{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T08:23:43Z","timestamp":1794039823656,"version":"4.8.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018628","name":"Scientific Research Foundation of Education Department of Anhui Province of China","doi-asserted-by":"publisher","award":["2025AHGXZK30175"],"award-info":[{"award-number":["2025AHGXZK30175"]}],"id":[{"id":"10.13039\/501100018628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273711"],"award-info":[{"award-number":["82273711"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504494"],"award-info":[{"award-number":["82504494"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Autoimmunity"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.jaut.2026.103612","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T21:59:33Z","timestamp":1786053573000},"page":"103612","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Child-to-adult body size trajectories and risk of rheumatoid arthritis: the mediating role of metabolic unhealthiness, low-grade inflammation, and the modifying effect of genetic susceptibility"],"prefix":"10.1016","volume":"163","author":[{"given":"Xing-Yu","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Xu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Han","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Hao","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Xue","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3663-4035","authenticated-orcid":false,"given":"Dong-Sheng","family":"Di","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jaut.2026.103612_bib1","article-title":"Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis","volume":"9","author":"Lin","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.jaut.2026.103612_bib2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.autrev.2004.09.002","article-title":"Epidemiology of adult rheumatoid arthritis","volume":"4","author":"Alamanos","year":"2005","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.jaut.2026.103612_bib3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.1076","article-title":"Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis","volume":"44","author":"Raychaudhuri","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.jaut.2026.103612_bib4","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/1529-0131(200001)43:1<30::AID-ANR5>3.0.CO;2-B","article-title":"Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins","volume":"43","author":"MacGregor","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.jaut.2026.103612_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtauto.2021.100119","article-title":"Causal risk and protective factors in rheumatoid arthritis: a genetic update","volume":"4","author":"Arleevskaya","year":"2021","journal-title":"J Transl Autoimmun"},{"key":"10.1016\/j.jaut.2026.103612_bib6","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1136\/annrheumdis-2014-205459","article-title":"Being overweight or obese and risk of developing rheumatoid arthritis among women: a prospective cohort study","volume":"73","author":"Lu","year":"2014","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.jaut.2026.103612_bib7","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13075-015-0601-x","article-title":"Body mass index and the risk of rheumatoid arthritis: a systematic review and dose-response meta-analysis","volume":"17","author":"Qin","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2026.103612_bib8","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1056\/NEJMoa1713231","article-title":"Change in overweight from childhood to early adulthood and risk of type 2 diabetes","volume":"378","author":"Bjerregaard","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.jaut.2026.103612_bib9","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1542\/peds.108.3.712","article-title":"Relationship of childhood obesity to coronary heart disease risk factors in adulthood: the Bogalusa heart study","volume":"108","author":"Freedman","year":"2001","journal-title":"Pediatrics"},{"key":"10.1016\/j.jaut.2026.103612_bib10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fendo.2016.00030","article-title":"Adipose tissue remodeling: its role in energy metabolism and metabolic disorders","volume":"7","author":"Choe","year":"2016","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.jaut.2026.103612_bib11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature21363","article-title":"Inflammation, metaflammation and immunometabolic disorders","volume":"542","author":"Hotamisligil","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2026.103612_bib12","first-page":"1077","article-title":"Cigarette smoking: a modifiable environmental factor in the pathogenesis of rheumatoid arthritis","volume":"8","author":"Masuko","year":"2025","journal-title":"JMA Journal"},{"key":"10.1016\/j.jaut.2026.103612_bib13","article-title":"Early-life famine exposure and rheumatoid arthritis in Chinese adult populations: a retrospective cohort study","volume":"11","author":"Liu","year":"2021","journal-title":"BMJ Open"},{"key":"10.1016\/j.jaut.2026.103612_bib14","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature12873","article-title":"Genetics of rheumatoid arthritis contributes to biology and drug discovery","volume":"506","author":"Okada","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.jaut.2026.103612_bib15","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-009161","article-title":"Cohort profile of the UK biobank: diagnosis and characteristics of cerebrovascular disease","volume":"6","author":"Hewitt","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.jaut.2026.103612_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med."},{"key":"10.1016\/j.jaut.2026.103612_bib17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.hlpt.2012.07.003","article-title":"UK biobank: current status and what it means for epidemiology","volume":"1","author":"Allen","year":"2012","journal-title":"Health Policy and Technology"},{"key":"10.1016\/j.jaut.2026.103612_bib18","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1007\/s00125-023-06058-4","article-title":"Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease","volume":"67","author":"Carrasquilla","year":"2024","journal-title":"Diabetologia"},{"key":"10.1016\/j.jaut.2026.103612_bib19","doi-asserted-by":"crossref","DOI":"10.1210\/endrev\/bnaa004","article-title":"Metabolically healthy obesity","volume":"41","author":"Bl\u00fcher","year":"2020","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.jaut.2026.103612_bib20","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1160\/th15-06-0487","article-title":"Polyphenol intake is associated with low-grade inflammation, using a novel data analysis from the Moli-sani study","volume":"115","author":"Pounis","year":"2016","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.jaut.2026.103612_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcrc.2023.154360","article-title":"Inflammatory biomarkers to predict the prognosis of acute bacterial and viral infections","volume":"78","author":"de Nooijer","year":"2023","journal-title":"J. Crit. Care"},{"key":"10.1016\/j.jaut.2026.103612_bib22","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1093\/eurjpc\/zwad116","article-title":"C-reactive protein and cardiovascular diseases: a synthesis of studies based on different designs","volume":"30","author":"Liu","year":"2023","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.jaut.2026.103612_bib23","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.bbi.2022.07.165","article-title":"Low-grade inflammation as mediator between diet and behavioral disinhibition: a UK Biobank study","volume":"106","author":"Shi","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.jaut.2026.103612_bib24","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1016\/S2666-7568(23)00220-9","article-title":"Associations between biological ageing and the risk of, genetic susceptibility to, and life expectancy associated with rheumatoid arthritis: a secondary analysis of two observational studies","volume":"5","author":"Chen","year":"2024","journal-title":"Lancet Healthy Longev."},{"key":"10.1016\/j.jaut.2026.103612_bib25","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/EDE.0000000000000651","article-title":"Causal mediation analysis of survival outcome with multiple mediators","volume":"28","author":"Huang","year":"2017","journal-title":"Epidemiology"},{"key":"10.1016\/j.jaut.2026.103612_bib26","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jare.2024.02.021","article-title":"Early-life tobacco smoke elevating later-life osteoporosis risk: mediated by telomere length and interplayed with genetic predisposition","volume":"68","author":"Di","year":"2025","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.jaut.2026.103612_bib27","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1093\/ije\/dyr218","article-title":"Recommendations for presenting analyses of effect modification and interaction","volume":"41","author":"Knol","year":"2012","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.jaut.2026.103612_bib28","doi-asserted-by":"crossref","DOI":"10.1289\/EHP10710","article-title":"Association of combined exposure to ambient air pollutants, genetic risk, and incident Rheumatoid arthritis: a prospective cohort study in the UK biobank","volume":"131","author":"Zhang","year":"2023","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.jaut.2026.103612_bib29","doi-asserted-by":"crossref","first-page":"9682","DOI":"10.1038\/s41598-025-94606-w","article-title":"Association between body roundness index and osteoarthritis\/rheumatoid arthritis: a cross-sectional study","volume":"15","author":"Gao","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.jaut.2026.103612_bib30","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s13075-025-03655-z","article-title":"Longitudinal patterns of obesity index changes and risk of incident rheumatoid arthritis: evidence from a population-based cohort","volume":"27","author":"Zhao","year":"2025","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2026.103612_bib31","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1080\/03009742.2021.1954772","article-title":"Birthweight, body size, and growth during childhood and risks of rheumatoid arthritis: a large Danish cohort study","volume":"51","author":"Thomas","year":"2022","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.jaut.2026.103612_bib32","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/rheumatology\/keac307","article-title":"Improved outcomes in rheumatoid arthritis with obesity after a weight loss intervention: randomized trial","volume":"62","author":"Ranganath","year":"2023","journal-title":"Rheumatology"},{"key":"10.1016\/j.jaut.2026.103612_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101009","article-title":"Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice","volume":"39","author":"Collotta","year":"2020","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.jaut.2026.103612_bib34","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1007\/s10753-022-01779-x","article-title":"Hypoxia and TNF-\u03b1 synergistically induce expression of IL-6 and IL-8 in human fibroblast-like synoviocytes via enhancing TAK1\/NF-\u03baB\/HIF-1\u03b1 signaling","volume":"46","author":"Wang","year":"2023","journal-title":"Inflammation"},{"key":"10.1016\/j.jaut.2026.103612_bib35","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1038\/s41467-018-04581-2","article-title":"Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation","volume":"9","author":"Lang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.jaut.2026.103612_bib36","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cmet.2014.03.029","article-title":"Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity","volume":"19","author":"Nagareddy","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.jaut.2026.103612_bib37","doi-asserted-by":"crossref","first-page":"9770","DOI":"10.3892\/mmr.2017.7797","article-title":"Leptin promotes IL-18 secretion by activating the NLRP3 inflammasome in RAW 264.7 cells","volume":"16","author":"Fu","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.jaut.2026.103612_bib38","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.lfs.2018.10.014","article-title":"Intracellular calcium and NF-(k)B regulate hypoxia-induced leptin, VEGF, IL-6 and adiponectin secretion in human adipocytes","volume":"212","author":"Al-Anazi","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.jaut.2026.103612_bib39","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1111\/bph.14181","article-title":"Adipokines and inflammation: is it a question of weight?","volume":"175","author":"Francisco","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.jaut.2026.103612_bib40","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory mechanisms in obesity","volume":"29","author":"Gregor","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.jaut.2026.103612_bib41","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/ar3490","article-title":"Evidence of a role for Th17 cells in the breach of immune tolerance in arthritis","volume":"13","author":"Yu","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.jaut.2026.103612_bib42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3390\/jcm13010055","article-title":"Tailoring rheumatoid arthritis treatment through a sex and gender lens","volume":"13","author":"Carmona","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.jaut.2026.103612_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.909879","article-title":"What is the impact of sex hormones on the pathogenesis of rheumatoid arthritis?","volume":"9","author":"Raine","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.jaut.2026.103612_bib44","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s10067-018-4261-5","article-title":"Inflammatory dietary pattern and risk of developing rheumatoid arthritis in women","volume":"38","author":"Sparks","year":"2019","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.jaut.2026.103612_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1051082","article-title":"Systemic complications of rheumatoid arthritis: focus on pathogenesis and treatment","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.jaut.2026.103612_bib46","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1097\/BOR.0b013e328336ba63","article-title":"The rheumatoid arthritis HLA-DRB1 shared epitope","volume":"22","author":"Holoshitz","year":"2010","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.jaut.2026.103612_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052859","article-title":"Leptin in osteoarthritis and rheumatoid arthritis: player or bystander?","volume":"23","author":"Ait Eldjoudi","year":"2022","journal-title":"Int. J. Mol. Sci."}],"container-title":["Journal of Autoimmunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841126000909?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0896841126000909?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T07:25:22Z","timestamp":1794036322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0896841126000909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":47,"alternative-id":["S0896841126000909"],"URL":"https:\/\/doi.org\/10.1016\/j.jaut.2026.103612","relation":{},"ISSN":["0896-8411"],"issn-type":[{"value":"0896-8411","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Child-to-adult body size trajectories and risk of rheumatoid arthritis: the mediating role of metabolic unhealthiness, low-grade inflammation, and the modifying effect of genetic susceptibility","name":"articletitle","label":"Article Title"},{"value":"Journal of Autoimmunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jaut.2026.103612","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"103612"}}