"4","key":"10.1016\/j.jaut.2024.103231_bib34","doi-asserted-by":"crossref","first-page":"e501","DOI":"10.1212\/WNL.0000000000011219","article-title":"Cancer incidence and mortality rates in multiple sclerosis: a matched cohort study","volume":"96","author":"Marrie","year":"2021","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.jaut.2024.103231_bib35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pharmthera.2013.09.004","article-title":"Targeting interleukin-6 in inflammatory autoimmune diseases and cancers","volume":"141","author":"Yao","year":"2014","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.jaut.2024.103231_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.32598\/rmm.8.1.1","article-title":"Interleukin 6 but not interleukin 8 might be an indicator of multiple sclerosis progression from relapse remitting to secondary progressive status","volume":"8","author":"Eslami","year":"2020","journal-title":"Res Mol Med (RMM)"},{"issue":"8","key":"10.1016\/j.jaut.2024.103231_bib37","doi-asserted-by":"crossref","first-page":"7282","DOI":"10.18632\/aging.103076","article-title":"HMGN5 promotes IL-6-induced epithelial-mesenchymal transition of bladder cancer by interacting with Hsp27","volume":"12","author":"Yao","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"10.1016\/j.jaut.2024.103231_bib38","doi-asserted-by":"crossref","first-page":"164","DOI":"10.21037\/tau-20-1020","article-title":"Does inflammatory bowel disease increase the risk of lower urinary tract tumors: a meta-analysis","volume":"10","author":"Zhang","year":"2021","journal-title":"Transl. Androl. Urol."}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841124000659?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841124000659?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T12:29:29Z","timestamp":1731846569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841124000659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":38,"alternative-id":["S0896841124000659"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2024.103231","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autoimmune diseases and the risk of bladder cancer: A Mendelian randomization analysis","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2024.103231","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"103231"}}