{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T12:13:52Z","timestamp":1782216832504,"version":"3.54.5"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,21]],"date-time":"2024-04-21T00:00:00Z","timestamp":1713657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Foundation for Medical Research","doi-asserted-by":"publisher","award":["EQU202203014690"],"award-info":[{"award-number":["EQU202203014690"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research Bonn Office","doi-asserted-by":"publisher","award":["01GM1915"],"award-info":[{"award-number":["01GM1915"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["ERARE18-052"],"award-info":[{"award-number":["ERARE18-052"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017732","name":"E-Rare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DO 420\/7-1"],"award-info":[{"award-number":["DO 420\/7-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2145"],"award-info":[{"award-number":["EXC 2145"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["390857198"],"award-info":[{"award-number":["390857198"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-INBS-09"],"award-info":[{"award-number":["ANR-10-INBS-09"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.jaut.2024.103234","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T19:14:32Z","timestamp":1713986072000},"page":"103234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy"],"prefix":"10.1016","volume":"146","author":[{"given":"Alina","family":"Huth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikram","family":"Ayoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Barateau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa Ann","family":"Gerdes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dany","family":"Severac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Krebs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Blum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrettin","family":"Tumani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Haas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Wildemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"K\u00fcmpfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Beltr\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland S.","family":"Liblau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Dauvilliers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Dornmair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2024.103234_bib1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(22)01018-2","article-title":"Understanding and approaching excessive daytime sleepiness","volume":"400","author":"P\u00e9rez-Carbonell","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2024.103234_bib2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/s41582-019-0226-9","article-title":"Narcolepsy \u2014 clinical spectrum, aetiopathophysiology, diagnosis and treatment","volume":"15","author":"Bassetti","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.jaut.2024.103234_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41577-023-00902-9","article-title":"The immunopathogenesis of narcolepsy type 1","author":"Liblau","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2024.103234_bib4","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.13631","article-title":"Narcolepsy","volume":"31","author":"Barateau","year":"2022","journal-title":"J. Sleep Res."},{"key":"10.1016\/j.jaut.2024.103234_bib5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.smrv.2017.06.006","article-title":"Incidence of narcolepsy after H1N1 influenza and vaccinations: systematic review and meta-analysis","volume":"38","author":"Sarkanen","year":"2018","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.jaut.2024.103234_bib6","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1038\/s41467-023-36120-z","article-title":"Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy","volume":"14","author":"Ollila","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2024.103234_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2019.03.010","article-title":"Shared T cell receptor chains in blood memory CD4+ T cells of narcolepsy type 1 patients","volume":"100","author":"Beltr\u00e1n","year":"2019","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2024.103234_bib8","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41586-018-0540-1","article-title":"T cells in patients with narcolepsy target self-antigens of hypocretin neurons","volume":"562","author":"Latorre","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2024.103234_bib9","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2205797119","article-title":"Characterization of T cell receptors reactive to HCRT NH2 , pHA 273-287 , and NP 17-31 in control and narcolepsy patients","volume":"119","author":"Luo","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jaut.2024.103234_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ygeno.2009.05.006","article-title":"Evidence for potential functionality of nuclearly-encoded humanin isoforms","volume":"94","author":"Bodzioch","year":"2009","journal-title":"Genomics"},{"key":"10.1016\/j.jaut.2024.103234_bib11","doi-asserted-by":"crossref","first-page":"6336","DOI":"10.1073\/pnas.101133498","article-title":"A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and A\u03b2","volume":"98","author":"Hashimoto","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.jaut.2024.103234_bib12","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00401-023-02537-5","article-title":"Persistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS","volume":"145","author":"Agrafiotis","year":"2023","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.jaut.2024.103234_bib13","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1038\/s41593-023-01432-2","article-title":"A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model","volume":"26","author":"Kendirli","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.jaut.2024.103234_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.crmeth.2023.100533","article-title":"A structured evaluation of cryopreservation in generating single-cell transcriptomes from cerebrospinal fluid","volume":"3","author":"Touil","year":"2023","journal-title":"Cell Reports Methods"},{"key":"10.1016\/j.jaut.2024.103234_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102901","article-title":"Antigen-specific immune reactions by expanded CD8+ T cell clones from HLA-B*27-positive patients with spondyloarthritis","volume":"133","author":"Deschler","year":"2022","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.jaut.2024.103234_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14049","article-title":"Massively parallel digital transcriptional profiling of single cells","volume":"8","author":"Zheng","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2024.103234_bib17","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/s41590-021-00948-8","article-title":"Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity","volume":"22","author":"Hiltensperger","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.jaut.2024.103234_bib18","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41592-019-0619-0","article-title":"Fast, sensitive and accurate integration of single-cell data with Harmony","volume":"16","author":"Korsunsky","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.jaut.2024.103234_bib19","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1084\/jem.20130958","article-title":"Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells","volume":"210","author":"Reantragoon","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jaut.2024.103234_bib20","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.jaut.2024.103234_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169836","article-title":"Narcolepsy type 1 is associated with a systemic increase and activation of regulatory T cells and with a systemic activation of global T cells","volume":"12","author":"Lecendreux","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.jaut.2024.103234_bib22","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1084\/jem.20160897","article-title":"High-dimensional single-cell analysis reveals the immune signature of narcolepsy","volume":"213","author":"Hartmann","year":"2016","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jaut.2024.103234_bib23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/eji.202048633","article-title":"Immunocyte single cell analysis of vaccine\u2010induced narcolepsy","volume":"51","author":"Lind","year":"2021","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.jaut.2024.103234_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1108682","article-title":"Cerebrospinal fluid proteomics in recent-onset Narcolepsy type 1 reveals activation of the complement system","volume":"14","author":"Ayoub","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2024.103234_bib25","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbi.2015.03.004","article-title":"Cerebrospinal fluid cytokine levels in type 1 narcolepsy patients very close to onset","volume":"49","author":"Kornum","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jaut.2024.103234_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2023.1023950","article-title":"Transcriptome analyses of the cortex and white matter of focal cortical dysplasia type II: insights into pathophysiology and tissue characterization","volume":"14","author":"Assis-Mendon\u00e7a","year":"2023","journal-title":"Front. Neurol."},{"key":"10.1016\/j.jaut.2024.103234_bib27","series-title":"Frontiers of Neurology and Neuroscience","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000514967","article-title":"Hypocretin\/orexin, sleep and Alzheimer's disease","author":"Dauvilliers","year":"2021"},{"key":"10.1016\/j.jaut.2024.103234_bib28","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1126\/science.1180962","article-title":"Amyloid-\u03b2 dynamics are regulated by orexin and the sleep-wake cycle","volume":"326","author":"Kang","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.jaut.2024.103234_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2014.00119","article-title":"Hypocretin and brain \u00ce2-amyloid peptide interactions in cognitive disorders and narcolepsy","volume":"6","author":"Dauvilliers","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.jaut.2024.103234_bib30","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/ana.25373","article-title":"The Alzheimer's disease neuroimaging initiative, multi-domain intervention Alzheimer's prevention trial study groups, reduced brain amyloid burden in elderly patients with narcolepsy type 1: amyloid load in narcolepsy","volume":"85","author":"Gabelle","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.jaut.2024.103234_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118679","article-title":"Humanin: a mitochondrial-derived peptide in the treatment of apoptosis-related diseases","volume":"264","author":"Hazafa","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.jaut.2024.103234_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2021.130024","article-title":"Humanin and Alzheimer's disease: the beginning of a new field","volume":"1866","author":"Niikura","year":"2022","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.jaut.2024.103234_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2022.130097","article-title":"Roles of humanin and derivatives on the pathology of neurodegenerative diseases and cognition","volume":"1866","author":"Thiankhaw","year":"2022","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.jaut.2024.103234_bib34","doi-asserted-by":"crossref","first-page":"5871","DOI":"10.2147\/IJN.S114838","article-title":"Apoptotic neuron-secreted HN12 inhibits cell apoptosis in Hirschsprung's disease","volume":"11","author":"Du","year":"2016","journal-title":"IJN"},{"key":"10.1016\/j.jaut.2024.103234_bib35","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsab285","article-title":"Narcolepsy with intermediate cerebrospinal level of hypocretin-1","volume":"45","author":"Postiglione","year":"2022","journal-title":"Sleep"}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841124000684?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841124000684?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T23:57:11Z","timestamp":1717631831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841124000684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":35,"alternative-id":["S0896841124000684"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2024.103234","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single cell transcriptomics of cerebrospinal fluid cells from patients with recent-onset narcolepsy","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2024.103234","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103234"}}