{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T05:47:06Z","timestamp":1749016026709,"version":"3.37.3"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100011495","name":"Massachusetts Life Sciences Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011495","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.jaut.2025.103358","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T02:10:34Z","timestamp":1736993434000},"page":"103358","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Janus kinase inhibition prevents autoimmune diabetes in LEW.1WR1 rats"],"prefix":"10.1016","volume":"151","author":[{"given":"Adediwura","family":"Arowosegbe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiru","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Vanderleeden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan G.","family":"Derr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-9100","authenticated-orcid":false,"given":"Jennifer P.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2025.103358_bib1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrendo.2016.30","article-title":"Viral infections in type 1 diabetes mellitus--why the beta cells?","volume":"12","author":"Op de Beeck","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jaut.2025.103358_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002552","article-title":"The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines","volume":"8","author":"Eizirik","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.jaut.2025.103358_bib3","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.2337\/db13-1775","article-title":"Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility","volume":"63","author":"Kallionpaa","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2025.103358_bib4","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.2337\/db13-1777","article-title":"A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes","volume":"63","author":"Ferreira","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2025.103358_bib5","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s12022-014-9297-8","article-title":"Pancreatic pathology in type 1 diabetes mellitus","volume":"25","author":"Richardson","year":"2014","journal-title":"Endocr. Pathol."},{"key":"10.1016\/j.jaut.2025.103358_bib6","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41574-020-0355-7","article-title":"Pancreatic beta-cells in type 1 and type 2 diabetes mellitus: different pathways to failure","volume":"16","author":"Eizirik","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jaut.2025.103358_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.881997","article-title":"Detection of antiviral tissue responses and increased cell stress in the pancreatic islets of newly diagnosed type 1 diabetes patients: results from the DiViD study","volume":"13","author":"Krogvold","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jaut.2025.103358_bib8","doi-asserted-by":"crossref","first-page":"3104","DOI":"10.2337\/db16-0616","article-title":"Expression of interferon-stimulated genes in insulitic pancreatic islets of patients recently diagnosed with type 1 diabetes","volume":"65","author":"Lundberg","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2025.103358_bib9","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1007\/s00125-016-4201-3","article-title":"Interferon-alpha mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes","volume":"60","author":"Marroqui","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.jaut.2025.103358_bib10","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1038\/s41467-020-16327-0","article-title":"An integrated multi-omics approach identifies the landscape of interferon-alpha-mediated responses of human pancreatic beta cells","volume":"11","author":"Colli","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2025.103358_bib11","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.2337\/diabetes.54.9.2727","article-title":"LEW.1WR1 rats develop autoimmune diabetes spontaneously and in response to environmental perturbation","volume":"54","author":"Mordes","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2025.103358_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.2337\/db16-0462","article-title":"A critical role for the type I interferon receptor in virus-induced autoimmune diabetes in rats","volume":"66","author":"Qaisar","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2025.103358_bib13","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.2337\/diab.41.8.1016","article-title":"Poly I:C accelerates development of diabetes mellitus in diabetes-prone BB rat","volume":"41","author":"Ewel","year":"1992","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2025.103358_bib14","doi-asserted-by":"crossref","first-page":"855","DOI":"10.4049\/immunohorizons.2100088","article-title":"Type I IFN-driven immune cell dysregulation in rat autoimmune diabetes","volume":"5","author":"Qaisar","year":"2021","journal-title":"Immunohorizons"},{"key":"10.1016\/j.jaut.2025.103358_bib15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2337\/db22-0521","article-title":"An early islet transcriptional signature is associated with local inflammation in autoimmune diabetes","volume":"72","author":"Derr","year":"2023","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2025.103358_bib16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2337\/db09-0255","article-title":"Infection with viruses from several families triggers autoimmune diabetes in LEW\u22171WR1 rats: prevention of diabetes by maternal immunization","volume":"59","author":"Tirabassi","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2025.103358_bib17","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/s12864-020-6714-x","article-title":"A distributed data processing platform for high throughput genomics","volume":"21","author":"Yukselen","year":"2020","journal-title":"BMC Genom."},{"key":"10.1016\/j.jaut.2025.103358_bib18","doi-asserted-by":"crossref","first-page":"E548","DOI":"10.1503\/jpn.200191","article-title":"The utility of maraviroc, an antiretroviral agent used to treat HIV, as treatment for opioid abuse? Data from MRI and behavioural testing in rats","volume":"46","author":"Iriah","year":"2021","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.jaut.2025.103358_bib19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00432-020-03382-9","article-title":"Antineoplastic effects of targeting CCR5 and its therapeutic potential for colorectal cancer liver metastasis","volume":"147","author":"Pervaiz","year":"2021","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.jaut.2025.103358_bib20","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.canlet.2020.01.009","article-title":"The CCR5 antagonist maraviroc causes remission of pancreatic cancer liver metastasis in nude rats based on cell cycle inhibition and apoptosis induction","volume":"474","author":"Huang","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.jaut.2025.103358_bib21","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1177\/1753425913502242","article-title":"Modulation of virus-induced innate immunity and type 1 diabetes by IL-1 blockade","volume":"20","author":"Hara","year":"2014","journal-title":"Innate Immun."},{"key":"10.1016\/j.jaut.2025.103358_bib22","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.3389\/fphar.2018.01405","article-title":"A comparative study on the efficacy of NLRP3 inflammasome signaling inhibitors in a pre-clinical model of bowel inflammation","volume":"9","author":"Pellegrini","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.jaut.2025.103358_bib23","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.014044","article-title":"Targeting the NLRP3 inflammasome with inhibitor MCC950 prevents aortic aneurysms and dissections in mice","volume":"9","author":"Ren","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.jaut.2025.103358_bib24","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1161\/CIRCULATIONAHA.122.060860","article-title":"NLRP3 inflammasome activation through heart-brain interaction initiates cardiac inflammation and hypertrophy during pressure overload","volume":"147","author":"Higashikuni","year":"2023","journal-title":"Circulation"},{"key":"10.1016\/j.jaut.2025.103358_bib25","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm.3806","article-title":"A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases","volume":"21","author":"Coll","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.jaut.2025.103358_bib26","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.2147\/DMSO.S199802","article-title":"A small molecule inhibitor MCC950 ameliorates kidney injury in diabetic nephropathy by inhibiting NLRP3 inflammasome activation","volume":"12","author":"Zhang","year":"2019","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.jaut.2025.103358_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115435","article-title":"Modulation of p38 MAPK and Nrf2\/HO-1\/NLRP3 inflammasome signaling and pyroptosis outline the anti-neuroinflammatory and remyelinating characters of Clemastine in EAE rat model","volume":"209","author":"Motawi","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.jaut.2025.103358_bib28","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/s41467-024-45573-9","article-title":"TYK2 signaling promotes the development of autoreactive CD8(+) cytotoxic T lymphocytes and type 1 diabetes","volume":"15","author":"Mine","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2025.103358_bib29","article-title":"Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in mice","author":"Syed","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.jaut.2025.103358_bib30","doi-asserted-by":"crossref","first-page":"131","DOI":"10.4049\/jimmunol.174.1.131","article-title":"TLR activation synergizes with Kilham rat virus infection to induce diabetes in BBDR rats","volume":"174","author":"Zipris","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2025.103358_bib31","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nature06406","article-title":"Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A","volume":"450","author":"Nejentsev","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2025.103358_bib32","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/cei.13353","article-title":"Immune cell trafficking to the islets during type 1 diabetes","volume":"198","author":"Sandor","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.jaut.2025.103358_bib33","doi-asserted-by":"crossref","first-page":"436","DOI":"10.2337\/db11-0853","article-title":"Expression and regulation of chemokines in murine and human type 1 diabetes","volume":"61","author":"Sarkar","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2025.103358_bib34","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1056\/NEJM198411293112205","article-title":"Interleukin-1 and the pathogenesis of the acute-phase response","volume":"311","author":"Dinarello","year":"1984","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jaut.2025.103358_bib35","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.97843","article-title":"Restoration of the type I IFN-IL-1 balance through targeted blockade of PTGER4 inhibits autoimmunity in NOD mice","volume":"3","author":"Rahman","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.jaut.2025.103358_bib36","doi-asserted-by":"crossref","first-page":"11318","DOI":"10.1073\/pnas.1513509112","article-title":"NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets","volume":"112","author":"Hu","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.jaut.2025.103358_bib37","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41589-019-0277-7","article-title":"MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition","volume":"15","author":"Coll","year":"2019","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.jaut.2025.103358_bib38","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41392-023-01468-7","article-title":"Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer","volume":"8","author":"Xue","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.jaut.2025.103358_bib39","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.virol.2014.07.041","article-title":"Kilham Rat Virus-induced type 1 diabetes involves beta cell infection and intra-islet JAK-STAT activation prior to insulitis","volume":"468\u2013470","author":"Alkanani","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.jaut.2025.103358_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104840","article-title":"Allosteric TYK2 inhibition: redefining autoimmune disease therapy beyond JAK1-3 inhibitors","volume":"97","author":"Jensen","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jaut.2025.103358_bib41","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1007\/s00125-016-4067-4","article-title":"Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes","volume":"59","author":"Richardson","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.jaut.2025.103358_bib42","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.2337\/db11-1520","article-title":"Circulating preproinsulin signal peptide-specific CD8 T cells restricted by the susceptibility molecule HLA-A24 are expanded at onset of type 1 diabetes and kill beta-cells","volume":"61","author":"Kronenberg","year":"2012","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2025.103358_bib43","doi-asserted-by":"crossref","first-page":"687","DOI":"10.2337\/db17-0021","article-title":"Molecular pathways for immune recognition of preproinsulin signal peptide in type 1 diabetes","volume":"67","author":"Kronenberg-Versteeg","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2025.103358_bib44","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3389\/fendo.2017.00232","article-title":"Type I interferon is a catastrophic feature of the diabetic islet microenvironment","volume":"8","author":"Newby","year":"2017","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jaut.2025.103358_bib45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ebiom.2017.06.014","article-title":"Type 1 diabetes and type 1 interferonopathies: localization of a type 1 common thread of virus infection in the pancreas","volume":"22","author":"Jean-Baptiste","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jaut.2025.103358_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1270325","article-title":"The role of the interferon\/JAK-STAT axis in driving islet HLA-I hyperexpression in type 1 diabetes","volume":"14","author":"Russell","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jaut.2025.103358_bib47","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3109\/08916930903246464","article-title":"CCR2 and CCR5 chemokine receptors differentially influence the development of autoimmune diabetes in the NOD mouse","volume":"43","author":"Solomon","year":"2010","journal-title":"Autoimmunity"},{"key":"10.1016\/j.jaut.2025.103358_bib48","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.4049\/jimmunol.165.2.1102","article-title":"Differential expression of CC chemokines and the CCR5 receptor in the pancreas is associated with progression to type I diabetes","volume":"165","author":"Cameron","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.jaut.2025.103358_bib49","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri3581","article-title":"Regulation of type I interferon responses","volume":"14","author":"Ivashkiv","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.jaut.2025.103358_bib50","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1007\/s001250100021","article-title":"A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis","volume":"44","author":"Eizirik","year":"2001","journal-title":"Diabetologia"},{"key":"10.1016\/j.jaut.2025.103358_bib51","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2337\/diabetes.53.1.113","article-title":"IL-1 receptor deficiency slows progression to diabetes in the NOD mouse","volume":"53","author":"Thomas","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2025.103358_bib52","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/nrendo.2009.271","article-title":"Blockade of interleukin 1 in type 1 diabetes mellitus","volume":"6","author":"Mandrup-Poulsen","year":"2010","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.jaut.2025.103358_bib53","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/S0140-6736(13)60023-9","article-title":"Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials","volume":"381","author":"Moran","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2025.103358_bib54","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.2337\/db18-0331","article-title":"Type I and II interferon receptors differentially regulate type 1 diabetes susceptibility in male versus female NOD mice","volume":"67","author":"Carrero","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2025.103358_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110747","article-title":"Interferons limit autoantigen-specific CD8(+) T-cell expansion in the non-obese diabetic mouse","volume":"39","author":"Jhala","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.jaut.2025.103358_bib56","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/S0140-6736(87)91128-7","article-title":"Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus","volume":"2","author":"Foulis","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.jaut.2025.103358_bib57","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.2337\/db15-0362","article-title":"TYK2, a candidate gene for type 1 diabetes, modulates apoptosis and the innate immune response in human pancreatic beta-cells","volume":"64","author":"Marroqui","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2025.103358_bib58","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/08830180902978120","article-title":"Molecular mechanisms of IFN-gamma to up-regulate MHC class I antigen processing and presentation","volume":"28","author":"Zhou","year":"2009","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.jaut.2025.103358_bib59","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1172\/JCI2899","article-title":"IFN-gamma action on pancreatic beta cells causes class I MHC upregulation but not diabetes","volume":"102","author":"Thomas","year":"1998","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.jaut.2025.103358_bib60","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1084\/jem.185.3.531","article-title":"Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus","volume":"185","author":"von Herrath","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.jaut.2025.103358_bib61","doi-asserted-by":"crossref","DOI":"10.1002\/cti2.1425","article-title":"Diabetes induced by checkpoint inhibition in nonobese diabetic mice can be prevented or reversed by a JAK1\/JAK2 inhibitor","volume":"11","author":"Ge","year":"2022","journal-title":"Clin Transl Immunology"},{"key":"10.1016\/j.jaut.2025.103358_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.588543","article-title":"The JAK1 selective inhibitor ABT 317 blocks signaling through interferon-gamma and common gamma chain cytokine receptors to reverse autoimmune diabetes in NOD mice","volume":"11","author":"Ge","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2025.103358_bib63","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.2337\/db16-1250","article-title":"Repurposed JAK1\/JAK2 inhibitor reverses established autoimmune insulitis in NOD mice","volume":"66","author":"Trivedi","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.jaut.2025.103358_bib64","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1056\/NEJMoa2306691","article-title":"Baricitinib and beta-cell function in patients with new-onset type 1 diabetes","volume":"389","author":"Waibel","year":"2023","journal-title":"N. Engl. J. Med."}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841125000034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841125000034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T16:13:07Z","timestamp":1740413587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841125000034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":64,"alternative-id":["S0896841125000034"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2025.103358","relation":{},"ISSN":["0896-8411"],"issn-type":[{"type":"print","value":"0896-8411"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Janus kinase inhibition prevents autoimmune diabetes in LEW.1WR1 rats","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2025.103358","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103358"}}